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A.D.A.M. Lung cancer – non-small cell. Available at: Last updated 9/20/2013a. Accessed 7/18/2014.

A.D.A.M. Bronchoscopy. MedlinePlus web page. Available at: Last updated 5/30/2013b. Accessed 2/24/2014. 

A.D.A.M. Mediastinal tumor. MedlinePlus web page. Available at: Last updated 6/5/2012b. Accessed 6/24/2014.

A.D.A.M. Mediastinoscopy with biopsy. MedlinePlus web page. Available at: Last updated 5/14/2012a. Accessed 2/25/2014.

AACR. American Association for Cancer Research. Preclinical study suggests e-cigarettes may promote lung cancer in high-risk individuals AACR in the News. January 8, 2014. Accessed February 4, 2014.

Abacioglu U, Caglar H, Atasoy BM, Abdulloev T, Akgun Z, Kilic T. Gamma knife radiosurgery in non small cell lung cancer patients with brain metastases: treatment results and prognostic factors. Journal of B.U.ON. : official journal of the Balkan Union of Oncology. Apr-Jun 2010;15(2):274-280.

ACR. American College of Radiology. Radiation Therapy for Small-Cell Lung Cancer. Available at: 2012. Accessed 2/24/2014.

ACS. American Cancer Society. Cancer Facts & Figures 2013a. Available at: Accessed 2/21/2014.

ACS. American Cancer Society. Lung Cancer (Non-Small Cell). Available at: Last updated 2/10/2014b. Accessed 2/21/2014.

ACS. American Cancer Society. Lung Cancer (Non-Small Cell). What is non-small cell lung cancer? Available at: Last updated 4/30/2014a. Accessed 6/24/2014.

ACS. American Cancer Society. Tobacco-Related Cancers Fact Sheet. Available at: Last updated 2/21/2014c. Accessed 6/24/2014.

ACS. American Cancer Society. Treatment choices by stage for small cell lung cancer. Available at: Last updated 2/11/2014d. Accessed 7/8/2014.

ACS. American Cancer Society. What are lung carcinoid tumors? Available at: Last updated 11/13/2013b. Accessed 7/8/2014.

Aggarwal BB, Gupta SC, Sung B. Curcumin: an orally bioavailable blocker of TNF and other pro-inflammatory biomarkers. British journal of pharmacology. Aug 2013;169(8):1672-1692.

Alberts B, Johnson A, Lewis J, et al. Molecular Biology of the Cell, 4th Edition. New York: Garland Science; 2002. Available at: Last accessed on July 9, 2014.

Alexandrow MG, Song LJ, Altiok S, et al. Curcumin: a novel Stat3 pathway inhibitor for chemoprevention of lung cancer. European journal of cancer prevention: the official journal of the European Cancer Prevention Organisation (ECP). Sep 2012;21(5):407-412.

Amann A, Corradi M, Mazzone P, et al. Lung cancer biomarkers in exhaled breath. Expert review of molecular diagnostics. Mar 2011;11(2):207-217.

American Lung Association. American Lung Association Statement on E-Cigarettes. Available at: Copyright © 2014a. Accessed 2/21/2014.

American Lung Association. Diagnosing Lung Cancer. Available at: Copyright © 2014b. Accessed 2/21/2014.

American Lung Association. Lung Cancer Fact Sheet. Available at: Copyright © 2014c. Accessed 7/9/2014.

Anderson MW, Goodin C, Zhang Y, et al. Effect of dietary green tea extract and aerosolized difluoromethylornithine during lung tumor progression in A/J strain mice. Carcinogenesis. Aug 2008;29(8):1594-1600.

Antman EM, Bennett JS, Daugherty A, et al. Use of Nonsteroidal Antiinflammatory Drugs: An Update for Clinicians: A Scientific Statement From the American Heart Association. Circulation. March 27, 2007 2007;115(12):1634-1642.

Arellano M, Lonial S. Clinical uses of GM-CSF, a critical appraisal and update. Biologics : targets & therapy. Mar 2008;2(1):13-27.

Arens R. Rational design of vaccines: learning from immune evasion mechanisms of persistent viruses and tumors. Advances in immunology. 2012;114:217-243.

Avril N, Menzel M, Dose J, et al. Glucose metabolism of breast cancer assessed by 18F-FDG PET: histologic and immunohistochemical tissue analysis. Journal of nuclear medicine: official publication, Society of Nuclear Medicine. Jan 2001;42(1):9-16.

Bacchi CE, Ciol H, Queiroga EM, et al. Epidermal growth factor receptor and KRAS mutations in Brazilian lung cancer patients. Clinics (Sao Paulo). 2012;67(5):419-424.

Bagan P, Berna P, De Dominicis F, et al. Nutritional status and postoperative outcome after pneumonectomy for lung cancer. Ann. Thorac. Surg. Feb 2013;95(2):392-396.

Bai X, Cerimele F, Ushio-Fukai M, et al. Honokiol, a small molecular weight natural product, inhibits angiogenesis in vitro and tumor growth in vivo. The Journal of biological chemistry. Sep 12 2003;278(37):35501-35507.

Baiocchi RA, Ward JS, Carrodeguas L, Eisenbeis CF, Peng R, Roychowdhury S, . . . Caligiuri MA. GM-CSF and IL-2 induce specific cellular immunity and provide protection against Epstein-Barr virus lymphoproliferative disorder. The Journal of clinical investigation. Sep 2001;108(6):887-894.

Bar-Sela G, Wollner M, Hammer L, et al. Mistletoe as complementary treatment in patients with advanced non-small-cell lung cancer treated with carboplatin-based combinations: a randomised phase II study. European journal of cancer (Oxford, England: 1990). Mar 2013;49(5):1058-1064.

Bartsch C, Kvetnoy I, Kvetnaia T, et al. Nocturnal urinary 6-sulfatoxymelatonin and proliferating cell nuclear antigen-immunopositive tumor cells show strong positive correlations in patients with gastrointestinal and lung cancer. J. Pineal Res. Sep 1997;23(2):90-96.

Baskar R, Lee KA, Yeo R, et al. Cancer and radiation therapy: current advances and future directions. International journal of medical sciences. 2012;9(3):193-199.

Belani CP. Adjuvant and neoadjuvant therapy in non-small cell lung cancer. Seminars in oncology. Apr 2005;32(2 Suppl 2):S9-15.

Bennett JS, Daugherty A, Herrington D, et al. The Use of Nonsteroidal Anti-Inflammatory Drugs (NSAIDs): A Science Advisory From the American Heart Association. Circulation. April 5, 2005 2005;111(13):1713-1716.

Biofocus. Molecular Oncology. Directory of Services. Available at: 2011.

Bodey B, Bodey B, Jr., Siegel SE, et al. Failure of cancer vaccines: the significant limitations of this approach to immunotherapy. Anticancer research. Jul-Aug 2000;20(4):2665-2676.

Boshuizen R, Kuhn P, van den Heuvel M. Circulating tumor cells in non-small cell lung carcinoma. J Thorac Dis. 2012 Oct;4(5):456-8.

Brahmer JR. Harnessing the immune system for the treatment of non-small-cell lung cancer. J. Clin. Oncol. Mar 10 2013;31(8):1021-1028.

Brambilla E, Gazdar A. Pathogenesis of lung cancer signalling pathways: roadmap for therapies. The European respiratory journal. Jun 2009;33(6):1485-1497.

Brennan P, Hainaut P, Boffetta P. Genetics of lung-cancer susceptibility. The lancet oncology. Apr 2011;12(4):399-408.

Brenner DR, Boffetta P, Duell EJ, et al. Previous lung diseases and lung cancer risk: a pooled analysis from the International Lung Cancer Consortium. Am. J. Epidemiol. Oct 1 2012;176(7):573-585.

Buchsel PC, DeMeyer ES. Dendritic cells: emerging roles in tumor immunotherapy. Clinical journal of oncology nursing. Oct 2006;10(5):629-640.

Bullen C, Howe C, Laugesen M, et al. Electronic cigarettes for smoking cessation: a randomised controlled trial. Lancet. Nov 16 2013;382(9905):1629-1637.

Bunn PA, Jr., Thatcher N. Systemic treatment for advanced (stage IIIb/IV) non-small cell lung cancer: more treatment options; more things to consider. Introduction. The oncologist. 2008;13 Suppl 1:1-4.

Buonaguro L, Petrizzo A, Tornesello ML, et al. Translating tumor antigens into cancer vaccines. Clinical and vaccine immunology: CVI. Jan 2011;18(1):23-34.

Bustamante E, Pedersen PL. High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase. Proceedings of the National Academy of Sciences of the United States of America. Sep 1977;74(9):3735-3739.

Butterfield LH, Buffo MJ. Immunologic monitoring of cancer vaccine trials using the ELISPOT assay. Methods in molecular biology (Clifton, N.J.). 2014;1102:71-82.

Buzzai M, Jones RG, Amaravadi RK, et al. Systemic treatment with the antidiabetic drug metformin selectively impairs p53-deficient tumor cell growth. Cancer Res. 2007;67(14):6745-52.

Byron E, Pinder-Schenck M. Systemic and targeted therapies for early-stage lung cancer. Cancer Control. Jan 2014;21(1):21-31.

Caligiuri MA, Zmuidzinas A, Manley TJ, Levine H, Smith KA, Ritz J. Functional consequences of interleukin 2 receptor expression on resting human lymphocytes. Identification of a novel natural killer cell subset with high affinity receptors. The Journal of experimental medicine. May 1 1990;171(5):1509-1526.

Canadian Cancer Society. Cancer Information page. Syndrome of Inappropriate Antidiuretic Hormone. Available at: Copyright © 2014. Accessed 2/25/2014.

Carmeliet P. Mechanisms of angiogenesis and arteriogenesis. Nature medicine. Apr 2000;6(4):389-395.

Cavalli LR, Urban CA, Dai D, et al. Genetic and epigenetic alterations in sentinel lymph notes metastatic lesions compared to their corresponding primary breast tumors. Cancer Genet Cytogenet. 2003; 146(1):33-40.

CDC. Centers for Disease Control and Prevention. Press Release. About one in five U.S. adult cigarette smokers have tried an electronic cigarette. Available at: Last updated 2/28/2013a. Accessed 2/21/2014.

CDC. Centers for Disease Control and Prevention. Press Release. E-cigarette use more than doubles among U.S. middle and high school students from 2011-2012. Available at: Last updated 9/5/2013b. Accessed 2/21/2014.

CDC. Centers for Disease Control and Prevention. The Health Consequences of Involuntary Exposure to Tobacco Smoke: A Report of the Surgeon General. Available at: 2006. Accessed 2/25/2014.

Chanvorachote P, Pongrakhananon V, Wannachaiyasit S, et al. Curcumin sensitizes lung cancer cells to cisplatin-induced apoptosis through superoxide anion-mediated Bcl-2 degradation. Cancer investigation. Jul 2009;27(6):624-635.

Cheever MA, Thompson JA, Peace DJ, Greenberg PD. Potential uses of interleukin 2 in cancer therapy. Immunobiology. Sep 1986;172(3-5):365-382.

Chen HW, Lee JY, Huang JY, et al. Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1. Cancer research. Sep 15 2008;68(18):7428-7438.

Chen ZW, Vignaud C, Jaafar A, et al. High resolution crystal structure of rat long chain hydroxy acid oxidase in complex with the inhibitor 4-carboxy-5-[(4-chlorophenyl)sulfanyl]-1, 2, 3-thiadiazole. Implications for inhibitor specificity and drug design. Biochimie. May 2012;94(5):1172-1179.

Cheng TY, Neuhouser ML. Serum 25-hydroxyvitamin D, vitamin A, and lung cancer mortality in the US population: a potential nutrient-nutrient interaction. Cancer Causes Control. Sep 2012;23(9):1557-1565.

Chi A, Ma P, Fu G, et al. Critical Structure Sparing in Stereotactic Ablative Radiotherapy for Central Lung Lesions: Helical Tomotherapy vs. Volumetric Modulated Arc Therapy. PloS one. 2013;8(4):e59729.

Chittezhath M, Deep G, Singh RP, et al. Silibinin inhibits cytokine-induced signaling cascades and down-regulates inducible nitric oxide synthase in human lung carcinoma A549 cells. Molecular cancer therapeutics. Jul 2008;7(7):1817-1826.

Cho WC, Leung KN. In vitro and in vivo anti-tumor effects of Astragalus membranaceus. Cancer Lett. Jul 8 2007a;252(1):43-54.

Cho WC, Leung KN. In vitro and in vivo immunomodulating and immunorestorative effects of Astragalus membranaceus. J. Ethnopharmacol. Aug 15 2007b;113(1):132-141.

Choi KS, Song EK, Yim CY. Cytokines secreted by IL-2-activated lymphocytes induce endogenous nitric oxide synthesis and apoptosis in macrophages. Journal of leukocyte biology. Jun 2008;83(6):1440-1450.

Cinciripini PM, Tsoh JY, Wetter DW, et al. Combined effects of venlafaxine, nicotine replacement, and brief counseling on smoking cessation. Experimental and clinical psychopharmacology. Nov 2005;13(4):282-292.

Clapp RW, Jacobs MM, Loechler EL. Environmental and occupational causes of cancer: new evidence 2005-2007. Rev. Environ. Health. Jan-Mar 2008;23(1):1-37.

Clinical Lung Cancer Genome Project (CLCGP) and Network Genomic Medicine (NGM). A Genomics-Based Classification of Human Lung Tumors. Science Translational Medicine. 2013;5(2009):209ra153.

Cohen AJ, Pope CA, 3rd. Lung cancer and air pollution. Environmental health perspectives. Nov 1995;103 Suppl 8:219-224.

Cooper GM. The Cell: A Molecular Approach. 2nd Edition. Sunderland (MA): Sinauer Associates; 2000. Available at: Last accessed on July 9, 2014.

Correale P, Tindara Miano S, Remondo C, Migali C, Saveria Rotundo M, Macri P, . . . Francini G. Second-line treatment of non small cell lung cancer by biweekly gemcitabine and docetaxel +/- granulocyte-macrophage colony stimulating factor and low dose aldesleukine. Cancer biology & therapy. Mar 15 2009;8(6):497-502.

Cote ML, Liu M, Bonassi S, et al. Increased risk of lung cancer in individuals with a family history of the disease: a pooled analysis from the International Lung Cancer Consortium. European journal of cancer (Oxford, England: 1990). Sep 2012;48(13):1957-1968.

Csiki I, et al. MO05.10 | Metformin as a Radiosensitizer for Lung Cancer Paper presented at: 15th World Conference on Lung Cancer; 2013; Sydney, Australia.

Cufi S, Bonavia R, Vazquez-Martin A, et al. Silibinin meglumine, a water-soluble form of milk thistle silymarin, is an orally active anti-cancer agent that impedes the epithelial-to-mesenchymal transition (EMT) in EGFR-mutant non-small-cell lung carcinoma cells. Food Chem. Toxicol. Oct 2013;60:360-368.

Da Costa ML, Redmond P, Bouchier-Hayes DJ. The effect of laparotomy and laparoscopy on the establishment of spontaneous tumor metastases. Surgery. Sep 1998;124(3):516-525.

Dagne A, Melkamu T, Schutten MM, et al. Enhanced inhibition of lung adenocarcinoma by combinatorial treatment with indole-3-carbinol and silibinin in A/J mice. Carcinogenesis. Apr 2011;32(4):561-567.

Daly BD, Cerfolio RJ, Krasna MJ. Role of surgery following induction therapy for stage III non-small cell lung cancer. Surg. Oncol. Clin. N. Am. Oct 2011;20(4):721-732.

Daniels JM, Sutedja TG. Detection and minimally invasive treatment of early squamous lung cancer. Therapeutic advances in medical oncology. Jul 2013;5(4):235-248.

Das M, Wakelee H. Targeting VEGF in lung cancer. Expert opinion on therapeutic targets. Apr 2012;16(4):395-406.

Davidson MR, Gazdar AF, Clarke BE. The pivotal role of pathology in the management of lung cancer. Journal of thoracic disease. Oct 2013;5(Suppl 5):S463-S478.

De Flora S, D'Agostini F, Masiello L, et al. Synergism between N-acetylcysteine and doxorubicin in the prevention of tumorigenicity and metastasis in murine models. Int. J. Cancer. Sep 17 1996;67(6):842-848.

De Flora S, Izzotti A, D'Agostini F, et al. Mechanisms of N-acetylcysteine in the prevention of DNA damage and cancer, with special reference to smoking-related end-points. Carcinogenesis. Jul 2001;22(7):999-1013.

Dela Cruz CS, Tanoue LT, Matthay RA. Lung cancer: epidemiology, etiology, and prevention. Clinics in chest medicine. Dec 2011;32(4):605-644.

Dell'amore A, Monteverde M, Caroli G, et al. Surgical results and survival of older patients with unsuspected N2 (stage IIIA) non-small cell lung cancer. G. Chir. Mar 2013;34(3):53-58.

Deng B, Li Y, Zhang Y, et al. Helicobacter pylori infection and lung cancer: a review of an emerging hypothesis. Carcinogenesis. Jun 2013;34(6):1189-1195.

Deng G, Lin H, Seidman A, et al. A phase I/II trial of a polysaccharide extract from Grifola frondosa (Maitake mushroom) in breast cancer patients: immunological effects. Journal of cancer research and clinical oncology. Sep 2009;135(9):1215-1221.

Deng YT, Lin JK. EGCG inhibits the invasion of highly invasive CL1-5 lung cancer cells through suppressing MMP-2 expression via JNK signaling and induces G2/M arrest. J. Agric. Food Chem. Dec 28 2011;59(24):13318-13327.

Detterbeck FC, Mazzone PJ, Naidich DP, et al. Screening for Lung Cancer. Diagnosis and Management of Lung Cancer, 3rd ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2013;143(5)(Suppl):e78S-e92S.

Dionne RA, Khan AA, Gordon SM. Analgesia and COX-2 inhibition. Clinical and experimental rheumatology. Nov-Dec 2001;19(6 Suppl 25):S63-70.

Domvri K, Zarogoulidis P, Darwiche K, et al. Molecular Targeted Drugs and Biomarkers in NSCLC, the Evolving Role of Individualized Therapy. J Cancer. 2013;4(9):736-754.

Dong X, Alpaugh KR, Cristofanilli M. Circulating tumor cells (CTCs) in breast cancer: a diagnostic tool for prognosis and molecular analysis. Chinese journal of cancer research = Chung-kuo yen cheng yen chiu. Dec 2012;24(4):388-398.

Douillard JY, Pirker R, O'Byrne KJ, et al. Relationship between EGFR expression, EGFR mutation status, and the efficacy of chemotherapy plus cetuximab in FLEX study patients with advanced non-small-cell lung cancer. Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer. May 2014;9(5):717-724.

Drilon A, Wang L, Hasanovic A, et al. Response to Cabozantinib in patients with RET fusion-positive lung adenocarcinomas. Cancer discovery. Jun 2013;3(6):630-635.

Elisei R, Schlumberger MJ, Muller SP, et al. Cabozantinib in progressive medullary thyroid cancer. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. Oct 10 2013;31(29):3639-3646.

Ellis PM. The importance of multidisciplinary team management of patients with non-small-cell lung cancer. Current oncology (Toronto, Ont.). Jun 2012;19(Suppl 1):S7-s15.

Emens LA. Cancer vaccines: on the threshold of success. Expert opinion on emerging drugs. Jun 2008;13(2):295-308.

Engels EA. Inflammation in the development of lung cancer: epidemiological evidence. Expert Rev Anticancer Ther. Apr 2008;8(4):605-615.

Etter JF, Bullen C. A longitudinal study of electronic cigarette users. Addict. Behav. Feb 2014;39(2):491-494.

Fakhrai H. Phase III Study of Lucanix™ (Belagenpumatucel-L) in Advanced Non-small Cell Lung Cancer. An International Multicenter, Randomized, Double-blinded, Placebo-controlled Study of Lucanix™ Maintenance Theapy for Stages III/IV NSCLC Subjects Who Have Responded to or Have Stable Disease Following One Regimen of Front-line, Platinum-based Combination Chemotherapy. In: [Internet]. Available at: Last updated 5/29/2012. Accessed 2/26/2014. NLM Identifier: NCT00676507.

Fan Y, Huang Z, Mao W. Bevacizumab treatment for advanced non-small cell lung cancer: A case report. Oncology letters. Dec 2013;6(6):1779-1783.

FDA. Food and Drug Administration. News & Events. FDA Approves New Combination Therapy for Lung Cancer. Available at: Last updated 4/5/2013. Accessed 6/25/2014.

Fehniger TA, Bluman EM, Porter MM, Mrozek E, Cooper MA, VanDeusen JB, . . . Caligiuri MA. Potential mechanisms of human natural killer cell expansion in vivo during low-dose IL-2 therapy. The Journal of clinical investigation. Jul 2000;106(1):117-124.

Fernandez Lorente A, Acosta Brooks S, Neninger Vinageras E, et al. Effect of blockade of the EGF system on wound healing in patients vaccinated with CIMAvax(R) EGF. World journal of surgical oncology. 2013;11:275.

Ferrara N, Hillan KJ, Gerber HP, et al. Discovery and development of bevacizumab, an anti-VEGF antibody for treating cancer. Nature reviews. Drug discovery. May 2004;3(5):391-400.

Ferri FF. Ferri's Clinical Advisor. Lung Neoplasms, Primary. Available at: Copyright © 2013. Accessed 5/12/2014. 2013.

Fleet JC, DeSmet M, Johnson R, et al. Vitamin D and cancer: a review of molecular mechanisms. The Biochemical journal. Jan 1 2012;441(1):61-76.

Fontaine E, McShane J, Page R, et al. Aspirin and non-small cell lung cancer resections: effect on long-term survival. Eur. J. Cardiothorac. Surg. Jul 2010;38(1):21-26.

Fortes C, Forastiere F, Farchi S, et al. The protective effect of the Mediterranean diet on lung cancer. Nutr. Cancer. 2003;46(1):30-37.

Freeman JL, Vari F, Hart DN. CMRF-56 immunoselected blood dendritic cell preparations activated with GM-CSF induce potent antimyeloma cytotoxic T-cell responses. Journal of immunotherapy (Hagerstown, Md. : 1997). Oct 2007;30(7):740-748.

Fritz H, Flower G, Weeks L, et al. Intravenous Vitamin C and Cancer: A Systematic Review. Integrative cancer therapies. May 26 2014.

Fritz H, Seely D, Kennedy DA, et al. Green tea and lung cancer: a systematic review. Integrative cancer therapies. Jan 2013;12(1):7-24.

Gadducci A, Sergiampietri C, Guiggi I. Antiangiogenic agents in advanced, persistent or recurrent endometrial cancer: a novel treatment option. Gynecological endocrinology: the official journal of the International Society of Gynecological Endocrinology. Sep 2013;29(9):811-816.

Galluzzi L, Vitale I, Senovilla L, et al. Prognostic impact of vitamin B6 metabolism in lung cancer. Cell Rep. Aug 30 2012;2(2):257-269.

Gandhi L, Janne PA. Crizotinib for ALK-rearranged non-small cell lung cancer: a new targeted therapy for a new target. Clinical cancer research: an official journal of the American Association for Cancer Research. Jul 15 2012;18(14):3737-3742.

Gandhi L, Johnson BE. Paraneoplastic syndromes associated with small cell lung cancer. Journal of the National Comprehensive Cancer Network: JNCCN. Jul 2006;4(6):631-638.

Gao G, Ren S, Li A, et al. Epidermal growth factor receptor-tyrosine kinase inhibitor therapy is effective as first-line treatment of advanced non-small-cell lung cancer with mutated EGFR: A meta-analysis from six phase III randomized controlled trials. Int. J. Cancer. Sep 1 2012;131(5):E822-829.

Gardin NE. Immunological response to mistletoe (Viscum album L.) in cancer patients: a four-case series. Phytotherapy research: PTR. Mar 2009;23(3):407-411.

Ghoneum M, Agrawal S. Activation of human monocyte-derived dendritic cells in vitro by the biological response modifier arabinoxylan rice bran (MGN-3/Biobran). International journal of immunopathology and pharmacology. Oct-Dec 2011;24(4):941-948.

Ghoneum M, Gollapudi S. Synergistic role of arabinoxylan rice bran (MGN-3/Biobran) in S. cerevisiae-induced apoptosis of monolayer breast cancer MCF-7 cells. Anticancer research. Nov-Dec 2005;25(6b):4187-4196.

Gilhus NE. Lambert-eaton myasthenic syndrome; pathogenesis, diagnosis, and therapy. Autoimmune diseases. 2011;2011:973808.

Gitlitz B, et al. APRiCOT-L: Results of a Biomarker Based Phase II Randomized Placebo-Controlled Study of Apricoxib in Combination with Erlotinib in Non-Small Cell Lung Cancer (NSCLC) patients. Journal of Clinical Oncology. 2011 ASCO Annual Meeting Abstracts Part 1. Vol 29, No 15_suppl (May 20 Supplement):7528.

Gnagnarella P, Maisonneuve P, Bellomi M, et al. Red meat, Mediterranean diet and lung cancer risk among heavy smokers in the COSMOS screening study. Ann. Oncol. Oct 2013;24(10):2606-2611.

Golden EB, Lam PY, Kardosh A, et al. Green tea polyphenols block the anticancer effects of bortezomib and other boronic acid-based proteasome inhibitors. Blood. Jun 4 2009;113(23):5927-5937.

Gollapudi S, Ghoneum M. MGN-3/Biobran, modified arabinoxylan from rice bran, sensitizes human breast cancer cells to chemotherapeutic agent, daunorubicin. Cancer detection and prevention. 2008;32(1):1-6.

Gomes M, Teixeira AL, Coelho A, et al. The role of inflammation in lung cancer. Advances in experimental medicine and biology. 2014;816:1-23.

Gomez M, Silvestri GA. Endobronchial ultrasound for the diagnosis and staging of lung cancer. Proceedings of the American Thoracic Society. Apr 15 2009;6(2):180-186.

Gonzalez M, Vignaud JM, Clement-Duchene C, et al. Smoking, occupational risk factors, and bronchial tumor location: a possible impact for lung cancer computed tomography scan screening. Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer. Jan 2012;7(1):128-136.

Goodin S. Oral chemotherapeutic agents: understanding mechanisms of action and drug interactions. American journal of health-system pharmacy: AJHP: official journal of the American Society of Health-System Pharmacists. May 1 2007;64(9 Suppl 5):S15-24.

Govindan R, Ding L, Griffith M, et al. Genomic landscape of non-small cell lung cancer in smokers and never-smokers. Cell. Sep 14 2012;150(6):1121-1134.

Guo L, Bai SP, Zhao L, et al. Astragalus polysaccharide injection integrated with vinorelbine and cisplatin for patients with advanced non-small cell lung cancer: effects on quality of life and survival. Med Oncol. Sep 2012;29(3):1656-1662.

Gupta SC, Kismali G, Aggarwal BB. Curcumin, a component of turmeric: from farm to pharmacy. BioFactors (Oxford, England). Jan-Feb 2013;39(1):2-13.

Gupta SK. Role of Crizotinib in previously treated non-small-cell lung cancer. South Asian journal of cancer. Apr 2014;3(2):138-140.

Gwinn DM, Shackelford DB, Egan DF, et al. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Molecular cell. Apr 25 2008;30(2):214-226.

Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell. Mar 4 2011;144(5):646-674.

Hardie DG, Ross FA, Hawley SA. AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol. Apr 2012;13(4):251-262.

Harrington LS, Lucas R, McMaster SK, et al. COX-1, and not COX-2 activity, regulates airway function: relevance to aspirin-sensitive asthma. FASEB journal: official publication of the Federation of American Societies for Experimental Biology. Nov 2008;22(11):4005-4010.

Harris RE, Beebe-Donk J, Alshafie GA. Reduced risk of human lung cancer by selective cyclooxygenase 2 (COX-2) blockade: results of a case control study. Int J Biol Sci. 2007;3(5):328-334.

Hashimoto M, Tanaka F, Yoneda K, et al. Significant increase in circulating tumour cells in pulmonary venous blood during surgical manipulation in patients with primary lung cancer. Interactive cardiovascular and thoracic surgery. Jun 2014;18(6):775-783.

Hayabuchi N, Russell WJ, Murakami J. Slow-growing lung cancer in a fixed population sample. Radiologic assessments. Cancer. Sep 15 1983;52(6):1098-1104.

Hayakawa K, Mitsuhashi N, Saito Y, et al. Effect of Krestin as adjuvant treatment following radical radiotherapy in non-small cell lung cancer patients. Cancer Detect. Prev. 1997;21(1):71-77.

He J, Xu X. Thoracoscopic anatomic pulmonary resection. Journal of thoracic disease. Oct 2012;4(5):520-547.

Health Canada. Health Concerns. Carcinogens in Tobacco Smoke. Available at: 3/20/2011. Accessed 2/21/2014.

Herbst RS, Heymach JV, Lippman SM. Lung cancer. N. Engl. J. Med. Sep 25 2008;359(13):1367-1380.

Heuvers ME, Aerts JG, Cornelissen R, et al. Patient-tailored modulation of the immune system may revolutionize future lung cancer treatment. BMC cancer. 2012;12:580.

Heuvers ME, Hegmans JP, Stricker BH, et al. Improving lung cancer survival; time to move on. BMC pulmonary medicine. 2012;12:77.

Hill G, Millar W, Connelly J. "The great debate" 1: Smoking, lung cancer, and cancer epidemiology. Canadian bulletin of medical history = Bulletin canadien d'histoire de la medecine. 2003;20(2):367-386.

Hillman GG, Singh-Gupta V, Hoogstra DJ, et al. Differential effect of soy isoflavones in enhancing high intensity radiotherapy and protecting lung tissue in a pre-clinical model of lung carcinoma. Radiother. Oncol. Oct 2013;109(1):117-125.

Hillman GG, Singh-Gupta V, Runyan L, et al. Soy isoflavones radiosensitize lung cancer while mitigating normal tissue injury. Radiother. Oncol. Nov 2011;101(2):329-336.

Hiltermann TJ, Pore MM, van den Berg A, et al. Circulating tumor cells in small-cell lung cancer: a predictive and prognostic factor. Annals of oncology: official journal of the European Society for Medical Oncology / ESMO. Nov 2012;23(11):2937-2942.

Hirsh V. Systemic therapies in metastatic non-small-cell lung cancer with emphasis on targeted therapies: the rational approach. Current oncology (Toronto, Ont.). Apr 2010;17(2):13-23.

Hofmann HS, Bartling B, Simm A, et al. Identification and classification of differentially expressed genes in non-small cell lung cancer by expression profiling on a global human 59.620-element oligonucleotide array. Oncology reports. Sep 2006;16(3):587-595.

Horn L, Eisenberg R, Gius D, et al. Cancer of the Lung: Non-Small Cell Lung Cancer and Small Cell Lung Cancer. In: Niederhuber JE, et al, eds. Abeloff's Clinical Oncology. Fifth ed. Philadelphia, PA: Elsevier; 2013a.

Horn L, Eisenberg R, Gius D, et al. Lung Cancer, Part II: Surgery and Adjuvant Therapies Targeted Therapy and New Anticancer Drugs in Advanced Disease. In: Niederhuber JE, et al, eds. Abeloff's Clinical Oncology. Fifth ed. Philadelphia, PA: Elsevier; 2013b.

Huang SC. Anatomy of SUV. Standardized uptake value. Nuclear medicine and biology. Oct 2000;27(7):643-646.

Huber R, Ludtke H, Wieber J, et al. Safety and effects of two mistletoe preparations on production of Interleukin-6 and other immune parameters - a placebo controlled clinical trial in healthy subjects. BMC complementary and alternative medicine. 2011;11:116.

Hughes JR, Stead LF, Hartmann-Boyce J, et al. Antidepressants for smoking cessation. The Cochrane database of systematic reviews. 2014;1:Cd000031.

Igawa S, Gohda K, Fukui T, et al. Circulating tumor cells as a prognostic factor in patients with small cell lung cancer. Oncology letters. May 2014;7(5):1469-1473.

Ishiguro H, Kawahara T. Nonsteroidal Anti-Inflammatory Drugs and Prostatic Diseases. BioMed research international. 2014;2014:436123.

Iwama E, Okamoto I, Harada T, et al. Development of anaplastic lymphoma kinase (ALK) inhibitors and molecular diagnosis in rearrangement-positive lung cancer. OncoTargets and therapy. 2014;7:375-385.

Jafri SH, Shi R, Mills G. Advance lung cancer inflammation index (ALI) at diagnosis is a prognostic marker in patients with metastatic non-small cell lung cancer (NSCLC): a retrospective review. BMC cancer. 2013;13:158.

Janssen Diagnostics. An FDA-cleared CTC test for metastatic breast cancer, metastatic prostate cancer and metastatic colorectal cancer. Available at: Last updated 7/7/2014. Accessed 7/18/2014.

Jeong JH, An JY, Kwon YT, et al. Effects of low dose quercetin: cancer cell-specific inhibition of cell cycle progression. Journal of cellular biochemistry. Jan 1 2009;106(1):73-82.

Jiang H, Wang J, Zhao W. Cox-2 in non-small cell lung cancer: a meta-analysis. Clin. Chim. Acta. Apr 18 2013;419:26-32.

Jiang QQ, Fan LY, Yang GL, et al. Improved therapeutic effectiveness by combining liposomal honokiol with cisplatin in lung cancer model. BMC cancer. 2008;8:242.

Jin X, Ruiz Beguerie J, Sze DM, et al. Ganoderma lucidum (Reishi mushroom) for cancer treatment. The Cochrane database of systematic reviews. 2012;6:Cd007731.

Johansson M, Relton C, Ueland PM, et al. Serum B vitamin levels and risk of lung cancer. JAMA. Jun 16 2010;303(23):2377-2385.

Kamaraj S, Vinodhkumar R, Anandakumar P, et al. The effects of quercetin on antioxidant status and tumor markers in the lung and serum of mice treated with benzo(a)pyrene. Biol. Pharm. Bull. Dec 2007;30(12):2268-2273.

Kasza KA, Bansal-Travers M, O'Connor RJ, et al. Cigarette Smokers' Use of Unconventional Tobacco Products and Associations With Quitting Activity: Findings From the ITC-4, U.S. Cohort. Nicotine & tobacco research: official journal of the Society for Research on Nicotine and Tobacco. Dec 27 2013.

Kaur M, Velmurugan B, Tyagi A, et al. Silibinin suppresses growth of human colorectal carcinoma SW480 cells in culture and xenograft through down-regulation of beta-catenin-dependent signaling. Neoplasia (New York, N.Y.). May 2010;12(5):415-424.

Khan N, Afaq F, Kweon MH, et al. Oral consumption of pomegranate fruit extract inhibits growth and progression of primary lung tumors in mice. Cancer Res. Apr 1 2007;67(7):3475-3482.

Khan N, Hadi N, Afaq F, et al. Pomegranate fruit extract inhibits prosurvival pathways in human A549 lung carcinoma cells and tumor growth in athymic nude mice. Carcinogenesis. Jan 2007;28(1):163-173.

Khan Z, Khan N, Tiwari RP, et al. Biology of Cox-2: an application in cancer therapeutics. Current drug targets. Jun 2011;12(7):1082-1093.

Killen JD, Fortmann SP, Schatzberg AF, et al. Nicotine patch and paroxetine for smoking cessation. Journal of consulting and clinical psychology. Oct 2000;68(5):883-889.

Kligerman S, White C. Epidemiology of lung cancer in women: risk factors, survival, and screening. AJR. American journal of roentgenology. Feb 2011;196(2):287-295.

Koda K, Saito N, Takiguchi N, Oda K, Nunomura M, Nakajima N. Preoperative natural killer cell activity: correlation with distant metastases in curatively research colorectal carcinomas. International surgery. Apr-Jun 1997;82(2):190-193.

Kodama N, Komuta K, Nanba H. Can maitake MD-fraction aid cancer patients? Alternative medicine review: a journal of clinical therapeutic. Jun 2002;7(3):236-239.

Koshiol J, Rotunno M, Consonni D, et al. Chronic obstructive pulmonary disease and altered risk of lung cancer in a population-based case-control study. PloS one. 2009;4(10):e7380.

Lam TK, Rotunno M, Lubin JH, et al. Dietary quercetin, quercetin-gene interaction, metabolic gene expression in lung tissue and lung cancer risk. Carcinogenesis. Apr 2010;31(4):634-642.

Lambert JD, Lu G, Lee MJ, et al. Inhibition of lung cancer growth in mice by dietary mixed tocopherols. Molecular nutrition & food research. Aug 2009;53(8):1030-1035.

Lan Q, Hsiung CA, Matsuo K, et al. Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia. Nature genetics. Dec 2012;44(12):1330-1335.

Landi S, Gemignani F, Canzian F, et al. DNA repair and cell cycle control genes and the risk of young-onset lung cancer. Cancer Res. 2006;66(22):11062-9.

Larsen JE, Minna JD. Molecular biology of lung cancer: clinical implications. Clin. Chest Med. Dec 2011;32(4):703-740.

Lattimer JM, Haub MD. Effects of dietary fiber and its components on metabolic health. Nutrients. Dec 2010;2(12):1266-1289.

Leone FT, Evers-Casey S, Toll BA, et al. Treatment of tobacco use in lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. May 2013;143(5 Suppl):e61S-77S.

Li W, Mu D, Song L, et al. Molecular mechanism of silymarin-induced apoptosis in a highly metastatic lung cancer cell line anip973. Cancer biotherapy & radiopharmaceuticals. Jun 2011;26(3):317-324.

Li X, Feng Y, Liu J, et al. Epigallocatechin-3-gallate inhibits IGF-I-stimulated lung cancer angiogenesis through downregulation of HIF-1alpha and VEGF expression. Journal of nutrigenetics and nutrigenomics. 2013;6(3):169-178.

Liberko M, Kolostova K, Bobek V. Essentials of circulating tumor cells for clinical research and practice. Critical reviews in oncology/hematology. Jul 4 2013.

Liberman M, Liberman D, Sampalis JS, et al. Delays to surgery in non-small-cell lung cancer. Canadian journal of surgery. Journal canadien de chirurgie. Feb 2006;49(1):31-36.

Lim WY, Chuah KL, Eng P, et al. Aspirin and non-aspirin non-steroidal anti-inflammatory drug use and risk of lung cancer. Lung cancer (Amsterdam, Netherlands). Aug 2012;77(2):246-251.

Lin CC, Yeh HH, Huang WL, et al. Metformin Enhances Cisplatin Cytotoxicity by Suppressing Stat3 Activity Independently of the LKB1-AMPK Pathway. Am. J. Respir. Cell Mol. Biol. Mar 22 2013.

Lissoni P, Chilelli M, Villa S, et al. Five years survival in metastatic non-small cell lung cancer patients treated with chemotherapy alone or chemotherapy and melatonin: a randomized trial. J. Pineal Res. Aug 2003;35(1):12-15.

Liu Y, Inoue M, Sobue T, et al. Reproductive factors, hormone use and the risk of lung cancer among middle-aged never-smoking Japanese women: a large-scale population-based cohort study. Int. J. Cancer. Nov 20 2005;117(4):662-666.

Lopez-Lazaro M. The warburg effect: why and how do cancer cells activate glycolysis in the presence of oxygen? Anti-cancer agents in medicinal chemistry. Apr 2008;8(3):305-312.

Lozic AA, Silconi ZB, Misljenovic N. Metastases to rare locations as the initial manifestation of non-small cell lung cancer: two case reports. Collegium antropologicum. Jun 2010;34(2):609-612.

Lu QY, Jin Y, Mao JT, et al. Green tea inhibits cycolooxygenase-2 in non-small cell lung cancer cells through the induction of Annexin-1. Biochem. Biophys. Res. Commun. Nov 2 2012;427(4):725-730.

Lucignani G, Paganelli G, Bombardieri E. The use of standardized uptake values for assessing FDG uptake with PET in oncology: a clinical perspective. Nuclear medicine communications. Jul 2004;25(7):651-656.

Luo J, Chen YJ, Chang LJ. Fasting blood glucose level and prognosis in non-small cell lung cancer (NSCLC) patients. Lung Cancer. May 2012;76(2):242-247.

Ma J, Ward EM, Smith R, et al. Annual number of lung cancer deaths potentially avertable by screening in the United States. Cancer. Apr 1 2013;119(7):1381-1385.

Ma YC, Li C, Gao F, et al. Epigallocatechin gallate inhibits the growth of human lung cancer by directly targeting the EGFR signaling pathway. Oncol. Rep. Mar 2014;31(3):1343-1349.

Mahabir S, Spitz MR, Barrera SL, et al. Dietary zinc, copper and selenium, and risk of lung cancer. Int. J. Cancer. 2006;120(5):1108-1115.

Majem M, Pallares C. An update on molecularly targeted therapies in second- and third-line treatment in non-small cell lung cancer: focus on EGFR inhibitors and anti-angiogenic agents. Clin Transl Oncol. May 2013;15(5):343-357.

Mancebo A, Casaco A, Gonzalez B, et al. Repeated dose intramuscular injection of the CIMAvax-EGF vaccine in Sprague Dawley rats induces local and systemic toxicity. Vaccine. May 9 2012;30(22):3329-3338.

Mani D, Haigentz M, Jr., Aboulafia DM. Lung cancer in HIV Infection. Clin Lung Cancer. Jan 2012;13(1):6-13.

Mao JT, Roth MD, Fishbein MC, et al. Lung cancer chemoprevention with celecoxib in former smokers. Cancer prevention research. Jul 2011;4(7):984-993.

Marchioli CC, Graziano SL. Paraneoplastic syndromes associated with small cell lung cancer. Chest surgery clinics of North America. Feb 1997;7(1):65-80.

Martinsson C. Characterisation of EGFR and KRAS mutations in non-small cell lung cancer. Uppsala University, Department of Molecular Pathology. 2010.

Mateen S, Tyagi A, Agarwal C, et al. Silibinin inhibits human nonsmall cell lung cancer cell growth through cell-cycle arrest by modulating expression and function of key cell-cycle regulators. Molecular carcinogenesis. Mar 2010;49(3):247-258.

Matthes H, Friedel WE, Bock PR, et al. Molecular mistletoe therapy: friend or foe in established anti-tumor protocols? A multicenter, controlled, retrospective pharmaco-epidemiological study in pancreas cancer. Current molecular medicine. Jun 2010;10(4):430-439.

Mayo Clinic. Lung Cancer. Available at: Last Updated 3/19/2014. Accessed 6/4/2014.

Mazhar D, Gillmore R, Waxman J. COX and cancer. Q J Med. 2005;98:711-718.

Mazzone P. Nanomedicine: Sniffing out lung cancer. Nature nanotechnology. Oct 2009;4(10):621-622.

Mazzone PJ, Rai H, Beukemann M, et al. The effect of metformin and thiazolidinedione use on lung cancer in diabetics. BMC cancer. 2012;12:410.

McCloskey P, Balduyck B, Van Schil PE, et al. Radical treatment of non-small cell lung cancer during the last 5 years. European journal of cancer (Oxford, England: 1990). May 2013;49(7):1555-1564.

McCulloch M, See C, Shu XJ, et al. Astragalus-based Chinese herbs and platinum-based chemotherapy for advanced non-small-cell lung cancer: meta-analysis of randomized trials. J. Clin. Oncol. Jan 20 2006;24(3):419-430.

McCulloch PG, MacIntyre A. Effects of surgery on the generation of lymphokine-activated killer cells in patients with breast cancer. The British journal of surgery. Aug 1993;80(8):1005-1007.

Mehta RS, Lenzner D, Argiris A. Race and health disparities in patient refusal of surgery for early-stage non-small cell lung cancer: a SEER cohort study. Annals of surgical oncology. Mar 2012;19(3):722-727.

Menter DG, Schilsky RL, DuBois RN. Cyclooxygenase-2 and cancer treatment: understanding the risk should be worth the reward. Clin. Cancer Res. Mar 1 2010;16(5):1384-1390.

Mikirova N, Casciari J, Rogers A, et al. Effect of high-dose intravenous vitamin C on inflammation in cancer patients. Journal of translational medicine. 2012;10:189.

Millea PJ. N-acetylcysteine: multiple clinical applications. Am. Fam. Physician. Aug 1 2009;80(3):265-269.

Misirlioglu CH, Demirkasimoglu T, Kucukplakci B, et al. Pentoxifylline and alpha-tocopherol in prevention of radiation-induced lung toxicity in patients with lung cancer. Medical oncology (Northwood, London, England). 2007;24(3):308-311.

Misirlioglu CH, Erkal H, Elgin Y, et al. Effect of concomitant use of pentoxifylline and alpha-tocopherol with radiotherapy on the clinical outcome of patients with stage IIIB non-small cell lung cancer: a randomized prospective clinical trial. Medical oncology (Northwood, London, England). 2006;23(2):185-189.

MNT. Medical News Today. Electronic Cigarettes Can Harm the Lungs. Available at: Last updated 6/10/2013. Accessed February 4, 2014.

Moyer VA. Screening for Lung Cancer: U.S. Preventive Services Task Force Recommendation Statement. Annals of Internal Medicine; 2013.

Muinelo-Romay L, Vieito M, Abalo A, et al. Evaluation of Circulating Tumor Cells and Related Events as Prognostic Factors and Surrogate Biomarkers in Advanced NSCLC Patients Receiving First-Line Systemic Treatment. Cancers. 2014;6(1):153-165.

Mukherjee S. The Emperor of All Maladies: A Biography of Cancer. Published 11/16/2010 by Scribner. ISBN: 978-1-4391-0795-9. 2010.

Murphy RA, Mourtzakis M, Chu QS, et al. Nutritional intervention with fish oil provides a benefit over standard of care for weight and skeletal muscle mass in patients with nonsmall cell lung cancer receiving chemotherapy. Cancer. Apr 15 2011b;117(8):1775-1782.

Murphy RA, Mourtzakis M, Chu QS, et al. Supplementation with fish oil increases first-line chemotherapy efficacy in patients with advanced nonsmall cell lung cancer. Cancer. Aug 15 2011a;117(16):3774-3780.

Nair R, Maseeh A. Vitamin D: The "sunshine" vitamin. Journal of pharmacology & pharmacotherapeutics. Apr 2012;3(2):118-126.

Nascimento AV, Bousbaa H, Ferreira D, et al. Non-small Cell Lung Carcinoma: An Overview on Targeted Therapy. Current Drug Targets. 2014 May 28. [Epub ahead of print]

National Lung Screening Trial Research Team, Aberle DR, Adams AM, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N. Engl. J. Med. Aug 4 2011;365(5):395-409.

NCCN. National Comprehensive Cancer Network. Non-Small Cell Lung Cancer. NCCN Guidelines Version 2.2014 Updates. Available at: 2014a.

NCCN. National Comprehensive Cancer Network. Small Cell Lung Cancer. NCCN Guidelines Version 2.2014 Updates. Available at: 2014b.

NCI. FDA Approval for Bevacizumab.  Available at: - Anchor-NSCLC Updated 7/1/13e. Accessed 5/30/2014.

NCI. National Cancer Institute. Cancer Topics page. Lung Cancer Prevention (PDQ®). Available at: Last updated 12/3/2013d. Accessed 5/30/2014.

NCI. National Cancer Institute. FactSheet. Targeted Cancer Therapies. Available at: 12/5/2012. Accessed 2/25/2014.

NCI. National Cancer Institute. FactSheet. Vitamin D and Cancer Prevention. Available at: 10/21/2013b. Accessed 2/21/2014.

NCI. National Cancer Institute. National Cancer Institute Fact Sheet. Radon and Cancer. Available at: 12/6/2011. Accessed 2/21/2014.

NCI. National Cancer Institute. Non-Small Cell Lung Cancer Treatment (PDQ®). General Information About Non-Small Cell Lung Cancer. Available at: Last updated 10/18/2013a. Accessed 2/21/2014.

NCI. National Cancer Institute. Non-Small Cell Lung Cancer Treatment (PDQ®). Stage IV NSCLC Treatment. Available at: Last updated 2/21/2014b. Accessed 7/2/2014.

NCI. National Cancer Institute. SEER: Surveillance, Epidemiology, and End Results Program. SEER Stat Fact Sheets: Lung and Bronchus Cancer. Available at: Accessed 7/9/2014d.

NCI. National Cancer Institute. Small Cell Lung Cancer Treatment (PDQ®). General Information About Small Cell Lung Cancer. Available at: Last updated 10/18/2013c. Accessed 2/25/2014.

NCI. National Cancer Institute. Small Cell Lung Cancer Treatment (PDQ®). Limited-Stage Small Cell Lung Cancer Treatment. Available at: Last updated 2/21/2014a. Accessed 7/2/2014.

NCI. National Cancer Institute. Small Cell Lung Cancer Treatment (PDQ®). Extensive-Stage Small Cell Lung Cancer Treatment. Available at: Last updated 2/21/2014c. Accessed 7/2/2014.

NCI. National Cancer Institute. Small Cell Lung Cancer Treatment (PDQ®). Patient Version. Available at: Last updated 5/2/2014e. Accessed 7/18/2014.

Noto H, Goto A, Tsujimoto T, et al. Cancer risk in diabetic patients treated with metformin: a systematic review and meta-analysis. PloS one. 2012;7(3):e33411.

Novello S, Milella M, Tiseo M, et al. Maintenance therapy in NSCLC: why? To whom? Which agent? Journal of experimental & clinical cancer research: CR. 2011;30:50.

Offermans NS, Vermeulen R, Burdorf A, et al. Occupational asbestos exposure and risk of pleural mesothelioma, lung cancer, and laryngeal cancer in the prospective Netherlands cohort study. Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine. Jan 2014;56(1):6-19.

Ogawa F, Amano H, Ito Y, et al. Aspirin reduces lung cancer metastasis to regional lymph nodes. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. Feb 2014;68(1):79-86.

O'Hanlon KM, Choy E, Sisson SD, et al. Lung cancer. First Consult; Clinical Key web page. Available at: Last updated 12/31/2013. Accessed 2/25/2014.

OSH. Office on Smoking and Health. The Health Consequences of Involuntary Exposure to Tobacco Smoke: A Report of the Surgeon General. Chapter 7: Cancer Among Adults from Exposure to Secondhand Smoke. 2006. Available at: Accessed 6/24/2014.

Pallis AG, Syrigos KN. Lung cancer in never smokers: Disease characteristics and risk factors. Crit. Rev. Oncol. Hematol. Dec 2013a;88(3):494-503.

Pallis AG, Syrigos KN. Targeting tumor neovasculature in non-small-cell lung cancer. Critical reviews in oncology/hematology. May 2013b;86(2):130-142.

Palucka K, Banchereau J. Dendritic-cell-based therapeutic cancer vaccines. Immunity. Jul 25 2013;39(1):38-48.

Paradise J. No sisyphean task: how the FDA can regulate electronic cigarettes. Yale journal of health policy, law, and ethics. Summer 2013;13(2):326-374.

Park KI, Park HS, Kang SR, et al. Korean Scutellaria baicalensis water extract inhibits cell cycle G1/S transition by suppressing cyclin D1 expression and matrix-metalloproteinase-2 activity in human lung cancer cells. J. Ethnopharmacol. Jan 27 2011;133(2):634-641.

Parsons A, Daley A, Begh R, et al. Influence of smoking cessation after diagnosis of early stage lung cancer on prognosis: systematic review of observational studies with meta-analysis. BMJ. 2010;340:b5569.

Peng G, Tisch U, Adams O, et al. Diagnosing lung cancer in exhaled breath using gold nanoparticles. Nature nanotechnology. Oct 2009;4(10):669-673.

Penn Medicine. Penn Study: Diabetes Drug Metformin with Chemo and Radiation May Improve Outcomes in Lung Cancer Patients. Available at: 10/23/2013. Accessed 2/25/2014.

Piao BK, Wang YX, Xie GR, et al. Impact of complementary mistletoe extract treatment on quality of life in breast, ovarian and non-small cell lung cancer patients. A prospective randomized controlled clinical trial. Anticancer research. Jan-Feb 2004;24(1):303-309.

Piccinini L, Borella P, Bargellini A, et al. A case-control study on selenium, zinc, and copper in plasma and hair of subjects affected by breast and lung cancer. Biological trace element research. Jan 1996;51(1):23-30.

Pine SR, Mechanic LE, Enewold L, et al. Increased levels of circulating interleukin 6, interleukin 8, C-reactive protein, and risk of lung cancer. Journal of the National Cancer Institute. Jul 20 2011;103(14):1112-1122.

Pirrotta MT, Bernardeschi P, Fiorentini G. Targeted-therapy in advanced renal cell carcinoma. Current medicinal chemistry. 2011;18(11):1651-1657.

Planchard D. Bevacizumab in non-small-cell lung cancer: a review. Expert review of anticancer therapy. Aug 2011;11(8):1163-1179.

PR Newswire. Simple blood test can detect lung cancer with high sensitivity and specificity - results from large clinical validation study published in the Journal of Clinical Oncology. Available at: 1/13/2014. Accessed 2/21/2014.

Prasad S, Tyagi AK, Aggarwal BB. Recent Developments in Delivery, Bioavailability, Absorption and Metabolism of Curcumin: the Golden Pigment from Golden Spice. Cancer research and treatment: official journal of Korean Cancer Association. Jan 2014;46(1):2-18.

Proctor RN. Tobacco and the global lung cancer epidemic. Nature reviews. Cancer. Oct 2001;1(1):82-86.

Provencio M, Isla D, Sanchez A, et al. Inoperable stage III non-small cell lung cancer: Current treatment and role of vinorelbine. Journal of thoracic disease. Sep 2011;3(3):197-204.

PubMed Health. How does chemotherapy work? Available at: Last updated 3/15/2012. Accessed 6/24/2014.

Raaschou-Nielsen O, Andersen ZJ, Beelen R, et al. Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE). The lancet oncology. Aug 2013;14(9):813-822.

Rafnar T, Sulem P, Besenbacher S, et al. Genome-wide significant association between a sequence variant at 15q15.2 and lung cancer risk. Cancer Res. Feb 15 2011;71(4):1356-1361.

Rahbari NN, Bork U, Kircher A, et al. Compartmental differences of circulating tumor cells in colorectal cancer.Ann Surg Oncol. 2012 Jul;19(7):2195-202.

Reck M, von Pawel J, Zatloukal P, et al. Phase III trial of cisplatin plus gemcitabine with either placebo or bevacizumab as first-line therapy for nonsquamous non-small-cell lung cancer: AVAil. Journal of clinical oncology: official journal of the American Society of Clinical Oncology. Mar 10 2009;27(8):1227-1234.

Rekhtman N. Neuroendocrine tumors of the lung: an update. Arch Pathol Lab Med. 2010;134(11):1628-38.

Rengan R, Maity AM, Stevenson JP, et al. New strategies in non-small cell lung cancer: improving outcomes in chemoradiotherapy for locally advanced disease. Clin. Cancer Res. Jul 1 2011;17(13):4192-4199.

Reungwetwattana T, Eadens MJ, Molina JR. Chemotherapy for non-small-cell lung carcinoma: from a blanket approach to individual therapy. Semin Respir Crit Care Med. Feb 2011;32(1):78-93.

Rho JK, Choi YJ, Jeon BS, et al. Combined treatment with silibinin and epidermal growth factor receptor tyrosine kinase inhibitors overcomes drug resistance caused by T790M mutation. Molecular cancer therapeutics. Dec 2010;9(12):3233-3243.

Ripley RT, Rusch VW. Role of induction therapy: surgical resection of non-small cell lung cancer after induction therapy. Thorac Surg Clin. Aug 2013;23(3):273-285.

Risser NL. Prevention of lung cancer: the key is to stop smoking. Seminars in oncology nursing. Nov 1996;12(4):260-269.

Rivera MP, Mehta AC, Wahidi MM. Establishing the diagnosis of lung cancer: Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest. May 2013;143(5 Suppl):e142S-165S.

Rosenne E, Shakhar G, Melamed R, Schwartz Y, Erdreich-Epstein A, Ben-Eliyahu S. Inducing a mode of NK-resistance to suppression by stress and surgery: a potential approach based on low dose of poly I-C to reduce postoperative cancer metastasis. Brain, behavior, and immunity. May 2007;21(4):395-408.

Rowe JM, Andersen JW, Mazza JJ, Bennett JM, Paietta E, Hayes FA, . . . Wiernik PH. A randomized placebo-controlled phase III study of granulocyte-macrophage colony-stimulating factor in adult patients (> 55 to 70 years of age) with acute myelogenous leukemia: a study of the Eastern Cooperative Oncology Group (E1490). Blood. Jul 15 1995;86(2):457-462.

Rüdiger N, Stein EL, Schill E, et al. Chemosensitivity Testing of Circulating Epithelial Tumor Cells (CETC) in Vitro: Correlation to in Vivo Sensitivity and Clinical Outcome. J Cancer Therapy 2013, 4:597-605.

Sadava D, Kane SE. Silibinin reverses drug resistance in human small-cell lung carcinoma cells. Cancer Lett. Oct 1 2013;339(1):102-106.

Sakagami H, Aoki T, Simpson A, et al. Induction of immunopotentiation activity by a protein-bound polysaccharide, PSK (review). Anticancer research. Mar-Apr 1991;11(2):993-999.

Samet JM, Avila-Tang E, Boffetta P, et al. Lung cancer in never smokers: clinical epidemiology and environmental risk factors. Clin. Cancer Res. Sep 15 2009;15(18):5626-5645.

Sanchez-Lara K, Turcott JG, Juarez E, et al. Association of nutrition parameters including bioelectrical impedance and systemic inflammatory response with quality of life and prognosis in patients with advanced non-small-cell lung cancer: a prospective study. Nutr. Cancer. 2012;64(4):526-534.

Sanders CL, Scott BR. Smoking and hormesis as confounding factors in radiation pulmonary carcinogenesis. Dose-response: a publication of International Hormesis Society. 2008;6(1):53-79.

Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. The New England journal of medicine. Dec 14 2006;355(24):2542-2550.

Saponara S, Sgaragli G, Fusi F. Quercetin as a novel activator of L-type Ca(2+) channels in rat tail artery smooth muscle cells. British journal of pharmacology. Apr 2002;135(7):1819-1827.

Sato M, Shames DS, Gazdar AF, et al. A translational view of the molecular pathogenesis of lung cancer. Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer. Apr 2007;2(4):327-343.

Schabath MB, Hernandez LM, Wu X, et al. Dietary phytoestrogens and lung cancer risk. JAMA. Sep 28 2005;294(12):1493-1504.

Schabath MB, Thompson ZJ, Gray JE. Temporal trends in demographics and overall survival of non-small-cell lung cancer patients at moffitt cancer center from 1986 to 2008. Cancer Control. Jan 2014;21(1):51-56.

Schober W, Szendrei K, Matzen W, et al. Use of electronic cigarettes (e-cigarettes) impairs indoor air quality and increases FeNO levels of e-cigarette consumers. International journal of hygiene and environmental health. Dec 6 2013.

Schrevens L, Lorent N, Dooms C, et al. The role of PET scan in diagnosis, staging, and management of non-small cell lung cancer. The oncologist. 2004;9(6):633-643.

Serizawa T, Iuchi T, Ono J, et al. Gamma knife treatment for multiple metastatic brain tumors compared with whole-brain radiation therapy. Journal of neurosurgery. Dec 2000;93 Suppl 3:32-36.

Serizawa T, Ono J, Iichi T, et al. Gamma knife radiosurgery for metastatic brain tumors from lung cancer: a comparison between small cell and non-small cell carcinoma. Journal of neurosurgery. Dec 2002;97(5 Suppl):484-488.

Shakhar G, Ben-Eliyahu S. Potential prophylactic measures against postoperative immunosuppression: could they reduce recurrence rates in oncological patients? Annals of surgical oncology. Oct 2003;10(8):972-992.

Shamji FM. Absolute and relative contraindications to pulmonary resection: effect of lung cancer surgery guidelines on medical practice. Thorac Surg Clin. May 2013;23(2):247-255.

Shaw AT, Kim DW, Nakagawa K, et al. Crizotinib versus chemotherapy in advanced ALK-positive lung cancer. The New England journal of medicine. Jun 20 2013;368(25):2385-2394.

Shiels MS, Pfeiffer RM, Hildesheim A, et al. Circulating inflammation markers and prospective risk for lung cancer. Journal of the National Cancer Institute. Dec 18 2013;105(24):1871-1880.

Shim JH, Su ZY, Chae JI, et al. Epigallocatechin gallate suppresses lung cancer cell growth through Ras-GTPase-activating protein SH3 domain-binding protein 1. Cancer prevention research. May 2010;3(5):670-679.

Siegel M, Skeer M. Exposure to secondhand smoke and excess lung cancer mortality risk among workers in the "5 B's": bars, bowling alleys, billiard halls, betting establishments, and bingo parlours. Tobacco control. Sep 2003;12(3):333-338.

Siegel MB, Tanwar KL, Wood KS. Electronic cigarettes as a smoking-cessation: tool results from an online survey. American journal of preventive medicine. Apr 2011;40(4):472-475.

Singh T, Katiyar SK. Honokiol inhibits non-small cell lung cancer cell migration by targeting PGE(2)-mediated activation of beta-catenin signaling. PloS one. 2013;8(4):e60749.

Singh-Gupta V, Joiner MC, Runyan L, et al. Soy isoflavones augment radiation effect by inhibiting APE1/Ref-1 DNA repair activity in non-small cell lung cancer. J Thorac Oncol. Apr 2011;6(4):688-698.

Skirecki T, Hoser G, Domagala-Kulawik J, et al. Characterization of a new small cell lung cancer (SCLC) cell line STP54 derived from a metastatic bioptate of a combined type of SCLC with Non-SCLC component. Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society. 2009;47(1):111-115.

Smiraglia DJ, Smith LT, Lang JC, et al. Differential targets of CpG island hypermethylation in primary and metastatic head and neck squamous cell carcinoma (HNSCC). J Med Genet. 2003 Jan; 40(1):25-33.

Sozzi G, Boeri M, Rossi M, et al. Clinical Utility of a Plasma-Based miRNA Signature Classifier Within Computed Tomography Lung Cancer Screening: A Correlative MILD Trial Study. J. Clin. Oncol. Jan 13 2014.

Srinivasan V, Spence DW, Pandi-Perumal SR, et al. Therapeutic actions of melatonin in cancer: possible mechanisms. Integrative cancer therapies. Sep 2008;7(3):189-203.

Stead LF, Perera R, Bullen C, et al. Nicotine replacement therapy for smoking cessation. Cochrane Database Syst Rev. 2008(1):CD000146.

Stinchcombe TE, Socinski MA. Maintenance therapy in advanced non-small cell lung cancer: current status and future implications. Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer. Jan 2011;6(1):174-182.

Storozhuk Y, Hopmans SN, Sanli T, et al. Metformin inhibits growth and enhances radiation response of non-small cell lung cancer (NSCLC) through ATM and AMPK. Br. J. Cancer. May 28 2013;108(10):2021-2032.

Suganuma M, Saha A, Fujiki H. New cancer treatment strategy using combination of green tea catechins and anticancer drugs. Cancer Sci. Feb 2011;102(2):317-323.

Sun C, Rosendahl AH, Wang XD, et al. Polysaccharide-K (PSK) in cancer--old story, new possibilities? Curr. Med. Chem. 2012;19(5):757-762.

Sunaga N, Shames DS, Girard L, et al. Knockdown of oncogenic KRAS in non-small cell lung cancers suppresses tumor growth and sensitizes tumor cells to targeted therapy. Molecular cancer therapeutics. Feb 2011;10(2):336-346.

Takahashi T, Kozaki K, Yatabe Y, et al. Increased expression of COX-2 in the development of human lung cancers. Journal of environmental pathology, toxicology and oncology: official organ of the International Society for Environmental Toxicology and Cancer. 2002;21(2):177-181.

Tan BX, Yao WX, Ge J, et al. Prognostic influence of metformin as first-line chemotherapy for advanced nonsmall cell lung cancer in patients with type 2 diabetes. Cancer. Nov 15 2011;117(22):5103-5111.

Teng MW, Swann JB, Koebel CM, Schreiber RD, Smyth MJ. Immune-mediated dormancy: an equilibrium with cancer. Journal of leukocyte biology. Oct 2008;84(4):988-993.

Thomas L, Kwok Y, Edelman MJ. Management of paraneoplastic syndromes in lung cancer. Current treatment options in oncology. Feb 2004;5(1):51-62.

Timmerman R, Paulus R, Galvin J, et al. Stereotactic body radiation therapy for inoperable early stage lung cancer. JAMA. Mar 17 2010;303(11):1070-1076.

Tochikura TS, Nakashima H, Hirose K, et al. A biological response modifier, PSK, inhibits human immunodeficiency virus infection in vitro. Biochemical and biophysical research communications. Oct 29 1987;148(2):726-733.

Tyagi A, Singh RP, Ramasamy K, et al. Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3. Cancer prevention research. Jan 2009;2(1):74-83.

UKCC. University of Kansas Cancer Center web page. Cancer Information: Specialties and Treatments page. Frequently Asked Questions About Lung Cancer Screening with Low-Dose CT. Available at: Accessed 6/24/2014.

Usuda J, Ichinose S, Ishizumi T, et al. Management of multiple primary lung cancer in patients with centrally located early cancer lesions. Journal of thoracic oncology: official publication of the International Association for the Study of Lung Cancer. Jan 2010;5(1):62-68.

Van Schooten FJ, Besaratinia A, De Flora S, et al. Effects of oral administration of N-acetyl-L-cysteine: a multi-biomarker study in smokers. Cancer Epidemiol Biomarkers Prev. 2002;11(2):167-75.

Varlotto J, Medford-Davis LN, Recht A, et al. Confirmation of the role of diabetes in the local recurrence of surgically resected non-small cell lung cancer. Lung Cancer. Mar 2012;75(3):381-390.

Verhagen AF, Bootsma GP, Tjan-Heijnen VC, et al. FDG-PET in staging lung cancer: how does it change the algorithm? Lung cancer (Amsterdam, Netherlands). May 2004;44(2):175-181.

Vermeulen R, Silverman DT, Garshick E, et al. Exposure-response estimates for diesel engine exhaust and lung cancer mortality based on data from three occupational cohorts. Environmental health perspectives. Feb 2014;122(2):172-177.

Vijayalaxmi, Thomas CR, Jr., Reiter RJ, et al. Melatonin: from basic research to cancer treatment clinics. J. Clin. Oncol. May 15 2002;20(10):2575-2601.

Vincent MD, Kuruvilla MS, Leighl NB, et al. Biomarkers that currently affect clinical practice: EGFR, ALK, MET, KRAS. Curr Oncol. Jun 2012;19(Suppl 1):S33-44.

Viollet B, Guigas B, Sanz Garcia N, et al. Cellular and molecular mechanisms of metformin: an overview. Clin Sci (Lond). Mar 2012;122(6):253-270.

Wang H, Bian S, Yang CS. Green tea polyphenol EGCG suppresses lung cancer cell growth through upregulating miR-210 expression caused by stabilizing HIF-1alpha. Carcinogenesis. Dec 2011;32(12):1881-1889.

Wang S, Liu K, Liu J, et al. Highly efficient capture of circulating tumor cells by using nanostructured silicon substrates with integrated chaotic micromixers. Angew Chem Int Ed Engl. 2011 Mar 21;50(13):3084-8.

Wang Y, Deng G, Liu X, et al. Monoclonal antibodies in lung cancer. Expert opinion on biological therapy. Feb 2013;13(2):209-226.

Wild P, Bourgkard E, Paris C. Lung cancer and exposure to metals: the epidemiological evidence. Methods in molecular biology (Clifton, N.J.). 2009;472:139-167.

Woo HD, Kim J. Dietary flavonoid intake and smoking-related cancer risk: a meta-analysis. PloS one. 2013;8(9):e75604.

Woodson K, Tangrea JA, Barrett MJ, et al. Serum α-Tocopherol and Subsequent Risk of Lung Cancer Among Male Smokers. Journal of the National Cancer Institute. 1999;91(20):1738 – 1743.

Wouters BG, Wang LH, Brown JM. Tirapazamine: a new drug producing tumor specific enhancement of platinum-based chemotherapy in non-small-cell lung cancer. Annals of oncology: official journal of the European Society for Medical Oncology / ESMO. 1999;10 Suppl 5:S29-33.

Xu J, Yin Z, Gao W, et al. Meta-analysis on the association between nonsteroidal anti-inflammatory drug use and lung cancer risk. Clin Lung Cancer. Jan 2012;13(1):44-51.

Yamauchi R, Sasaki K, Yoshida K. Identification of epigallocatechin-3-gallate in green tea polyphenols as a potent inducer of p53-dependent apoptosis in the human lung cancer cell line A549. Toxicol In Vitro. Aug 2009;23(5):834-839.

Yang CL, Liu YY, Ma YG, et al. Curcumin blocks small cell lung cancer cells migration, invasion, angiogenesis, cell cycle and neoplasia through Janus kinase-STAT3 signalling pathway. PloS one. 2012;7(5):e37960.

Yang G, Shu XO, Li HL, et al. Prediagnosis soy food consumption and lung cancer survival in women. J. Clin. Oncol. Apr 20 2013;31(12):1548-1553.

Yang JH, Hsia TC, Kuo HM, et al. Inhibition of lung cancer cell growth by quercetin glucuronides via G2/M arrest and induction of apoptosis. Drug Metab. Dispos. Feb 2006;34(2):296-304.

Yang SE, Hsieh MT, Tsai TH, et al. Down-modulation of Bcl-XL, release of cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human squamous lung cancer CH27 cells. Biochemical pharmacology. May 1 2002;63(9):1641-1651.

Yao QH, Zhang XC, Fu T, et al. omega-3 polyunsaturated fatty acids inhibit the proliferation of the lung adenocarcinoma cell line A549 in vitro. Molecular medicine reports. Feb 2014;9(2):401-406.

Yasufuku K. Early diagnosis of lung cancer. Clinics in chest medicine. Mar 2010;31(1):39-47, Table of Contents.

Yoh K, Kubota K, Nomura M, et al. Cushing's syndrome associated with adenocarcinoma of the lung. Internal medicine (Tokyo, Japan). Sep 2003;42(9):831-833.

Yoon YK, Kim HP, Han SW, et al. KRAS mutant lung cancer cells are differentially responsive to MEK inhibitor due to AKT or STAT3 activation: implication for combinatorial approach. Molecular carcinogenesis. Apr 2010;49(4):353-362.

Youlden D, Cramb SM, Baade P. The International Epidemiology of Lung Cancer: Geographical Distribution and Secular Trends. Journal of Thoracic Oncology. 2008;3(8):819-831.

Zandberg DP, Bhargava R, Badin S, et al. The role of human papillomavirus in nongenital cancers. CA. Cancer J. Clin. Jan 2013;63(1):57-81.

Zheng SY, Li Y, Jiang D, et al. Anticancer effect and apoptosis induction by quercetin in the human lung cancer cell line A-549. Mol Med Rep. Mar 2012;5(3):822-826.

Zhou B, Liu J, Wang ZM, et al. C-reactive protein, interleukin 6 and lung cancer risk: a meta-analysis. PloS one. 2012;7(8):e43075.

Zhou W, Park S, Liu G, et al. Dietary iron, zinc, and calcium and the risk of lung cancer. Epidemiology. Nov 2005;16(6):772-779.

Zhou W, Suk R, Liu G, et al. Vitamin D is associated with improved survival in early-stage non-small cell lung cancer patients. Cancer Epidemiol. Biomarkers Prev. Oct 2005;14(10):2303-2309.

Zhu A, Lee D, Shim H. Metabolic positron emission tomography imaging in cancer detection and therapy response. Seminars in oncology. Feb 2011;38(1):55-69.

Zou YH, Liu XM. [Effect of astragalus injection combined with chemotherapy on quality of life in patients with advanced non-small cell lung cancer]. Zhongguo Zhong Xi Yi Jie He Za Zhi. Oct 2003;23(10):733-735.