ApoE Genetic Test for Alzheimer’s and Cardiac Risk
Apolipoprotein E (ApoE) is an important regulator of cholesterol and triglyceride levels in your blood and supports lipid transport and injury repair in your brain.1
Alzheimer's disease (AD) is a progressive disease associated with the aggregation of proteins called amyloidβ (Aβ) and tau, which deposit in AD brains as plaques and tangles. These plaques and tangles injure synapses in your brain and ultimately cause neurodegeneration and dementia.2,3
AD usually occurs later in life (>65 years) and is referred to as late-onset AD (LOAD). Although multiple genetic and environmental risk factors are involved in LOAD, impairment in Aβ clearance by ApoE is a major contributor to development of the disease.4
There are three different forms of the APOE gene known as E2, E3 and E4 alleles. Genetically, E4 is the strongest risk factor for developing LOAD.5-7 According to the National Institute of Health, inheriting a single copy of ApoE4 from a parent increases the risk of Alzheimer's disease by about three-fold. Inheriting two copies, one from each parent, increases the risk by about 12-fold.8 In fact almost 40% of AD patients have inherited an E4 allele.9
In the cardiovascular system ApoE is involved in the transportation of fat molecules out of circulation and into your cells.10 Each of the allele variations, E2, E3 and E4 mediate cholesterol metabolism in a different manner. E4 is associated with increased levels of cholesterol and triglycerides, which leads to atherosclerosis, heart disease and stroke.11
This panel identifies your risk category so you can take important steps to change your lifestyle before symptoms become evident!
It is important to understand that although carrying the APOE E4 allele increases your likelihood of developing disease, it does not mean that you will. Genetic testing is about probabilities, not guarantees - and should always be interpreted in the light of other considerations such as age, family history, environmental factors, ethnicity, and other coexisting medical conditions.
The following documents provide a full set of instructions and the contents of the lab kit for completing the test:
Results take 2-3 weeks from when specimen is received. This test is not available in Pennsylvania. The results for this test can only be received via mail, e-mail, or fax. Since genetic mutations do not change over time, each person needs to be tested only once in their lifetime.
The laboratory services are for informational purposes only. It is not the intention of National Diagnostics, Inc and Life Extension to provide specific medical advice but rather to provide users with information to better understand their health. Specific medical advice including diagnosis and treatment will not be provided. Always seek the advice of a trained health professional for medical advice, diagnosis or treatment.
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