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What's Hot in Nutrition, Dietary Supplements, Health and Wellness Today

What's Hot features original summaries of the latest peer-reviewed journal articles published in the fields of longevity, dietary supplements, health and wellness, and nutrition. Access the latest news concerning nutritional supplements and vitamins online at What's Hot each Monday, Wednesday and Friday. Articles are archived by month and year of publication for easy retrieval. What's Hot reports exciting findings on everything from the vitamins and supplements you and your family use on a daily basis to advanced high tech breakthroughs in the field of gerontology.

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Study uncovers decreased vitamin B12 levels in older, autistic and schizophrenic brains

July 22 2016. An article appearing in PLOS One reports the finding of abnormally low levels of vitamin B12 (cobalamin) in the brains of humans affected by aging, autism or schizophrenia.

"To our knowledge, this is the first report of pathologically reduced levels of active cobalamin species in autistic and schizophrenic brain," Richard C. Deth of Boston's Northeastern University and colleagues announce.

Five types of vitamin B12, including methylcobalamin, adenosylcobalamin, cyanocobalamin, hydroxocobalamin and glutathionylcobalamin, were measured in postmortem frontal cortex brain samples from 9 schizophrenic, 12 autistic and 43 control subjects. The researchers found that methylcobalamin and adenosylcobalamin were three times lower in the brains of those with autism or schizophrenia in comparison with levels measured in age-matched controls and that low methylcobalamin levels in autistic brains were associated with higher homocysteine levels. Brains from control subjects over 60 years of age had more than ten-fold lower methylcobalamin levels compared to those 20 years of age and younger.

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