A study conducted by researchers at the National Institutes of Health has provided the first epidemiologic evidence that the use of multivitamins by women is associated with longer telomeres: the protective caps at the ends of chromosomes that shorten with the aging of a cell. The study was reported online on March 11, 2009 in the American Journal of Clinical Nutrition.
Telomere length has been proposed as a marker of biological aging. Shorter telomeres have been linked with higher mortality within a given period of time and an increased risk of some chronic diseases.
For the current research, Honglei Chen and colleagues evaluated 586 participants aged 35 to 74 in the Sister Study, an ongoing prospective cohort of healthy sisters of breast cancer patients. Dietary questionnaires completed upon enrollment collected information concerning food and nutritional supplement intake. Stored blood samples were analyzed for leukocyte (white blood cell) DNA telomere length.
Sixty-five percent of the participants reported using multivitamin supplements at least once per month, and 74 percent consumed them daily. Eighty-nine percent of all multivitamin users consumed one a day multivitamin formulas, 21 percent consumed antioxidant combinations, and 17 percent were users of "stress-tabs" or B complex vitamins.
The researchers found 5.1 percent longer telomeres on average in daily users of multivitamins compared with nonusers. Increased telomere length was associated with one a day and antioxidant formula use, but not with stress-tabs or B complex. Individual vitamin B12 supplements were associated with increased telomere length and iron supplements with shorter telomeres. When nutrients from food were analyzed, vitamins C and E emerged as protective against telomere loss.
In their discussion of the findings, the authors explain that telomeres are particularly vulnerable to oxidative stress. Additionally, inflammation induces oxidative stress and lowers the activity of telomerase, the enzyme that that is responsible for maintaining telomeres. Because dietary antioxidants, B vitamins, and specific minerals can help reduce oxidative stress and inflammation, they may be useful for the maintenance of telomere length. In fact, vitamins C and E have been shown in cell cultures to retard telomere shortening and increase cellular life span.
"Our study provides preliminary evidence linking multivitamin use to longer leukocyte telomeres," the authors conclude. "This finding should be further evaluated in future epidemiologic studies and its implications concerning aging the etiology of chronic diseases should be carefully evaluated."
The premise of taking actions to maintain youthful health and vigor is based on findings from peer-reviewed scientific studies that identify specific factors that cause us to develop degenerative disease. These studies suggest that the consumption of certain foods, food extracts, hormones, or drugs will help to prevent common diseases that are associated with normal aging.
The National Academy of Sciences published three reports showing that the effects of aging may be partially reversible with a combination of acetyl-L-carnitine and lipoic acid (Hagen et al. 2002). One of these studies showed that supplementation with these two nutrients resulted in a partial reversal of the decline of mitochondrial membrane function while consumption of oxygen significantly increased. This study demonstrated that the combination of acetyl-L-carnitine and lipoic acid improved ambulatory activity, with a significantly greater degree of improvement in the old rats compared to the young ones. Human aging is characterized by lethargy, infirmity, and weakness. There is now evidence that supplementation with two over-the-counter supplements can produce a measurable antiaging effect.
The second study published by the National Academy of Sciences showed that supplementation with acetyl-L-carnitine and lipoic acid resulted in improved memory in old rats. Electron microscopic studies in the hippocampus region of the brain showed that acetyl-L-carnitine and lipoic acid reversed age-associated mitochondrial structural decay. In the third National Academy of Sciences study, scientists tested acetyl-L-carnitine and lipoic acid to see if an enzyme used by the mitochondria as biologic fuel could be restored in old rats. After 7 weeks of supplementation with acetyl-L-carnitine and lipoic acid, levels of this enzyme (carnitine acetyl-transferase) were significantly restored in the aged rats. Supplementation also inhibited free radical-induced lipid peroxidation, which enhanced the activity of the energy-producing enzyme in the mitochondria. The scientists concluded that feeding old rats acetyl-L-carnitine and lipoic acid can ameliorate oxidative damage, along with mitochondrial dysfunction.
If you’re one of the more than 72 million people in America who use a computer daily at work, you’re probably familiar with eye fatigue. Staring at a fixed distance object such as a computer screen for a long period of time can cause the muscles that focus your eyes (called the ciliary body) to tire or go into spasm. This can result in physical symptoms such as head discomfort, sensitivity to glare, tiredness, soreness, dryness, and blurry vision.
The new Super Zeaxanthin with Lutein & Meso-zeaxanthin Plus Astaxanthin contains a potent dose of astaxanthin, a carotenoid found in red algae called Haematococcus pluvialis. Studies show that taking astaxanthin with other carotenoids protects against free-radical induced DNA damage, repairs UVA-irradiated cells, and inhibits inflammatory cell infiltration. Astaxanthin also helps support vascular health within the eye and improves visual acuity. Its fat-soluble nature offers protection to sensitive cells inside the eye.
With its special combination of ingredients that targets eyestrain and protects visual acuity, new Super Zeaxanthin with Lutein & Meso-zeaxanthin Plus Astaxanthin is an exciting breakthrough in eye care.
Safely managing blood lipid levels can be a challenge for people as they get older. Yet an increasing number of doctors recognize the critical need to protect the arterial wall against low-density lipoprotein (LDL) oxidation and inflammatory insults.
For those who want to maintain healthful levels of lipids in the blood, Advanced Lipid Control contains a combination of two powerful nutrients that help protect key aspects of cardiovascular function. This special formula supports healthy cholesterol levels for those already within normal range and safeguards vascular and heart health, while providing excellent antioxidant protection.
Advanced Lipid Control contains theaflavins, which scientists have discovered hold multiple applications for arterial health. As well as supporting cholesterol levels that are already within the normal range, theaflavins have been shown in human studies to protect against LDL oxidation and favorably affect endothelial function, thus helping to maintain a healthy circulation.