St. John's Wort

60 liquid vegetarian capsules Item # 13757

St. John's Wort 60 liquid vegetarian capsules - Life Extension

St. John's Wort

60 liquid vegetarian capsules Item # 13757

St John’s Wort promotes positive emotional health by inhibiting monoamine oxidase and the reuptake of specific neurotransmitters.

Benefits at a Glance:

  • Promotes mental well-being
  • Provides stress support
  • Liquid Phyto-Caps® are a convenient way to consume liquid herbal extracts

St John’s Wort (Hypericum perforatum) is an herb that is used to support a healthy mood. Hypericin and hyperforin appear to be the main active compounds in St John’s wort flowers.

St John’s wort has the property of weakly inhibiting monoamine oxidase (MAO) A and B activity.1,2 Monoamine oxidase adversely affects monoamine neurotransmitters including dopamine in the brain, leading to poor mood. St John’s Wort has also been shown to inhibit reuptake of several neurotransmitters in the brain, including serotonin, dopamine, noradrenaline, GABA and glutamate.3 This contributes to alleviating low mood by slowing the recycling of neurotransmitters needed for maintaining emotional balance.

A systematic review of 29 randomized, double-blinded trials which compared the effects of St John’s wort to a placebo or standard antidepressant treatment among a total of 5,489 individuals with major depressive symptoms concluded that St John performed better than a placebo and was equally effective as other drug treatments and was associated with fewer side effects.4

Other benefits associated with St John’s wort include antiviral and antibacterial effects, support of healthy blood pressure, pain relief, antioxidant effects, an antispasmodic effect, and potential treatment of hematologic malignancies.5,6 A randomized trial that included 36 participants with premenstrual syndrome resulted in improvement in physical and behavioral symptoms among women who received St John’s wort in comparison with a placebo.7

People who use St John’s wort should check with their physicians concerning the possibility of any interactions with medications they are taking.

Always get the lowest price
Learn More
AutoShip Price: $27.83

First shipment within 1 business day with FREE standard shipping.

SALE: $27.83
Save 0%
$0.46 / count

Frequently Bought Together

Total Price:


Life Extension - Why Do We Do It?

The Best Supplements Science Can Offer

When putting something in your body, you should be confident that you’re getting the nutritional benefits your body deserves. We've been delivering the highest-quality products—backed by science and formulated with the finest ingredients—for over 40 years.

What Matters to You, Matters to Us

We're committed to empowering you to live a healthier life. Whether it’s finding sustainable partners for our ingredients or funding the latest anti-aging research, we're all about your health & wellness.

Highly Recommended

98% of our customers recommend us to family and friends. We're very proud of that because our loved ones matter to us—and we're willing to bet you feel the same way.

Product Transparency

40 years of research dedicated to bringing you premium, scientifically-validated formulations.

  1. Müller WE et al. Schweiz Rundsch Med Prax. 2000 Dec 14;89(50):2111-21.
  2. Butterweck V et al. CNS Drugs. 2003;17:539-562.
  3. Nathan PJ. J Psychopharmacol. 2001 Mar;15(1):47-54.
  4. Linde K et al. Cochrane Database Syst Rev. 2008 Oct 8;2008(4):CD000448.
  5. Barnes J et al. J Pharm Pharmacol. 2001 May;53(5):583-600.
  6. Allegra A et al. Int J Mol Sci. 2020 Dec 25;22(1):146.
  7. Canning S et al. CNS Drugs. 2010 Mar;24(3):207-25.

Serving Size 1 capsule

Servings Per Container 60
Amount Per Serving

Total Carbohydrate


Proprietary extract blend

500 mg

St. John's Wort (Hypericum perforatum) aerial parts, St. John's Wort (Hypericum perforatum) aerial parts extract  


0.9 mg

Other ingredients: Vegetable glycerin, water, vegan capsule (hypromellose), and olive oil.

No Corn, Dairy, Gluten, Peanuts, Shellfish, Soy, Sugar, Tree Nuts, Yeast

Dosage and Use
  • Adults take 1 capsule 3 times daily between meals.

Not for use during pregnancy or lactation. If you have a medical condition or take medications, please consult with your doctor before use. Avoid excessive exposure to UV radiation (e.g. sunlight, tanning) when using this product. Store away from children. Use only as directed on label. Safety-sealed for your protection. Keep bottle capped at all times and store in a cool, dry place. Natural separation may occur. This does not affect product quality.

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Life Extension. We do not verify or endorse any claims made in these reviews. Full product reviews disclaimer

Mood & Stress

Mood & Stress

Feeling out of sorts? Find out which mood-boosting nutrients can keep the stress away.

Related Products

St. John's Wort

60 liquid vegetarian capsules


$0.46/count |