What Doctors Don't Know about InflammationJanuary 2013
By Logan Bronwell
Colitis and Gastro-Protection
Colitis—meaning inflammation of the colon, or large intestine—is most commonly seen in inflammatory bowel disease, including Crohn's disease. The Centers for Disease Control estimates that up to 1.4 million Americans suffer from this condition.27
There is still no medical cure.
However, black cumin seed oil and its components exert powerful effects that can slow colonic inflammation.6 Lab studies reveal that pre-treating animals with thymoquinone as extracted from black cumin seed oil completely prevents experimentally-induced colitis.28
Importantly, treatment with black cumin seed oil lowers levels of pro-inflammatory cytokines.29
Studies have shown that both black cumin seed oil and thymoquinone strongly protect the delicate stomach lining against the injurious effects of alcohol and other toxins, and even against the effects of stress.30,31 Markers of tissue oxidation were sharply reduced.30
Atherosclerosis is a major consequence of chronic inflammation—making it an appropriate target for therapy with anti-inflammatory black cumin seed oil, with its powerful antioxidant effects. Working together, these two mechanisms lower the risk of atherosclerosis and consequently, heart attacks, strokes, and other artery diseases.
Animals supplemented with black cumin seed oil demonstrated lower levels of dangerous LDL-cholesterol, and higher levels of HDL cholesterol, which may be protective.32,33
Black cumin seed oil neutralizes lipid oxidation and reduces the impact of oxidized LDL, a major trigger for the atherosclerotic plaques that block blood flow to cause heart attacks and strokes.33
Black cumin seed oil has a major impact on a destructive process known as ischemia-reperfusion injury. This serious damage occurs to tissue and organs when, following blockage of an artery, the oxygen-rich blood flow is then restored. This complex phenomenon releases a massive outpouring of reactive oxygen species that can damage tissue as severely as the original blockage! Ischemia-reperfusion injury is responsible for many of the debilitating long-term effects seen in survivors of strokes and heart attacks.
For example, the powerful protection provided by black cumin seed oil against ischemia-reperfusion injury has now been convincingly demonstrated in the kidney—one of the main targets of the insidious effects of atherosclerosis.34
The twin problems of increased harmful chronic inflammation combined with decreased beneficial immune responses are major contributors to aging, chronic disease, and early death.
The oil of black cumin seed has historically been used to combat conditions we now understand to be related to these fundamental, age-related, inflammatory and immunological disturbances.
Modern scientific analysis shows that black cumin seed oil contains components that re-establish optimal inflammatory balance—powerfully suppressing chronic inflammation, while at the same time promoting healthy immune responses.
As a result of that delicate immunological balancing, supplementation with black cumin seed oil has the potential to slow—and even reverse—many of the most devastating aging-related conditions.
If you have any questions on the scientific content of this article, please call a Life Extension® Wellness Specialist at 1-866-864-3027.
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- Franceschi C. Inflammaging as a major characteristic of old people: can it be prevented or cured? Nutr Rev. 2007 Dec;65(12 Pt 2):S173-6.
- Kanapeckiene V, Kalibatas J, Redaitiene E, Ceremnych J. The association between cytomegalovirus infection and aging process. Medicina (Kaunas). 2007;43(5):419-24.
- Padhye S, Banerjee S, Ahmad A, Mohammad R, Sarkar FH. From here to eternity - the secret of Pharaohs: Therapeutic potential of black cumin seeds and beyond. Cancer Ther. 2008;6(b):495-510.
- Shahzad M, Yang X, Raza Asim MB, et al. Black seed oil ameliorates allergic airway inflammation by inhibiting T-cell proliferation in rats. Pulm Pharmacol Ther. 2009 Feb;22(1):37-43. Epub 2008 Nov 27.
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- Finlay TM, Abdulkhalek S, Gilmour A, et al. Thymoquinone-induced Neu4 sialidase activates NFkappaB in macrophage cells and pro-inflammatory cytokines in vivo. Glycoconj J. 2010 Aug;27(6):583-600.
- Finlay TM, Jayanth P, Amith SR, et al. Thymoquinone from nutraceutical black cumin oil activates Neu4 sialidase in live macrophage, dendritic, and normal and type I sialidosis human fibroblast cells via GPCR Galphai proteins and matrix metalloproteinase-9. Glycoconj J. 2010 Apr;27(3):329-48.
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