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High Potency Optimized Folate

5000 mcg, 30 vegetarian tablets
Item# 01913


High Potency Optimized Folate


Promotes all-around cardiovascular health

5000 mcg, 30 vegetarian tablets
Item# 01913


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  • High Potency Optimized Folate
  • 5000 mcg, 30 vegetarian tablets
  • Item Catalog Number: 01913

Part of the B vitamin family, folate is an important nutrient that promotes cardiovascular health, supports cognitive health, and more. However, not everyone can convert folate to its most biologically active form. This form of folate, called 5-MTHF or L-methylfolate, provides the greatest health benefits. Our High Potency Optimized Folate provides 5000 mcg of 5-MTHF.

Benefits at a Glance:

  • Super-high-potency dose of bioavailable 5-MTHF folate
  • Supports both heart and cognitive health
  • Promotes healthy homocysteine levels
  • 5-MTHF folate overcomes the enzyme inefficiency roadblock

More facts about High Potency Optimized Folate (L-Methylfolate)

Folate is in the most common form of folic acid supplements. Once ingested, your body is supposed to convert folic acid, a synthetic version of folate, into 5-methyltetrahydrofolate, or 5-MTHF. But research shows that a substantial portion of the population lacks robust activity of the enzyme that’s necessary to convert folic acid to 5-MTHF.1 A more useful approach is to take 5-MTHF directly.

5-MTHF, homocysteine, and cardiovascular health

Folate helps maintain healthy homocysteine levels already within the normal range. By helping to inhibit excess homocysteine, folate supports healthy levels of this important cardiovascular health biomarker. And because 5-MTHF is up to seven times more bioavailable than folic acid, it significantly increases folate levels within red blood cells.2,3

5-MTHF, homocysteine, and cognitive health

5-MTHF’s greater bioavailability is especially important for people who don’t have enough activity of the enzyme necessary to convert folic acid to its biologically active form. Since people with elevated homocysteine levels have a greater risk of cognitive decline,4 the increased efficiency of 5-MTHF in supporting healthy folate status is especially crucial for aging individuals.

Take alone or with B12 for enhanced effect

The RDA for folate is 400 mcg a day, but this high-potency formula provides 5000 mcg of this super-bioavailable form of folate. For even greater health benefits, take 5-MTHF folate with methylcobalamin (the active form of vitamin B12), vitamin B6, and/or riboflavin.

Whether you take it alone or with other B vitamins, be sure to add High Potency Optimized Folate to your nutritional regimen today!

These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.

  1. Proc Natl Acad Sci U S A. 2009; 106(36): 15424–15429.
  2. Am J Clin Nutr. 2006 Jul;84(1):156-61.
  3. Br J Pharmacol. 2004 Mar;141(5):825-30.
  4. N Engl J Med. 2002 Feb 14;346(7):476-83.


Supplement Facts

Serving Size 1 vegetarian tablet

Amount Per Serving

Folate [as (6S)-5-Methyltetrahydrofolate, calcium salt]

5,000 mcg

Other ingredients: microcrystalline cellulose, dicalcium phosphate, stearic acid, croscarmellose sodium, silica, vegetable stearate.


Dosage and Use
  • Take one (1) tablet daily with food, or as recommended by a healthcare practitioner.

Do not use this product if treated with methotrexate, fluorouracil, phenytoin, phenobarbital, primidone, or levodopa prior to consultation with your personal physician.



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