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Circadian Sleep

30 liquid vegetarian capsules
Item# 02300

Super Sale Price:
$18.90 $21.00

Circadian Sleep

Restore circadian rhythms for better sleep & overall health

30 liquid vegetarian capsules
Item# 02300

Retail Price: $28.00

Super Sale Price: $18.90 $21.00

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Description

  • Circadian Sleep
  • 30 liquid vegetarian capsules
  • Item Catalog Number: 02300

Our NEW Circadian Sleep formula combines melatonin with a unique citrus-peel extract to encourage healthy function of both central and peripheral circadian clocks, respectively. MicroActive® Melatonin promotes optimal sleep-wake cycles, and nobiletin from young citrus peel supports healthy expression of genes that govern your peripheral circadian rhythms.

Benefits at a Glance:

  • Promotes healthy whole-body circadian rhythms1-3
  • Supports healthy sleep-wake cycles1
  • Helps maintain whole-body health
  • Contains both melatonin and nobiletin citrus extract

More facts about Circadian Sleep

You’ve probably heard of circadian rhythms — they’re best-known for regulating your sleep-wake cycles. In addition to the central circadian “clock” in your brain, the internal-time keeper that regulates sleep, you also have peripheral circadian clocks in various organs that govern essential biological processes: heart rate, body temperature, hormone release, blood pressure, liver, kidney and pancreatic function, and more.4-6

But aging, hectic modern lifestyles, and other factors can disrupt all of your circadian clocks — which can affect your health.7-9 So we developed our Circadian Sleep formula to restore these natural rhythms: MicroActive® Melatonin targets the central clock in your brain, while nobiletin young citrus peel extract promotes healthy peripheral clocks, which control the rest of your body.

Melatonin for healthy sleep-wake cycling

Peripheral circadian clocks exist in virtually every cell of your body and are organized hierarchically, with the central clock setting the pace by regulating healthy sleep-wake cycles.1 Melatonin, known as the “sleep hormone,” is primarily synthesized at night in the brain by the pineal gland.10 Melatonin ensures that the central clock is properly regulating sleep-wake cycles and aligning the peripheral clocks with the sleep-wake cycles for whole-body health.

So the first step to healthy, whole-body circadian rhythms is to restore that central clock with Melatonin.

Nobiletin for healthy peripheral circadian rhythms

Nobiletin is a polymethoxylated flavone isolated from young citrus peel. It has been shown to exhibit neuroprotective and antioxidant properties as well as promote a healthy inflammatory response.11

Results from a recent pre-clinical study suggest that nobiletin may also help positively regulate peripheral circadian rhythms.2 It does so by directly activating a unique set of receptors widely expressed throughout the body,12 and known to play a key role in regulating circadian rhythms.13-16

Nobiletin promotes whole-body health

In another pre-clinical study, nobiletin regulates the expression of circadian genes which themselves control the expression of other genes with specific circadian functions in every cell.3 Healthy expression of genes controlling circadian rhythms supports metabolic, cognitive, liver, and kidney health and also helps maintain healthy blood pressure, cholesterol, and triglyceride levels already within the normal range.17-20

Unique circadian health formula

By targeting both “central” and “peripheral” circadian clocks, our Circadian Sleep represents a novel, restorative approach to whole-body health. Try Circadian Sleep today!

These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.


  1. Annu Rev Neurosci. 2012;35:445-62.
  2. PLoS One. 2017;12(2):e0170904.
  3. Cell Metab. 2016 Apr 12;23(4):610-21.
  4. Sleep Med Clin. 2015 Dec;10(4):413-21.
  5. Handb Exp Pharmacol. 2013 (217):3-27.
  6. Neuron. 2012 Apr 26;74(2):246-60.
  7. Curr Opin Insect Sci. 2015 Feb 1;7:82-86.
  8. Neurobiol Stress. 2017 Feb;6:57-67.
  9. Iran J Public Health. 2018 Aug;47(8):1068-1076.
  10. J Neuroendocrinol. 2003 Apr;15(4):432-7.
  11. Evid Based Complement Alternat Med. 2016;2016:2918796.
  12. Acta Pharmacol Sin. 2015 Jan;36(1):71-87.
  13. J Biol Rhythms. 2005 Oct;20(5):391-403.
  14. Nat Struct Mol Biol. 2005 May;12(5):441-8.
  15. Embo j. 1998 Jul 15;17(14):3867-77.
  16. Nucleic Acids Res. 2012 Sep 1;40(17):8519-35.
  17. Sleep Med Rev. 2012 Apr;16(2):151-66.
  18. Proc Nutr Soc. 2016 Nov;75(4):440-450.
  19. Front Mol Neurosci. 2012;5:50.
  20. Nat Rev Nephrol. 2018 Oct;14(10):626-635.

SUPPLEMENT FACTS

Supplement Facts

Serving Size 1 liquid vegetarian capsule

Amount Per Serving
Nobiletin [from young citrus fruit (peel)] 50 mg

Melatonin (as MicroActive®)

1.5 mg

Other ingredients: medium chain triglycerides, vegetable capsule (hydroxypropyl methylcellulose, chlorophyllin), microcrystalline cellulose, sodium alginate, carnuba wax, silica.

Non-GMO

MicroActive® Melatonin is a registered trademark of Bioactives LLC.
Dosage and Use
  • Take one (1) capsule daily, before bedtime, or as recommended by a healthcare practitioner.
  • Melatonin is naturally secreted from the pineal gland at night, and should be taken at night for optimal results.
Caution
Do not consume alcohol, drive or operate machinery after taking this product.
Warnings

REVIEWS

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Life Extension. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer.

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