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Improve womens daytime and nighttime urinary symptoms

Relief for Women's Urinary Symptoms

A clinical study showed that a blend of three plant extracts was effective in improving women’s daytime and nighttime urinary symptoms, with 79% of women reporting improvements.

Scientifically reviewed by: Gary Gonzalez, MD, in March 2024. Written by: Heather L. Makar.

As women get older, many experience urinary problems.

They may need to make frequent trips to the restroom or wake up multiple times a night with an urgent need to use the bathroom.

Jogging, lifting a heavy object, or even just having a laugh with friends may cause urinary leakage.1,2

It doesn't have to be this way.

In an eight-week clinical trial, a combination of three plant-based extracts dramatically improved these and other urinary symptoms in women. Among other improvements, taking this blend once a day:3,4

  • Normalized frequency of daytime urination,
  • Decreased episodes of incontinence related to urgency by 65%,
  • Reduced the urgent need to urinate by 57%, and
  • Decreased nightly waking up to urinate by 43%.

A remarkable 79% of women who took the extract blend noted a substantial improvement in symptoms, compared to just 17% in a placebo group.4

Aging Worsens Bladder Symptoms

Many women experience urinary symptoms as they grow older, typically beginning after age 40.5

The severity and frequency of these symptoms are greater in women than in men. A population study using data from the U.S., UK, and Sweden found that among women aged 40-99:6

  • 56% reported experiencing incontinence,
  • 36% dealt with urinary urgency,
  • 34% complained of nocturnal urination, and
  • 25% needed to urinate frequently throughout the day.

Most people need to urinate every three to four hours (5-7 times daily).7 Those with an overactive bladder may need to urinate more than 8 times during the day, and two times or more at night.1

Available medications provide little help. Only about 13% of patients taking medications find relief from incontinence symptoms, with many discontinuing use due to side effects.3

Many women feel embarrassed by their symptoms, and simply assume they are an inevitable part of aging.5,8 But they don't have to be.

A clinical study demonstrated that a blend of three plant-based extracts3,4 made a significant difference in urinary symptoms and quality of life, with virtually no side effects.

Two Decades of Development

More than 20 years ago, Dr. Tracey Seipel, a naturopath and medical herbalist, sought an effective solution for her patients' urinary problems.9 She gradually began administering several traditionally used plant compounds to address bladder issues.3,9

Feedback from Dr. Seipel's patients led to research to fine-tune a treatment using three plant extracts, each with a proven track record of effectiveness:

  • Horsetail (Equisetum arvense), used in Western herbal medicine, contains high levels of silica, which can improve urinary tissue strength and elasticity.
  • Lindera (Lindera aggregata), long used in traditional Chinese medicine, is known for improving kidney and bladder health and may calm feelings of urgency.
  • Three-leaf caper (Crateva nurvala), from Indian Ayurvedic medicine, is known for easing tense muscles and relaxing bladder spasms.

In a rodent model of symptomatic overactive bladder, a blend of these three extracts reversed changes in multiple biomarkers in urine, the bladder lining, and bladder control muscles.8
This improved bladder control symptoms in the:8

  • Storage phase (frequency and urgency, waking to urinate), and the
  • Void and post-void phase (dribbling, stream weakness, intermittency, hesitancy).

What You Need To Know

A Solution for Women's Bladder Problems

  • Many aging women experience urinary symptoms, which include frequent urination, urinary incontinence, urinary urgency, and nocturnal urination.
  • In a clinical trial, a blend of extracts of the plants horsetail, lindera, and three-leaf caper significantly improved women's urinary symptoms and quality of life without side effects often seen in medication use.
  • After only eight weeks, women taking this extract blend had their daytime urination frequency return to normal; incontinence episodes decreased by 65%, urinary urgency episodes were reduced 60%, and nighttime urination episodes declined 43%.
  • A whopping 79% of women who took the plant extract blend reported feeling a significant benefit, compared to just 17% of those taking a placebo.

Validated In Human Trials

Researchers conducted a placebo-controlled clinical trial of this three-extract blend. They worked with 88 women with an average age of 62 years who displayed two or more of these symptoms:

  • 10 or more episodes of daytime urination,
  • One episode or more of incontinence per day,
  • Two or more episodes of urinary urgency per day, and
  • Two or more nighttime urination episodes per night.

Those in the treatment arm of the trial took 840 mg of the extract blend once daily. After only eight weeks:3,4

  • Daytime urination episodes returned to normal levels, falling from an average of more than 11 times a day to an average of under eight times a day.
  • Episodes of incontinence associated with urgency were reduced by 65%, from an average of nearly three times a day to an average of just once per day,
  • Urgent urinary episodes decreased nearly 60%, from an average of almost four times a day to an average of only 1.6 times a day, and
  • Episodes of waking to urinate were reduced 43%, from an average of 3.8 times a night to an average of just over two times a night.

Better Quality of Life

Women who took the plant extract blend also reported substantial improvements in their quality of life, including:3,4

  • A 50% decrease in overactive bladder symptoms,
  • A 39% reduction in incontinence episodes, and
  • A 39% reduction in bladder discomfort.
  • In total, a stunning 79% of women in the plant extract group reported a dramatic improvement, compared to only 17% of participants taking the placebo.4

These benefits came without side effects typically seen with medications,3,4 providing relief for many women who might otherwise have resigned themselves to living with urinary problems.


Many women suffer from urinary symptoms, especially after age 40.

A clinical study has shown that a blend of extracts of the plants horsetail, lindera, and three-leaf caper was effective in reducing daytime urinary frequency, urinary incontinence, urinary urgency, and nocturnal urination in women.

It achieved these benefits and improved quality of life without side effects that often come with medications.

If you have any questions about the scientific content of this article, please call a Life Extension Health Advisor at 1-866-864-3027.


  1. Corcos J, Przydacz M, Campeau L, et al. CUA guideline on adult overactive bladder. Can Urol Assoc J. 2017 May;11(5):E142-E73.
  2. Available at: Accessed December 14, 2023.
  3. Schoendorfer N, Sharp N, Seipel T, et al. Urox containing concentrated extracts of Crataeva nurvala stem bark, Equisetum arvense stem and Lindera aggregata root, in the treatment of symptoms of overactive bladder and urinary incontinence: a phase 2, randomised, double-blind placebo controlled trial. BMC Complement Altern Med. 2018 Jan 31;18(1):42.
  4. Schoendorfer Dof. Supplier Internal Analysis, unpublished. 2018.
  5. Leron E, Weintraub AY, Mastrolia SA, Schwarzman P. Overactive Bladder Syndrome: Evaluation and Management. Curr Urol. 2018 Mar;11(3):117-25.
  6. Coyne KS, Sexton CC, Thompson CL, et al. The prevalence of lower urinary tract symptoms (LUTS) in the USA, the UK and Sweden: results from the Epidemiology of LUTS (EpiLUTS) study. BJU International. 2009;104(3):352-60.
  7. Lukacz ES, Whitcomb EL, Lawrence JM, et al. Urinary frequency in community-dwelling women: what is normal? Am J Obstet Gynecol. 2009 May;200(5):552 e1-7.
  8. Zapala L, Juszczak K, Adamczyk P, et al. New Kid on the Block: The Efficacy of Phytomedicine Extracts Urox((R)) in Reducing Overactive Bladder Symptoms in Rats. Front Mol Biosci. 2022;9:896624.
  9. Available at: https:/ Accessed December 14, 2023.