High Potency Optimized Folate


  • 8500 mcg, 30 vegetarian tablets
  • Item # 01913

High Potency Optimized Folate


  • 8500 mcg, 30 vegetarian tablets
  • Item # 01913

Brain and heart health support

Our High Potency Optimized Folate is a cardiovascular health supplement that also supports cognitive health and more with 8500 mcg of metabolically active 5-MTHF.
Gluten free Non-GMO Vegetarian
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$0.45 / count | 30 Day Supply
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$0.40/count | 30 Day Supply

Good product that I use daily. Easy to swallow tablet. Gives high dose of Folate.

David, Sedona

This has more of what I wanted than I even knew was available

MS, North Carolina

Easy to take, works well with other products I am taking.

Grammiee, Oregon

This is one of my all time favorite products!

Jill, Plymouth IN

Frequently Bought Together

  • This Item: High Potency Optimized Folate, 8500 mcg, 30 vegetarian tablets
  • Vitamin B12 Methylcobalamin, 5 mg, 60 vegetarian lozenges

Total Price:


High Potency Optimized Folate


8500 mcg, 30 vegetarian tablets


$0.45/count | 30 Day Supply

Maintaining normal levels of homocysteine, a metabolic byproduct, is associated with both cardiovascular and cognitive health. Folate, a B vitamin, helps maintain homocysteine levels already within normal range. However, not everyone can efficiently convert folate to its biologically active form. Our formula provides 5-MTHF, so you don’t have to.

The 5-MTHF folate in High Potency Optimized Folate is an ultra-bioavailable form of the B-vitamin commonly called folic acid.

High Potency Optimized Folate Benefits

  • Super high-potency dose of bioavailable 5-MTHF folate
  • Supports both cardiovascular & cognitive health
  • Helps maintain already-healthy homocysteine levels
  • 5-MTHF folate overcomes the enzyme inefficiency roadblock

For the Greatest Health Benefits

Folic acid is a common B-vitamin supplement. Once ingested, your body is supposed to convert folic acid into 5-methyltetrahydrofolate, or 5-MTHF. But research shows that many people lack sufficient activity of the enzyme that’s necessary to do this. So we formulated High Potency Optimized Folate with 8500 mcg of 5-MTHF, saving your body the trouble.

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Folic acid is the most common form of folate supplements. Once ingested, your body is supposed to convert folic acid, a synthetic version of folate, into 5-methyltetrahydrofolate, or 5-MTHF. But research shows that many people lack sufficient activity of the enzyme that's necessary to convert folic acid to 5-MTHF.1-3 A more useful approach is to take 5-MTHF directly.4-6

These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
  1. Circulation. 2015;132(1):e6-e9.
  2. European Journal of Medical Genetics. 2015;58(1):1-10.
  3. Arteriosclerosis, Thrombosis, and Vascular Biology. 1997;17(6):1157-1162.
  4. The Journal of Nutrition. 2018;148(6):885-890.
  5. The Journal of Alternative and Complementary Medicine. 2019;25(2):169-180.
  6. The FASEB Journal. 2017;31(1_supplement):lb399-lb399.
  7. The American Journal of Clinical Nutrition. 2006;84(1):156-161.
  8. The American Journal of Clinical Nutrition. 2005;82(3):627-635.
  9. Dementia and Geriatric Cognitive Disorders. 2001;12(5):309-313.

Serving Size 1 vegetarian tablet

Amount Per Serving

Folate [as (6S)-5-Methyltetrahydrofolate, calcium salt]

8500 mcg°

Other ingredients: microcrystalline cellulose, dicalcium phosphate, stearic acid, croscarmellose sodium, silica, vegetable stearate.

°DFE (dietary folate equivalents)


Dosage and Use
  • Take one (1) tablet daily with food, or as recommended by a healthcare practitioner.

Do not use this product if treated with methotrexate, fluorouracil, phenytoin, phenobarbital, primidone, or levodopa prior to consultation with your personal physician.

  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Actual Size

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