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Life Extension Magazine

The Purest EPA-DHA Fish Oil in the World

By William Faloon

Virtues of the Mediterranean diet

A large body of human data indicates potent health benefits in those who consume a Mediterranean diet, characterized by relatively copious amounts of fish, olive oil, fruits, vegetables, and herbs.

The predominant fats in the Mediterranean diet are the omega-3s and monounsaturated fats from olive oil. While the monounsaturated fats in olive oil are a crucial component of the Mediterranean diet, the rich mixture of polyphenols in the olive fruit appears to be equally important.17

For example, published studies have shown that the olive fruit polyphenol—hydroxytyrosol—scavenges the dangerous free radical hydrogen peroxide and reduces LDL susceptibility to oxidation.18 The oxidation of LDL plays a significant role in the development of vascular impairment.

In a randomized, double-blind, crossover study, human subjects consumed three different extra-virgin olive oils with incrementally greater levels of polyphenols. The results showed that as the polyphenol content of the olive oil increased, the oxidation of LDL decreased. Polyphenol-rich olive oil also raised beneficial HDL levels. Both effects are associated with an improved cardiovascular risk profile.19

In another study, researchers tested the effects of feeding three olive oils with incrementally greater levels of polyphenols to a group of healthy male volunteers. Subjects in this randomized, double-blind study consumed standardized doses of polyphenol-rich olive oil. The results showed that oxidized LDL decreased, glutathione antioxidant activity increased, and beneficial HDL levels increased in the participants. These effects were proportionally greater as olive polyphenol content increased. All of these changes reflect improvements in surrogate markers of cardiovascular health.20

Super Omega-3 contains a standardized olive fruit extract to provide the full spectrum of benefits associated with the ingestion of fish and olive oils, including the potent hydroxytyrosol polyphenol.

Arachidonic Acid’s Destructive Cascade

One reason people supplement with fish oil is to suppress the production of arachidonic acid in the body. To better understand how arachidonic acid can cause arthritic and cardiovascular conditions, the chart below shows how arachidonic acid cascades down into joint-destroying, pro-thrombotic compounds.

Chart 2: This chart shows the pathways down which arachidonic acid cascades to form toxic inflammatory compounds. Fish oil and a healthy diet help suppress arachidonic acid production in the body.

New olive oil extract

When investigating why consumption of olive foods results in such marked reductions in human maladies, scientists uncovered another olive polyphenol that functions via specific beneficial mechanisms.

Blood platelets guard against excessive bleeding. When our platelets become over-activated, they can form clots inside arteries leading to acute circulatory disruptions. An olive fruit polyphenol called oleuropein has been shown to specifically reduce blood platelet activity in humans,21 thus providing yet another explanation as to why those who consume a Mediterranean diet have such low rates of sudden vascular events.

Oleuropein from olive fruit has additional biological properties. When administered to human fibroblast skin cells cultures, oleuropein delays the appearance of senescent (aging) structural changes and increases the life span of these cells by approximately 15%.22 The scientists who conducted this study stated: “these data demonstrate the beneficial effect of oleuropein on human fibroblasts undergoing replicative senescence and provide new insights toward enhancement of cellular antioxidant mechanisms by natural compounds that can be easily up-taken through normal diet.”

Those afflicted with certain inherited genetic mutations are predisposed to contracting disorders related to defects in cell replication. A gene of particular concern to some women is HER2. When evaluating various olive polyphenols on HER2 expression, oleuropein most effectively down-regulated HER2 expression.23 The scientists who conducted this study remarked that their findings help explain why those who consume a Mediterranean diet have such marked reductions in disorders related to excess expression of the HER2 gene.

Super Omega-3 not only contains the finest omega-3 fish oil blend in the world, but also provides an olive blend standardized for hydroxytyrosol and oleuropein.

Olive oil and fish oil work better together than fish oil alone

Patients suffering from chronic age-related discomforts were randomized into three groups. The first group received EPA/DHA-rich fish oil, the second group received the same fish oil with polyphenol-rich olive oil, while the third group received a placebo.

At the study’s end, the fish oil-only group showed significant improvement in several measurements. The group receiving both fish oil and polyphenol-enriched olive oil, however, exhibited an “accentuated improvement” across a broad-spectrum of parameters including patients’ subjective assessments and satisfaction with their daily living activities.24

This study helps further corroborate the multiple health benefits associated with the Mediterranean diet, rich in monounsaturated and omega-3 fatty acids, along with plant polyphenols.

The new Super Omega-3…even better quality…same low price! No drug has ever shown the broad-spectrum health benefits of fish oil.

Each year, consumers pay higher prices for patented medications that have only limited therapeutic targets. These drugs are also known to induce side effects, despite the FDA’s assurance of their safety.

Life Extension’s new Super Omega-3 provides the purest EPA/DHA fish oil blend, standardized sesame lignans, and the most beneficial extracts from the olive fruit at no additional charge.

If the government ever turned dietary supplements into prescription drugs, it would not be possible to make these rapid improvements, as the FDA would mandate a new round of costly clinical testing every time a change was made. The end result might be an improved (and higher priced) drug many years down the road, depending on the FDA bureaucratic decision-making process.

Life Extension has a dual mission of providing members with the finest nutritional formulations while leading by example in showing the superiority of the free market over today’s regulatory quagmire that strangles medical innovation.

The new Super Omega-3 with Sesame Lignans and Olive Fruit Extract is a prime example of how consumers benefit when free market competition is allowed to create superior products without increasing prices.


1. David Pimentel, et al. Ecology of Increasing Disease. BioScience, Vol. 48, No. 10 (Oct., 1998), pp. 817-826

2. Ide, T, Hong, DD, Ranasinghe, P, et al. Interaction of dietary fat types and sesamin on hepatic fatty acid oxidation in rats. Biochem Biophys Acta. 2004 Jun 1;1682(1-3):80-91.

3. Utsunomiya, T, Chavali, SR, Zhong, WW, et al. Effects of sesamin-supplemented dietary fat emulsions on the production of lipopolysaccharide-induced prostanoids and tumor necrosis factor alpha in rats. Am J Clin Nutr. 2000 Sep;72(3):804-8.

4. Chavali, SR, Zhong, WW, Forse, RA Dietary alpha-linolenic acid increases TNF-alpha, and decreases IL-6, IL-10 in response to LPS: effects of delta-5-desaturation of omega6 and omega3 fatty acids in mice. Prostaglandins Leukot Essent Fatty Acids. 1998 Mar;58(3):185-91.

5. Umeda-Sawada R, Ogawa M, Igarashi O. The metabolism and N-6/N-3 ratio of essential fatty acids in rats: effect of dietary arachidonic acid and a mixture of sesame lignans (sesamin and episesamin). Lipids. 1998 Jun;33(6):567-72.

6. Shimizu S, Akimoto K, Shinmen Y, et al. Sesamin is a potent and specific inhibitor of delta-5-desaturase in polyunsaturated fatty acid biosynthesis. Lipids. 1991 Jul;26(7):512-6.

7. Fujiyama-Fujiwara Y, Umeda-Sawada R, Kuzuyama M, Igarashi O. Effects of sesamin on the fatty acid composition of the liver of rats fed N-6 and N-3 fatty acid rich diet. J. Nutr. Sci. Vitaminol. (Tokyo) 1995 Apr;41(2):217-25.

8. Gu JY, Wakizono Y, Tsujita A, et al. Effects of sesamin and alpha-tocopherol, individually or in combination, on the polyunsaturated fatty-acid metabolism, chemical mediator production, and immunoglobulin levels in Sprague-Dawley rats. Biosci. Biotechnol. Biochem. 1995 Dec; 59(12):2198-202.

9. Chavali SR, Zhong WW, Forse RA. Dietary alpha-linolenic acid increases TNF-alpha, and decreases IL-6, IL-10 in response to LPS: effects of sesamin on the delta-5 desaturation of omega6 and omega3 fatty acids in mice. Prostaglandins Leukot Essent Fatty Acids. 1998 Mar;58(3):185-91.

10. Akimoto K, Kitagawa Y, Akamatsu T, et al. Protective effects of sesamin against liver damage caused by alcohol or carbon tetrachloride in rodents. Ann Nutr Metab. 1993;37(4):218-24.

11. Ikeda S, Kagaya M, Kobayashi K, et al. Dietary sesame lignans decrease lipid peroxidation in rats fed docosahexaenoic acid. J Nutr Sci Vitaminol. (Tokyo). 2003 Aug;49(4):270-6.

12. Kang M, Katsuzaki H, Osawa T. Inhibition of 2,2’-azobis[2,4-dimethylvaleronitrile]-induced lipid peroxidation by sesaminols. Lipids. 1998;33(10):1031-6.

13. Chavali SR, Zhong WW, Forse RA. Dietary alpha-linolenic acid increases TNF-alpha, and decreases IL-6, IL-10 in response to LPS: effects of delta-5-desaturation of omega6 and omega3 fatty acids in mice. Prostaglandins Leukot Essent Fatty Acids. 1998 Mar;58(3):185-91.

14. Yamashita K, Kagaya M, Higuti N, et al. Sesamin and alpha-tocopherol synergistically suppress lipid-peroxide in rats fed a high docosahexaenoic acid diet. Biofactors. 2000;11(1-2):11-3.

15. Ashakumary L, Rouyer I, Takahashi Y, et al. Sesamin, a sesame lignan is a potent inducer of hepatic fatty acid oxidation in the rat. Metabolism. 1999 Oct;48(10):1303-13.

16. Kushiro M, Masaoka T, Hageshita S, et al. Comparative effect of sesamin and episesamin on the activity and gene expression of enzymes in fatty acid oxidation and synthesis in rat liver. J Nutr Biochem. 2002 May;13(5):289-295.

17. Trichopoulou A, Vasilopoulou E. Mediterranean diet and longevity. Br J Nutr. 2000 Dec;84 Suppl 2:S205-9.

18. Rietjens SJ, Bast A, Haenen GR. New insights into controversies on the antioxidant potential of the olive oil antioxidant hydroxytyrosol. J Agric Food Chem. 2007 Sep 5;55(18):7609-14.

19. Weinbrenner T, Fito M, de la Torre R, et al. Olive oils high in phenolic compounds modulate oxidative/antioxidative status in men. J Nutr. 2004 Sep;134(9):2314-21.

20. Gimeno E, Fito M, Lamuela-Raventos RM, et al. Effect of ingestion of virgin olive oil on human low-density lipoprotein composition. Eur J Clin Nutr. 2002 Feb;56(2):114-20.

21. Singh I, Mok M, Christensen AM, Turner AH, Hawley JA. The effects of polyphenols in olive leaves on platelet function. Nutr Metab Cardiovasc Dis. 2007 Mar 6.

22. Katsiki M, Chondrogianni N, Chinou I, Rivett AJ, Gonos ES. The olive constituent oleuropein exhibits proteasome stimulatory properties in vitro and confers life span extension of human embryonic fibroblasts. Rejuvenation Res. 2007 Jun;10(2):157-72.

23. Menendez JA, Vazquez-Martin A, Colomer R, Brunet J, Carrasco-Pancorbo A, Garcia-Villalba R, Fernandez-Gutierrez A, Segura-Carretero A. Olive oil’s bitter principle reverses acquired autoresistance to trastuzumab (Herceptin) in HER2-overexpressing breast cancer cells. BMC Cancer. 2007 May 9;7:80.

24. Berbert AA, Kondo CR, Alemendra CL, Matsuo T, Dichi I. Supplementation of fish oil and olive oil in patients with rheumatoid arthritis. Nutrition. 2005 Feb;21(2):131-6.