What's Hot in Nutrition, Dietary Supplements, Health and Wellness Today
What's Hot features original summaries of the latest peer-reviewed journal articles published in the fields of longevity, dietary supplements, health and wellness, and nutrition. Access the latest news concerning nutritional supplements and vitamins online at What's Hot each Monday, Wednesday and Friday. Articles are archived by month and year of publication for easy retrieval. What's Hot reports exciting findings on everything from the vitamins and supplements you and your family use on a daily basis to advanced high tech breakthroughs in the field of gerontology.
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Dietary restriction helps maintain circadian rhythms
November 23 2015. Findings obtained from a randomized trial reported in the journal Cancer Epidemiology, Biomarkers, and Prevention reveal a previously unknown mechanism for aspirin in cancer prevention.
Forty men and women received 325 milligrams aspirin or a placebo for 60 days. Using a new technique known as metabolic profiling, levels of 363 metabolites involved in most human biochemical pathways were measured in all participants. Researchers Cornelia Ulrich, PhD and her associates found that aspirin decreased levels of both forms of the oncometabolite 2-hydroxyglutarate by 12% among the trial subjects and by 34% in colorectal cancer cell lines. (Increased levels of 2-hydroxyglutarate have been found in blood and brain cancers, and the compound is believed to promote tumor development.) The researchers also determined that salicylate, the primary aspirin metabolite, inhibits an enzyme involved in 2-hydroxyglutarate production.
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