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Abrams DI, Vizoso HP, Shade SB, Jay C, Kelly ME, Benowitz NL.  Vaporization as a smokeless cannabis delivery system: A pilot study.  Clin Pharmacol Ther 2007;82:572-578.

Anker SD, John M, Pedersen PU, Raguso C, Cicoira M, Dardai E, . . . Vogelmeier C. ESPEN Guidelines on Enteral Nutrition: Cardiology and pulmonology. Clinical nutrition (Edinburgh, Scotland). Apr 2006;25(2):311-318.

Anukam KC, Osazuwa EO, Osadolor HB, Bruce AW, Reid G. Yogurt containing probiotic Lactobacillus rhamnosus GR-1 and L. reuteri RC-14 helps resolve moderate diarrhea and increases CD4 count in HIV/ AIDS patients. J Clin Gastroenterol 2008; 42(3):239-243.

Arends J, Bodoky G, Bozzetti F, Fearon K, Muscaritoli M, Selga G, . . . Zander A. ESPEN Guidelines on Enteral Nutrition: Non-surgical oncology. Clinical nutrition (Edinburgh, Scotland). Apr 2006;25(2):245-259.

Argiles JM, Busquets S, Lopez-Soriano FJ, Costelli P, Penna F. Are there any benefits of exercise training in cancer cachexia? Journal of cachexia, sarcopenia and muscle. Jun 2012;3(2):73-76.

Attie KM, Borgstein NG, Yang Y, et al.  A single ascending-dose study of muscle regulator ACE-031 in healthy volunteers.  Muscle Nerve 2013;47(3):416-423.

Baer JT.  Testosterone replacement therapy to improve health in older males.  Nurse Practitioner 2012;37:39-44.

Baier S, Johannsen D, Abumrad N, Rathmacher JA, Nissen J, Flaholl P. Year-long changes in protein metabolism in elderly men and women supplemented with a nutrition cocktail of β-hydoxy-β-methylbutryate (HMB), L-arginine and L-lysine. J Parenter Enter Nutr 2009;33(1):71-82.

Batterham MJ, Garsia R.  A comparison of megstrol acetate, nandrolone decanote and dietary counseling for HIV associated weight loss.  Int J Andrology 2001;24(4):232-240.

Baumgartner RN., Koehler KM, Gallagher D, et al. Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epid 1998;147(8):755-763.

Baur JA, Pearson KJ, Price NL, et al.  Resveratrol improves health and survival of mice on a high-calorie diet.  Nature 2006a:444(7117):337-342.

Baur JA, Sinclair DA.  Therapeutic potential of resveratrol: the in vivo evidence. Nature Rev Drug Discov 2006b;5(6):493-506

Beal JE, Olson R, Lefkowitz L, et al.  Long-term efficacy and safety of dronabinol for acquired immunodeficiency syndrome-associated anorexia. J Pain Symptom Manage  1997;14(1):7-14.

Berger JR, Pall L, Hall CD, Simpson DM, Berry PS, Dudley R. Oxandrolone in AIDS-wasting myopathy. AIDS (London, England). Dec 1996;10(14):1657-1662.

Bischoff-Ferrari A, Dawson-Hughes B, Staehelin HB, et al. Fall prevention with supplemental and active forms of vitamin D: a meta-analysis of randomized controlled trials. BMJ 2009;339:b3692.

Bocock MA, Keller HH.   Hospital diagnosis of malnutrition: a call for action.   Can J Diet Prac Res 2009;70:37-41.

Bonet Saris A, Marquez Vacaro JA, Seron Arbeloa C. [Guidelines for specialized nutritional and metabolic support in the critically-ill patient. Update. Consensus of the Spanish Society of Intensive Care Medicine and Coronary Units-Spanish Society of Parenteral and Enteral Nutrition (SEMICYUC-SENPE): macro-and micronutrient requirements]. Medicina intensiva / Sociedad Espanola de Medicina Intensiva y Unidades Coronarias. Nov 2011;35 Suppl 1:17-21.

Brotto M, Abreu EL.  Sarcopenia: Pharmacology for today and tomorrow.  JPET 2012;343:510-512.

Brown VA, Patel KR, Viskaduarki M, et al. Repeat dose study of cancer chemopreventive agent resveratrol in healthy volunteers: Safety, pharmacokinetics and effect on the insulin-like growth factor axis. Cancer Res 2010;70(22):9003-9011.

Buehring R, Binley N.  Myostatin- The Holy Grail for muscle, bone and fat?  Curr Osteoporos Rep. 2013; In Press.

Burney BO, Hayes TG, Smiechowska J, et al.  Low testosterone levels and increased inflammatory markers in patients with cancer and relationship with cachexia. J Clin Endocrin Metab 2012;97(5):E700-E709.

Busquets S, Fuster G, Ametller E, et al.  Resveratrol does not ameliorate muscle wasting in different types of cancer cachexia models. Clin Nutr 2007;26(2):239-244.

Campbell WW, Barton ML, Cyr-Campbell D, et al. Effects of an omnivorous diet compared with a lacotovovegtarian diet on resistance-training induced changes in body composition and skeletal muscle in older men. Am J Clin Nutr 1999;70(6):1032-1039.

Candow DG, Little JP, Chilibeck PD., et al.  Low-dose creatine combined with protein during resistance training in older men. Med Sci Sports Exerc 2008;40(9):1645-1652.

Carrocio A, Guarino A, Zuin G, et al. Efficacy of oral pancreatic enzyme therapy for the treatment of fat malabsorption in HIV-infected patients.  Aliment Pharmacol Ther 2001;15:1619-1625.

Cawthon PM, Marshall LM, Michael I, et al. Frailty in older men: Prevalence, progression, and relationship with mortality. J Am Geriatr Soc 2007;55(8):1216-1223.

CDC- US Centers for Disease Control.  State Indicator Reporty on Fruits and Vegetables 2013.    Washington, DC. 

Chanou K, Gerodimos V, Karatrantou K, Jamurtas A. Whole-Body Vibration and Rehabilitation of Chronic Diseases: A Review of the Literature. Journal of sports science & medicine. 2012;11(2):187-200.

Chapman CMC, Gibson GR, Rowland I.  Health benefits of probiotics: are mixtures more effective than single strains?  Eur J Nutr 2011;50:1-17.

Churchward-Venne TA, Breen L, Phillips SM.  Alterations in human muscle protein metabolism with aging: Protein and exercise as countermeasures to offset sarcopenia.  Biofactors 2013; In Press

Clark R, Feleke G, Din M, et al. Nutritional treatment for acquired immunodeficiency virus-associated wasting using HMB, glutamine and arginine: A double-blind, placebo controlled study. JPEN - J Parenter Enter Nutr 2000;24(3):133-139.

Cosqueric G, Sebag A, Ducolombier C, Piette F, Weill-Engerer S. Sarcopenia is predictive of nosocomial infection in the elderly. Br J Nutr 2006;96(5):895-901.

Coulson JM, Jones RD, Hubbard RE, et al.  Pancreatic insufficiency and weight loss in older patients.  QJM (Quartely Journal of Medicine) 2004;97:377-380.

Cruciani RA, Zhang JJ, Manola J, Cella D, Ansari B, Fisch MJ.  L-carnitine supplementation for the management of fatigue in patients with cancer: an Eastern Cooperative Oncology Group Phase III, randomized, double-blind, placebo-controlled trial.  J Clin Oncol 2012;30:3864-3869.

Cruz-Jentoft AJ, Baeyens JP, Bauer JM, et al.  Sarcopenia: European consensus on definition and diagnosis. Age Ageing 2010;39(4):412-423.

Dalton JT, Barnette KG, Bohl CE, et al. The selective androgen receptor modulator GTx-024 (enobosarm) improves lean body mass and physical function in healthy elderly men and postmenopausal women: results of a double-blind, placebo controlled phase II trial. J Cachexia Sarcopenia Muscle 2011;2(3):153-161.

Dardevet D, Remond D, Peyron MA, Papet I, Savas-Auzeloux I, Mosoni I  Muscle wasting and resistance of muscle anabolism: The “Anabolic Threshold Concept” for adapted nutritional strategies during sarcopenia.  ScientificWorldJournal 2012; In Press

Dawson-Hughes B. Serum 25-hydroxyvitamin D and functional outcomes in the elderly.  Am J Clin Nutr 2008;88(supplement):537S-540S.

de Oliveira TRC, Frigerio MLMA. Association between nutrition and the prosthetic condition in edentulous elderly. Gerodontology 2004;21(4):205-208.

de Souza PML, Jacob-Filho W, Santarem JM, Zomignan AA, Burattini MN. Effect of progressive resistance exercise on strength evolution in patients living with HIV compared to healthy controls. Clinics (Sao Paulo) 2011;66(2):261-266.

de Souza Vasconcelos KS, Dias JM, De Araulo MC, et al.  Land-based versus aquatic resistance therapeutic exercises for older women with sarcopenia obesity: study protocol for a randomized controlled trial.Trials 2013;14(1):296.

Delia P, Sansotta, Donato V, et al.  Use of probiotics for prevention of radiation-induced diarrhea. World J Gastroenterol 2007;13:912-915.

Diaz JJ, Pousman R, Mills B, et al. Critical Care Nutrition Practice Management Guidelines. Vanderbilt University Medical Center: TICU, SICU, NCU, BICU. Available at: Last updated 11/2004. Accessed 1/22/2014.

Drey M. Sarcopenia- pathophysiology and clinical relevance. Wien Medical Wochenschr 2011;161(17-18):402-408.

Drummond MJ, Dickinson JM, Fry CS, et al. Bed rest impairs skeletal muscle amino acid transporter expression, mTORC1 signaling, and protein synthesis in response to essential amino acids in older adults. Am J Physiol Endocrin Metab 2012;302(9):E1113-1122.

Earleywine M, Barnwell SS.  Decreased repsuiratory symptoms in cannabis users who vaporize.  Harm Reduct J 2007;4:11.

Elliot B, Renshaw D, Getting S, Mackenzie R. The central role of myostatin in skeletal muscle body homeostasis. Acta Physiol (Oxford) 2012;205(3):324-340.

Evans WJ, Morley JE, Argiles JM, et al.  Cachexia: a new definition. Clin Nutr 2008;27:793-799.

Fearon K, Arends J, Baracos V.  Understanding the mechanisms and treatment options in cancer cachexia.  Nat Rev Clin Oncol 2013;10(2):90-99.

Fearon K, Evans WJ, Anker SD.  Myopenia- a new universal term for muscle wasting.  J Cachexia Sarcopenia Muscle  2011;2(1):1-3.

Fiatarone  MA, Marks EC, Ryan NC, Meredith CN, Lipsitz LA, Evans WJ. High-intensity strength training in nonagenerians. JAMA 1990;263(22):3029-3034.

Fillipas S, Cherry CL, Cicuttini F, Smirness L, Holland AE.  The effects of exercise training on metabolic and morphological outcomes for people living with HIV: A systematic review of randomized clinical trials. HIV Clin Trials 2010:11(5):270-283.

First Consult. Megestrol. Copyright © 2014 Elsevier, Inc. Clinical Key website. Drug Monograph page. Available at:!/ContentPlayerCtrl/doPlayContent/6-s2.0-370/{"scope":"all","query":"megestrol"}. Accessed 1/20/14.

Fox CB, Treadway AK, Blaszczyk AT, Sleeper RB.  Megestrol acetate and mirtazapine for the treatment of unplanned weight loss in the elderly. Pharmacotherapy 2009;29(4):383-397.

Fuccio L, Guido A, Eusebi LH, et al. Effects of probiotics for the prevention and treatment of radiation-induced diarrhea. J Clin Gastroenterol 2009;43(5):506-513.

Ginde AA, Liu MC, Camargo CA, et al. Demographic differences and trends of vitamin D insufficiency in the US population. Arch Int Med 2009;169:629-632.

Glover EI, Phillips SM.  Resistance exercise and appropriate nutrition to counteract muscle wasting and promote muscle hypertrophy. Curr Opin Clin Nutr Metab Care 2010;13(6):630-634.

Gordon JN, Trebble TM, Ellis RD, Duncan HD, Johns T, Goggin PM.  Thaldomide in the treatment of cancer cachexia: a randomized placebo controlled trial.  Gut 2005;54:540-545.

Gramignano G, Lusso MR, Madeddu C, et al.  Efficacy of l-carnitine administration on fatigue, nutritional status, oxidative stress, and related quality of life in 12 advanced cancer patients undergoing anticancer therapy.  Nutrition 2006;22:136-145.

Graziano F, Bisonni R, Catalano V, et al.  Potential role of levocarnitine supplementation for the treatment of chemotherapy-induced fatigue in non-anemic cancer patients.  Br J Cancer 2002;86:1854-1857.

Grunfeld C, Kotler DP, Dobs A, Glesby M, Bhasin S. Oxandrolone in the treatment of HIV-associated weight loss in men: a randomized, double-blind, placebo-controlled study. Journal of acquired immune deficiency syndromes (1999). Mar 2006;41(3):304-314.

Gryson C, Walrand S, Giraudet C, et al.  “Fast proteins” with a unique amino acid content as an optimal nutrition in the elderly: Growing evidence. Clin Nutr 2013; In Press.

Guillory B, Splenser A, Garcia J.  The role of ghrelin in anorexia-cachexia syndrome.  Vitam Horm 2013;92:61-106.

Gullett NP, Hebbar G, Ziegler TR. Update on clinical trials of growth factors and anabolic steroids in cachexia and wasting. Am J Clin Nutr 2010;91(supplement):1143-1147S.

Gullett NP, Mazurak VC, Hebbar G, Ziegler TR. Nutritional interventions for cancer-induced cachexia. Current problems in cancer. Mar-Apr 2011;35(2):58-90.

Haney M, Gunderson EW, Rabkin J, et al.  Dronabinol and marijuana in HIV-positive marijuana smokers.  J Acquir Immune Defic Syndr 2007;45:545-554.

Hayes A, Cribb PJ. Effect of whey protein isolate on strength, body composition and muscle hypertrophy during resistance training. Curr Opin Clin Nutr Metab Care 2008; 11(1):40-44.

Holt PR.  Intestinal malabsorption in the elderly.  Dig Dis 2007;144-150.

Houston DK, Nicklas BJ, Ding J, et al. Dietary protein intake is associated with lean mass in older, community-dwelling adults: the Health, Aging and Body Composition (Health ABC) Study. Am J Clin Nutr 2008;87(1):150-155. Accessed November 22, 2013.

Hughes VA, Frontera WR, Roubenoff R, Evans WJ, Singh MA. Longitudinal changes in body composition in older men and women: Role of body weight change and physical activity. Am J Clin Nutr 2002;76(2):473-481.

Hutton B, Feine J, Morais J. Is there an association between edentulism and nutritional state? J Can Dent Assoc  2002;68(3):182-187.

Hwang AC, Liu LK, Lee WJ, et al. Association of androgen with skeletal muscle mass and muscle function among men and women age 50 years older in Taiwan.  Rejuvenation Res 2013; In Press

Iannuzzi-Sucich M, Prestwood KM, Kenny AM. Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. The journals of gerontology. Series A, Biological sciences and medical sciences. Dec 2002;57(12):M772-777.

Jackson JR, Ryan MJ, Alway SE. Long term supplementation with resveratrol alleviates oxidative stress but does not attenuate sarcopenia in old mice. J Gerontol A- Biol Sci Med Sci 2011;66(7):751-754.

Jackson JR, Ryan MJ, Hao Y, Alway SE. Mediation of endogenous antioxidant enzymes and aptotic signaling by resveratrol following muscle disuse in the gastrocnemius muscles of young and old rats. Am J Physiol Regulat Integr Comp Physiol 2010;299(6):R1572-1581. 

Janssen I, Baumgartner RN, Ross R, Rosenberg IH, Roubenoff R. Skeletal muscle cutpoints associated with elevated physical disability risk in older men and women. Am J Epidemiol 2004;159(4):413-421.

Janssen I, Shepard DS, Katzmarzyk PT, Roubenoff R. The healthcare costs of sarcopenia in the United States. Journal of the American Geriatrics Society. Jan 2004;52(1):80-85.

Jiméenez Jiméenez FJ, Cervera Montes M, Blesa Malpica AL. [Guidelines for specialized nutritional and metabolic support in the critically-ill patient. Update. Consensus of the Spanish Society of Intensive Care Medicine and Coronary Units-Spanish Society of Parenteral and Enteral Nutrition (SEMICYUC-SENPE): cardiac patient]. Medicina intensiva / Sociedad Espanola de Medicina Intensiva y Unidades Coronarias. Nov 2011a;35 Suppl 1:81-85.

Jiméenez Jiméenez FJ, Cervera Montes M, Blesa Malpica AL. Guidelines for specialized nutritional and metabolic support in the critically-ill patient: update. Consensus SEMICYUC-SENPE: cardiac patient. Nutricion hospitalaria. Nov 2011b;26 Suppl 2:76-80.

Jones TE, Stephenson KW, King JG, Knight KR, Marshall TL, Scott WB.  Sarcopenia- mechanisms and treatments.  J Geriatr Phys Ther 2009;32:39-45.

Katsanos CS, Chinkes DL, Paddon-Jones D, Zhang XJ, Aarsland A, Wolfe RR   Whey protein ingestion in elderly results in greater muscle protein accrual than ingestion of its constituent amino acid content. Nutr Res 2008;28(10):651-658.

Kemmler W, Bebenek M, Engelke K, Von Stengel S. Impact of whole-body electromyo-stimulation on body composition in elderly women at risk for sarcopenia: the Training and Electrostimulation Tral (TEST-III). Age (Dordr) 2013; In Press.

Khan ZH, Simpson EJ, Cole AT.  Oesophageal cancer and cachexia: the effect of short-0term treatment with thalidomide on weight loss and lean body mass.  Aliment Pharmacol Ther 2003;17:677-682.

Kim JS, Wilson JM, Lee SR. Dietary implications on mechanisms of sarcopenia: roles of protein, amino acids, and antioxidants. J Nutr Biochem 2010;21(1):1-13.

Kim MK, Baek KH, Song KH, et al. Vitamin D deficiency is associated with sarcopenia in older Koreans, regardless of obesity: The Fourth Korea National Health and Nutrition Examination Surveys (KNHANES IV) 2009. J Clin Endocrinol Metab 2011;96(10):3250-3256.

Kong NP, Edmonds P. Testosterone therapy in HIV wasting syndrome: systematic review and meta-analysis. Lancet Infect Dis 2002;2(11):692-699.

Koopman R, Ryall JG, Church JE, Lynch GS. The role of β-adrenoceptor signaling in skeletal muscle: therapeutic implications for muscle wasting disorders. Curr Opin Clin Nutr Metab Care 2009;12(16):601-606.

Lee P, Day RO, Greenfield JR, Ho KK. Formoterol, a highly beta2-selective agonist, increases energy expenditure and fat utilisation in men. International journal of obesity (2005). Apr 2013;37(4):593-597.

Leeanders M, Verdijk LB, Van Den Hoeven L, et al.  Patients with type 2 diabetes show a greater decline in muscle mass, muscle strength, and functional capacity with aging.  J Am Med Directors Assoc  2013;14(8):585-592.

Leifke E, Gorenoi V, Wichers C, von zur Muhlen A, von Buren E, Brabant G.  Age-related changes in serum sex hormones, insulin like growth factor-1 and sex-hormone binding globulin levels in men: cross-sectional data from a healthy male cohort.  Clin Endrocrin (Oxford) 2000;53:689-695.

Liu H, Bravata DM, Olkin I, et al. Systematic review: The safety and efficacy of growth hormone in the healthy elderly.  Ann Intern Med 2007;146(2):104-115.

Logemann JA.  Swallowing disorders. Best Pract Res Clin Gastroenterol 2007;21(5): 563-573.

Machado A, Garcia-Lopez D, Gonazlez-Gallego J, Garatachea N. Whole-body vibration training increases muscle strength and mass in older women: a randomized-controlled trial. Scand J Med Sci Sports 2010;20:200-207.

Maclaran KI, Panay N.  The safety of postmenopausal testosterone therapy.  Women’s Health 2012;8:263-275.

Maesta N, Nahas EAP, Nahas-Neto, et al.  Effects of soy protein and resistance on body composition and blood lipids in postmenopausal women. Mauritas 2007;56(4): 350-358.

Mantovani G, Maccio A, Madeddu C, et al.  A phase II study with antioxidants, both in diet and supplemented, pharmaconutritional support, progrestagen, and anti-cyclooxygenase-2 showing efficacy and safety in patients with cancer-related anorexia/ cachexia and oxidative stress. Cancer Epidemiol Biomarkers Prevent 2006;15(5):1030-1034.

Mantovani G, Maccio A, Madeddu C, et al.  Randomized phase III clinical trial of 5 different arms of treatment in 332 patients with cancer cachexia.  Eur Rev Med Pharmacol Sci 2010;14:292-301.

Martin WF, Armstrong LE, Rodriguez NY. Dietary intake and renal function. Nutr Metabol (London) 2005;2:25.

Marzetti E, Calvani R, Cesari M, et al. Mitochondrial dysfunction and sarcopenia of aging: From signaling pathways to clinical trials. Int J Biochem Cell Biol 2013;45(10): 2288-2301.

Marzetti E, Lees HA, Wohlgemuth SE, Leeuwenburgh C  Sarcopenia of aging: Underlying cellular mechanisms and protection by calorie restriction. Biofactors 2009;35(1):28-35.

Mathey MF, Vanneste V, De Graaf C, DeGroot LC, Van Stavern WA.  Health improvement of improved meal ambience in a Dutch nursing home: 1-year intervention study. Prev Med 2001;32(8):416-423.

May PE, Barber A, D’Olimpio JT,Hourihane A, Abumrad NN. Reversal of cancer-related wasting using oral supplementation with combination of β-hydroxy-β-methylbutyrate, arginine and glutamine.  Am J Surg 2002;183(1$):471-479.

Mayo Clinic. DHEA. Available at: 2012.

McGlory C, Gorissen SHM, Kamal M, Bahniwal R, Hector AJ, Baker SK, . . . Phillips SM. Omega-3 fatty acid supplementation attenuates skeletal muscle disuse atrophy during two weeks of unilateral leg immobilization in healthy young women. The FASEB Journal. 2019;33(3):4586-4597.

Mercadante S. Parenteral versus enteral nutrition in cancer patients: indications and practice. Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer. Mar 1998;6(2):85-93.

Merck Manual 2013.  Cachexia in Cancer.  Last accessed 11/29/2013 at

Mithal A, Bonjour JP, Boonen S, et al. Impact of nutrition on muscle mass, strength and performance in older adults. Osteoporos Int 2013;24(8):1555-1566.

Moeller LE, Peterson CT, Hanson KB, et al. Isoflavone-rich soy protein prevents loss of hip lean mass but does not prevent the shift in regional fat distribution in perimenopausal women. Menopause 2003;10(4):322-331.

Montero-Fernandez N, Serra-Rexach JA.  Role of exercise on sarcopenia in the elderly.  Eur J Phys Rehabil Med 2013;49(1):131-143.

Moon SS.  Low skeletal muscle mass is associated with insulin resistance, diabetes and metabolic syndrome in the Korean population: The Korea National Health and Nutrition Examination Survey (KNHANES) 2009-2010.  Endocr J, 2013, In Press.

Moore DR, Robinson MJ, Fry JL, et al.  Ingested protein dose response of muscle and albumin protein synthesis after resistance exercise in young men.  Am J Clin Nutr 2009; 89(1):161-168.

Morley JE, Thomas DR, Wilson MM. Cachexia: pathophysiology and clinical relevance. The American journal of clinical nutrition. Apr 2006;83(4):735-743.

Morley JE. Calories and cachexia. Curr Opin Clin Nutr Metab Care 2009;12(6):607-610.

Muscaritoli A, Lucia S, Molfino A, Cederholm MT, Rossi Fanelli F,  Muscle atrophy in aging and chronic diseases: is it sarcopenia or cachexia? Intern Emerg Med 2013;8: 553-560.

Muscaritoli M, Anker SD, Argiles J, Aversa Z, Bauer JM, Biolo G, . . . Sieber CC. Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) "cachexia-anorexia in chronic wasting diseases" and "nutrition in geriatrics". Clinical nutrition (Edinburgh, Scotland). Apr 2010;29(2):154-159.

Nicolini A, Ferrari P, Masoni MC, et al.  Malnutrition, anorexia, and cachexia in cancer patients: a mini-review on pathogenesis and treatment. Biomed Pharmacother 2013; In Press.

Nitenberg G, Raynard B. Nutritional support of the cancer patient: issues and dilemmas. Critical reviews in oncology/hematology. Jun 2000;34(3):137-168.

Norman K, Pichard C, Lochs H, Pirlich M. Prognostic impact of disease-related malnutrition. Clinical nutrition (Edinburgh, Scotland). Feb 2008;27(1):5-15.

NORML.  National Organization for the Reform of Marijuana Laws. Medical Marijuana- Laws by State 2013 accessed  1-27-14  at

Orr R, Fiatarone Singh M. The anabolic androgenic steroid oxandrolone in the treatment of wasting and catabolic disorders: review of efficacy and safety. Drugs. 2004;64(7):725-750.

Paddon-Jones D, Rasmussen BB. Dietary protein recommendations and the prevention of sarcopenia. Curr Opin Clin Nutr Metab Care 2009;12(1):86-90.

Park S, Johnson MA, Fischer JG. Vitamin and mineral supplements: Barrier and challenges for older adults. J Nutr Elderly 2008;27(3-4):297-317.

Penna F, Busquets S, Pin F, Toledo M, Baccino FM, Lopez-Soriano FJ, . . . Argiles JM. Combined approach to counteract experimental cancer cachexia: eicosapentaenoic acid and training exercise. Journal of cachexia, sarcopenia and muscle. Jun 2011;2(2):95-104.

Pennings B, Senden JMG, Gijsen AP, Gijsen AP, Kuipers H, Van Loon LJ.  Whey protein stimulates postprandial protein accretion more effectively than do casein and casein hydrolysate in older men. Am J Clin Nutr 2011;93:997-1005.

Petersen AM, Magkos F, Atherton P, et al.  Smoking impairs muscle protein synthesis and the expression of myostatin and MAFbx in muscle. Am J Physiol Endocrinol Metab  2007;293(3):E843-848.

Peterson MD, Sen A, Gordon PM. Influence of resistance exercise on lean body mass in aging adults: a meta-analysis. Med Sci Sports Exerc 2011;43(2):249-258.

Phillips SM, Tang JE, Moore DR. The role of milk- and soy-bean protein in support of muscle protein synthesis and muscle protein accretion in young and elderly persons.  J Am Coll Nutr 2009;28(4):343-354.

Poulsen MM, Jorgensen JOL, Jessen N, et al. Resveratrol in metabolic health: an overview of the current evidence and perspectives. Ann NY Acad Sci 2013;1290:74-82.

Prado CMM, Bekaii-Saab T, Doyle LA, et al. Skeletal muscle anabolism is a side effect of therapy with the MEK inhibitor: selumetinib in patients with cholangiocarcinoma. Br J Cancer 2012;106(10):1583-1586.

Price DA, Schmid ML, Ong ELC, Adjukeiwicz KMB, Peaston B, Snow MH.  Pancreatic exocrine unsufficiency in HIV-positive patients.  HIV Medicine 2005;6:33-36.


Rahman MM, Halade GV, El Jamali A, Fernandes G. Conjugated linoleic acid (CLA) prevents age associated skeletal muscle loss. Biochem Biophys Res Commun 2009;383(4):513-518.

Rawson ES, Venezia AC. Use of creatine and evidence for effects of cognitive function in the young and old.  Amino Acids 2011;40(5):1349-1362.

Reagan-Shaw S, Nihal M, Ahmad N.  Dose translation from animal to human studies revisited.  FASEB J 2007;22:659-661.

Ringseis R, Keller J, Eder K.  Mechanisms underlying the anti-wasting effect of l-carnitine supplementation under pathologic conditions: evidence from experimental and clinical studies.  Eur J Nutr 2013;52:1421-42.

Robinson SM, Jameson KA, Batelaan SF, et al. Diet and its relationship with grip strength in community-dwelling older men and women: the Hertfordshire Cohort Study.  J Am Geriatr Soc 2008;56(1):84-90.

Rolland Y, VanKan GA, Gillette-Guyonnet S, Vellas B.  Cachexia versus sarcopenia.  Curr Opin Clin Nutr Metab Care. 2010;14(1):15-21.

Rom O, Kaisari S, Aizenbud D, Reznick AZ. Identification of possible cigarette smoke constituents responsible for muscle catabolism. J Muscle Res Cell Motil 2012;33(3-4):199-208.

Ruiz Garcia V, Lopez-Briz E, Carbonell Sanchis R, Gonzalvez Perales JL, Bort-Marti S. Megestrol acetate for treatment of anorexia-cachexia syndrome. The Cochrane database of systematic reviews. 2013;3:Cd004310.

Samaras  N, Samaras D, Frangos E, et al.  A review of age-related dehydroepiandrosterone decline and its association with well-known geriatric syndromes: Is treatment beneficial?  Rejuvenation Res 2013;16(4):285-294.

Schambelan M, Mulligan K, Grunfeld C, et al. Recombinant human growth hormone in patients with HIV-associated wasting. Ann Intern Med 1996;125(11):873-882.

Schols AM. Pulmonary cachexia. International journal of cardiology. Sep 2002;85(1):101-110.

Scott D, Blizzard L, Fell J, Giles G, Jones G. Associations between dietary nutrient intake and muscle mass and strength in community-dwelling older adults: The Tasmanian older adult cohort study. J Am Geriatr Soc 2010;58:2129-2134.

Semba RD, Lauretani F, Ferrucci L. Carotenoids as protection against sarcopenia in older adults.  Arch Biochem Biophys 2007;458(2):141-145.

Seo MH, Kim MK, Park SE, et al. The association between daily calcium intake and sarcopenia in older, non-obese Korean adults: the Fourth Korea National Health and Nutrition Examination Survey (KNHANES IV) 2009. Endocr J 2013;60(5):679-686.

Shadfar S, Couch ME, McKinney KA, Weinstein LJ, Yin X. Oral resveratrol inhibits cancer-induced skeletal and cardiac atrophy in vivo. Nutr Cancer 2011;63(5):749-762.

Sheffield-Moore M, Dillon EL, Casperson SL, et al.  A randomized pilot study of monthly cycled testosterone replacement or continuous testosterone replacement versus placebo in older men. J Clin Endocrinol Metab 2011;96(11):E1831-1837.

Sheffield-Moore M, Paddon-Jones D, Casperson SL, et al.  Androgen therapy induces muscle protein anabolism in older women. J Clin Endocrin Metab 2006;91(10):3844-3849.

Siddiqui R, Pandya D, Harvey K, Zaloga GP. Nutrition modulation of cachexia/ proteolysis. Nutr Clin Pract 2006;21(2):155-167.

Silverio R, Laviano A, Rossi Fanelli FR, Seelander M.  L-carnitine and cancer cachexia: Clinical and experimental aspects. J Cachexia Sarcopenia Muscle 2011;2:37-44.

Sirola J, Kroger H. Similarities in acquired factors related to postmenopausal osteoporosis and sarcopenia. J Osteroporos 2011. Doi: 4061/2011/536735

Smith GI, Atherton P, Reeds DN, et al.  Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial. Am J Clin Nutr 2011;93(2):402-412.

Smith GI, Yoshino J, Reeds DN, Bradley D, Burrows RE, Heisey HD, . . . Mittendorfer B. Testosterone and progesterone, but not estradiol, stimulate muscle protein synthesis in postmenopausal women. The Journal of clinical endocrinology and metabolism. Jan 2014;99(1):256-265.

Solheim TS, Blum D, Fayers PM, Hjermstad MJ, Stene GB, Strasser F, Kaasa S. Weight loss, appetite loss and food intake in cancer patients with cancer cachexia: Three peas in a pod? - analysis from a multicenter cross sectional study. Acta oncologica (Stockholm, Sweden). Sep 2 2013.

Solheim TS, Laird BJA.  Evidence base for multimodal therapy in cachexia. Curr Opin Support Palliat Care 2012;6(4):424-431.

Srinivas-Shankar U, Roberts SA, Connolly MJ, et al.  Effects of testosterone in muscle strength, physical function, body composition, and quality of life in intermediate-frail and frail elderly men: A randomized, double-blind, placebo-controlled study.  J Clin Endocrinol Metab 2010;95:639-650.

Stene GB, Helbostad JL, Balstad TR, Riphagen II, Kaasa S, Oldervoll LM. Effect of physical exercise on muscle mass and strength during treatment- A systematic review. Crit Rev Oncol Hematol 2013; In Press,

Strawford A, Barbieri T, Van Loan M, Parks E, Catlin D, Barton N, . . . Hellerstein MK. Resistance exercise and supraphysiologic androgen therapy in eugonadal men with HIV-related weight loss: a randomized controlled trial. JAMA : the journal of the American Medical Association. Apr 14 1999;281(14):1282-1290.

Sullivan DH, Roberson PK, Smith ES, Price JA, Bopp MM.  Effects of muscle strength training and megestrol acetate on strength, muscle mass, and function in frail older people. J Am Geriatr Soc 2007;55(1):20-28.

Suzuki H, Asakawa A, Amitani H, Fujitsuka N, Nakamura N, Inui A. Cancer cachexia pathophysiology and translational aspect of herbal medicine. Japanese journal of clinical oncology. Jul 2013;43(7):695-705.

Suzuki H, Asakawa A, Li B, et al. Zinc as an appetite stimulator- the possible role of zinc in the progression of diseases such as cachexia and sarcopenia. Recent Pat Food Nutr Agric  2011;3(3):226-231.

Taaffe DR. 2006. Sarcopenia: Exercise as a treatment strategy. Aust Fam Physician 35(3):130-133.

Tang B, Eslick G, Nolwson C, Smith C, Bensoussan A. Use of calcium in combination with vitamin D supplementation to prevent fractures and bone loss in people aged 50 years or older: a meta-analysis. Lancet 2007;370(9844):657-666.

Tarnopolsky M, Zimmer A, Paikin J, et al. Creatine monohydrate and conjugated linoleic acid improve strength and body composition following resistance exercise in older adults. PLoS One 2007;2(10):e991.

Tassinari D, Fochessati F, Panzini I, Poggi B, Sartori S, Ravaioli A. Rapid progression of advanced "hormone-resistant" prostate cancer during palliative treatment with progestins for cancer cachexia. Journal of pain and symptom management. May 2003;25(5):481-484.

Thomas DR. Loss of skeletal muscle mass in aging: Examining the relationship of starvation, sarcopenia and cachexia. Clin Nutr 2007;26(4): 389-399.

Tieland M, Brouwer-Brolsma EM, Nienaber-Rousseau C, van Loon LJ, De Groot LC. Low vitamin D status is associated with reduced muscle mass and impaired physical performance in frail elderly people. European journal of clinical nutrition. Oct 2013;67(10):1050-1055.

Timmers SW, Konings E, Bilet L, et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans.  Cell Metab 2011;14(5):612-622.

UMMC. University of Maryland Medical Center (UMMC). Dehydroepiandrosterone. Available at: 2013.

Vaitkevicius PV, Ebersold C, Shah MS, et al. Effects of exercise training in community-based subjects aged 80 and older: A pilot study. J Am Geriatr Soc 2002;50(12):2009-2013.

Vaquero MP. Magnesium and trace elements in the elderly: Intake, status, and recommendations. J Nutr Health Aging 2002;6(2):147-153.

von Haehling S, Anker SD. Cachexia as a major underestimated and unmet medical need: facts and numbers. Journal of cachexia, sarcopenia and muscle. Sep 2010;1(1):1-5.

Weiss EP, Shah K, Fontana L, Lambert CP, Holloszy J, Villareal DT.  Dehydroepidandrosterone replacement therapy in older adults: 1- and 2- year effects on bone. Am J Clin Nutr 2009;89(5):1459-1467.

Wigmore SJ, Ross JA, Falconer JS, et al.  The effect of polyunsaturated fatty acids with the progress of cachexia in patients with pancreatic cancer.  Nutrition 1996;12 (supplement 1):S27-S30.

Wolfe RA. Protein summit: consensus and further research. Am J Clin Nutr 2008;87(supplement 5 )1582S-1583S.

Wong YY, McCaul KA, Yeap BB, Hankey GJ, Flicker L. Low vitamin D status is an independent predictor of increased frailty and all-cause mortality in older men: the Health in Men Study. The Journal of clinical endocrinology and metabolism. Sep 2013;98(9):3821-3828.

Wright L, Hickson M, Frost G. Eating together is important: using a dining room in acute elderly medical wards increases energy intake. J Human Nutr Diet 2006;19(1):23-26.

Yeh KY, Wang HM, Change JWC, et al.  Omega-3 fatty acid-, micronutrient-, and probiotic-enriched nutrition helps body weight stabilization in head and neck cancer cachexia.  Oral Surg Oral Med Oral Path Oral Radiol 2013;116(1):41-48.

Yeh SS, Marandi M, Thode HC, et al.  Report of a pilot, double-blind, placebo-controlled study of megestrol acetate in elderly dialysis patients with cachexia. J Ren Nutr 2010;20(1):52-62.

Zacker RJ. Health-related implications and management of sarcopenia. JAAPA 2006;19(10):24-29.

Zamboni M, Mazzali G, Fantin F, Rossi A, Di Francesco V.  Sarcopenic obesity: A new category of obesity in the elderly. Nutr Metab Cardiovasc Dis. 2008;18(5):388-395.