T-Lymphocyte Helper/Suppressor Profile (CD4+ CD8+) Blood Test

  • Item # LC096925

T-Lymphocyte Helper/Suppressor Profile (CD4+ CD8+) Blood Test

  • Item # LC096925
The T-Lymphocyte Helper/Suppressor Profile blood test measures T-helper (CD4+) cells and cytotoxic T-cells (CD8+) cells, which are types of white blood cells that are important for immune function.

This panel contains the following tests:

  • Absolute CD4 helper T cells (CD3+CD4+)
  • Absolute CD8 cytotoxic T cells (CD3+CD8+)
  • Absolute lymphocyte count
  • Absolute T cells (CD3+)
  • CD4+:CD8+ ratio
  • CBC with differential and platelet count

Sample Report

This test evaluates two important types of T-lymphocytes which are critical immune response, CD4+, aka T helper cells and CD8+, aka cytotoxic T-cells (note: does not measure natural killer cells or suppressor cells as the old terminology name seems to imply). T-helper cells (CD4+) play a critical immune role by activating our B-cell antibody production in response to extracellular pathogens, and activating our macrophages in response to intracellular pathogens. Cytotoxic cells (CD8+), on the other hand, are specialized T-cells which can recognize and directly kill cells that are damaged or infected with intracellular pathogens without CD4+ activation. Cytotoxic T-cells (CD8+ cells) are important in our daily battle against rogue cells that could potentially give rise to cancer cells and against viruses.

Both CD4+ and CD8+ are types of T-lymphocytes that are necessary for healthy immune function and our ability to fend off microbial invaders such as virus, bacteria and parasites, as well as to clear cells that have undergone damage and pose a cancer risk. Testing the number of each of these cells can provide information on immune status and response.

This test also has a special application for monitoring HIV. HIV-1 infection results in a decrease of CD4+ T cells, an increase in CD8+ T cells, and thus a decrease in the CD4+:CD8+ ratio, equating to a progressive destruction of immune function. Enumeration of CD4+ and CD8+ T cells in HIV-1 seropositive patients may be used for prognostic purposes, to monitor disease progression and retroviral therapy.


Fasting is not required for this test. Take all medications as prescribed.


The name of this test is based on older immunology nomenclature used by LabCorp (i.e. suppressor T cells). It is now known that CD8+ cells are primarily representative of the cytotoxic T-cell population rather than the suppressor/regulator T-cell population. Therefore, those who run this test should be aware that it is the cytotoxic cell population that is represented by the results, rather than the suppressor T-cell population (aka T-reg population). LabCorp is investigating a name change to remove suppressor from the name of the test.

The laboratory services are for informational purposes only. It is not the intention of National Diagnostics, Inc and Life Extension to provide specific medical advice but rather to provide users with information to better understand their health. Specific medical advice including diagnosis and treatment will not be provided. Always seek the advice of a trained health professional for medical advice, diagnosis or treatment.

Both the physician and the testing laboratory are independent contractors with whom National Diagnostics, Inc makes arrangements for your blood tests. Neither National Diagnostics, Inc or Life Extension will be liable for any acts or omissions of the physician, the testing laboratory, or their agents or employees.

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T-Lymphocyte Helper/Suppressor Profile (CD4+ CD8+) Blood Test


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