CoQ10 also has powerful antioxidant properties, protecting important proteins and mitochondrial DNA from oxidation.^7,8 Unfortunately, CoQ10 levels in the body decrease over time.^9,10

Improved bioavailability with ubiquinol

The traditional ubiquinone form of CoQ10 is difficult for the body to absorb.¹¹ That’s why Life Extension offers a highly bioavailable form of ubiquinol CoQ10 in a patented delivery system shown to absorb up to 8x better than ubiquinone.^12,13 In people taking this form of ubiquinol, high levels of plasma CoQ10 can be achieved in only four weeks.¹⁴

Shilajit enhances CoQ10 effectiveness

PrimaVie® shilajit has been shown to promote mitochondrial metabolism, helping mitochondria convert fats and sugars into adenosine triphosphate (ATP), which is the main source of cellular energy.^15-17  When combined with ubiquinol CoQ10, shilajit doubles levels of CoQ10 in the mitochondria.¹⁸ Shilajit also prolongs CoQ10’s efficacy at the cellular level by stabilizing it in its ubiquinol form and promotes greater cellular energy output by improving delivery of CoQ10 into the mitochondria. ^18-20

PQQ Promotes Growth of New Mitochondria

PQQ (pyrroloquinoline quinone) is a nutrient that promotes the production of new mitochondria. In fact, PQQ promotes youthful cellular function in three distinct ways:

• Promotes mitochondrial biogenesis. PQQ activates genes that promote the formation of fresh mitochondria. It also beneficially interacts with genes directly involved in mitochondrial health.²¹
• Mitochondrial support.  PQQ's antioxidant potency and favorable gene-expression profile act to support mitochondrial defense.²²
• Antioxidant power. PQQ is a potent antioxidant and its molecular stability enables PQQ to facilitate thousands of antioxidant reactions in the mitochondria, without breaking down, for maximum antioxidant and bioenergetic support.²³

CoQ10 & aging

In a pre-clinical model, ubiquinol was up to 40% more effective at slowing measurements of aging compared to ubiquinone.²⁴ In another pre-clinical study, the combination of CoQ10 and shilajit produced a 56% increase in cellular energy production in the brain—40% better than CoQ10 alone. Muscle tissue saw a 144% increase, which was 27% better than with CoQ10 by itself.²⁵