High Dose Vitamin K2 Builds New Bone

Osteoporosis is astonishingly common in men and women.

Roughly 50% of American women and 25% of American men age 50 and older will suffer a fracture due to this condition.¹

These bone breaks are a leading cause of disability. Within a year of suffering a hip fracture, up to 20% of patients over 50 will die.²

For decades, doctors in Japan have been using high doses of vitamin K2 as a prescription drug to prevent bone loss and protect against fractures.³

It is now available in the U.S. without a prescription.

Clinical trials have demonstrated that 45 mg of vitamin K2 (menaquinone-4) helps to:^4-11

• Slow bone loss,
• Reduce fracture risk, and
• Build new bone.

A two-year study of older osteoporosis patients showed that high-dose vitamin K2 cut the number of people suffering a vertebral fracture by half.¹¹

The Danger of Osteoporosis

Osteoporosis is a condition that causes bones to become weak, brittle, and prone to fractures. After suffering one fracture, the risk of future breaks increases by 86%.²

Fractures of the hip and vertebra are particularly associated with loss of mobility and risk of death. People who suffer a vertebral fracture have an eight-fold increase in mortality compared to other individuals their age.²

But almost any kind of broken bone increases the risk of death in older people.¹² That’s why it is imperative to not just slow, but reverse bone loss as soon as it begins to take hold.

Comparing the left (normal) and right (osteoporosis) images, the increase in dark areas involving this cross-section of the femur are simplified visual depictions of the increase in bone marrow fat, and thinning (decrease) in cancellous/ trabecular bone, that occur with osteoporosis.

How Bone Loss Happens

The body constantly breaks down old bone and builds up new bone.

In the first decades of life, bone density increases. Then it plateaus for about two more decades.

At around age 40, bone density begins to decrease. In women, the speed of bone loss accelerates with the onset of menopause.

This decline in bone mineral density leads to a reduction in bone strength. Bones become brittle and prone to fractures, even from minor injuries and stress fractures that occur during normal movement.

Osteopenia is the term for the early stage of weakening bones.

If no action is taken and bone density continues to drop, osteoporosis develops. Osteoporosis means “bone full of pores or holes.”

Most people who suffer from osteopenia or osteoporosis are unaware of it until it’s too late—when they suffer a fracture.

High-Dose Vitamin K2

The good news: There is something we can do about age-related bone loss and risk of fractures.

In low doses of 45-60 mcg, vitamin K promotes normal blood clotting. This small amount of vitamin K is normally obtained from dietary sources.

Japanese doctors have long been prescribing much higher doses of a specific form of vitamin K2 as a treatment for osteoporosis.³

They have amassed decades of evidence that 45 mg (45,000 mcg) of vitamin K2 in the form of menaquinone-4 (MK-4), leads to improvements in bone health.³

Now scientists have confirmed that oral intake of high-dose vitamin K2 is critical for bone strength and other aspects of healthy aging.

Increased Bone Density

Human trials have demonstrated that vitamin K2 maintains or even increases bone mineral density. It also helps prevent fractures, even in older patients who have already developed osteoporosis.^4-11

In one of these studies, Japanese researchers randomized older osteoporosis patients into two groups. One received 150 mg/day of calcium alone. The other received this same modest calcium dose plus 45 mg of vitamin K2 (as MK-4) daily.¹¹

Over a two-year period:¹¹

• Patients who received only calcium continued to lose bone density, dropping by about 3%.
• Patients receiving vitamin K2 in addition to calcium largely maintained their bone mineral density.

A 10% drop in bone density more than doubles the risk for fractures of the vertebra and hip.¹³ This suggests that patients in this study who were treated only with calcium may have an increased risk of fracture.

But adding vitamin K2 to calcium largely arrested bone loss, possibly preventing an increase in fracture risk.¹¹

Patients receiving K2 also had a significant increase in levels of active osteocalcin.¹¹ This protein binds calcium to bone, helping the body turn calcium into healthy new bone.¹⁴

Preventing Fractures

In the same study, scientists assessed the effect of vitamin K2 on the incidence of bone fractures.

During the two-year study, the group receiving calcium alone sustained 35 fractures, compared to only 14 fractures in the vitamin K2 group.¹¹

In another Japanese clinical trial, scientists evaluated the effect of vitamin K2 on women with osteoporosis.⁶

Taking 45 mg of oral vitamin K2 daily:⁶

• Maintained mineral density to a significantly greater degree than in the untreated group, and
• Reduced the incidence of vertebral fractures to a degree similar to the drug etidronate.

Etidronate (most commonly sold as Didronel^®) is from the class of drugs known as bisphosphonates. It is used to treat Paget’s disease, a condition characterized by bones that are soft, weak, or easily broken.

It is sometimes used to treat osteoporosis, but its side effects can include nausea, diarrhea, heartburn, chest pain, and skin blisters.¹⁵ Vitamin K2, on the other hand, is not associated with significant side effects.

How Vitamin K2 Keeps Bones Strong

Vitamin K2 works by restoring a healthy balance between the two types of bone cells that influence bone density: osteoclasts and osteoblasts.

Osteoclasts break down old bone. Osteoblasts build new bone.

Healthy bone relies on a balance of activity between these two types of cells.

Aging disrupts this delicate balance. Osteoclast activity overtakes osteoblast activity. Bone is