Human Epididymis Protein 4 (HE4) Blood Test

Item # LC081700

Human epididymis protein 4 (HE4) test is used to monitor ovarian cancer

Human Epididymis Protein 4 (HE4) Blood Test  - Life Extension

Human Epididymis Protein 4 (HE4) Blood Test

Item # LC081700

Human epididymis protein 4 (HE4) test is used to monitor ovarian cancer

Human epididymis protein 4 (HE4) is produced by the majority of epithelial ovarian cancer cells and is used as a tumor biomarker in ovarian cancer patients. HE4 can also be elevated in other cancerous and noncancerous conditions.

Human Epididymis Protein 4 (HE4) is used as an aid in monitoring recurrence of progressive disease in women with epithelial ovarian cancer. Combining Cancer Antigen 125 (CA 125) and HE4 provides a more accurate predictor of malignancy than either alone.1


Fasting is not required for this test. Take all medications as prescribed.


HE4 should not be used for monitoring women with mucinous or germ cell ovarian cancer and should not be used for cancer screening.


  1. Hellstrom I, Hellstrom KE, "SMRP and HE4 as Biomarkers for Ovarian Carcinoma When Used Alone and in Combination With CA125 and/or Each Other," Adv Exp Med Biol, 2008, 622:15-21. PubMed 18546615

The laboratory services are for informational purposes only. It is not the intention of National Diagnostics, Inc and Life Extension to provide specific medical advice but rather to provide users with information to better understand their health. Specific medical advice including diagnosis and treatment will not be provided. Always seek the advice of a trained health professional for medical advice, diagnosis or treatment.

Both the physician and the testing laboratory are independent contractors with whom National Diagnostics, Inc makes arrangements for your blood tests. Neither National Diagnostics, Inc or Life Extension will be liable for any acts or omissions of the physician, the testing laboratory, or their agents or employees.

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Human Epididymis Protein 4 (HE4) Blood Test

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