Life Extension Magazine®

Man going into bathroom at night due to LUTS

Reduce Nighttime Urinary Frequency in Men

Multiple trips to the bathroom at night increase risk of falls and decrease quality sleep. In a recent human study, 64% of men using a nutrient combination experienced a reduction in nighttime overactive bladder.

Scientifically reviewed by: Dr. Heidi Yanoti, DC, in August 2023. Written by: Stephen Harrington.

Waking up multiple times during the night to urinate is more than an inconvenience.

It’s one of the most common lower urinary tract symptoms in older men.

The medical term for this is nocturia.

It disrupts sleep patterns, which can lead to a host of health problems, and it’s a frequent cause of falls and resulting fractures.1,2

Current medical therapies offer limited improvements.3

A recently conducted pilot trial evaluated the effect of four nutrient compounds plus melatonin on mild, lower urinary tract symptoms, especially nocturia in healthy, older men.4

The primary study outcome was a decrease in nighttime urination.4

By the end of the study, the number of people suffering from nocturia at all was reduced by 64%. And not a single participant was left waking up more than one time a night.4

This finding can potentially help millions of men who suffer from an overactive bladder to improve their sleep health, while reducing risk for falls and injuries.

A Common Aging Problem

Man sleeping

The male urinary tract is prone to problems that worsen with age.

Lower urinary tract symptoms (LUTS) are a broad spectrum of clinical manifestations related to the bladder, urethra, and prostate gland. LUTS affect as many as 70% of men over 80 years of age.5

Besides nocturia, these symptoms can include increased urinary frequency, urgency, incontinence, incomplete bladder emptying, hesitancy, prolonged micturition, dribbling and a weak urine stream.6

The worsening of LUTS as men get older is due to various factors that cause dysfunction of the urinary system.7 An overactive bladder, enlargement of the prostate gland, and damage to the urethra can all contribute to urinary symptoms.

Compounds that incite chronic inflammation in the urinary tract can contribute to the development of LUTS and prostate enlargement.8,9 Men with LUTS have increased levels of plasma pro-inflammatory biomarkers.8

The aging process increases the risk for all of these problems. Obesity, diabetes, high blood pressure, smoking, some medications, nervous system disorders, and others can also contribute to LUTS.10

The Dangers of Nocturia

The most common LUTS, and the one which can lead to the most serious problems, is nocturia, the need to get up to urinate during the night, often more than once.1,2

Nocturia can occur in at least half of all men over 50 years of age.11 Clinically relevant nocturia, defined as having to get up to urinate two or more times each night, increases significantly with advancing age, affecting as many as 62% of those aged 70-80.1

Aside from being annoying, nocturia is also a serious health condition that should not be trivialized. Nighttime urinary frequency has the greatest impact of any of the LUTS on quality of life.1,2,11,12

By disturbing sleep, nocturia can contribute to poor health, lower energy, depression, and increased overall mortality.1,13-16

Frequent nocturia can result in falls. Particularly in older individuals who may suffer from frailty, poor balance, and bad vision, navigating the way to the bathroom multiple times in the middle of the night can be treacherous.

What you need to know
Very tired man


  • Lower urinary tract symptoms (LUTS) is a constellation of symptoms that affect urinary function in men, caused in part by an overactive bladder, enlargement of the prostate gland, and/or injury to the urethra.
  • With advancing age, LUTS is increasingly common, affecting up to 70% of all men over 80 years of age.
  • The most common symptom of LUTS is nocturia , the need to wake one or more times during the night to urinate.
  • Untreated nocturia is associated with risk for falls and related injuries, poor sleep, and diminishing physical and mental health.
  • Five compounds—beta-sitosterol, pygeum bark extract, lycopene, boron, and melatonin—have been shown to reduce LUTS and nighttime urination frequency.
  • A pilot clinical trial of these ingredients showed a significant reduction in nocturia in older men suffering from mild LUTS.

Remedies for Nocturia

Most pharmaceutical approaches to treating LUTS focus on controlling bladder overactivity and obstruction of urine flow. These drugs are far more effective in treating the daytime symptoms of LUTS, but have little impact on nocturia.17

But research has shown that several compounds have beneficial effects on the aging urinary system and can potentially reduce nocturia. A study showed that the following five compounds work together to maximize the relief from nighttime urinary problems.


Beta-sitosterol is a plant sterol isolated from the oils of certain vegetables and nuts. A study in an animal model established this compound is an inhibitor of an enzyme in the prostate gland, called 5a-reductase, which converts testosterone to dihydrotestosterone.18

By reducing the levels of dihydrotestosterone, beta-sitosterol helps reduce age-related prostate enlargement. When the prostate is enlarged, it blocks the flow of urine through the urethra. This contributes to nocturia and other LUTS. Reducing prostate enlargement supports healthy urine flow.19-22

Clinical studies in men with prostate enlargement show beta-sitosterol improves urinary symptoms. In a randomized, double-blind, placebo-controlled study, scoring of LUTS severity was reduced by 50% and measures of quality of life improved by 42%.20

Experimental evidence also points to anti-inflammatory activities of beta-sitosterol.23-25

Pygeum bark extract

Pygeum africanum is the scientific name for the African cherry tree. The bark of this tree has been used in Africa to improve urinary symptoms and bladder discomfort for centuries. Modern science has revealed that this extract works through several mechanisms. In addition to anti-inflammatory effects, it helps control bladder overactivity and reduces prostate enlargement.26,27

Clinical trials of pygeum bark extract have shown a reduction in frequency of nighttime urination. Two meta-analyses of existing studies found an average 19% reduction in nocturia,26,27 and one trial found as much as a 32% reduction in the frequency of nocturnal urination.28

It also has anti-inflammatory properties relevant to prostate enlargement and LUTS.29


Scientist looking into a microphone

Found in tomatoes and some other red or pink fruits and vegetables, lycopene is a carotenoid pigment with anti-inflammatory properties.30 Lycopene naturally tends to concentrate in the prostate gland,31 making it ideal for reducing the inflammation that can contribute to frequent nighttime urination.32

Like beta-sitosterol, lycopene also has the ability to reduce the production of dihydrotestosterone in the prostate, removing one of the major drivers of prostate enlargement.33,34

Lycopene has anti-proliferative properties, which means it helps prevent the abnormal growth of cells. In studies of prostate cells, lycopene blocks cell division, which may help prevent enlargement.35

Lycopene was shown to inhibit pro-inflammatory cytokines such as IL-6 and IL-8, further supporting benefits on LUTS.32,36


In further support of inflammation management relevant to LUTS, the mineral boron has been shown to reduce several markers of inflammation, such as TNF-a, IL-6, and C-reactive protein.37

Boron has effects on other signaling compounds in the body that are associated with development of LUTS and nocturia. It modulates sex hormone function and ameliorates the impact of growth factors, such as IGF-1, which may contribute to prostate enlargement.37,38


Melatonin is a hormone produced by the pineal gland that is involved in the regulation of sleep-wake cycles. Supplemental melatonin can help induce better sleep.

But beyond sleep support, melatonin has been shown to be helpful in treating nocturia. A randomized controlled trial published in the Journal of Urology evaluated its use in men suffering from significant nocturia, waking on average three times each night to urinate.39 In these men, 2 mg of melatonin before bed was superior to a placebo in reducing the frequency of nocturia.

Another human study of melatonin found similar effects. Men receiving the same dose of melatonin reduced the frequency of nighttime urination from an average of 3.4 times per night to 2.6 times per night.40

Successful Pilot Human Trial

Man laying down smiling.

A pilot trial studied a group of men with mild nighttime (LUTS) urinary issues to analyze the effects of a formula containing:

  • Beta-sitosterol 180 mg
  • Pygeum extract (bark) 100 mg
  • Lycopene [LycoBeads® from 15 mg natural tomato extract (fruit)]
  • Boron (as Albion® bororganic glycine) 10 mg
  • Melatonin 2 mg

Healthy men with mild LUTS, aged 45 to 72 years, were recruited for the trial.4 Baseline urinary symptoms including the frequency of nocturia were assessed before treatment began. Subjects were then instructed to take one capsule of the bladder control supplement formula daily, just before bedtime. At the end of the 60-day trial period, urinary symptoms were again evaluated.

At the start of the trial, 87% of men reported some degree of nighttime urination. This included roughly 50% of men who had to get up one time at night, and 37% who reported waking two to three times each night to urinate at the beginning of the study.

At the end of the 60 days, the researchers observed a remarkable improvement in nighttime urination frequency. Those suffering from nocturia declined from 87% at the start of the trial to only 23% by the trial conclusion—a 64% reduction!

Particularly notable was the reduction in the most severe cases of nocturia. While 37% of the men originally complained of waking two or more times each night to urinate, none suffered from this degree of nocturia at the end of the study. The 23% who continued to report nocturia by the study’s end were all a single awakening per night.

This means that those who suffered the most extreme nocturia, and were at highest risk for falls, loss of sleep, and diminished quality of life, all had a significant positive impact on their symptoms. Some of these men went from two or three nightly wakings to none—a major impact for those at greatest risk.


Lower urinary tract symptoms (LUTS) are very common in men as they get older. The most prevalent and potentially dangerous of these symptoms is nocturia, the need to get up one or more times during the night to urinate.

Conventional medical treatments for urinary disorders mostly address daytime symptoms. They do relatively little to remedy nocturia, which can increase risk of falls and related injuries, and can lead to diminishing physical and mental health and increased rate of mortality.

In a pilot clinical study, five compounds that included beta-sitosterol, pygeum bark extract, lycopene, boron, and melatonin were shown to improve LUTS, and reduce the frequency of nighttime urination in men.

These findings can potentially improve quality-of-life in men who suffer urinary symptoms.

If you have any questions on the scientific content of this article, please call a Life Extension® Wellness Specialist at 1-866-864-3027.


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