Life Extension Magazine®

Why Aging People Fail to Lose Weight

In response to remarkable fat-loss results shown in human studies, Life Extension® introduced a nutrient called Irvingia in November 2008. Since then, Irvingia has become an enormously popular supplement, the latest Irvingia weight-loss trial has been published in a prestigious scientifi c journal, and the re-order rate for Irvingia is higher than any other product. Despite impressive clinical data and actual fat-loss results, Life Extension explains why it is not satisfied with Irvingia and what it is doing to rectify the issue.

Scientifically reviewed by Dr. Gary Gonzalez, MD, in May 2022. Written by: William Faloon.

William Faloon Picture taken February 2009 Age 54 (About 20 pounds lighter in response to Irvingia) 
William Faloon Picture taken February 2009 Age 54 (About 20 pounds lighter in response to Irvingia)
William Faloon Picture taken December 2007 
William Faloon Picture taken December 2007

My photo is updated every few years so that members can see that I too am aging. Beginning in July 2008, however, a pleasant personal ambiance set in as my appetite diminished in response to taking two Irvingia capsules each day.

When reviewing scientific studies, I consistently observe that the incidence of most diseases directly correlates with how many calories one consumes. If we eat less, our risk of contracting age-related disease is considerably reduced. I analogize excess calorie intake to cigarette smoking: just as every inhaled cigarette reduces life span, so may every excess calorie bring us closer to personal extinction.

So you can imagine how enthusiastic I was when Irvingia enabled satiety to occur in me after eating relatively few calories. I lost four inches off my waistline and about 20 pounds of total weight—and have kept it off!

Not everyone has obtained the same benefits from Irvingia as I have. In this issue of Life Extension® magazine, we uncover why some aging people find it so difficult to shed fat pounds. We then reveal real-world strategies that are proven to work (some even FDA-approved), but have been overlooked by both conventional and complementary medical doctors.

Customer Responses to Irvingia

In November 2008, Life Extension® introduced a product called Irvingia gabonensis that had demonstrated dramatic results in human clinical studies.

Since its launch six months ago, Irvingia has become the most popular supplement that Life Extension has ever offered. The weight-loss study we reported on last November is now formally published in a peer-reviewed scientific journal.1 Publication provides Irvingia with important standing in the medical community, as doctors expect studies they rely on to undergo rigorous review by outside experts.

Customer Responses to Irvingia

We have received an unusual number of positive responses from Irvingia users describing weight loss, along with consistent reports of a reduction in appetite without stimulating effects. Most of our members want to eat less without feeling hungry.

The re-order rate on Irvingia is almost double that of any other product, which reflects a high level of customer satisfaction. Scientific studies continue to validate the novel mechanisms by which Irvingia has been described to induce body fat loss.2-4

Why We Are Not Satisfied With Irvingia

Despite the impressive clinical data and fat-loss results we are seeing, too many members state that they are not achieving the expected benefits in response to Irvingia. Here is a brief summary of the issues we have with Irvingia:

  1. The reductions in cardiac risk markers that occurred in two human clinical studies (LDL, total cholesterol, glucose, etc.) probably happened in direct response to body fat loss. In other words, Irvingia itself may not have been responsible for these extremely favorable changes in cardiovascular risk profiles.1,5
  2. Too many members report that they are not losing weight, or not losing the desired amount of weight in response to Irvingia.
  3. Obesity-inducing factors prevalent in the Western diet have been identified that require more than Irvingia alone to circumvent.

Missing Links That Preclude Weight Loss

Life Extension’s research staff conducted an exhaustive search of the published scientific literature to uncover why so many overweight Americans cannot shed significant fat pounds.

Why We Are Not Satisfied With Irvingia

As you will read in the three articles in this month’s issue, most of us have become addicted to a lifestyle that virtually guarantees chronic age-associated weight gain, especially in the abdominal region.

The good news is that when properly taken, currently available nutrients, drugs, and hormones can thwart these insidious obesity-inducers. In fact, the underlying scientific data supporting these approaches are quite impressive. Lacking up until now, however, is a cohesive approach that incorporates all of these discoveries into a comprehensive weight-loss program.

For example, drugs that block dietary fat absorption into the bloodstream have proven efficacy.6-9 Using this fat-blocking method alone, however, fails to meet the expectations of most overweight individuals. One reason is that excess carbohydrate absorption will cause the same disruption of metabolic processes as does overconsumption of dietary fats.

On the flip side, drugs or nutrients that block the rate of carbohydrate absorption may not induce profound weight loss if too many dietary fats wind up in the bloodstream.

Missing Links That Preclude Weight Loss

What people fail to accept is that as they grow older, they lack the metabolic capacity to efficiently convert ingested calories into energy. These metabolic deficits are increasingly being referred to as “postprandial disorders.” The term postprandial means after-meal and the disorders they refer to are too many fats and sugars remaining in the bloodstream long after meals are eaten.

Overweight individuals today suffer chronically high blood levels of fat remnants and glucose that may frustrate the best laid-out weight-loss program.8,10

One might think that by merely eating less, blood fat (triglycerides) and sugar (glucose) levels will drop low enough to prompt weight reduction. The harsh reality is that many overweight individuals are so severely compromised on a metabolic and hormonal basis that sustained fat loss cannot be achieved unless corrective actions are first taken. An imbalance of insulin, thyroid, and/or sex steroid hormones, for example, may prevent the desired release of stored body fat, even in response to calorie restriction.

As humans age, there is a progressive and extensive decline in resting cellular energy expenditure. This reduction in metabolic rate is another reason that people accumulate more body fat, even though they may be eating less than they used to.

Combat These Obesity-Inducers

Combat These Obesity-Inducers

In response to compelling evidence that unwanted weight gain is a multi-factorial process, Life Extension® has developed the world’s most comprehensive fat-loss program! One prong of this aggressive multi-model approach is a new formula that provides four ingredients, three that have clinically substantiated weight-loss benefits (the fourth has strong laboratory data to support its efficacy).1,11-13

This new Enhanced Irvingia formula provides an amylase inhibitor that took 1.2 inches of abdominal fat off human study subjects in only 30 days,14 and a non-stimulating booster of resting metabolic rate (proprietary green tea phytosome) that when combined with calorie reduction, resulted in 30 pounds of weight loss in 90 days. The placebo group who followed this same lifestyle modification (without the tea phytosome) lost only 9.9 pounds.15

Another effect of this novel metabolic enhancer is to inhibit the lipase enzyme used by the body to break down and absorb dietary fats16 (though many people may still consider the temporary use of a more potent lipase-inhibiting drug we will suggest).17,18

In order to optimally impede carbohydrate (sugar) absorption, more than an amylase inhibitor is often needed. Alpha-glucosidase is another enzyme the body uses to assimilate carbohydrates from the small intestine.19 The new Enhanced Irvingia contains an alpha-glucosidase inhibitor that in laboratory studies resulted in a 90% reduction in postprandial blood glucose spikes with a dramatic 40% reduction in postprandial insulin.13

This new formula contains the standardized Irvingia gabonensis used in the most recent human study to induce weight loss and a reduction in abdominal adiposity via four different mechanisms.1,13-15

Managing Unrealistic Expectations

Based on the multiple pathways that the four ingredients in the new Enhanced Irvingia function, overweight members may think this one formula will make them thin again. While this formula may function in an impressive manner for some individuals, the majority of people will need to follow at least some of the aggressive protocols laid out in the articles contained in this month’s issue of Life Extension® magazine.

Please know that even in tightly regimented clinical studies, doctors find it remarkably challenging to manage the weight-loss expectations of study participants. One study documented that no matter how many times study subjects were told that they would not achieve immediate results, many dropped out because they were not losing weight fast enough.20

Based on the accumulation of everything we now know, the only way for most people to achieve substantial and sustained control over their body weight is to adopt the clearly defined protocols outlined in the articles you are about to read.

You Don’t Have to Go it Alone!

Many of our members are proficient enough to comprehend these new weight-loss data and incorporate the protocols we suggest into their everyday lifestyle.

If you are ever confused by what we publish, please remember that as a Life Extension member, you have direct access to our dedicated team of health advisors.

For instance, if you utilize the new Life Extension Weight Loss Blood Test Panel (click here for panel), you can call a health advisor and ask what specifically you should do to achieve optimal weight loss. Our health advisors will listen to your personal history and make suggestions based on the obesity factors (as revealed by your blood tests) that may be causing you to be overweight or obese.

If after you implement some of the strategies we outline, you are not satisfied with your achieved weight-loss result, our health advisors may be able to identify the missing link(s) that preclude you from shedding excess fat pounds.

Clinically Proven Weight-Loss Strategies

Our position, based on a myriad of published findings, is that sustained weight loss is achievable. The problem up until now is that no one put together all the pieces to enable aging humans to avail themselves of proven fat-reducing strategies.

In this month’s issue, you’ll learn about methods that have been documented in human clinical trials (and some approved by the FDA) to safely induce weight loss—while simultaneously improving cardiac risk markers.

P.S. Our health advisors are available from 8 am to 12 midnight Eastern Standard Time seven days a week and can be reached by calling 1-800-226-2370.

For longer life,

For Longer Life

William Faloon


1. Lipids Health Dis. 2009 Mar 2;8:7.

2. Lipids Health Dis. 2008 Nov 13;7:44.

3. Lipids Health Dis. 2008 Mar 31;7:12.

4. West Afr J Med. 1990 Apr-Jun;9(2):108-15.

5. Lipids Health Dis. 2005 May 25;4:12.

6. Ann Pharmacother. 2001 Mar;35(3):314-28.

7. Best Pract Res Clin Endocrinol Metab. 2002 Dec;16(4):717-42.

8. Curr Diabetes Rev. 2008 Nov;4(4):340-56.

9. J Am Diet Assoc. 1998 Oct;98(10 Suppl 2):S23-6.

10. Am J Physiol Endocrinol Metab. 2001 Sep;281(3):E626-32.

11. Altern Med Rev. 2004 Mar;9(1):63-9.

12. Integr Nutr. 2008;11(2):15-21.


14. Int J Med Sci. 2007 Jan 24;4(1):45-52.

15. Nutrafoods. 2008;7(4):21-8.

16. J Nutr Biochem. 2006 Jul;17(7):492-8.

17. Drugs Today (Barc). 1999 Feb;35(2):139-45.

18. Obes Res. 2000 Jan;8(1):49-61.

19. Eur J Clin Invest. 1994 Aug;24(Suppl 3):3-10.

20. J Consult Clin Psychol. 2003 Dec;71(6):1084-9.