Utilizing advanced epigenetic methylation analysis, this test offers the latest and most comprehensive collection of epigenetic age measurements available. The TruAge test reveals whether DNA is aging more rapidly or slower than expected, and provides key metrics about intrinsic biological age, extrinsic immune age, as well as your current rate of biological aging (whether your DNA is aging more rapidly or slowly). Over and under-methylation can also reveal important health information.

While there is no one perfect biological age estimation, the TruAge test provides the most evidence-based, validated approach, using algorithms developed and licensed by leading research universities.

The TruAge report includes the following sections:

Intrinsic Biological Age – Epigenetics-based age indicator, independent of immune system.

Extrinsic Immune Age – Epigenetics-based age indicator, based on the immune system impact on aging.

Immune Cell deconvolution an estimation of types of immune cells, based on epigentic signature, including:

• Total Lymphocytes %
  • B cell %
  • CD4+ T cell %
  • CD8+ T cell %
  • NK Cell %
• CD4+ : CD8+ T cell Ratio
• Neutrophils %
• Monocytes %
• Eosinophils%

Dunedin PACE – This is a “rate of aging” algorithm which predicts how rapidly your biological age is changing based on published correlation between measured epigenetic patterns with phenotypic measures of age (e.g. balance, strength, cognitive decline, facial aging) as well as mortality and chronic disease risk.

Average telomere length – provides average telomere length measured in DNA from sample submitted, and how this compares to others in your chronological age group.

Weight Loss response – determines percent methylation at multiple gene loci associated with response to low calorie diets. Results help provide insight into how well you may respond to calorie restriction as a weight-loss strategy.

Smoking risk – determine percent methylation related to smoke exposure on health and risk of developing smoking-related conditions

Alcohol risk – determines alcohol-related epigenetic risk pattern and how it compares to the epigenetic pattern of others with similar reported alcohol consumption.

Epigenetic methylation patterns are influenced by various factors including diet, supplementation, and lifestyle. This test can be useful to repeat over time as any favorable lifestyle and dietary changes can reveal changes in rate of aging and biological age.

Notes

This kit is provided as an at-home blood spot collection kit. One circle must be fully saturated to provide sufficient DNA for analysis. If you have trouble with the collection, please contact Life Extension for assistance.

Online registration is required to associate your sample with your personal information. Please ensure you complete the online registration process to avoid delays in specimen processing. Life Extension will be notified of any samples missing registration, and we will attempt to contact you to provide details to complete the registration process.

Turnaround Time: 2-3 weeks from date received

Restrictions: No kits available in PA, AK, or HI.

Processing Lab: TruDiagnostic

*If you wish to receive your raw epigenetic data after receiving your final results, please email bloodlab@lifeextension.com.