Circadian Sleep

30 liquid vegetarian capsules Item # 02300 UPC: 737870230038

Restore your body's sleep-wake cycle, 1.5 mg melatonin

4.0

64 Reviews | Write a review

Circadian Sleep 30 liquid vegetarian capsules - Life Extension

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Circadian Sleep

30 liquid vegetarian capsules Item # 02300 UPC: 737870230038

Restore your body's sleep-wake cycle, 1.5 mg melatonin

4.0

64 Reviews | Write a review

By supporting both central and peripheral circadian clocks, our Circadian Sleep represents an innovative, restorative approach to promoting healthy circadian rhythms, resulting in multiple benefits for whole-body health.

For occasional sleeplessness

Gluten free Non-GMO Vegetarian

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This is a go to for me since I tried it! I take one before I head to bed.

DENICE

This definitely enhances the quality of sleep for both my husband and me.

Liz, WA

Sound restful sleep. I will certainly buy it again.

Jan

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What Is Circadian Sleep?

A central circadian clock located in the brain helps regulate our sleep-wake cycles. We also have peripheral circadian clocks that govern essential biological processes, such as blood pressure and kidney function. But aging and other lifestyle factors can disrupt circadian clocks. Circadian Sleep combines melatonin with a novel citrus peel extract to help encourage healthy function of both central and peripheral circadian clocks.

Circadian clocks exist in virtually every cell of our bodies and are organized hierarchically, with the central clock setting the pace by regulating healthy sleep-wake cycles.

Circadian Sleep Benefits

Restores healthy circadian rhythms
Supports healthy sleep-wake cycles
Promotes peripheral circadian rhythms
Supports whole-body health

For occasional sleeplessness.

Our Circadian Health Formula

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Circadian Sleep combines melatonin with a novel citrus peel extract to encourage healthy function of both central and peripheral circadian clocks, respectively. MicroActive® Melatonin promotes optimal sleep-wake cycles, and nobiletin from young citrus peel supports healthy expression of genes that govern peripheral circadian rhythms.

More

More facts about Circadian Sleep

Aging, hectic modern lifestyles and other factors can disrupt our circadian clocks, which can affect our health.^1-3 So we developed our Circadian Sleep formula to restore these natural rhythms: MicroActive® Melatonin supports the central clock in the brain, while nobiletin young citrus peel extract promotes healthy peripheral clocks, which control the rest of the body.

Melatonin for healthy sleep-wake cycling

Peripheral circadian clocks exist in virtually every cell of our bodies and are organized hierarchically, with the central clock setting the pace by regulating healthy sleep-wake cycles.⁴ Melatonin, known as the “sleep hormone,” is primarily synthesized at night in the brain by the pineal gland.⁵ Melatonin ensures that the central clock is properly supporting sleep-wake cycles and aligning the peripheral clocks with the sleep-wake cycles for whole-body health.

The first step to healthy, whole-body circadian rhythms is to restore that central clock with melatonin.

Nobiletin for healthy peripheral circadian rhythms

Peripheral circadian clocks in various organs govern essential biological processes: heart rate, body temperature, hormone release, blood pressure, liver, kidney and pancreatic function and more.^6-8 Nobiletin is a polymethoxylated flavone isolated from young citrus peel. Results from a recent pre-clinical study suggest that nobiletin may also help positively support peripheral circadian rhythms.⁹ It does so by directly activating a unique set of receptors widely expressed throughout the body and known to play a key role in supporting circadian rhythms.^10-14 It has also been shown to exhibit neuroprotective and antioxidant properties as well as promote a healthy inflammatory response.¹⁵

Nobiletin promotes whole-body health

In another pre-clinical study, nobiletin supports the expression of circadian genes which themselves control the expression of other genes with specific circadian functions in every cell.¹⁶ Healthy expression of genes controlling circadian rhythms supports metabolic, cognitive, liver and kidney health and also helps maintain healthy blood pressure, cholesterol and triglyceride levels already within the normal range.^17-20

Innovative circadian health formula

By supporting both “central” and “peripheral” circadian clocks, our Circadian Sleep represents an innovative, restorative approach to whole-body health. Try Circadian Sleep today!

These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.

Serving Size 1 liquid vegetarian capsule
Amount Per Serving
Nobiletin [from young citrus fruit (peel)]	50 mg
Melatonin (as MicroActive®)	1.5 mg
Other ingredients: medium chain triglycerides, vegetable capsule (hydroxypropyl methylcellulose, chlorophyllin), microcrystalline cellulose, sodium alginate, carnauba wax, silica.

Non-GMO

MicroActive® Melatonin is a registered trademark of Bioactives LLC.

Dosage and Use

Take one (1) capsule daily, before bedtime, or as recommended by a healthcare practitioner.
Melatonin is naturally secreted from the pineal gland at night, and should be taken at night for optimal results.

Caution

Do not consume alcohol, drive or operate machinery after taking this product.

Warnings

KEEP OUT OF REACH OF CHILDREN
DO NOT EXCEED RECOMMENDED DOSE
Do not purchase if outer seal is broken or damaged.
When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Actual Size

Curr Opin Insect Sci. 2015;7:82-86.
Neurobiol Stress. 2017;6:57-67.
Iran J Public Health. 2018;47(8):1068-1076.
Annu Rev Neurosci. 2012;35:445-62.
J Neuroendocrinol. 2003;15(4):432-7.
Sleep Med Clin. 2015;10(4):413-21.
Handb Exp Pharmacol. 2013(217):3-27.
Neuron. 2012;74(2):246-60.
PLoS One. 2017;12(2):e0170904.
J Biol Rhythms. 2005;20(5):391-403.
Nat Struct Mol Biol. 2005;12(5):441-8.
Embo j. 1998;17(14):3867-77.
Nucleic Acids Res. 2012;40(17):8519-35.
Acta Pharmacol Sin. 2015;36(1):71-87.
Evid Based Complement Alternat Med. 2016;2016:2918796.
Cell Metab. 2016;23(4):610-21.
Sleep Med Rev. 2012;16(2):151-66.
Proc Nutr Soc. 2016;75(4):440-450.
Front Mol Neurosci. 2012;5:50.
Nat Rev Nephrol. 2018;14(10):626-635.

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