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Fats for Life

July 2001

By Karin Granstrom Jordan, M.D.


Barbagallo CM et al.: Lipoprotein profile and high-density lipoproteins: subfractions distribution in centenarians. Gerontology 1998; 44(2):106-10.

Biagi PL et al.: Gamma-linolenic acid dietary supplementation can reverse the aging influence on rat liver microsome delta 6-desaturase activity. Biochim Biophys Acta. 1991; 1083(2):187-92.

Birch EE et al.: A randomized controlled trial of early dietary supply of long-chain polyunsaturated fatty acids and mental development in term infants. Dev Med Child Neurol. 2000; 42(3):174-81.

Bolton-Smith C et al.: Evidence for age-related differences in the fatty acid composition of human adipose tissue, independent of diet. Eur J Clin Nutr. 1997; 51(9):619-24.

Borkman M, Storlien LH et al.: The relation between insulin sensitivity and the fatty-acid composition of skeletal-muscle phospholipids. N Engl J Med. 1993; 328(4):238-44.

Christensen NJ et al.: Resting venous plasma adrenalin in 70-year-old men correlated positively to survival in a population study: the significance of the physical working capacity. J Intern Med. 1994; 235(3):229-32.

Daviglus ML et al.: Fish consumption and the 30-year risk of fatal myocardial infarction. N Engl J Med. 1997; 336(15):1046-53.

de Urquiza AM et al.: Docosahexaenoic acid, a ligand for the retinoid X receptor in mouse brain. Science. 2000; 290(5499):2140-4.

Engler MM: Comparative study of diets enriched with evening primrose, black currant, borage or fungal oils on blood pressure and pressor responses in spontaneously hypertensive rats. Prostaglandins Leukot Essent Fatty Acids. 1993; 49(4):809-14.

Engler MM et al.: Dietary gamma-linolenic acid lowers blood pressure and alters aortic reactivity and cholesterol metabolism in hypertension. J Hypertens. 1992; 10(10):1197-204.

Engler MM et al.: Effects of dietary gamma-linolenic acid on blood pressure and adrenal angiotensin receptors in hypertensive rats. Proc Soc Exp Biol Med. 1998; 218(3):234-7.

Engler MM et al.: Docosahexaenoic acid is an antihypertensive nutrient that affects aldosterone production in SHR. Proc Soc Exp Biol Med. 1999; 221(1):32-8.

Fardella CE et al.: Primary hyperaldosteronism in essential hypertensives: prevalence, biochemical profile, and molecular biology. J Clin Endocrinol Metab. 2000; 85(5):1863-7.

Forman BM et al.: Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc Natl Acad Sci U S A. 1997; 94(9):4312-7.

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Greiner RS et al.: Rats with low levels of brain docosahexaenoic acid show impaired performance in olfactory-based and spatial learning tasks. Lipids. 1999; 34 Suppl:S239-43.

Guivernau M et al.: Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production. Prostaglandins Leukot Essent Fatty Acids. 1994; 51(5):311-6.

Hamazaki T, Sawazaki S et al.: The effect of docosahexaenoic acid on aggression in young adults. A placebo-controlled double-blind study. J Clin Invest. 1996; 97(4):1129-33.

Hamazaki T, Sawazaki S et al.: Administration of docosahexaenoic acid influences behavior and plasma catecholamine levels at times of psychological stress. Lipids. 1999; 34 Suppl:S33-7.

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Horrocks LA, Yeo YK: Health benefits of docosahexaenoic acid (DHA) Pharmacol Res. 1999; 40(3):211-25.

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Kimura S etal.: Dietary docosahexaenoic acid (22:6n-3) prevents the development of hypertension in SHRSP. Clin Exp Pharmacol Physiol. 1995; 22 Suppl 1:S308-9.

Kyle DJ et al.: Low serum docosahexaenoic acid is a significant risk factor for Alzheimer's dementia. Lipids. 1999; 34 Suppl:S245.

Lim SY and Suzuki H: Intakes of dietary docosahexaenoic acid ethyl ester and egg phosphatidylcholine improve maze-learning ability in young and old mice. J Nutr. 2000; 130(6):1629-32.

Lim SY and Suzuki H: Changes in Maze Behavior of Mice Occur after Sufficient Accumulation of Docosahexaenoic Acid in Brain. J Nutr. 2001; 131(2):319-324.

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Mori TA et al.: Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans. Hypertension. 1999; 34(2):253-60.

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Prisco D et al.: Effect of medium-term supplementation with a moderate dose of n-3 polyunsaturated fatty acids on blood pressure in mild hypertensive patients. Prostaglandins Leukot Essent Fatty Acids. 2000; 62(2):129-34.

Sawazaki S et al.: The effect of docosahexaenoic acid on plasma catecholamine concentrations and glucose tolerance during long-lasting psychological stress: a double-blind placebo-controlled study. J Nutr Sci Vitaminol (Tokyo). 1999; 45(5):655-65.

Singer P et al.: Effects of dietary oleic, linoleic and alpha-linolenic acids on blood pressure, serum lipids, lipoproteins and the formation of eicosanoid precursors in patients with mild essential hypertension. J Hum Hypertens. 1990; 4(3):227-33.

Stark KD et al.: Effect of a fish-oil concentrate on serum lipids in postmenopausal women receiving and not receiving hormone replacement therapy in a placebo-controlled, double-blind trial. Am J Clin Nutr. 2000; 72(2):389-94.

Storlien LH et al.: Fat feeding causes widespread in vivo insulin resistance, decreased energy expenditure, and obesity in rats. Am J Physiol. 1986; 251(5 Pt 1):E576-83.

Storlien LH et al.: Fish oil prevents insulin resistance induced by high-fat feeding in rats. Science. 1987; 237(4817):885-8.

Storlien LH et al.: Dietary fats and insulin action. Diabetologia 1996; 39(6):621-31.

Terano T et al.: Docosahexaenoic acid supplementation improves the moderately severe dementia from thrombotic cerebrovascular diseases. Lipids. 1999; 34 Suppl:S345-6.

van Jaarsveld PJ et al.: The influence of different ratios and dosages of an w6:w3 fatty acid supplement on the lipoprotein cholesterol and fatty acid profile in nonhuman primates on a Western atherogenic diet. Nutrition Research 1997; 17 (11/12);1733-1747.

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Vessby B et al.: Insulin sensitivity is related to the fatty acid composition of serum lipids and skeletal muscle phospholipids in 70-year-old men. Diabetologia. 1994; 37(10):1044-50.

Wahli W et al.: Fatty acids, eicosanoids, and hypolipidemic agents regulate gene expression through direct binding to peroxisome proliferator-activated receptors. Adv Exp Med Biol. 1999; 447:199-209.

Weber KT: Aldosterone and spironolactone in heart failure. N Engl J Med. 1999; 341(10):753-5.