Historically Innovative

Historically Innovative

Scientifically Yours

From revolutionary formulas to amazing innovations, again and again, our commitment to scientific and medical advances has made history, but that’s not why we do what we do. It’s our passion to promote longevity and wellness to anyone who wants it. Every strategy we've recommended we’ve done so in a relentless quest to deliver what you need to live your best life possible. Here are just a few of our milestones.

A Track Record of Achievements

Life Extension recommended the hormone DHEA to slow aging. There are now hundreds of published papers substantiating DHEA's youth-promoting properties. DHEA has become one of the most popular anti-aging supplements, and Life Extension's dosing protocols enable people to derive optimal benefits from it.



Life Extension warned against the intake of supplemental iron because of studies showing that excessive iron causes cancer.

Life Extension introduced lycopene as a dietary supplement for the purpose of preventing some forms of cancer. Lycopene is now accepted as one of the components of plants that has cancer-prevention properties.



Life Extension recommended the broad-spectrum antiviral drug ribavirin to treat lethal viral infections. Twelve years later, the FDA approved ribavirin as a treatment for hepatitis C.

Life Extension introduced phosphatidylserine to improve memory and slow brain aging. At a scientific conference on anti-aging medicine held in December 1997, phosphatidylserine was the hottest topic of discussion by speakers who were lecturing to 1,500 physicians about how to slow the aging process.



Life Extension sued the FDA because the agency failed to approve tacrine to treat Alzheimer's disease. While the lawsuit was dismissed on technical grounds, it forced the FDA to finally approve tacrine seven years after it was shown in a New England Journal of Medicine report to slow the progression of Alzheimer's disease.

Life Extension introduced melatonin to the American public based on evidence that this natural hormone is an effective anti-aging therapy. After several books were published extolling melatonin’s multiple benefits, every health food store in the United States began selling it in 1995.



Life Extension warned that the commonly prescribed estrogen and synthetic progestin drugs could increase breast and ovarian cancer risk. Findings published years later confirmed these dangers. The natural hormone-balancing approaches long recommended by Life Extension have a better safety profile.

Life Extension founded the first mail-order blood-screening service that offered state-of-the-art tests for age-related diseases directly to the public.



Life Extension published a new theory on why cells malfunction as they age (decline in DNA methylation) and introduced several therapies that could help rejuvenate aging cells. These therapies, which have been documented by hundreds of studies, are currently being prescribed for the treatment of depression, liver disease, and atherosclerosis.

Life Extension introduced Americans to a Japanese drug called methylcobalamin, a form of vitamin B12 that was particularly effective in protecting the brain against damaging excitotoxicity and also reversing the course of certain neurological disorders.



Life Extension showed how vitamin C may prevent nitroglycerin drug intolerance in patients with coronary artery disease.

Life Extension unveiled a European therapy (polyenylphosphatidylcholine) that may protect against fatty liver disease and hepatitis C, alleviate pancreatitis, and ease drug-induced gastric toxicity.



Life Extension recommended a drug to treat Alzheimer's disease and Parkinson’s disease called memantine that had been used in Germany since 1991 but was not FDA approved. The FDA approved memantine 2.5 years later.

Life Extension showed that doctors are overlooking thyroid hormone deficiency because of the improper interpretation of a common blood test.



Life Extension published research showing that topical and orally ingested antioxidants can prevent and reverse skin aging.

Life Extension reported that optimal glucose levels should be lower than current guidelines to reduce heart attack risk by 40%. Soon after, national standards for the upper-scale limit of blood glucose were lowered (to under 100 mg/dL), but still not to the lower levels recommended by Life Extension (under 86 mg/dL).



Life Extension announced the startling finding that PSA (prostate-specific antigen) itself could promote prostate cancer and provided novel methods to lower PSA levels in aging men.

Life Extension set forth a comprehensive strategy for guarding against metabolic syndrome, a deadly, often-overlooked condition that drastically increases the risk of heart attack, stroke, and diabetes.



Life Extension showed how cancer cells lurk in the prostate glands of many aging men and how to inhibit an enzyme (5-lipoxygenase) that enables these isolated malignant cells to develop into full-blown prostate cancer.

Life Extension issued a meticulous rebuttal to the FDA’s attack against bioidentical hormones and provided a scientific rationale for using natural testosterone and estrogen to reverse certain manifestations of aging.



Obese Americans were shown for the first time to outnumber those who are merely overweight. Life Extension published overlooked research findings indicating substantial fat-loss effects in response to the proper use of bioidentical hormones, certain prescription drugs, and nutrients, along with lifestyle changes.

Life Extension reported that curcuminoids and andrographolides, a set of safe, multi-targeted natural agents, have been identified to disrupt the inflammatory cascade involved in rheumatoid arthritis and reduce joint swelling, pain, and stiffness.



Life Extension introduced a proprietary complex of bioactive milk peptides, widely used in Europe to promote sustained and restful sleep patterns and promote a healthy response to stress.

In an effort to combat the increasing incidence of nonalcoholic fatty liver disease, Life Extension introduced a phytosupplement containing extracts from the adaptogenic vine Schisandra chinensis and from muskmelon. This formulation helps to detoxify the liver and restore its antioxidant function to youthful levels.



Life Extension formulated a supplement containing extracts of mung bean seed coat and EGCG (the major beneficial component in green tea), both powerful inhibitors of HMGB-1, the molecule that induces chronic inflammation, a chief accelerator of aging.

Life Extension revealed how comprehensive annual blood testing could spare hundreds of thousands of American lives each year.



Life Extension described photodynamic immunotherapy, a new outpatient therapy for breast cancer patients that provides a nontoxic alternative, allowing them to avoid surgery, radiation, and chemotherapy.

Life Extension funded a super-centenarian project that provided valuable data for Harvard researcher Dr. George Church in his quest to reverse human aging.



Life Extension reported on innovative studies that showed astaxanthin has potential in cancer treatment. These initial findings offer hope that astaxanthin could play a significant role in combating some of the most common forms of cancer, including solid tumors and hematologic malignancies such as leukemia.

The American Cancer Society issued new colorectal cancer screening guidelines echoing Life Extension’s long-standing recommendation that screening should begin earlier in life. Since the early 2000s, Life Extension has advocated starting screening as young as age 40. (The new ACS guidelines call for screening beginning at age 45 instead of 50.)



Six scientists from Life Extension and Life Extension Clinical Research, Inc., had an article published in the Journal of Integrative Medicine entitled "Kaempferia parviflora ethanol extract improves self-assessed sexual health in men: a pilot study."