Life Extension researchers have developed a three-ingredient formula designed to combat immune senescence. Immune Senescence Protection Formula™ is composed of standardized Cistanche, reishi, and pu-erh tea extracts — three botanical ingredients that work to rejuvenate an aging immune system through innovative mechanisms.

Benefits at a Glance:

• Helps rejuvenate an aging immune system
• Supports immune system response to new invaders
• Helps maintain a healthy naive-to-memory immune-cell ratio

More facts about Immune Senescence Protection Formula™

As we age, our immune system begins to decline, a process known as immune senescence.¹ A vital immune system is made up of a healthy balance of naive T-cells that attack new invaders and memory T-cells that attack previously known invaders.

However, after a naive T-cell attacks a new threat, it becomes a memory T-cell, which will only go after a threat that it remembers.^2,3 The result is that the delicate immune balance tips, so we have a surplus of memory T-cells and a deficit of naïve T-cells. Therefore our body is less able to defend itself against new invasions. This produces a less-vigilant immune system — or immune senescence.^4,5

Cistanche rejuvenates an aging immune system

The echinacoside compound found in Cistanche plant extract stimulates the development of naive T-cells and leads to a lower number of memory T-cells, thereby creating a healthy immune response. Cistanche also increases natural killer (NK) cell activity — resulting in a 15% life span increase in those cells in pre-clinical research.⁶

A 12-week human study of standardized Cistanche yielded positive results in regard to immune profile: subjects had an 11.7% increase in NK cell activity and a 20.2% improvement in the ratio of CD4 to CD8 cells. An increased CD4-to-CD8 ratio is indicative of healthy, youthful immune function.⁷

Reishi mushroom combats immune senescence

The numerous bioactive components of the reishi mushroom exert powerful effects that may reverse many of the factors of immune senescence.⁸ Primarily, reishi extracts boost the function of innate immune cells, the immune system’s first line of defense.^8-10

It has long been known that reishi’s unique polysaccharides, triterpenes, and other constituents^11,12 enhance the body’s hematopoietic stem cells, T-cells, and other crucial immune factors.^13-16 Animal research shows reishi supports multiple aspects of immune function and longevity.^17-18

Pu-erh tea extract supports immune balance

Pu-erh tea is rich in polyphenols and other bioactive molecules. Pu-erh tea extract may support healthy bone marrow function, which helps to rebuild the peripheral immune cellular components.¹⁹

A pre-clinical study demonstrated that pu-erh tea extract supports a healthy immune response by decreasing interleukin-6 (IL-6) by a remarkable 43%, as well as increasing NK cells by 7% and naïve T-cells by 10%.²⁰

Our Best-in-Class formula for immune system support

This one potent, triple-action formulation delivers Cistanche, Reishi and Pu-erh Tea. For year-round support of the aging immune system, add this Best-in-Class formula to your regimen today.