PLAC® Test for Lp-PLA2 Activity Blood Test

  • Item # LC123283
PLAC Test for Lp-PLA2 Activity Blood Test - Life Extension

PLAC® Test for Lp-PLA2 Activity Blood Test

  • Item # LC123283
Lp-PLA2 activity helps predict whether you're at risk for a cardiac event. This test measures the function of lipoprotein-associated phospholipase A2 (Lp-PLA2), an inflammatory marker critical in rupture-prone plaque formation.

Despite significant advances in heart attack prevention over the past 40 years, cardiovascular disease remains the leading cause of death for Americans! Unfortunately, for many people, the first sign of disease is a heart attack or stroke since they are mainly caused by plaque rupture,1-3 not narrowing of the arteries. In fact, 50% of all heart attacks occur in individuals with normal cholesterol levels.

The PLAC® Test for Lp-PLA2 Activity measures the function of Lp-PLA2 in the artery wall— a vascular-specific inflammatory marker critical in the formation of rupture-prone plaque.4 Lp- PLA2 activity is a novel risk predictor in people with no prior history of cardiovascular events with a prognostic value independent of standard lipid profile testing.

The greater the Lp-PLA2 Activity, the greater the risk of fatal and non-fatal CHD events.5 PLAC Activity above 225 nmol/min/mL identifies people at increased risk of CHD events.6 An absolute risk of CHD events is 2.1 times greater with a PLAC test result over 225 and is associated with high risk for a first time myocardial infarction, cardiac revascularization and cardiac death!6,7

PLAC Test Low-High Graphic


Fasting is not required. Take all medications as prescribed.

  1. Myerburg RJ, Junttila MJ. Sudden cardiac death caused by coronary heart disease. Circulation. 2012;125:1043-1052.
  2. Falk E, Shah PK, Fuster V. Coronary plaque disruption. Circulation. 1995;92:657-671.
  3. Golledge J, Greenhalgh RM, Davies AH. The symptomatic carotid plaque. Stroke. 2000;31:774-781.
  4. Kolodgie FD, Burke AP, Skorija KS, et al. Lipoprotein-associated phospholipase A2 protein expression in the natural progression of human coronary atherosclerosis. Arterioscler Thromb Vasc Biol. 2006;26(11):2523-2529. 
  5. Thompson, A. et al. Lancet 2010; 375:1536–44.
  6. Adapted from the PLAC Test for Lp-PLA2 Activity Package Insert.
  7. PLAC Test for Lp-PLA2 Activity Package Insert.

The laboratory services are for informational purposes only. It is not the intention of National Diagnostics, Inc and Life Extension to provide specific medical advice but rather to provide users with information to better understand their health. Specific medical advice including diagnosis and treatment will not be provided. Always seek the advice of a trained health professional for medical advice, diagnosis or treatment.

Both the physician and the testing laboratory are independent contractors with whom National Diagnostics, Inc makes arrangements for your blood tests. Neither National Diagnostics, Inc or Life Extension will be liable for any acts or omissions of the physician, the testing laboratory, or their agents or employees.

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PLAC® Test for Lp-PLA2 Activity Blood Test


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