Suppress Deadly After-Meal Blood Sugar SurgesFebruary 2012
By Daniel Becker
High blood sugar is fast becoming the leading preventable killer of maturing individuals in the United States. In addition to the 26 million Americans with diabetes, the Centers for Disease Control estimate that more than a third of the general population is now pre-diabetic.1
This may be just the tip of the iceberg.
As Life Extension® members know, recent data confirm that risk for most degenerative diseases and death rise dramatically when fasting blood glucose exceeds 85 mg/dL.2
Yet the medical establishment persists in defining readings up to 99 mg/dL as "safe." By this measure, virtually all of us are vulnerable to diabetic complications.
Even more alarming is widespread physician ignorance of the stealth danger posed by blood sugar surges after meals that can reach diabetic levels and last for hours—or even days.
These after-meal glucose "spikes" inflict silent damage to cells via multiple mechanisms and have been linked to cardiovascular disease, cancer, Alzheimer’s disease, kidney failure, and retinal damage.3-16
The good news is there are documented ways to suppress deadly after-meal glucose surges.
The most recent is a green coffee bean extract shown to neutralize a key enzyme that facilitates after-meal glucose surges.
When tested on humans in a placebo-controlled study, this natural extract produced an extraordinary 24% drop in after-meal blood sugar in just 30 minutes!17
Silent Epidemic of High Blood Sugar
The percentage of adults suffering from dangerous, chronically high blood sugar has been vastly underestimated.
Currently, you aren’t considered diabetic unless your fasting blood glucose is higher than 125 mg/dL. The range from 100-125 mg/dL is considered "pre-diabetic," while anything lower is defined as normal.
Unfortunately, your risk for age-related disease is far greater at these "normal levels" than has been previously recognized. Optimal fasting glucose should be within the range of 70-85 mg/dL.
A recent study of 46,000 middle-aged individuals revealed that more than 80% had fasting blood sugar of 85 mg/dL or higher.18 A similar epidemiological analysis of 11,000 middle-aged and older people found that more than 85% had fasting blood sugar of 85 mg/dL or higher.19
As Life Extension®has long warned, a thorough survey of the scientific literature confirms that maturing individuals with blood sugar levels in these ranges—below 100 mg/dL—are nonetheless at substantially increased risk of virtually all degenerative diseases, including:
One team of researchers found that the risk of developing diabetes itself was increased more than seven-fold in people with fasting glucose levels of 105-109 mg/dL, compared with people with fasting glucose levels less than 85 mg/dL.19
An analysis of 1,800 maturing individuals revealed that coronary artery disease rates over a 10-year period in individuals currently defined as "pre-diabetic" were nearly identical to those with full-blown diabetes.39
A similar analysis of 33,230 men found that high glucose within the "normal" range was independently associated with a 38% increase in deaths from digestive tract cancers.40
These results underscore the critical need to redefine diabetes as fasting glucose above 85 mg/dL.
Table 1: Increased Health Risks in People with "Normal" Glucose Levels
Undetected Daily Diabetic Glucose Levels?
Conventional medicine’s approach to glucose control goes beyond the problem of outdated reference ranges. Fasting blood glucose concentrations alone do not identify individuals with an increased risk of glucose-related disease onset because they do not detect dangerous after-meal glucose spikes.41,42
The current diagnostic of fasting glucose readings is only a snapshot that does not adequately measure of an aging individual’s hour-to-hour glucose status over the course of the entire day.
By definition, fasting blood glucose tests are conducted eight or more hours or more after your last meal. This method fails to account for a vital risk marker specific to you as an individual: after each meal, your blood sugar rises sharply for at least two hours before returning to normal.
Depending on the number and frequency of meals consumed, an aging individual may sustain dangerously high blood sugar throughout the day that will not be detected by conventional measures.
A mounting body of scientific evidence suggests that after-meal glucose spikes inflict as much or more damage than high fasting blood sugar.43-46
For example, in aging individuals with "normal" blood sugar readings and "normal" glucose-tolerance tests, heart attack risk increases by 58% for a 21 mg/dL increase in after-meal blood sugar.47 And for a similar after-meal increase, risk of cardiac death increases by 26%.48
This means that if your blood sugar surges 63 mg/dL after a meal, your risk of cardiac death increases nearly twofold.
One research team found that risk of stroke increased when fasting glucose rose above 83 mg/dL. And every 18 mg/dL increase beyond 83 mg/dL resulted in a 27% greater risk of dying from stroke!5
This means that an individual with a fasting blood glucose level of 119 mg/dL has a 54% higher risk of stroke-related death compared to an individual whose fasting blood glucose is only 83 mg/dL. If you wonder why stroke continues to disable and kill so many—despite better control of hypertension than ever—look no further than the epidemic of high blood glucose plaguing aging humans.
These alarming data underscore the vital importance of suppressing after-meal glucose surges and controlling fasting blood glucose in order to prolong healthy life span.
The Little-Known Enzyme Behind Chronic Blood Sugar Overload
Most people think blood sugar levels are determined by the amount of carbohydrates or sugar they eat and how well their pancreas is working.
The truth is more complex.
You won’t hear this from most physicians, but your liver also plays a key role in regulating blood sugar, one that contributes directly to dangerous blood glucose surges after heavy meals.
Under normal conditions, the liver keeps a certain amount of sugar in storage. If your blood sugar falls too low, it releases this stored sugar in order to boost blood glucose back to healthy levels in a process called glycogenolysis.
If its stores of sugar are depleted, your liver has another means at its disposal to boost blood sugar: making sugar on its own from other sources, including fats and protein through a process called gluconeogenesis.
Humans evolved this capability to prevent acute, potentially deadly hypoglycemia (low blood sugar) during near-starvation states.
In young, healthy individuals, both these processes—sugar release or glycogenolysis and blood sugar synthesis or gluconeogenesis—are naturally suppressed after a meal to prevent blood sugar from getting too high.
As you age, this balancing mechanism may become impaired. Your liver releases stored sugar and makes additional sugar after you finish a meal—precisely when your body needs additional blood sugar the least.
At the core of pathologic glycogenolysis (release of stored blood sugar) and gluconeogenesis (synthesis of new sugar) is the enzyme glucose-6-phosphatase. Heavy meals can activate this enzyme, which in turn tells your liver to release its sugar stores and helps it to make more sugar, despite the flood of glucose from the meal you just finished.
It is this age-related dysregulation of glucose-6-phosphatase activity that accounts for the difficulty many maturing individuals face in maintaining optimal glucose levels. The dual processes of glycogenolysis and gluconeogenesis triggered by glucose-6-phosphatase can keep blood sugar high even with a lower-calorie or low-carbohydrate diet since glucose can also be synthesized from proteins and fats. (Note those who practice calorie restriction are usually able to keep their fasting glucose below 86 mg/dL and after-meal glucose surges below 120 mg/dL.)
Suppressing the activity of glucose-6-phosphatase is a cornerstone strategy in maintaining control of after-meal blood sugar spikes and limiting their potentially destructive impact.
In the quest to identify compounds that might favorably target the glucose-6-phosphatase enzyme, researchers turned their attention to the fact that heavy coffee drinkers enjoyed dramatically lower risk of diabetes.
Chlorogenic Acid Combats Excess Glucose
An abundance of studies confirms that, in addition to protection against various diseases,5,51-56 increased coffee consumption results in a substantially reduced risk of diabetes.56-61
The prestigious journal Lancet published a 2002 population study that included over 17,000 people. The researchers found a 50% lower risk of diabetes among those who consumed 7 cups of coffee a day compared to those who drank only 2 cups a day.61
Coffee’s anti-diabetic benefits are dose-dependent. In other words, the more you drink, the greater the benefit. And therein lies the problem: drinking seven cups or more of coffee every day is impractical for most people. This set researchers on a quest to uncover the specific glucose-lowering agents contained in coffee.
Coffee’s contents are complex, containing more than 1,000 discrete compounds.62
Compelling new data reveal that the chlorogenic acid content in coffee is primarily responsible for its glucose-lowering effects via several interesting mechanisms.63,64
Chlorogenic acid inhibits the glucose-6-phosphatase enzyme that stimulates glycogenolysis and gluconeogenesis.65,66 As discussed earlier, excessive activity of this enzyme contributes to dangerous after-meal blood sugar spikes and high blood glucose levels between meals.67
Chlorogenic acid directly inhibits glucose absorption from the intestinal tract. Studies show that coffee with a high chlorogenic acid content delays intestinal glucose absorption.59
Chlorogenic acid inhibits the intestinal enzyme alpha-glucosidase that breaks apart complex sugars and enhances their absorption.68 Slowing the breakdown of those common sugars (including sucrose, or table sugar), dramatically limits after-meal glucose spikes.
Chlorogenic acid-rich plant extracts have been shown to reduce fasting blood glucose values by more than 15% in diabetic patients with poor response to medication.69 A similar effect was seen in healthy volunteers, whose intestinal absorption of glucose was reduced by 7% following a chlorogenic acid-enriched coffee drink.70 And a chlorogenic acid supplement of 1 gram reduced glucose levels by 13 mg/dL, 15 minutes after an oral glucose challenge, demonstrating its ability to lower the after-meal spike in humans.71
A chlorogenic acid-rich extract of green coffee beans is also effective in animal studies against weight gain, reducing total weight and body fat accumulation by inhibiting fat absorption and preventing new fat production in liver tissue.72,73 Chlorogenic acid reduces liver fat content in animal studies as well, a vital factor in reducing the impact of overweight and obesity.74
Compelling Confirmatory Data
A team of Japanese researchers recorded a 43% drop in blood sugar levels after administering green coffee bean extract to mice after a heavy meal.75
In a clinical trial presented in 2011, researchers gave different dosages of standardized green coffee bean extract, each containing 50% chlorogenic acid, to 56 people. Next, they gave the participants 100 grams of glucose in an oral glucose challenge test. The oral glucose tolerance test is a standard method of gauging an individual’s response to after-meal sugar exposure.
Blood sugar levels dropped by an increasingly greater amount as the test dosage of green coffee bean extract was raised, from 100 mg up to 400 mg. At the 400 mg dosage, there was a full 32% decrease in blood sugar—two hours after glucose ingestion.17
This means that if you had a dangerous after-meal glucose reading of 160 mg/dL, the proprietary green coffee bean extract would slash it to 109 mg/dL.
These findings are in line with supportive data demonstrating green coffee bean extract’s numerous glucose-fighting mechanisms of action.
Other models reveal that chlorogenic acid favorably modulates gene expression to enhance the activity of liver cells and increase levels of the hormone adiponectin, which enhances insulin sensitivity and exerts anti-inflammatory, anti-diabetic, and anti-atherogenic effects.76
Twenty-six million Americans are now considered diabetic, while more than one in three are pre-diabetic. Recent data confirm that your risk for degenerative disease and premature death increases substantially when fasting blood glucose exceeds 85 mg/dL. Yet the medical establishment persists in defining readings up to 99 mg/dL as "safe."
Also overlooked in the effort to combat today’s diabetes epidemic is the insidious process of after-meal blood sugar surges. Regardless of whether your fasting glucose readings are "normal," these surges can cause a diabetic-like state in the body that lasts for hours, inflicting undetected, system-wide damage to healthy tissues.
Driving this danger is the little-known role your liver plays in creating and releasing additional glucose into the blood. This process, which regulates blood sugar in the absence of food when you’re young, becomes detrimentally stimulated after heavy meals by the enzyme glucose-6-phosphatase as you age. The result is a dangerous flood of sugar into your bloodstream after every meal.
A breakthrough weapon to control these after-meal blood sugar surges has been identified: green coffee bean extract. It contains a compound called chlorogenic acid shown to target glucose-6-phosphatase and blunt post-consumption blood sugar levels by up to 32% in human trials.
If you have any questions on the scientific content of this article, please call a Life Extension® Health Advisor at 1-866-864-3027.
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