Best In Class


  • 60 AM/PM vegetarian tablets
  • Item # 02202
Best In Class


  • 60 AM/PM vegetarian tablets
  • Item # 02202

Honokiol and PEA for nerve support & discomfort relief

PEA inhibits inflammatory factors to support nerve cell health. Honokiol encourages healthy levels of calming neurotransmitters in the brain. Together, they help alleviate minor discomfort.
Gluten free Non-GMO Vegetarian
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$0.48/count | 30 Day Supply

This stuff really works

Jimmy, Cedarville

I have been using ComfortMAX now for over a month. Very effective results.

Seascout, Seattle

Frequently Bought Together

  • This Item: ComfortMAX™, 60 AM/PM vegetarian tablets
  • Discomfort Relief (Berry Flavor), 60 vegetarian chewable tablets

Total Price:



60 AM/PM vegetarian tablets


$0.55/count | 30 Day Supply

What Is ComfortMAX?

ComfortMAX™ delivers two potent ingredients: palmitoylethanolamide (PEA) and honokiol, a compound derived from Magnolia bark. By promoting nerve comfort in two separate yet complementary ways, the ingredients in ComfortMAX™ help to inhibit nerve discomfort.

The reasons for physical discomfort vary, but the way we experience that discomfort doesn't. That's why we’ve created ComfortMAX™.

ComfortMAX™ Benefits

  • Dual-action formula helps alleviate minor nerve discomfort
  • Helps you stay comfortable throughout the day
  • Provides morning and nighttime doses for around-the-clock support

What is PEA?

Palmitoylethanolamide (PEA) is a fatty acid your body produces as part of a healthy inflammatory and immune response. PEA can inhibit occasional minor discomfort.

Why did we add honokiol?

Honokiol is a lignan compound derived from several species of magnolia. Its calming effect on nerve receptors helps to alleviate discomfort.

The How & Why Behind ComfortMAX™

By inhibiting inflammatory compounds to promote nerve health and encouraging healthy neurotransmitter levels in your brain, ComfortMAX™ helps to reduce discomfort. Formulated to be taken twice a day, one tablet in the morning and one tablet at night right before bed, it helps with relieving discomfort—day and night.

Why Life Extension?

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According to the National Institutes of Health, nearly 25 million Americans experience daily discomfort.1 This kind of discomfort can affect mood, mobility and quality of life.2 The reasons for physical discomfort vary, but the way we experience that discomfort doesn’t: Our peripheral nerves are responsible for delivering sensory information (an itch, temperature change, physical pressure, etc.) to the brain. And that’s where ComfortMAX™ comes in.

These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
  1. J Pain. 2015;16(8):769-80.
  2. J Pain Res. 2016;9:457-467.
  3. Pain Physician. 2016;19(2):11-24.
  4. CNS Neurol Disord Drug Targets. 2013;12(1):78-83.
  5. Adv Gerontol. 2017;7(1):68-75.
  6. Eur J Pharmacol. 1996;300(3):227-36.
  7. Brain Behav Immun. 2011;25(6):1099-112.
  8. CNS Neurol Disord Drug Targets. 2013;12(1):34-44.
  9. Br J Clin Pharmacol. 2016;82(4):932-42.
  10. Dolor. 2010;25(1):35-42.
  11. J Orofac Pain. 2012;26(2):99-104.
  12. J Nat Prod. 1998;61(1):135-8.
  13. Adv Pharmacol. 2006;54:1-27.
  14.  Neuropharmacology. 2012;62(8):2507-14.
  15. Neurochem Res. 1999;24(12):1593-602.
  16. Eur J Drug Metab Pharmacokinet. 2016;41(5):587-94.
  17. PloS one. 2011;6(4):e18490.

Serving Size 1 AM vegetarian tablet (white)

Amount Per Serving

Calcium (as calcium carbonate)

60 mg

Palmitoylethanolamide (PEA)

600 mg

Other ingredients: microcrystalline cellulose, croscarmellose sodium, hydroxypropyl methylcellulose, stearic acid, vegetable stearate, silica, maltodextrin, hydroxypropyl cellulose, glycerin.

Serving Size 1 PM vegetarian tablet (blue)

Amount Per Serving

Calcium (as calcium carbonate)

30 mg

Palmitoylethanolamide (PEA)

600 mg

Honokiol [from magnolia extract (bark)]

180 mg

Other ingredients: croscarmellose sodium, microcrystalline cellulose, hydroxypropyl methylcellulose, stearic acid, hydroypropyl cellulose, vegetable stearate, silica, maltodextrin, spirulina extract color, glycerin.


Dosage and Use
  • Take one (1) AM tablet in the morning and one (1) PM tablet before bed, or as recommended by a healthcare practitioner.

The blue PM tablet may cause mild sedation in some people. Take at bedtime.

  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Actual Size

Pill Size Image

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Life Extension. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer.

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