Curcumin 95™

500 mg, 60 capsules Item # 01104

Curcumin 95™ 500 mg, 60 capsules - Life Extension

Curcumin 95™

500 mg, 60 capsules Item # 01104

Jarrow's Curcumin 95™ is an 18:1 concentrate of the antioxidants found in the spice turmeric root. Curcumin 95™ contains 95% curcuminoids, which are powerful antioxidants. Specifically, curcumin and its derivatives protect DNA against oxidative damage induced by reactive oxygen species.

Curcumin is impressing scientists around the world with its remarkable multiple health benefits. Curcumin is a polyphenol present in the spice turmeric and was first used by Indians over 3,000 years ago in traditional Ayurvedic medicine. Modern science has found that curcumin has remarkable antioxidative, immunomodulatory, proapoptotic, hepatoprotective and antiangiogenic properties.1-6 Curcumin is also found to increase detoxifying enzymes and promote healthy DNA function.7-11

Studies have tied inflammation to overexpression of a protein molecule called nuclear factor-kappa B (NF-kappaB). NF-kappaB acts like a switch to turn on genes that produce the body’s inflammatory responses. Because NF-kappaB’s expression increases in aging adults, scientists have sought ways to modulate NF-kappaB and its effects in the body.

Curcumin has been shown to exert powerful inhibitory effects on NF-kappaB activation within the body.12 Curcumin inhibits overexpression of NF-kappaB. In addition, curcumin inhibits the metabolism of arachidonic acid, as well as activities of cyclooxygenase, lipoxygenase, and cytokines (interleukins and tumor necrosis factor).13,14

Other clinical trials suggest roles for curcumin in helping maintain healthy lipid profile, bowel, and joint functions.15,16 Curcumin can also help maintain normal healthy platelet function,17-20 and have immunomodulatory effects by inhibiting histamine release from mast cells.21 Other studies show curcumin’s potential for supporting healthy brain function and offering neuroprotection.22-28

Curcumin may effectively support pancreatic islet health.29,30 Curcumin’s multifaceted effects include protecting against estrogen-mimicking chemicals,31,32 protecting against damaging free radicals, and promoting normal cell cycle growth.

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  1. Anticancer Res. 2004 Mar-Apr;24(2B):563-9.
  2. Toxicol Lett. 2000 Mar 15;112-113:499-505.
  3. J Pharm Pharmacol. 1997 Jan;49(1):105-7.
  4. 4. Antioxid Redox Signal. 2008 Mar;10(3):511-45.
  5. J Ethnopharmacol. 2010 Jan 18. [Epub ahead of print]
  6. Arch Toxicol. 2010 Jan 30. [Epub ahead of print]
  7. Asia Pac J Clin Nutr. 2008;17 Suppl 1:265-8.
  8. Phytother Res. 2010 Jan 13;24(2):189-192. [Epub ahead of print]
  9. Zhonghua Nei Ke Za Zhi. 2009 Sep;48(9):760-3.
  10. Mol Nutr Food Res. 2010 Jan 19. [Epub ahead of print]
  11. Nutr Cancer. 2010;62(2):148-53.
  12. J Alzheimer’s Dis. 2004 Aug;6(4):367-7.
  13. Chin Med. 2008 Sep 17;3:11.
  14. Int Braz J Urol. 2009 Sep-Oct;35(5):599-606
  15. Dig Dis Sci. 2005 Nov;50(11):2191-3.
  16. Biochem Pharmacol. 2008 Feb 15;75(4):787-809.
  17. J Endotoxin Res. 2007;13(1):15-23.
  18. Prostaglandins Leukot Essent Fatty Acids. 1995 Apr;52(4):223-7.
  19. Mol Cancer Ther. 2006 May;5(5):1371-82.
  20. J Ethnopharmacol. 1993 Mar;38(2-3):113-9.
  21. Mol Nutr Food Res. 2008 Sep;52(9):1031-9.
  22. Journal of Neuroscience. 2001;21(21):8370–8377.
  23. Journal of Biological Chemistry. 2005;280(7):5892–5901.; discussion 606-7.
  24. Cellular and Molecular Life Sciences. 2006;63(13):1538–1552.
  25. Parkinsonism Relat Disord. 2009 Dec;15 Suppl 3:S189-94.
  26. J Neurochem. 2009 Dec 26. [Epub ahead of print]
  27. Biochem Biophys Res Commun. 2010 Jan 21. [Epub ahead of print]
  28. PLoS One. 2010 Jan 8;5(1):e8643.
  29. Eur J Pharmacol. 2007 Dec 22;577(1-3):183-91.
  30. Br J Pharmacol. 2008 Nov;155(5):702-13. Epub 2008 Aug 11.
  31. Environ Health Perspect. 1998 Dec;106(12):807-12.
  32. Biochem Biophys Res Commun. 1997 Apr 28;233(3):692-6.

Serving Size 1 tablet

Servings Per Container 60

Amount Per Serving

Turmeric concentrate (curcuma longa) (18:1) (95% total curcuminoids) (rhizome)

500 mg

Other ingredients: Cellulose, magnesium stearate (vegetable source) and silicon dioxide.

Capsule consists of gelatin. No wheat, no gluten, no soybeans, no dairy, no egg, no fish/shellfish, no peanuts/tree nuts.

Dosage and Use
  • Take one capsule per day, with food, or as directed by your qualified health care consultant.

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Life Extension. We do not verify or endorse any claims made in these reviews. Full product reviews disclaimer



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