Life Extension Magazine®
Example of DNA that has been protected from damage

Issue: Oct 2012

Defend Against DNA Destruction

Research shows that a special group of carotenoid nutrients, the xanthophylls, combat DNA damage, boost DNA repair mechanisms, and may prevent or slow the development of cancer, age-related macular degeneration, and other diseases of aging.

Scientifically reviewed by: Dr. Carol Campi, RN, DC, on August 2020. Written By Alex Richter.

 
Defend Against DNA DESTRUCTION

As each second goes by, your DNA is being attacked by internal and environmental factors that can result in potentially lethal mutations.1

This accumulated DNA damage underlies most of the conditions that kill us, such as atherosclerosis, cancer, and Alzheimer's disease.2-5

Fortunately, there are steps that you can take to protect your DNA from the onslaught of around-the-clock damage.

Scientists have demonstrated that a special group of plant compounds known as xanthophylls have shown protective effects against DNA damage.6 These molecules have been researched for their ability to prevent DNA damage and reduce disease risk.

Xanthophylls have not only been shown to prevent deadly genomic damage but they simultaneously boost your body's natural DNA repair mechanisms which help it recover from damage that's already occurred.7,8

Widespread Impact of DNA Damage

The DNA molecule is extremely vulnerable to injury from internal and external sources.9,10 Oxygen radicals, toxins, and even sunlight all induce breaks, nicks, and other injuries to the delicate DNA strands. 10,11 Without knowing it, you experience millions of such DNA "accidents" each day. Fortunately, your body has no fewer than five interrelated mechanisms for repairing that damage.9 Those mechanisms are so efficient and accurate that your cells and tissues remain stable and disease-free year after year.9 Periodically, even the most efficient and accurate repair systems make small errors. And these errors add up. Scientists now recognize that the ability to identify and repair DNA damage is the leading discriminator of who does and does not get cancer and probably many of the other diseases of aging.9,10,12

Carotenoid Consumption Lowers Cancer Risk
Ovarian Cancer 55%56
Non-Hodgkin Lymphoma 46%13
Invasive Breast Cancer 17%57
Lung Cancer 17%16
Estrogen Receptor-Negative (Treatment-Resistant) Breast Cancer 13%58

People with the highest intake of the caroteniods lutein, zeaxanthin, and astaxanthin are protected against developing many different kinds of cancers.

Xanthophylls Fight DNA Damage

Xanthophylls Fight DNA Damage

Xanthophylls are concentrated in yellow, orange, and deep green leafy vegetables.14,39 Epidemiological studies show that people who consume large amounts of fruit and vegetables have lower rates of cancer and other DNA damage-related diseases.15,16 But studies that take a closer look show that supplying up to 8 servings of carotenoid-containing fruits and vegetables per day don't demonstrate a reduction in DNA damage or improvement in repair mechanisms.17 Eating 12 servings per day did produce some benefit particularly with regards to reduction of damaging inflammatory molecules, but most people can't sustain that level of vegetable consumption.18 True DNA protection seems to require supplementation to achieve higher levels of these valuable nutrients in your blood.

When human volunteers took capsules containing concentrated xanthophylls, they demonstrated a 40% reduction in markers of DNA damage in their white blood cells.19 Individually, lutein, zeaxanthin, and astaxanthin supplements each reduce oxidative stress and DNA destruction in both animal and human studies.20-23 Doses of 4 to 12 mg/day of xanthophylls, alone or in combination, have been reported to reduce DNA damage in various studies.24,25

Let's turn now to the compelling body of science that demonstrates how these three xanthophylls can work to prevent catastrophic age-related diseases such as cancer and eye disease by protecting DNA from damage.

Xanthophylls Prevent Cancer

Scientists estimate that poor nutrition and lifestyle habits, including inadequate intake of nutrients known to help prevent DNA damage and promote DNA repair, may play a role in up to 80% of colon, breast, and prostate cancers and 33% of all other cancers.12,26 Large epidemiological studies consistently show that higher intake of foods rich in lutein, zeaxanthin, and astaxanthin reduce the risk of several different cancer types.16,27

Laboratory studies reveal the reasons for this impressive protection. When tumors are experimentally implanted into mice supplemented with xanthophylls, the rate of tumor growth and the final size of the tumors are reduced by as much as 40%, compared with unsupplemented animals.28-30 The number of tumors triggered by exposure to a carcinogenic chemical can be reduced by 55% in animals supplemented with xanthophylls such as lutein.34 It takes supplemented animals significantly longer to develop those artificial cancers.31-33 How do the xanthophylls exert their powerful anticancer actions?

They do it through a number of mechanisms that strike at different targets throughout the cancer development process:

  • They block cancer initiation by limiting DNA damage and strengthening DNA repair mechanisms.12,26
  • They suppress genes that promote tumor growth after cancer initiation.34
  • They turn on genes that suppress tumor promotion.30
  • They reduce inflammation that can promote cancer growth and spread.33-34
  • They switch on cancer cells' defective suicide programming (apoptosis), helping to shrink existing cancers and prevent metastatic spread.30
  • They slow the development of new blood vessels needed by a rapidly-growing tumor, starving it of its vital nutrient and oxygen supplies.30

Research has shown that supplementation with lutein, zeaxanthin, and astaxanthin boosts the immune system in ways that help it identify and destroy cancerous cells in their earliest stages.29,31 Most scientists today recognize that, after prevention of DNA damage, this kind of "immune-surveillance" is an essential and efficient means of preventing a full-blown cancer from emerging.35 The effects of the xanthophylls on skin cancer, the most common cancer in the United States, are especially prominent. Sunlight and especially its ultraviolet rays trigger high rates of DNA damage in skin cells that initiate certain types of skin cancer.36,37 Ultraviolet radiation weakens the immune system's anti-cancer surveillance mechanisms.36

In a study of Australians with a prior history of skin cancer, those with the highest intake of lutein and zeaxanthin had a 53% lower risk of developing squamous cell carcinoma, a type of skin cancer, compared to those with the lowest intake levels.38 Studies show that supplementation with xanthophylls reduces skin's unhealthy responses to ultraviolet light and enhances its resistance to cancer development.36,37 Increased survival time in an animal model of skin cancer has been demonstrated as a result of supplementation.37

Interestingly, lutein, zeaxanthin, and astaxanthin supplements reduce light-induced skin aging, again in large part because of their ability to combat age-promoting DNA damage.37 Their unique molecular structure seems to make them especially potent at taming the destructive effects of light bombardment on vulnerable tissues. Nowhere is that protection more essential than in the retina of the eye, as we'll see next.

What You Need to Know

Defend Your DNA with Carotenoids
  • Damage to DNA, the universal blueprint for life, is a fundamental cause of aging and age-related chronic disease.
  • DNA repair mechanisms begin to fail with advancing age, resulting in accumulation of damaged DNA throughout the body.
  • Growing evidence implicates DNA damage and impaired repair mechanisms in the causation, not only, of cancer but of the eye disease called age-related macular degeneration (AMD) as well.
  • A special group of carotenoid nutrients, the xanthophylls, combat DNA damage and boost DNA repair mechanisms.
  • Supplementation with the xanthophyll nutrients lutein, zeaxanthin, and astaxanthin may help to prevent or slow the development of cancer and other age-related disorders such as AMD.
 
 
 
 
 
 

Carotenoids Prevent AMD

What Is Age-Related Macular Degeneration?

The macula is the part of the retina that's most densely packed with vision-producing nerve cells. Despite its tiny size (about 5 mm in diameter), the macula accounts for the majority of our vision, and virtually all of our "central vision" (what we see when we look directly at something.)

The intense flow of light onto the macula, and the steady production of free radicals by its intensely active mitochondria, imposes massive stresses on the cells, in this region. Over time, they can begin to die off, producing a growing "blind spot" directly in the center of our visual field.39 This condition is called age-related macular degeneration or AMD.

People with early AMD may think they are having trouble focusing, but in fact they simply can't see well in regions directly in front of their eyes. As time goes on, they develop a sort of "donut" vision able to see clearly around the edges but unable to see at all in the center. Because we need our central vision to read, watch television, or do most other vision-requiring tasks, AMD produces a significant reduction in the quality of life, and in fact can leave many people functionally blind.39

What Is Age-Related Macular Degeneration?

Macular degeneration may cause abnormal new blood vessels to grow under the retina and leak fluid and blood. This is one of the most common causes of decreased vision after age 60.

Age-related macular degeneration, or AMD, produces more irreversible loss of vision than any other single cause.39,40 As we've seen, AMD is the result of constant assault on retinal cells by light energy, which damages their mitochondrial DNA. The retina is protected by cells packed with lutein, zeaxanthin, and meso-zeaxanthin (formed from lutein in the retina). These three nutrients produce light-absorbing characteristics that protect the light-sensing cells from damage.41-44

But levels of these three nutrients in retinal tissue decline with age, as does their dietary intake, leaving your retina — and your vision— increasingly vulnerable to damage.43,44

DNA damage and repair are essential in understanding age-related macular degeneration. In this case, damage to DNA in mitochondria is the culprit.45,46 Mitochondria generate the power for all of our cells and they are especially important in tissues with high energy demands, such as the heart muscle, nerve tissue, and cells in the retina.

Mitochondrial DNA is highly vulnerable to damage both by light and by oxidant stress, and it has limited repair mechanisms.45,47 Unrepaired mitochondrial DNA damage causes cells to become unstable, malfunction, and eventually die, leading to the loss of central vision we identify as age-related macular degeneration.47 And the more severe the DNA damage, the more advanced the damage to the retina in AMD.48

You can replace your dwindling stores of retinal pigment, however, by raising your consumption of these xanthophyll nutrients.

Studies show that people with the highest intake of xanthophylls such as lutein, zeaxanthin, and astaxanthin are at 35% less risk of developing the most serious form of AMD, so-called "wet," or neo-vascular disease.49 High xanthophyll intake provides up to a 55% reduction in risk of the less severe, but still disabling, "dry" form of AMD. 49

Unfortunately, you can't get enough of these protective xanthophylls from your diet alone.44 Supplementation at fairly high levels is required in order to restore protective levels of retinal pigment.50

Supplementation studies demonstrate two important and related outcomes of increased xanthophyll consumption. First, people who supplement with these nutrients develop greater concentrations of protective retinal pigments, resulting in improved light protection in their eyes, and lower risk for AMD.41,44,50-52

Second, supplemented people see better. Vision testing shows increased visual acuity in AMD patients taking xanthophyll supplements. One study demonstrated a 5.4 letter improvement on the standard office eye chart,40 while another showed an incredible 1.5 line improvement.53 The ability to see visual contrast improves with xanthophyll supplementation, as does overall retinal sensitivity to visual images.40,52 Xanthophyll supplementation produces objective improvements in the intensity of electrical impulses produced by the retina, a direct measure of increased visual functioning.54

These improvements in retinal pigmentation and visual function have been seen with daily doses of lutein, 12 mg, and zeaxanthin, 1 mg, though 10 to 20 mg have been found to be safe daily doses of each nutrient.41,44,50,51,55 Studies using lower doses of lutein (up to 6 mg/day) generally fail to show any effect.52 Products containing free lutein, as opposed to lutein bound up to other molecules, appear to have superior effectiveness.55 You may be able to protect vital eye structures by supplementing with the omega-3 fatty acid DHA, 800 mg/day as well.41

Big Pharma wants to sell expensive drugs that have only limited benefits (and many side effects) in managing AMD, but experts now agree that supplementation with xanthophylls is "a simple, cost-effective public health intervention that might help to decrease the incidence of AMD."39

C3G Offers More Help for Aging Eyes

AMD is the most common cause of major vision loss in older people, but it is far from the only one. Almost everyone suffers from progressive loss of night vision with age. That "night blindness" is the result of slowed regeneration of a pigment called "rhodopsin" that the eye relies on for detection of very low levels of light.

Studies show that a natural plant compound, an anthocyanin called cyanidin 3-glucoside, or C3G, can accelerate the regeneration of rhodopsin, potentially restoring dim-light visual sensitivity.59,60 C3G, derived from natural dark berries, is therefore a promising addition to any supplement meant to combat age-related vision changes.

Summary

Carotenoids Prevent AMD

It’s becoming increasingly understood that damage to DNA underlies many age-related diseases. 

Prominent conditions in which we understand the role of DNA damage are cancer and the eye disease called age-related macular degeneration (AMD). Seemingly disparate, these diseases share a common cause and are showing encouraging signs of responding to a common nutritional supplement.

The xanthophyll molecules, lutein, zeaxanthin, and astaxanthin are powerful preventers of DNA damage. They stimulate DNA repair mechanisms, which fail with advancing age. Studies are showing that these nutrients may slow the development of cancer and prevent the onset of eye disease. Safe even in high doses, the xanthophylls deserve a place in your age-prevention toolkit. 

Editor's Note

Science continues to evolve, and new research is published daily. As such, we have a more recent article on this topic: Tocotrienols Prevent DNA Damage and Combat Aging

 
 
 
 

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