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CR Mimetic Longevity Formula

60 vegetarian capsules
Item# 01429

Your Price:
$29.25 Save 25%

CR Mimetic Longevity Formula

60 vegetarian capsules
Item# 01429

Retail Price: $39.00

Your Price: $29.25 Save 25%

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  • CR Mimetic Longevity Formula
  • 60 vegetarian capsules
  • Item Catalog Number: 01429

CR Mimetic Longevity Formula mimics the anti-aging effects of calorie restriction and triggers youthful gene expression. This comprehensive formula provides a powerful blend of six phytonutrients, including resveratrol, pterostilbene, quercetin, grape seed polyphenols, black tea extract, and fisetin, a natural fruit antioxidant. All these phytonutrients have been shown to generate many of the same effects in the body as caloric restriction, without significant dietary modification. In particular, they help mimic caloric restriction’s favorable impact on genes that influence the aging process. Get broad-spectrum support for youthful gene expression from scientifically validated phytonutrients in this comprehensive formulation.

Benefits at a Glance

  • Mimic the anti-aging effects of calorie restriction
  • Trigger youthful gene expression
  • Favorably impact genes that influence the aging process
  • Powerful blend of six anti-aging nutrients

Trigger Youthful Gene Expression

Life Extension® has gone to extraordinary lengths to identify those compounds that simulate calorie restriction’s ability to trigger youthful gene expression— the process by which genes transmit signals that slow certain aspects of aging. In 2003, we introduced standardized extract of resveratrol.

In 2009, we introduced the “other” resveratrol, pterostilbene, a compound whose effects were found to work in synergy with resveratrol to activate your “longevity genes.”

We’ve combined six known calorie restriction mimetics — trans-resveratrol, trans-pterostilbene, quercetin, grape seed polyphenols, black tea extract, and fisetin — in one, high-potency formula.1-9

The Original 5 – Powerful Phytonutrients for Living Longer

Trans-resveratrol is the form of resveratrol used in scientific studies documenting remarkable longevity enhancing effects. You would have to drink many bottles of red wine to obtain a fraction of the trans-resveratrol (250 mg) found in CR Mimetic Longevity Formula.

Trans-pterostilbene directly activates genes “downstream” from the sites of resveratrol’s action, providing a powerful complementary stimulus to resveratrol’s ability to induce youthful gene expression. You would have to eat 135 cups of blueberries to obtain the amount of trans-pterostilbene that is contained in CR Mimetic Longevity Formula.

Quercetin inhibits the actions of enzymes in the liver from rapidly breaking down resveratrol in the bloodstream, thus enabling resveratrol to remain active longer in the body.

Grape seed extract provides proanthocyanidins that have multiple health benefits and work together with resveratrol to trigger favorable gene expression changes. Theaflavins from black tea inhibit the pro-inflammatory transcription factor NF-kB10,11 and stimulate the longevity factor Forkhead box 1 (FOXO1) in invertebrate and mammalian cells.12 You would have to drink 12 six-ounce cups of black tea each day to obtain the amount of theaflavins contained in CR Mimetic Longevity Formula.

The Sixth CR Mimetic Discovered – Fisetin!

This innovative formulation features the little-known flavonoid fisetin (which is most abundantly found in strawberries). It is the sixth compound shown to simulate a youthful gene expression pattern similar to calorie restriction13 without significant dietary modification.

Fisetin may also enhance the effects of resveratrol.14 Researchers have uncovered compelling evidence of fisetin’s ability to stabilize resveratrol by shielding it from metabolic breakdown14… thus extending its effects.

Fisetin has been shown to have the power to “switch on” powerful cell-signaling molecules that support youthful gene expression, DNA protection, and healthy cellular function.15 Fisetin also supports aging neurons in the presence of oxidative stress.15-17

And each serving of CR Mimetic Longevity Formula contains fisetin in an amount equivalent to 2 cups of strawberries, helping to further emulate calorie restriction’s favorable influence on your longevity genes.

Get the Longevity Benefits of Calorie Restriction without Restricting Calories

This unique formula provides cutting-edge broad-spectrum support for youthful gene expression from scientifically validated phytonutrients. Just two capsules a day of CR Mimetic Longevity Formula mimics the aging benefits of calorie restriction by triggering youthful gene expression — without restricting calories!

This supplement should be taken in conjunction with a healthy diet and regular exercise program. Individual results are not guaranteed and results may vary.

Ratings based on results of the 2017 Survey of Supplement Users. More information at

  1. Cell. 2006 Dec 15;127(6):1109-22.
  2. Curr Genomics. 2010 Dec;11(8):562-7.
  3. Mech Ageing Dev. 2008 Oct;129(10):611-3.
  4. Mol Nutr Food Res. 2008 Jun;52 Suppl 1:S62-70.
  5. Proc Jpn Acad Ser B Phys Biol Sci. 2011;87(3):104-13.
  6. Cytokine. 2009 Aug;47(2):137-42.
  7. Oxid Med Cell Longev. 2012;2012:741468.
  8. Anticancer Agents Med Chem. 2006 Sep;6(5):389-406.
  9. Nature. 2006 Nov 16;444(7117):337-42.
  10. Mol Nutr Food Res. 2011;55:198-208.
  11. J Biochem Mol Biol. 2003 Jan 31;36(1):66-77.
  12. Aging Cell. 2008;7(1):69-77.
  13. Aging Cell. 2011 Oct;10(5):908-11.
  14. Xenobiotica. 2000 Sep;30(9):857-66.
  15. Genes Nutr (2009) 4:297–307.
  16. Proc Natl Acad Sci U S A. 2006 Oct 31;103(44):16568-73.
  17. Brain Res. 2007 Oct 10;1173:117-25.


Supplement Facts

Serving size 2 vegetarian capsules

Servings per container 30

Amount per serving

Trans-Resveratrol [from Japanese knotweed extract (root)]

250 mg

Trans-Pterostilbene (from pTeroPure®)

3 mg

Quercetin (as quercetin dihydrate)

150 mg

Masquelier’s® Original OPCs [single and condensed (2-5 units) of flavanols & polyphenols from grape seeds]

50 mg

Black tea decaffeinated extract (leaf) [providing 36 mg TF2a theaflavin fraction]

300 mg

Fisetin [from wax tree extract (stem)]

48 mg

Other ingredients: vegetable cellulose (capsule), microcrystalline cellulose, stearic acid, silica.


pTeroPure® is a registered trademark of ChromaDex, Inc.
MASQUELIER’s® is a registered trademark of International Nutrition Company BV (INC), Loosdrecht, The Netherlands.

Dosage and Use
  • Take two (2) capsules daily with or without food, or as recommended by a healthcare practitioner.
  • Can be taken together or in divided doses.

Consult with your doctor before using this product if you have a bleeding disorder, or if you are taking anti-coagulant, anti-platelet, or diabetic medications.



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