Brain Tumor - Glioblastoma
Glioblastoma multiforme is an aggressive type of brain tumor for which new and better treatment options are urgently needed (Paolillo 2018; Alexander 2017). Surgery, radiotherapy, and chemotherapy are currently used to treat glioblastoma, but are far from ideal interventions, as they cause many side effects and have limited efficacy (Paolillo 2018; Arevalo 2017; Bianco 2017; Polivka 2017; Anjum 2017).
Recent cases of glioblastoma in prominent individuals—including Senators John McCain and Edward Kennedy—have helped raise awareness about this harrowing disease (Razmara 2018), and researchers are beginning to uncover promising novel therapies (Polivka 2017). In recent years, tremendous progress has been made toward developing better treatments for glioblastoma (Paolillo 2018).
Emerging evidence has identified a virus called cytomegalovirus (CMV) and a potential relationship with the development of glioblastoma (Dziurzynski 2012; Barami 2010). Also, a groundbreaking study published in 2013 in the New England Journal of Medicine showed that the antiviral drug valganciclovir (Valcyte) improved survival in some glioblastoma patients (Soderberg-Naucler 2013). Pioneering work at Duke University using a bioengineered poliovirus produced remarkable response rates in glioblastoma patients (Brown 2014; Inman 2016). New evidence on the effects of some off-label drugs in glioblastoma has been encouraging as well (Abbruzzese 2017). For instance, drugs such as metformin (Kast 2011) and cimetidine (Berg 2016) have shown promise in laboratory studies. Also, integrative, natural interventions, such as vitamin D, quercetin, selenium, and melatonin are being actively explore, with intriguing preliminary results (Park 2017; Yakubov 2014).
This protocol aims to empower people affected by glioblastoma with knowledge about the disease and how it is typically managed, as well as emerging treatment strategies potentially accessible through clinical trials. This protocol will also present evidence for the potential complementary role of dietary and integrative interventions in glioblastoma management.
This protocol should be consulted along with other relevant protocols, including: