Life Extension Magazine®
Woman eating a tomato rich in lycopene for absorption

Issue: Jul 2015

Nutrients That Are Best Absorbed With Your Heaviest Meal

Research shows that fat-soluble vitamins are absorbed differently than water-soluble vitamins. For optimal absorption, critical fat-soluble nutrients should be taken with the day’s heaviest meal, which usually contains the most dietary fat.

By Michael Downey, Health & Wellness Author.

Scientists are increasingly focused on the fact that fat-soluble vitamins are absorbed differently—and at different intestinal locations—than water-soluble vitamins.1,2 For optimal health, both water and fat-soluble vitamins are needed.3

For maximum absorption, fat-soluble nutrients should be taken in conjunction with the daily meal containing the most dietary fat, which is typically the heaviest meal of the day.

Most people get a wide assortment of vitamins from their daily multivitamin tablets. However, to ensure an optimum intake of critical fat-soluble nutrients, it is wise to take most of these at the time of your largest meal.

The heaviest meal of the day is often the one that contains the most DNA mutagens. Fortunately, chlorophyllin and blueberry have been shown to protect DNA and promote its repair. These two nutrients should also be taken with your heaviest meal of the day.

Critical Differences Between Fat-Soluble And Water-Soluble Vitamins

Critical Differences Between Fat-Soluble And Water-Soluble Vitamins  

Most water-soluble vitamins travel from the small intestine to the bloodstream with relative ease.1

Fat-soluble vitamins, however, rely on bile for absorption. Bile is produced in the liver and then travels into the small intestine, where it helps break down fats. Fat-soluble nutrients are then absorbed through the intestinal wall and enter the lymph vessels. From there, these fat-soluble nutrients make their way into the bloodstream.2

With the exception of vitamin B12, which can be stored in your liver, most water-soluble vitamins are utilized around the time of absorption and later excreted in the urine.4

Unused fat-soluble nutrients are stored in the liver and in fat tissue. As additional amounts are needed at a later time, they are then released from these storage areas into the bloodstream.5

Many people don’t get enough oil-based vitamins from their diet. Those on low-fat or vegan diets might be at even greater risk of receiving inadequate amounts, which is understandable when you consider that dietary fat must be consumed for the absorption of fat-soluble vitamins.6

Because dietary fat is generally consumed with the heaviest meal of the day—and because fat-soluble nutrients interact synergistically with each other6—this fattiest, largest meal provides an ideal window of opportunity for taking fat-soluble nutrients.

Let’s now examine the critical body functions served by individual fat-soluble nutrients.

Vitamin E

Alpha tocopherol is the best known form of vitamin E and is widely distributed in the body.7,8 It is critical, however, for anyone supplementing with vitamin E to make sure they are also getting adequate gamma tocopherol each day—and both are best absorbed with dietary fat.

Both alpha and gamma tocopherols powerfully fight free radicals, however, studies demonstrate gamma tocopherol’s superior ability to neutralize reactive nitrogen oxides.9,10

Current research supports the importance of gamma tocopherol in preventing numerous components of the degenerative diseases associated with aging.11,12

Gamma tocopherol has far more powerful anti-inflammatory actions than the alpha form.13,14 Furthermore, it is more potent at inhibiting certain inflammatory cytokines in cell culture and in living animals.15-17 And it inhibits production of stress-related “heat shock proteins” that result from inflammatory stimuli.18

Research shows that gamma tocopherol helps prevent migration of inflammatory cells into the airways at the beginning of an attack of asthma or allergic rhinitis and also reduces overgrowth of inflammatory cells in the nose and upper airways.19

Gamma tocopherol also provides anti-inflammatory effects that are important for fighting atherosclerosis.20-23 It is converted in your body to gamma-CEHC, a metabolite that helps shed excess sodium—an important property if mealtime sodium intake has been high.24-27

Another benefit of gamma tocopherol is its ability to improve endothelial function by increasing nitric oxide synthase, the enzyme responsible for producing vessel-relaxing nitric oxide.28 One major way it produces this effect is by sponging up destructive reactive nitrogen species, such as peroxynitrite.29 In fact, gamma tocopherol is able to “trap” a variety of reactive nitrogen species and halt their negative effects on a host of cellular processes.30

Strenuous exercise, while beneficial for people in good physical shape, does tend to increase blood coagulation and platelet aggregation in sedentary individuals—a bad thing in people with pre-existing atherosclerosis. Gamma tocopherol supplementation can mitigate these effects, potentially lowering stroke and heart attack risk.31

Gamma tocopherol inhibits cancer cell growth in culture through a number of different mechanisms.32 By decreasing the levels of proteins responsible for controlling cancer cell reproduction, gamma tocopherol effectively halts the spread of malignancy.33 This anticancer effect appears to be based on a mechanism separate from the vitamin’s well-known ability to fight free radicals.

A nuclear hormone receptor called PPAR-gamma is a promising target for anticancer therapies because it affects genes that control cancer cell growth and death.34-36 Gamma tocopherol is more powerful than alpha tocopherol at stimulating PPAR-gamma activity especially in colon cancer cells.37, 38

In a mouse model of Parkinson’s disease, gamma tocopherol has been shown to be more effective than alpha tocopherol at preventing loss of the essential neurotransmitter dopamine, the chemical defect that produces Parkinson’s symptoms.39

Those wishing to further boost tissue vitamin E levels should take a supplement that also contains sesame lignans—the 1% solid portion of sesame oil. In animal studies, sesame lignans have been shown to increase tissue and blood levels of both alpha and gamma tocopherol.40,41

What You Need To Know
Vitamins To Take With Your Heaviest Meal

Vitamins To Take With Your Heaviest Meal

  • Fat-soluble vitamins—which are absorbed differently than water-soluble vitamins—are best taken with the meal providing the most dietary fat, usually the day’s heaviest meal.
  • Most people take multivitamin tablets daily. But to ensure optimum levels of the fat-soluble vitamins (and other fat-soluble nutrients), it’s wise to take additional doses of these along with your largest meal.
  • It’s at the time of your largest meal that you generally ingest the most dietary mutagens, often from deep-fried or high-temperature-cooked foods—so it’s also wise to supplement your heaviest meal with DNA-protective chlorophyllin, which binds to mutagens and excretes them from the body, and blueberry extract, which protects DNA and promotes its accurate repair.

Vitamin K

A 2014 study confirms that ample intake of fat-soluble vitamin K supports longevity. In a group of more than 7,000 people at high risk for cardiovascular disease, those with the highest vitamin K intake were 36% less likely to die from any cause, compared with those with the lowest intake.42

Vitamin K may reduce the risk of many of the leading causes of American deaths—including atherosclerosis,43,44 osteoporosis,45,46 diabetes,47,48 cardiovascular-related deaths,42 and cancer.42,49 Vitamin K is such a versatile protective nutrient because it has the unique ability to activate proteins involved in these conditions. In fact, a large European study showed that cancer death was 28% less likely overall in those with the highest versus lowest consumption of vitamin K2.50

Vitamin K plays a critical role in maintaining healthy bone density by facilitating the transport of calcium from the bloodstream into the bone.51-54 Without adequate vitamin K, calcium in the blood does not adequately bind to bone and instead infiltrates into the arterial wall, resulting in calcification.55,56 Poor vitamin K status is associated with increased bone loss in postmenopausal women.57,58

Humans get most of their vitamin K from green vegetables in the form of vitamin K1.59 The problem is that K1 is tightly bound to plant fiber and only a small fraction absorbs into the bloodstream.59-61

Vitamin K2 (menaquinones) is found in meat, eggs, and dairy products and is also made by bacteria in the human gut, which provide a certain amount of the human vitamin K requirement.62,63 Human studies show that vitamin K2 is up to 10 times more bioavailable than K1. Vitamin K2 remains biologically active in the body far longer than K1. For instance, K1 is rapidly cleared by the liver within eight hours, whereas measurable levels of K2 (MK-7) have been detected 72 hours after ingestion.54

The MK-4 form of vitamin K2 is the most rapidly absorbed and is now routinely used in Japan to maintain healthy bone density.64 MK-4, however, only remains active in the blood for a few hours.65,66

The MK-7 form of K2, on the other hand, remains bioavailable to the human body over a sustained period65 and at higher levels— 7- to 8-fold—during prolonged intake.54 Both MK-4 and MK-7 have demonstrated remarkable health benefits when studied in human populations.

Vision-Supporting Carotenoids

Vision-Supporting Carotenoids  

Fat-soluble nutrients include carotenoids that are essential for vision support.

For example, carotenoid nutrients such as lutein and specific forms of zeaxanthin make up your macular pigment—the part of your retina that protects underlying photoreceptor cells from the harmful effects of excess blue and ultraviolet light.67-70 And the density of your macular pigment is essential to healthy vision.71-73

Unfortunately, this density naturally declines with age74 and some of us lose the ability to synthesize meso-zeaxanthin from lutein over time.75 For this reason, it is critical to supplement with lutein, as well as trans-zeaxanthin and meso-zeaxanthin, which are difficult to get from diet alone.

Additionally, phospholipids help drive these eye-healthy nutrients to where they’re needed most. Phospholipids mix well with lutein and are an integral part of the cell membrane. Studies show that they support lutein absorption75-80 and improve the circulation and accumulation of lutein within the retina.80

Delayed regeneration of rhodopsin, a retinal compound that absorbs light, is associated with the loss of night vision humans experience as they age.81 To help maintain night vision in your later years, it is advisable to take cyanidin-3-glucoside—a purple pigment in the anthocyanin family of flavonoid molecules.

Derived from blackberries or black currants, cyanidin-3-glucoside encourages the regeneration of rhodopsin82 and beneficially changes its molecular structure.83 In one study, volunteers who took a berry extract concentrate containing cyanidin-3-glucoside experienced improved ability to see in darkness after just 30 minutes.84 Beyond eye health, this flavonoid also helps to induce apoptosis in a number of human cancer lines, important to cancer prevention85,86—and was discovered to be neuroprotective, helping to prevent the disastrous effects of the Alzheimer’s-related protein amyloid beta on brain cells.87


Lycopene is a fat-soluble carotenoid with a unique structure that drives its intense free-radical-trapping activity. Controlled studies show that increased lycopene levels result in broad cellular benefits—and reduced incidences of cancer, diabetes, Alzheimer’s, and cardiovascular disease.88

Prostate cancer is the disease that is best known as a target for prevention by lycopene.89,90 But lycopene is also associated with preventive effects against breast,91,92 cervical,93 lung,94,95 and colon cancer.96,97

Research indicates that people with the highest blood lycopene levels also have greater glucose tolerance than do those with lower lycopene levels.98 Diabetics with healthy eyes were found to have higher levels of lycopene than those with the blindness-inducing condition called diabetic retinopathy.99 Similarly, diabetic neuropathy, a painful and debilitating nerve condition that is among the hardest of pain syndromes to treat, is substantially ameliorated in animal studies of lycopene supplementation.100,101 And the cognitive decline associated with diabetes can be decreased with long-term lycopene supplementation.102

Lycopene may help prevent Alzheimer’s by inhibiting formation of oxidant-producing amyloid beta proteins,103 and lycopene studies demonstrate decreased death rates of neurons, especially in the memory-processing hippocampus area of the brain.104

A lycopene-rich tomato powder supplement completely prevented destruction of essential dopamine-producing brain cells in a mouse model of Parkinson’s disease,105 and other studies showed that lycopene successfully prevented the neurobehavioral deficits associated with the disease.106 In animal models of Huntington’s disease, lycopene reduced memory impairment while blocking the behavioral and biochemical abnormalities,107 apparently by inhibiting inflammatory peroxynitrite production and inducing protective effects on brain mitochondria.108

Individuals with the highest lycopene blood levels have a 45% lower risk of atherosclerosis.109 In a human study, supplementation with tomato products decreased total cholesterol by 5.9% and LDL cholesterol by 12.9%.110 And in animals, lycopene supplementation reduced both LDL cholesterol and total cholesterol by 50%.111 Lab and human studies demonstrate that lycopene decreases production of multiple proinflammatory mediators and markers of inflammation.112-114

Popular Fat-Soluble Nutrients
Popular Fat-Soluble Nutrients

What follows is a list of popular fat-soluble supplements best taken with meals that contain at least some dietary fat:

  • Vitamin D
  • Fish oil
  • Coenzyme Q10
  • Vitamin E (alpha and gamma forms)
  • Vitamin K
  • Lycopene
  • Zeaxanthin
  • Meso-zeaxanthin
  • Astaxanthin

You can absorb substantially higher quantities of fat-soluble nutrients when taking them with a meal that contains fat.


Your heaviest meal of the day often contains the most dietary mutagens. So this is the ideal time to supplement with chlorophyllin—a mutagen-neutralizing substance derived from the plant pigment chlorophyll.

Your body encounters environmental toxins such as cigarette smoke and diesel-emission particles on a regular basis.115-117 But it’s your largest meal that can inflict the most cellular damage as a result of the formation of gene-mutating heterocyclic amines caused by heavily cooked foods.118,119 Even healthy foods can hold small amounts of DNA mutating substances.120

Chlorophyllin is able to bind to mutagenic substances and excrete them from the body before they can do any damage.121

In addition, chlorophyllin has been demonstrated to possess DNA-protective and radical-quenching properties that inhibit the creation of DNA adducts—pieces of DNA bonded to a cancer-causing chemical.118,122-124 Animal and human studies show that these adducts contribute to cancer by causing extensive and irreversible DNA damage.125-128 By inhibiting harmful substances123 and helping to prevent induced DNA mutations,124 chlorophyllin acts as an “interceptor molecule”—isolating carcinogens so that they cannot form dangerous adducts.129,130

Chlorophyllin also quenches a wide variety of reactive oxygen radicals131 and can powerfully induce enzymes that protect cells from other unstable molecules.132 It also has a role in protecting against a naturally occurring mold called aflatoxin, which is a potent carcinogen found in plant foods.121,133,134

Blueberry Extract

Blueberry Extract  

Another DNA-guarding nutrient best taken with a heavy meal is blueberry extract.

Recent studies now demonstrate that blueberry extract prevents DNA damage and promotes rapid and accurate DNA repair.135-143 These dual effects of blueberries block environmental (and age-related) impacts that lead to cancer,144,145 cardiovascular disease,146,147 and the loss of metabolic control148,149 that underlies obesity and diabetes.

An animal study found that blueberry compounds increased mean life span by 28%, representing over 22 years in human terms.150 Further research on humans showed that, within just one hour of ingesting ground blueberries, participants experienced an 18% reduction in the amount of oxidation-induced DNA damage compared to control subjects.151

In addition to DNA protection, blueberry has been found in several studies to benefit the cognitive health of older adults. The compounds in blueberries protect against age-related changes in neuronal aging and have been associated with slower rates of cognitive decline.152

In 2014, a double-blind, placebo-controlled clinical trial gave some of the 105 cognitively intact adults, aged 65 to 85, a formulation of blueberry (and other nutrients). After two months of daily supplementation, a battery of cognitive tests showed that the intervention group had improved significantly on two measures of cognitive processing speed, while the control group did not show improvement.153

Vitamin B12

Aging individuals154-157 and vegetarians are at significant risk of vitamin B12 (or cobalamin) deficiency.158,159

Intrinsic factor, a compound secreted by the cells lining the stomach, is crucially important for the absorption of vitamin B12 from the small intestine.160 However, intrinsic factor production diminishes as your body ages. Worse, it is estimated that up to 30% of individuals over age 50 secrete low amounts of stomach acid,161,162 further decreasing bioavailability of vitamin B12 from food.

Deficiency of vitamin B12 principally affects the peripheral nerves, and in later stages may target the spinal cord.163,164 Impaired mental function is the usual result, often manifesting as slower thinking, confusion, and memory lapses.164

Also, cobalamin deficiency leads to inhibition of methionine synthase, the key enzyme responsible for the conversion of homocysteine to methionine.165,166 The result is a high level of serum homocysteine,167 which may be toxic to the cells that line blood vessels168 and may increase clotting.169


Critical to life, fat-soluble vitamins are absorbed and stored differently than water-soluble vitamins. Fat-soluble nutrients are best absorbed when taken with the meal providing the most dietary fat—usually the heaviest meal of the day.

Even if, like most people, you take daily multivitamin tablets, it is wise to ensure optimum levels of the fat-soluble vitamins (and other fat-soluble nutrients) by taking additional doses of these along with your largest meal.

Also important to take with your largest meal—the meal that usually contains the most dietary mutagens—is DNA-protective chlorophyllin, which binds to mutagens and carries them from your body, and blueberry extract, which protects DNA and promotes its repair.

If you have any questions on the scientific content of this article, please call a Life Extension® Health Advisor at 1-866-864-3027.


  1. Available at: Accessed April 17, 2015.
  2. Available at: Accessed April 17, 2015.
  3. Fletcher RH, Fairfield KM. Vitamins for chronic disease prevention in adults: clinical applications. JAMA. 2002 Jun 19;287(23):3127-9.
  4. Available at: Accessed April 17, 2015.
  5. Available at: Accessed April 17, 2015.
  6. Available at: Accessed April 17, 2015.
  7. Manolescu B, Atanasiu V, Cercasov C, Stoian I, Oprea E, Buşu C. So many options but one choice: the human body prefers alpha-tocopherol. A matter of stereochemistry. J Med Life. 2008 Oct-Dec;1(4):376-82. Review.
  8. Wang X, Quinn PJ. Vitamin E and its function in membranes. Prog Lipid Res. 1999 Jul;38(4):309-36.
  9. Cooney RV, Franke AA, Harwood PJ, et al. Gamma-tocopherol detoxification of nitrogen dioxide: superiority to alpha-tocopherol. Proc Natl Acad Sci USA. 1993 Mar 1;90(5):1771-5.
  10. Cooney RV, Harwood PJ, Franke AA, et al. Products of gamma-tocopherol reaction with NO2 and their formation in rat insulinoma (RINm5F) cells. Free Radic Biol Med. 1995 Sep;19(3):259-69.
  11. Christen S, Woodall AA, Shigenaga MK, Southwell-Keely PT, Duncan MW, Ames BN. gamma-tocopherol traps mutagenic electrophiles such as NO(X) and complements alpha-tocopherol: physiological implications. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):3217-22.
  12. Devaraj S, Leonard S, Traber MG, Jialal I. Gamma-tocopherol supplementation alone and in combination with alpha-tocopherol alters biomarkers of oxidative stress and inflammation in subjects with metabolic syndrome. Free Radic Biol Med. 2008 Mar 15;44(6):1203-8.
  13. Reiter E, Jiang Q, Christen S. Anti-inflammatory properties of alpha- and gamma-tocopherol. Mol Aspects Med. 2007 Oct-Dec;28(5-6):668-91.
  14. Wiser J, Alexis NE, Jiang Q, et al. In vivo gamma-tocopherol supplementation decreases systemic oxidative stress and cytokine responses of human monocytes in normal and asthmatic subjects. Free Radic Biol Med. 2008 Jul 1;45(1):40-9.
  15. Devaraj S, Traber MG. Gamma-tocopherol, the new vitamin E? Am J Clin Nutr. 2003 Mar;77(3):530-1.
  16. Jiang Q, Elson-Schwab I, Courtemanche C, Ames BN. Gamma-tocopherol and its major metabolite, in contrast to alpha-tocopherol, inhibit cyclooxygenase activity in macrophages and epithelial cells. Proc Natl Acad Sci USA. 2000 Oct 10;97(21):11494-9.
  17. Jiang Q, Ames BN. Gamma-tocopherol, but not alpha-tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats. FASEB J. 2003 May;17(8):816-22.
  18. Fischer CP, Hiscock NJ, Basu S, et al. Vitamin E isoform-specific inhibition of the exercise-induced heat shock protein 72 expression in humans. J Appl Physiol. 2006 May;100(5):1679-87.
  19. Wagner JG, Jiang Q, Harkema JR, et al. Gamma-tocopherol prevents airway eosinophilia and mucous cell hyperplasia in experimentally induced allergic rhinitis and asthma. Clin Exp Allergy. 2008 Mar;38(3):501-11.
  20. Jiang Q, Lykkesfeldt J, Shigenaga MK, Shigeno ET, Christen S, Ames BN. Gamma-tocopherol supplementation inhibits protein nitration and ascorbate oxidation in rats with inflammation. Free Radic Biol Med. 2002 Dec 1;33(11):1534-42.
  21. Li D, Saldeen T, Mehta JL. Gamma-tocopherol decreases ox-LDL-mediated activation of nuclear factor-kappaB and apoptosis in human coronary artery endothelial cells. Biochem Biophys Res Commun. 1999 May 27;259(1):157-61.
  22. Devaraj S, Jialal I. Failure of vitamin E in clinical trials: is gamma-tocopherol the answer? Nutr Rev. 2005 Aug;63(8):290-3.
  23. Jiang Q, Moreland M, Ames BN, Yin X. A combination of aspirin and gamma-tocopherol is superior to that of aspirin and alpha-tocopherol in anti-inflammatory action and attenuation of aspirin-induced adverse effects. J Nutr Biochem. 2009 Nov;20(11):894-900.
  24. Jiang Q, Christen S, Shigenaga MK, Ames BN. Gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr. 2001 Dec;74(6):714-22.
  25. Hensley K, Benaksas EJ, Bolli R, et al. New perspectives on vitamin E: gamma-tocopherol and carboxyelthylhydroxychroman metabolites in biology and medicine. Free Radic Biol Med. 2004 Jan 1;36(1):1-15.
  26. Wagner KH, Kamal-Eldin A, Elmadfa I. Gamma-tocopherol--an underestimated vitamin? Ann Nutr Metab. 2004;48(3):169-88.
  27. Uto H, Kiyose C, Saito H, Ueda T, Nakamijra T, Igarashi O, Kondo K. Gamma-tocopherol enhances sodium excretion as a natriuretic hormone precursor. J Nutr Sci Vitaminol (Tokyo). 2004 Aug;50(4):277-82.
  28. Li D, Saldeen T, Romeo F, Mehta JL. Relative effects of alpha- and gamma-tocopherol on low-density lipoprotein oxidation and superoxide dismutase and nitric oxide synthase activity and protein expression in rats. J Cardiovasc Pharmacol Ther. 1999 Oct;4(4):219-26.
  29. McCarty MF. Gamma-tocopherol may promote effective no synthase function by protecting tetrahydrobiopterin from peroxynitrite. Med Hypotheses. 2007;69(6):1367-70.
  30. Saito F, Iwamoto S, Yamauchi R. Reaction products of gamma-tocopherol with (E)-4-oxo-2-nonenal in acidic acetonitrile. Biosci Biotechnol Biochem. 2010;74(1):168-74.
  31. Vucinic L, Singh I, Spargo FJ, Hawley JA, Linden MD. Gamma tocopherol supplementation prevents exercise induced coagulation and platelet aggregation. Thromb Res. 2010 Feb;125(2):196-9.
  32. Moyad MA, Brumfield SK, Pienta KJ. Vitamin E, alpha- and gamma-tocopherol, and prostate cancer. Semin Urol Oncol. 1999 May;17(2):85-90.
  33. Gysin R, Azzi A, Visarius T. Gamma-tocopherol inhibits human cancer cell cycle progression and cell proliferation by down-regulation of cyclins. FASEB J. 2002 Dec;16(14):1952-4.
  34. Campbell SE, Stone WL, Whaley SG, Qui M, Krishnan K. Gamma (gamma) tocopherol upregulates peroxisome proliferator activated receptor (PPAR) gamma (gamma) expression in SW 480 human colon cancer cell lines. BMC Cancer. 2003 Oct 1;3:25.
  35. Semple RK, Chatterjee VK, O’Rahilly S. PPAR gamma and human metabolic disease. J Clin Invest. 2006 Mar;116(3):581-9.
  36. Harris SG, Phipps RP. The nuclear receptor PPAR gamma is expressed by mouse T lymphocytes and PPAR gamma agonists induce apoptosis. Eur J Immunol. 2001 Apr;31(4):1098-105.
  37. Stone WL, Krishnan K, Campbell SE, Qui M, Whaley SG, Yang H. Tocopherols and the treatment of colon cancer. Ann N Y Acad Sci. 2004 Dec;1031:223-33.
  38. Campbell SE, Musich PR, Whaley SG, et al. Gamma tocopherol upregulates the expression of 15-S-HETE and induces growth arrest through a PPAR gamma-dependent mechanism in PC-3 human prostate cancer cells. Nutr Cancer. 2009;61(5):649-62.
  39. Itoh N, Masuo Y, Yoshida Y, Cynshi O, Jishage K, Niki E. Gamma-Tocopherol attenuates MPTP-induced dopamine loss more efficiently than alpha-tocopherol in mouse brain. Neurosci Lett. 2006 Jul 31;403(1-2):136-40.
  40. Yamashita K, Nohara Y, Katayama K. Sesame seed lignans and gamma-tocopherol act synergistically to produce vitamin E activity in rats. J Nutr. 1992 Dec;122(12):2440-6.
  41. Yamashita K, Lisuka Y. Sesame seed and its lignans produce marked enhancement of vitamin E activity in rats fed a low a-tocopherol diet. Lipids 1995 Nov;30(11):1019-28.
  42. Juanola-Falgarona M, Salas-Salvado J, Martinez-Gonzalez MA, et al. Dietary intake of vitamin K is inversely associated with mortality risk. J Nutr. 2014 May;144(5):743-50.
  43. Shea MK, Holden RM. Vitamin K status and vascular calcification: evidence from observational and clinical studies. Adv Nutr. 2012 Mar 1;3(2):158-65.
  44. Shea MK, O’Donnell CJ, Hoffmann U, Dallal GE, Dawson-Hughes B, Ordovas JM, Price PA, Williamson MK, Booth SL. Vitamin K supplementation and progression of coronary artery calcium in older men and women. Am J Clin Nutr. 2009 Jun;89(6):1799-807.
  45. Prabhoo R, Prabhoo TR. Vitamin K2: a novel therapy for osteoporosis. J Indian Med Assoc. 2010 Apr;108(4):253-4, 256-8.
  46. Cockayne S, Adamson J, Lanham-New S, Shearer MJ, Gilbody S, Torgerson DJ. Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials. Arch Intern Med. 2006;166(12):1256-61.
  47. Beulens JW, van der AD, Grobbee DE, Sluijs I, Spijkerman AM, van der Schouw YT. Dietary phylloquinone and menaquinones intakes and risk of type 2 diabetes. Diabetes Care. 2010 Aug;33(8):1699-705.
  48. Ibarrola-Jurado N, Salas-Salvado J, Martinez-Gonzalez MA, Bullo M. Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease. Am J Clin Nutr. 2012 Nov;96(5):1113-8.
  49. Nimptsch K, Rohrmann S, Linseisen J. Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg). Am J Clin Nutr. 2008 Apr;87(4):985-92.
  50. Nimptsch K, Rohrmann S, Kaaks R, Linseisen J. Dietary vitamin K intake in relation to cancer incidence and mortality: results from the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition (EPIC-Heidelberg). Am J Clin Nutr. 2010 May;91(5):1348-58.
  51. Knapen MH, Schurgers LJ, Vermeer C. Vitamin K2 supplementation improves hip bone geometry and bone strength indices in postmenopausal women. Osteoporos Int. 2007 Jul;18(7):963-72.
  52. Bolton-Smith C, McMurdo ME, Paterson CR, et al. Two-year randomized controlled trial of vitamin K1 (phylloquinone) and vitamin D3 plus calcium on the bone health of older women. J Bone Miner Res. 2007 Apr;22(4):509-19.
  53. Van Summeren MJ, Braam LA, Lilien MR, Schurgers LJ, Kuis W, Vermeer C. The effect of menaquinone-7 (vitamin K2) supplementation on osteocalcin carboxylation in healthy prepubertal children. Br J Nutr. 2009 Oct;102(8):1171-8.
  54. Schurgers LJ, Teunissen KJ, Hamulyák K, Knapen MH, Vik H, Vermeer C. Vitamin K-containing dietary supplements: comparison of synthetic vitamin K1 and natto-derived menaquinone-7. Blood. 2007 Apr 15;109(8):3279-83.
  55. Schurgers LJ, Cranenburg EC, Vermeer C. Matrix Gla-protein: the calcification inhibitor in need of vitamin K. Thromb Haemost. 2008 Oct;100(4):593-603.
  56. Danziger J. Vitamin K-dependent proteins, warfarin, and vascular calcification. Clin J Am Soc Nephrol. 2008 Sep;3(5):1504-10.
  57. Bügel S. Vitamin K and bone health in adult humans. Vitam Horm. 2008;78:393-416.
  58. Iwamoto J, Takeda T, Sato Y. Role of vitamin K2 in the treatment of postmenopausal osteoporosis. Curr Drug Saf. 2006 Jan;1(1):87-97.
  59. Garber AK, Binkley NC, Krueger DC, Suttie JW. Comparison of phylloquinone bioavailability from food sources or a supplement in human subjects. J Nutr. 1999 Jun;129(6):1201-3.
  60. Novotny JA, Kurilich AC, Britz SJ, Baer DJ, Clevidence BA. Vitamin K absorption and kinetics in human subjects after consumption of 13C-labelled phylloquinone from kale. Br J Nutr. 2010 Sep;104(6):858-62.
  61. Booth SL, Lichtenstein AH, Dallal GE. Phylloquinone absorption from phylloquinone-fortified oil is greater than from a vegetable in younger and older men and women. J Nutr. 2002 Sep;132(9):2609-12.
  62. Elder SJ, Haytowitz DB, Howe J, Peterson JW, Booth SL. Vitamin k contents of meat, dairy, and fast food in the U.S. diet. J Agric Food Chem. 2006 Jan 25;54(2):463-7.
  63. Komai M, Shirakawa H. Vitamin K metabolism. Menaquinone-4 (MK-4) formation from ingested VK analogues and its potent relation to bone function. Clin Calcium. 2007 Nov;17(11):1663-72.
  64. Koitaya N, Sekiguchi M, Tousen Y, et al. Low-dose vitamin K2 (MK-4) supplementation for 12 months improves bone metabolism and prevents forearm bone loss in postmenopausal Japanese women. J Bone Miner Metab. 2014 Mar;32(2):142-50.
  65. Sato T, Schurgers LJ, Uenishi K. Comparison of menaquinone-4 and menaquinone-7 bioavailability in healthy women. Nutr J. 2012 Nov 12;11:93.
  66. Vermeer C. Vitamin K: the effect on health beyond coagulation - an overview. Food Nutr Res. 2012;56.
  67. Krinsky NI, Landrum JT, Bone RA. Biologic mechanisms of the protective role of lutein and zeaxanthin in the eye. Annu Rev Nutr. 2003;23:171-201.
  68. Moukarzel AA, Bejjani RA, Fares FN. Xanthophylls and eye health of infants and adults. J Med Liban. 2009 Oct-Dec;57(4):261-7.
  69. Semba RD, Dagnelie G. Are lutein and zeaxanthin conditionally essential nutrients for eye health? Med Hypotheses. 2003 Oct;61(4):465-72.
  70. Schweigert FJ, Reimann J. Micronutrients and their relevance for the eye--function of lutein, zeaxanthin and omega-3 fatty acids. Klin Monbl Augenheilkd. 2011 Jun;228(6):537-43.
  71. Mitamura Y, Mitamura-Aizawa S, Nagasawa T, Katome T, Eguchi H, Naito T. Diagnostic imaging in patients with retinitis pigmentosa. J Med Invest. 2012;59(1-2):1-11.
  72. Nag TC, Wadhwa S. Ultrastructure of the human retina in aging and various pathological states. Micron. 2012 Jul;43(7):759-81.
  73. Bernstein PS, Delori FC, Richer S, van Kuijk FJ, Wenzel AJ. The value of measurement of macular carotenoid pigment optical densities and distributions in age-related macular degeneration and other retinal disorders.Vision Res. 2010 Mar 31;50(7):716-28.
  74. Lima VC, Rosen RB, Prata TS, et al. Association of age and macular pigment optical density using dual-wavelength autofluorescence imaging. Clin Ophthalmol. 2013;7:685-90.
  75. Abdel-Aal el-SM, Akhtar H, Zaheer K, Ali R. Dietary sources of lutein and zeaxanthin carotenoids and their role in eye health. Nutrients. 2013 Apr 9;5(4):1169-85.
  76. Marisiddaiah R, Baskaran V. Bioefficacy of beta-carotene is improved in rats after solubilized as equimolar dose of beta-carotene and lutein in phospholipid-mixed micelles. Nutr Res. 2009 Aug;29(8):588-95.
  77. Mamatha BS, Baskaran V. Effect of micellar lipids, dietary fiber and β-carotene on lutein bioavailability in aged rats with lutein deficiency. Nutrition. 2011 Sep;27(9):960-6.
  78. Lakshminarayana R, Raju M, Keshava Prakash MN, Baskaran V. Phospholipid, oleic acid micelles and dietary olive oil influence the lutein absorption and activity of antioxidant enzymes in rats. Lipids. 2009 Sep;44(9):799-806.
  79. Lakshminarayana R, Raju M, Krishnakantha TP, Baskaran V. Enhanced lutein bioavailability by lyso-phosphatidylcholine in rats. Mol Cell Biochem. 2006 Jan;281(1-2):103-10.
  80. Shanmugam S, Park JH, Kim KS, et al. Enhanced bioavailability and retinal accumulation of lutein from self-emulsifying phospholipid suspension (SEPS). Int J Pharm. 2011 Jun 30;412(1-2):99-105.
  81. Jackson GR, Owsley C, McGwin G Jr. Aging and dark adaptation. Vision Res. 1999 Nov;39(23):3975-82.
  82. Matsumoto H, Nakamura Y, Tachibanaki S, Kawamura S, Hirayama M. Stimulatory effect of cyanidin 3-glycosides on the regeneration of rhodopsin. J Agric Food Chem. 2003 Jun 4;51(12):3560-3.
  83. Tirupula KC, Balem F, Yanamala N, Klein-Seetharaman J. pH-dependent interaction of rhodopsin with cyanidin-3-glucoside. 2. Functional aspects. Photochem Photobiol. 2009 Mar-Apr;85(2):463-70.
  84. Nakaishi H, Matsumoto H, Tominaga S, Hirayama M. Effects of black currant anthocyanoside intake on dark adaptation and VDT work-induced transient refractive alteration in healthy humans. Alt Med Rev. 2000 Dec;5(6):553-62.
  85. Fimognari C, Berti F, Nusse M, Cantelli-Forti G, Hrelia P. Induction of apoptosis in two human leukemia cell lines as well as differentiation in human promyelocytic cells by cyanidin-3-O-beta-glucopyranoside. Biochem Pharmacol. 2004 Jun 1;67(11):2047-56.
  86. Chen PN, Chu SC, Chiou HL, Chiang CL, Yang SF, Hsieh YS. Cyanidin 3-glucoside and peonidin 3-glucoside inhibit tumor cell growth and induce apoptosis in vitro and suppress tumor growth in vivo. Nutr Cancer. 2005;53(2):232-43.
  87. Tarozzi A, Morroni F, Merlicco A, et al. Neuro-protective effects of cyanidin 3-O-glucopyranoside on amyloid beta (25-35) oligomer-induced toxicity. Neurosci Lett. 2010 Apr 5;473(2):72-6.
  88. Qu M, Li L, Chen C, et al. Protective effects of lycopene against amyloid β-induced neurotoxicity in cultured rat cortical neurons. Neurosci Lett. 2011 Nov 21;505(3):286-90.
  89. Kucuk O, Sarkar FH, Djuric Z, et al. Effects of lycopene supplementation in patients with localized prostate cancer. Exp Biol Med (Maywood). 2002 Nov;227(10):881-5.
  90. Dahan K, Fennal M, Kumar NB. Lycopene in the prevention of prostate cancer. J Soc Integr Oncol. 2008 Winter;6(1):29-36.
  91. Moselhy SS, Al mslmani MA. Chemopreventive effect of lycopene alone or with melatonin against the genesis of oxidative stress and mammary tumors induced by 7,12 dimethyl(a)benzanthracene in sprague dawely female rats. Mol Cell Biochem. 2008 Dec;319(1-2):175-80.
  92. Chalabi N, Delort L, Le Corre L, Satih S, Bignon YJ, Bernard-Gallon D. Gene signature of breast cancer cell lines treated with lycopene. Pharmacogenomics. 2006 Jul;7(5):663-72.
  93. Sedjo RL, Roe DJ, Abrahamsen M, et al. Vitamin A, carotenoids, and risk of persistent oncogenic human papillomavirus infection. Cancer Epidemiol Biomarkers Prev. 2002 Sep;11(9):876-84.
  94. Arab L, Steck-Scott S, Fleishauer AT. Lycopene and the lung. Exp Biol Med (Maywood). 2002 Nov;227(10):894-9.
  95. Holick CN, Michaud DS, Stolzenberg-Solomon R, et al. Dietary carotenoids, serum beta-carotene, and retinol and risk of lung cancer in the alpha-tocopherol, beta-carotene cohort study. Am J Epidemiol. 2002 Sep 15;156(6):536-47.
  96. Vrieling A, Voskuil DW, Bonfrer JM, et al. Lycopene supplementation elevates circulating insulin-like growth factor binding protein-1 and -2 concentrations in persons at greater risk of colorectal cancer. Am J Clin Nutr. 2007 Nov;86(5):1456-62.
  97. Walfisch S, Walfisch Y, Kirilov E, et al. Tomato lycopene extract supplementation decreases insulin-like growth factor-I levels in colon cancer patients. Eur J Cancer Prev. 2007 Aug;16(4):298-303.
  98. Coyne T, Ibiebele TI, Baade PD, et al. Diabetes mellitus and serum carotenoids: findings of a population-based study in Queensland, Australia. Am J Clin Nutr. 2005 Sep;82(3):685-93.
  99. Brazionis L, Rowley K, Itsiopoulos C, O’Dea K. Plasma carotenoids and diabetic retinopathy. Br J Nutr. 2009 Jan;101(2):270-7.
  100. Kuhad A, Sharma S, Chopra K. Lycopene attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain. Eur J Pain. 2008 Jul;12(5):624-32.
  101. Kuhad A, Chopra K. Lycopene ameliorates thermal hyperalgesia and cold allodynia in STZ-induced diabetic rat. Indian J Exp Biol. 2008 Feb;46(2):108-11.
  102. Kuhad A, Sethi R, Chopra K. Lycopene attenuates diabetes-associated cognitive decline in rats. Life Sci. 2008 Jul 18;83(3-4):128-34.
  103. Obulesu M, Dowlathabad MR, Bramhachari PV. Carotenoids and Alzheimer’s disease: an insight into therapeutic role of retinoids in animal models. Neurochem Int. 2011 Oct;59(5):535-41.
  104. Qu M, Zhou Z, Chen C, et al. Lycopene protects against trimethyltin-induced neurotoxicity in primary cultured rat hippocampal neurons by inhibiting the mitochondrial apoptotic pathway. Neurochem Int. 2011 Dec;59(8):1095-103.
  105. Suganuma H, Hirano T, Arimoto Y, Inakuma T. Effect of tomato intake on striatal monoamine level in a mouse model of experimental Parkinson’s disease. J Nutr Sci Vitaminol (Tokyo). 2002 Jun;48(3):251-4.
  106. Kaur H, Chauhan S, Sandhir R. Protective effect of lycopene on oxidative stress and cognitive decline in rotenone induced model of Parkinson’s disease. Neurochem Res. 2011 Aug;36(8):1435-43.
  107. Kumar P, Kumar A. Effect of lycopene and epigallocatechin-3-gallate against 3-nitropropionic acid induced cognitive dysfunction and glutathione depletion in rat: a novel nitric oxide mechanism. Food Chem Toxicol. 2009 Oct;47(10):2522-30.
  108. Sandhir R, Mehrotra A, Kamboj SS. Lycopene prevents 3-nitropropionic acid-induced mitochondrial oxidative stress and dysfunctions in nervous system. Neurochem Int. 2010 Nov;57(5):579-87.
  109. Klipstein-Grobusch K, Launer LJ, Geleijnse JM, Boeing H, Hofman A, Witteman JC. Serum carotenoids and atherosclerosis. The Rotterdam Study. Atherosclerosis. 2000 Jan;148(1):49-56.
  110. Silaste ML, Alfthan G, Aro A, Kesaniemi YA, Horkko S. Tomato juice decreases LDL cholesterol levels and increases LDL resistance to oxidation. Br J Nutr. 2007 Dec;98(6):1251-8.
  111. Lorenz M, Fechner M, Kalkowski J, et al. Effects of lycopene on the initial state of atherosclerosis in New Zealand White (NZW) rabbits. PLoS One. 2012;7(1):e30808.
  112. Lee W, Ku SK, Bae JW, Bae JS. Inhibitory effects of lycopene on HMGB1-mediated pro-inflammatory responses in both cellular and animal models. Food Chem Toxicol. 2012 Jun;50(6):1826-33.
  113. Ghavipour M, Saedisomeolia A, Djalali M, et al. Tomato juice consumption reduces systemic inflammation in overweight and obese females. Br J Nutr. 2013 Jun;109(11):2031-5.
  114. McEneny J, Wade L, Young IS, et al. Lycopene intervention reduces inflammation and improves HDL functionality in moderately overweight middle-aged individuals. J Nutr Biochem. 2013 Jan;24(1):163-8.
  115. Nazaroff WW, Singer BC. Inhalation of hazardous air pollutants from environmental tobacco smoke in US residences. J Expo Anal Environ Epidemiol. 2004;14 Suppl 1:S71-7.
  116. Zhang JJ, McCreanor JE, Cullinan P, et al. Health effects of real-world exposure to diesel exhaust in persons with asthma. Res Rep Health Eff Inst. 2009 Feb;(138):5-109; discussion 111-23.
  117. Ong TM, Whong WZ, Stewart J, Brockman HE. Chlorophyllin: a potent antimutagen against environmental and dietary complex mixtures. Mutat Res. 1986 Feb;173(2):111-5.
  118. Sugimura T, Wakabayashi K, Nakagama H, Nagao M. Heterocyclic amines: Mutagens/carcinogens produced during cooking of meat and fish. Cancer Sci. 2004 Apr;95(4):290-9.
  119. Skog K, Steineck G, Augustsson K, Jägerstad M. Effect of cooking temperature on the formation of heterocyclic amines in fried meat products and pan residues. Carcinogenesis. 1995 Apr;16(4):861-7.
  120. Ames BN, Profet M, Gold LS. Dietary pesticides (99.99% all natural). Proc Natl Acad Sci USA. 1990 Oct;87(19):7777-81.
  121. Egner PA, Munoz A, Kensler TW. Chemoprevention with chlorophyllin in individuals exposed to dietary aflatoxin. Mutat Res. Feb-Mar 2003;523-524:209-16.
  122. Mata JE, Yu Z, Gray JE, Williams DE, Rodriguez-Proteau R. Effects of chlorophyllin on transport of dibenzo(a, l)pyrene, 2-amino-1-methyl-6-phenylimidazo-[4,5-b]pyridine, and aflatoxin B(1) across Caco-2 cell monolayers. Toxicology. 2004 Mar 1;196(1-2):117-25.
  123. Hernaez J, Xu M, Dashwood R. Effects of tea and chlorophyllin on the mutagenicity of N-hydroxy-IQ: studies of enzyme inhibition, molecular complex formation, and degradation/scavenging of the active metabolites. Environ Mol Mutagen. 1997;30(4):468-74.
  124. Dashwood R, Yamane S, Larsen R. Study of the forces of stabilizing complexes between chlorophylls and heterocyclic amine mutagens. Environ Mol Mutagen. 1996;27(3):211-8.
  125. Cross AJ, Sinha R. Meat-related mutagens/carcinogens in the etiology of colorectal cancer. Environ Mol Mutagen. 2004;44(1):44-55.
  126. Poirier MC. Chemical-induced DNA damage and human cancer risk. Discov Med. 2012 Oct;14(77):283-8.
  127. Chen T, Mittelstaedt RA, Beland FA, Heflich RH, Moore MM, Parsons BL. 4-Aminobiphenyl induces liver DNA adducts in both neonatal and adult mice but induces liver mutations only in neonatal mice. Int J Cancer. 2005 Nov 1;117(2):182-7.
  128. Beland FA, Fullerton NF, Smith BA, Heflich RH. Formation of DNA adducts and induction of mutations in rats treated with tumorigenic doses of 1,6-dinitropyrene. Environ Health Perspect. 1994 Oct;102 Suppl 6:185-9.
  129. Ibrahim MA, Elbehairy AM, Ghoneim MA, Amer HA. Protective effect of curcumin and chlorophyllin against DNA mutation induced by cyclophosphamide or benzo[a]pyrene. Z Naturforsch C. 2007 Mar-Apr;62(3-4):215-22.
  130. Pietrzak M, Wieczorek Z, Wieczorek J, Darzynkiewicz Z. The “interceptor” properties of chlorophyllin measured within the three-component system: intercalator-DNA-chlorophyllin. Biophys Chem. 2006 Aug 20;123(1):11-9.
  131. Kumar SS, Devasagayam TP, Bhushan B, Verma NC. Scavenging of reactive oxygen species by chlorophyllin: an ESR study. Free Radic Res. 2001 Nov;35(5):563-74.
  132. Fahey JW, Stephenson KK, Dinkova-Kostova AT, Egner PA, Kensler TW, Talalay P. Chlorophyll, chlorophyllin and related tetrapyrroles are significant inducers of mammalian phase 2 cytoprotective genes. Carcinogenesis. 2005 Jul;26(7):1247-55.
  133. Sudakin DL. Dietary aflatoxin exposure and chemoprevention of cancer: a clinical review. J Toxicol Clin Toxicol. 2003;41(2):195-204.
  134. Hayashi T, Schimerlik M, Bailey G. Mechanisms of chlorophyllin anticarcinogenesis: dose-responsive inhibition of aflatoxin uptake and biodistribution following oral co-administration in rainbow trout. Toxicol Appl Pharmacol. 1999 Jul 15;158(2):132-40.
  135. Liu W, Lu X, He G, et al. Protective roles of Gadd45 and MDM2 in blueberry anthocyanins mediated DNA repair of fragmented and non-fragmented DNA damage in UV-irradiated HepG2 cells. Int J Mol Sci. 2013;14(11):21447-62.
  136. Aiyer HS, Kichambare S, Gupta RC. Prevention of oxidative DNA damage by bioactive berry components. Nutr Cancer. 2008;60 Suppl 1:36-42.
  137. Del Bo C, Martini D, Vendrame S, et al. Improvement of lymphocyte resistance against H(2)O(2)-induced DNA damage in Sprague-Dawley rats after eight weeks of a wild blueberry (Vaccinium angustifolium)-enriched diet. Mutat Res. 2010 Dec 21;703(2):158-62.
  138. Dulebohn RV, Yi W, Srivastava A, Akoh CC, Krewer G, Fischer JG. Effects of blueberry (Vaccinium ashei) on DNA damage, lipid peroxidation, and phase II enzyme activities in rats. J Agric Food Chem. 2008 Dec 24;56(24):11700-6.
  139. Langie SA, Wilms LC, Hamalainen S, Kleinjans JC, Godschalk RW, van Schooten FJ. Modulation of nucleotide excision repair in human lymphocytes by genetic and dietary factors. Br J Nutr. 2010 Feb;103(4):490-501.
  140. Riso P, Klimis-Zacas D, Del Bo C, et al. Effect of a wild blueberry (Vaccinium angustifolium) drink intervention on markers of oxidative stress, inflammation and endothelial function in humans with cardiovascular risk factors. Eur J Nutr. 2013 Apr;52(3):949-61.
  141. Srivastava A, Akoh CC, Fischer J, Krewer G. Effect of anthocyanin fractions from selected cultivars of Georgia-grown blueberries on apoptosis and phase II enzymes. J Agric Food Chem. 2007 Apr 18;55(8):3180-5.
  142. Wang L, Gao S, Jiang W, et al. Antioxidative dietary compounds modulate gene expression associated with apoptosis, DNA repair, inhibition of cell proliferation and migration. Int J Mol Sci. 2014;15(9):16226-45.
  143. Wilms LC, Boots AW, de Boer VC, et al. Impact of multiple genetic polymorphisms on effects of a 4-week blueberry juice intervention on ex vivo induced lymphocytic DNA damage in human volunteers. Carcinogenesis. 2007 Aug;28(8):1800-6.
  144. Fecci PE, Mitchell DA, Whitesides JF, et al. Increased regulatory T-cell fraction amidst a diminished CD4 compartment explains cellular immune defects in patients with malignant glioma. Cancer Res. 2006 Mar 15;66(6):3294-302.
  145. Lappin MB, Campbell JD. The Th1-Th2 classification of cellular immune responses: concepts, current thinking and applications in haematological malignancy. Blood Rev. 2000 Dec;14(4):228-39.
  146. Tanigawa T, Iso H, Yamagishi K, et al. Association of lymphocyte sub-populations with clustered features of metabolic syndrome in middle-aged Japanese men. Atherosclerosis. 2004 Apr;173(2):295-300.
  147. Mauro C, Marelli-Berg FM. T-cell immunity and cardiovascular metabolic disorders: does metabolism fuel inflammation? Front Immunol. 2012 Jun 26;3:173.
  148. Rakhshandehroo M, Kalkhoven E, Boes M. Invariant natural killer T-cells in adipose tissue: novel regulators of immune-mediated metabolic disease. Cell Mol Life Sci. 2013 Dec;70(24):4711-27.
  149. Huh JY, Park YJ, Ham M, Kim JB. Crosstalk between adipocytes and immune cells in adipose tissue inflammation and metabolic dysregulation in obesity. Mol Cells. 2014 May;37(5):365-71.
  150. Wilson MA, Shukitt-Hale B, Kalt W, Ingram DK, Joseph JA, Wolkow CA. Blueberry polyphenols increase life span and thermotolerance in Caenorhabditis elegans. Aging Cell. 2006 Feb;5(1):59-68.
  151. Del Bo C, Riso P, Campolo J, et al. A single portion of blueberry (Vaccinium corymbosum L) improves protection against DNA damage but not vascular function in healthy male volunteers. Nutr Res. 2013 Mar;33(3):220-7.
  152. Casadesus G, Shukitt-Hale B, Stellwagen HM, et al. Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats. Nutr Neurosci. 2004 Oct-Dec;7(5-6):309-16.
  153. Small BJ, Rawson KS, Martin C, et al. Nutraceutical intervention improves older adults’ cognitive functioning. Rejuvenation Res. 2014 Feb;17(1):27-32.
  154. Allen LH. How common is vitamin B-12 deficiency? Am J Clin Nutr. 2009 Feb;89(2):693S-6S.
  155. Wolters M, Ströhle A, Hahn A. Cobalamin: a critical vitamin in the elderly. Prev Med. 2004 Dec;39(6):1256-66.
  156. Carmel R, Green R, Jacobsen DW, Rasmussen K, Florea M, Azen C. Serum cobalamin, homocysteine, and methylmalonic acid concentrations in a multiethnic elderly population: ethnic and sex differences in cobalamin and metabolite abnormalities. Am J Clin Nutr. 1999 Nov;70(5):904-10.
  157. Winkels RM, Brouwer IA, Clarke R, Katan MB, Verhoef P. Bread cofortified with folic acid and vitamin B-12 improves the folate and vitamin B-12 status of healthy older people: a randomized controlled trial. Am J Clin Nutr. 2008 Aug;88(2):348-55.
  158. Watanabe F. Vitamin B12 sources and bioavailability. Exp Biol Med (Maywood). 2007 Nov;232(10):1266-74.
  159. Pawlak R, Lester SE, Babatunde T. The prevalence of cobalamin deficiency among vegetarians assessed by serum vitamin B12: a review of literature. Eur J Clin Nutr. 2014 May;68(5):541-8.
  160. Alpers DH, Russell-Jones G. Gastric intrinsic factor: the gastric and small intestinal stages of cobalamin absorption - a personal journey. Biochimie. 2013 May;95(5):989-94.
  161. Krasinski SD, Russell RM, Samloff IM, et al. Fundic atrophic gastritis in an elderly population. Effect on hemoglobin and several serum nutritional indicators. J Am Geriatr Soc. 1986 Nov;34(11):800-6.
  162. Quadros EV. Advances in the understanding of cobalamin assimilation and metabolism. Br J Haematol. 2010 Jan;148(2):195-204.
  163. Savage DG, Lindenbaum J. Neurological complications of acquired cobalamin deficiency: clinical aspects. Baillieres Clin Haematol. 1995 Sep;8(3):657-78.
  164. Briani C, Dalla Torre C, Citton V, et al. Cobalamin deficiency: clinical picture and radiological findings. Nutrients. 2013 Nov 15;5(11):4521-39.
  165. Markle HV. Cobalamin. Crit Rev Clin Lab Sci. 1996;33(4):247-356.
  166. Jensen KP, Ryde U. Conversion of homocysteine to methionine by methionine synthase: a density functional study. J Am Chem Soc. 2003 Nov 19;125(46):13970-1.
  167. Beyer K, Lao JI, Latorre P, et al. Methionine synthase polymorphism is a risk factor for Alzheimer’s disease. Neuroreport. 2003 Jul 18;14(10):1391-4.
  168. Pushpakumar S, Kundu S, Sen U. Endothelial dysfunction: the link between homocysteine and hydrogen sulfide.Curr Med Chem. 2014;21(32):3662-72.
  169. Jensen OK, Ingerslev J. Increased p-homocysteine--a risk factor for thrombosis. Ugeskr Laeger. 1998 Jul 20;160(30):4405-10.