Life Extension Magazine®

Issue: Sep 1999

MSM the Multi-Purpose Compound

A multi-purpose compound and the antler phenomenon.

PRODUCTS

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MSM The Multi-Purpose
Compound
MSM

(methyl-sulfonyl-methane), also known as dimethyl sulfone, is a naturally occurring sulfur compound, found in human diets and those of virtually all other vertebrates. In its purified form, it is an odorless, slightly bitter tasting, water soluble, white, crystalline powder containing 34% elemental sulfur. Its chemical formula is (CH3)2SO2.

Some atmospheric chemists have suggested that MSM and its related compounds, DMSO (dimethylsulfoxide), and DMS (dimethylsulfide) provide the source for 85% of sulfur compounds in all living organisms. These naturally occurring compounds begin in the ocean where phytoplankton convert inorganic sulfur present in the sea water to terniary dimethyl sulfonium salts. These salts are later broken down, by enzymatic action, into the volatile compound called dimethylsulfide (DMS), which escapes the ocean as a gas, rises into the upper atmosphere to be oxidized there in the presence of ozone and ultraviolet light to its chemical cousins, DMSO and MSM. Unlike DMS, both DMSO and MSM are water soluble and are returned to the earth in rain. Plants rapidly absorb the two compounds, concentrating them up to a hundred-fold. Animals eat the plants and the distribution of these sulfur compounds is then complete. MSM has been found in the blood and adrenal glands of cows. Cows' milk contains between two and six parts per million MSM.

MSM occurs naturally in the human body as a result of the food we eat. It is a normal component of fresh fruits, vegetables, seafood and meat. It has also been found in tea, coffee and chocolate. It has been detected in normal human urine. The amount of MSM present in the circulatory system of an adult human male is about 0.2 parts per million. Normal adult humans excrete from four to eleven milligrams of MSM per day in their urine. In vertebrates, the concentration of MSM decreases with age. Some research suggests that there is a minimum concentration of MSM that must be maintained in the body to preserve normal function and structure.

Experiments using MSM that contains radiolabled sulfur (35S) have shown that after ingestion, MSM gives up its sulfur to the essential amino acids methionine, cysteine and other serum proteins, eventually finding its way into the collagen of skin, joints and blood vessels. It is also incorporated into the keratin of hair and nails.

MSM is rated as one of the least toxic substances in biology. It is so inert and nontoxic that aqueous solutions can even be used as a blood diluent. In mice, no clinical changes were observed at oral doses of 2000 mg per kilogram of body weight. The lethal dose (LD50) of MSM for mice is over 20 grams per kilogram of body weight. Hundreds of patients have been treated at the Oregon Health Sciences University with oral MSM at levels above two grams daily for many years without serious toxicity.

Scientists don't yet know all the functions of MSM in the human body, but at the Oregon Health Sciences University the following conditions have responded well to supplemental MSM:

  • Pollen
  • Allergy Response to pollens and foods is sharply curtailed. Medication may be reduced or eliminated.
  • Control of hyperacidity. Patients who have used antacids and histamine-receptor antagonists to control hyperacidity can employ MSM with excellent results.
  • Relief from constipation. Patients with chronic constipation have had prompt and continuing relief with a daily supplement of MSM.

Research done at Ohio State University College of Medicine showed that oral MSM can protect rats against the onset of breast cancer. Rats bred to be susceptible to breast cancer when given certain carcinogenic compounds were fed a diet containing added MSM for eight days. Following this period the rats were given 15 mg doses of 7,12-dimethylbenzanthracene by oral gastric intubation. The health of the rats was monitored for nearly one year and compared to a similar group of carcinogen-dosed rats that had not received the MSM diet. Although there was no statistical difference in the number of tumors developing in the two groups, the MSM diet rats developed their first tumors 100 days later than the non-MSM diet rats, and these tumors became cancerous about 130 days later than those in the control group.

The same researchers from the Ohio State University College of Medicine also studied the protection that dietary MSM provided rats injected with 1,2-dimethylhydrazine, a compound that induces colon cancer. One group of rats received MSM as a 1% solution in their drinking water during the experiment. The control group received only tap water. One week after the start of the dietary regimen, all rats were injected with the carcinogen. At two-month intervals the rats were examined under anesthesia for tumors. Rats without any appearance of tumors were returned to the experiment. Again, the number of bowel tumors occurring in the rats was statistically the same for treated and untreated rats over the entire nine-month experiment. However, the time of appearance of the first bowel tumors was considerably longer in the MSM treated rats. The conclusion of the researchers was that MSM significantly lengthens the time of tumor onset compared to controls and MSM should be further investigated as a preventive for colon cancer.

Researchers at Oregon Health Sciences University studied a strain of mice that were prone to spontaneous development of joint lesions similar to those in rheumatoid arthritis. They found that animals fed a diet that included a 3% solution of MSM, in drinking water from the age of two months until the age of five months, suffered no degeneration of articular cartilage. In the control group of mice receiving only tap water, 50% of the animals were found to have focal degeneration of articular cartilage.

Finally, recent human research at the UCLA School of Medicine found an 82% reduction in pain after six weeks of oral MSM use in a double blind study on degenerative arthritis. The study spanned four months and involved sixteen patients: ten patients on MSM and six on placebo. After only six weeks, those patients using the MSM experienced better than 80% control of their pain, while those on the placebo experienced on average an 18% improvement at six weeks.

-Gary Prater


References

  • Crown-Zellerbach Corp., Toxicity bulletin 1983.
  • Herschler, R. J., U.S. Patent No. 4,973,605, Nov. 27, 1990.
  • Istituto di Ricerche Biomediche, RBM EXP., No. 980174, Aug. 19, 1998.
  • Jacob, J.W. and Herschler, R., Ann. N.Y. Acad. Sci., Vol. 411, xiii, 1983.
  • Jacob, S.W., Oregon Health Sciences University, Portland, Oregon, personal communication.
  • Lawrence, R. M., U.C.L.A. School of Medicine, Methyl-Sulfonyl-Methane, A Preliminary Correspondence.
  • Lovelock, J.E. et al., Nature, Vol. 237, 452, 1972.
  • McCabe, D. et al., Arch. Surg., Vol. 121, 1455, 1986.
  • Morton, J. I. & Moore, R. D., Federation of American Societies for Experimental Biology, 69th Annual Meeting, April 21-26, 1985, 692, 1985.
  • O'Dwyer, P.J. et al., Cancer, Vol. 62, 944, 1988.
  • Richmond, V. L., J. Nutrition, Vol. 116, No. 6, June 1986.
  • Williams, K.I.H. et al., Arch. Biochem. Biophys., Vol. 113, 251, 1966.
  • Williams, K.I.H. et al., Proc. Exp. Biol. & Med., Vol. 122, 865, 1966.






PRODUCTS

The Life Extension Foundation regularly profiles and evaluates important new products on the market, often making them available directly to you, as well as to Foundation members at a discount via the Life Extension Buyers Club.


Deer Antler
A Natural Phenomenon

The popularity and use of velvet antler consumption is on a rapid rise in the U.S. With its TV debut, this once "secret" and mysterious substance is no longer a stranger to the anti-aging and health industries. Since antler possesses a myriad of attributes, many are beginning to pay attention. Athletes are known to consume antler to boost strength, nerve function and endurance, and to accelerate recuperation. Others have touted antler as a natural alternative to Viagra. And the anti-aging and wellness circles rely on antler to promote youthfulness, mental clarity and joint mobility, among other benefits.

Since the 1920's, antler extracts have been manufactured by Soviet state agencies for use in hospitals to assist with the treatment of a wide range of medical conditions. It has also been used to accelerate the post-operative recovery of patients. In Korea-the biggest market in the world for antler-advocates claim this product can increase the stamina of athletes, improve mental function, treat sexual dysfunction and help control disease.

Antler is said to build up the body's natural defenses against disease, and provides increased energy for both men and women. According to reports from the Orient, Russia and New Zealand, antler generates hemoglobin (blood protein), controls blood pressure, increases lung efficiency, improves glandular functions, sharpens mental alertness, heals stomach ulcers and eases the diseases associated with aging.

According to Chinese herbal doctors, antler is used to strengthen memory and balance the endocrine system. The Chinese use antler as a tonic to maintain vibrant health and strengthen a weak body, promote rapid healing and regeneration of damaged tissues, treat menstrual disorders, and much more. According to studies by a Japanese scientist named Wang, a 1988 report explains that antler may have an anti-aging effect.

Nutrinfo is a food and nutritional, technical and legal consulting firm out of Watertown, MA. It provided a review of velvet antler, complete with a composition list of antler components including proteoglycan, a protein/carbohydrate of which chondroitin sulfate (CS) is by far the predominantly ingredient.

Nutrinfo's director of sciences, Thomsen Hansen, Ph.D. stated, "Serious scientific substantiation exists for claims regarding the anti-inflammatory actions of velvet antler. [It] contains respectable amounts of chondroitin sulfate, which supports antler's anti-arthritic benefits." The Nutrinfo report also stated: "Based on scientific support for the anti-inflammatory claims, we have determined that reasonable basis exists that velvet antler provides nutritional support for joint structure and function."

CS belongs to the class of glycosaminoglycans (GAGs) which are naturally occurring high viscosity carbohydrate polymers. In the body, GAGs are important constituents of connective tissue in both soft tissue and in the skeletal system. CS is the most abundant GAG in the human body and is used extensively as a medicinal agent, which helps establish the CS safety in antler. Clinical studies have found that orally administered CS is absorbed into the body and is active against the symptoms of arthritis. A subsequent study evaluated the clinical efficacy of CS in knee osteoarthritis. Treatment of CS for this condition over a 90 day period provided significant relief from symptoms as reported by the patients.

Upcoming studies are targeted toward investigating the claims made by oriental and New Zealand advocates of antler. Such reports indicate antler's benefits for strengthening the immune system, reversing aging, boosting muscle strength and endurance, and stimulating sexual vitality.

-John Abdo


References

  • Burgio, Clinical study to identify the health benefits of velvet antler.
  • Chemical Characteristics and Processing Technology of Alberta Wapiti Velvet Antlers, Wildlife Production Conservation and Sustainable Development, University of Edmonton, Edmonton, Alberta, Canada.
  • Chen, J. Chinese Materia Medica, 1992.
  • Conference on "Health Problems Related to the Chinese In America," U of C, School of Medicine, San Francisco, CA, 5/82.
  • Conte et al, Biochemical and pharmacokinetic aspects of oral treatment with chondroitin sulfate, 1995.
  • Conte et al, Metabolic fate of exogenous chondroitin sulfate in man, 1991.
  • Deer Farmer magazine, Wellington, NZ, 9/92, deer antler velvet.
  • Deer Farmer, 11/86.
  • Gerrard, clinical evaluation of New Zealand deer velvet antler on muscle strength and endurance in healthy male university athletes.
  • Morreale et al, Comparison of anti-inflammatory efficacy of chondroitin sulfate and diclofenac sodium in patients with knee osteoarthritis, 1996.
  • National Geographic, 10/86.
  • North American Elk Breeders Association; News Release, 1/8/99, 1/15/99.
  • Nutrinfo, Watertown, MA, review for the North American Elk Breeders Association, 12/15/98.
  • Palmiera et al, Metabolic fate of exogenous chondroitin sulfate in the experimental animal, 1990.
  • Sim and Sunwoo, Antler products for the treatment of osteoarthritis, NAEBA article.
  • Sunwoo et al, (a) Chemical composition of antlers, 1995.
  • The Velvet Antler Industry, 1983, Texas A&I University, Kingsville, TX.
  • Velvet Antlers for Medicine, University of Edmonton, Edmonton, Alberta, Canada, 6/90.
  • Wang, Chem. Pharm. Bull, 1988.







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