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Mercury Amalgam Toxicity

Your Next Visit to the Dentist May Not be as Innocent as You Think

May 2001

By Jim O'Brien

Mercury Detoxification Protocol

To treat patients for mercury overload, doctors prescribe a variety of nutrients and drugs to chelate mercury out of the body and protect cells from the effects of the large amounts of free mercury being released into the bloodstream for urinary excretion. It is especially important to initiate this protocol at least two weeks before mercury dental fillings (amalgams) are to be removed.

What follows is a 33-day mercury detoxification protocol used by many alternative medicine doctors.

For weeks one and two, the following nutrients should be taken:
N-Acetyl-Cysteine (NAC) 600 mg twice a day
Alpha Lipoic Acid 250 mg two times a day
250 mg twice a day
Glycine 500 mg twice a day
Vitamin C 5,000 to 10,000 mg a day
Vitamin E 400 to 800 IU a day
MSM (methylsulphonyl methane)
1000 mg twice a day
Garlic (high-allicin form such as Pure Gar) Avoid if offensive odor becomes a social problem. 900 mg a day
Cilantro (Chinese parsley)
Stop using Cilantro after two weeks or on the day that mercury chelation therapy begins during the third week.
1 drop, rubbed on to the wrist two times a day
Chlorella may cause diarrhea, so starting off at the lower dose is important.
1500 to 3000 mg a day for the first 14 days. On days13-33 increase to 7000 to 8000 mg a day.
Avoid selenium for the 19 days of Chemet therapy that begins in the third week.
200 mcg
Multi-vitamin If Life Extension Mix were used, it would provide some of the individual nutrients recommended above.
Note: Health conscious people are already taking many of these natural mercury chelating and glutathione-enhancing nutrients.


Starting at week three, continue taking all of the above nutrients except selenium and cilantro and initiate treatment with the drug Chemet using the following dose:
First five days Days six through nineteen
Chemet (DMSA)
(meso-2,3-dimercaptosuccinic acid)
100 mg every eight hours 100 mg every twelve hours

Chemet (DMSA) is a sulfhydryl-containing, water-soluble, non-toxic, orally-administered metal chelator which has been in use as an antidote to heavy metal toxicity since the 1950s. More recent clinical use and research substantiates this compound’s efficacy and safety, and establishes it as the premier metal chelation compound, based on oral dosing, urinary excretion, and its safety characteristics compared to other chelating substances. Chemet is a prescription drug.

In lieu of oral Chemet therapy, some doctors prefer to use intravenous mercury chelation therapy which is described later in the protocol.

Blood and urine testing

Before initiating this 33-day mercury detoxification protocol, doctors suggest that a CBC-Chemistry blood test be performed that includes kidney-liver-thyroid function, lipids and magnesium. Of greatest concern is potential kidney toxicity that can occur when the body releases its mercury stores for excretion through the kidneys. Those with underlying kidney disease may not be able to undergo aggressive mercury detoxification therapy.

The only proven method of diagnosing mercury overload in the body is a 24 hour urine collection. This involves a laboratory sending you a urine collection bag for you to urinate in over a 24 hour period. If urine mercury levels are elevated, the 33-day protocol is advised. At the end of the 33-days, another 24-hour urine collection is recommended to verify that sufficient mercury detoxification has really occurred.

Intravenous mercury chelation therapy

Some doctors aggressively treat mercury overload with intravenous therapy designed to specifically chelate mercury from the body. The chelating agent used to remove mercury from the body is called DMPS (dimercapto-propanyl-sulfate). In addition to DMPS, doctors often add ten grams of vitamin C and other nutrients to further help detoxify the body and protect cells during this mercury removal process.

It is important to note that while standard chelation therapy using EDTA (ethylene diamine tetra acidic acid) removes calcium and lead, it does not adequately bind to and remove mercury.

Intravenous therapy using DMPS may involve six monthly visits to the doctor’s office until a urine test shows that mercury levels have dropped to the safest possible level.

Drug and supplement availability

Intravenous therapies are available from physicians who specialize in mercury detoxification therapy. Chemet is a prescription drug sold at most pharmacies. Nutrients such as cilantro, chlorella, alpha lipoic acid, etc. are available from The Life Extension Buyers Club.

The need for professional expertise

When undergoing mercury detoxification therapy, using a doctor with particular expertise in this field provides the greatest assurance of a safe and effective outcome. At the end of this article, we have provided contact information for Dr. Williamson’s clinic in Boca Raton, Florida.

For a list of alternative physicians in your area that may be knowledgeable about mercury detoxification, refer to the “Innovative Physician” section on The Foundation's Home Page at It is important to note that not all of these doctors have expertise in mercury detoxification.

Undergoing complete mercury detoxification requires strict adherence to an individualized regimen of diet modification, supplements, drugs, multiple physician visits, blood-urine tests, etc. For more detailed information about what is involved in mercury detoxification, refer to the Life Extension Abstracts section.