Maintaining a Healthy Microbiome
Probiotics And Mood
A randomized controlled clinical trial, which examined participants with low urinary free cortisol levels, reported that Lactobacillus helveticus R0052 and Bifidobacterium longum R0175 improved mental well-being, and could have a preventive role against stress-related psychological changes (Messaoudi, Violle 2011).
In a double-blind placebo-controlled clinical trial on human volunteers, a probiotic formulation containing L. helveticus R0052 and B. longum R0175, taken for 30 days, led to beneficial psychological effects, including improvements in scales that measure depression, anger-hostility, and problem solving. This same probiotic combination also reduced anxiety-like behavior in rats (Messaoudi, Lalonde 2011). In another rat model, the combination of probiotics reduced depression scores after a heart attack and restored gut permeability (Arseneault-Breard 2012), and it decreased cell death in various brain regions (Girard 2009). In mice, it prevented brain changes that occur as a result of chronic psychological stress (Ait-Belgnaoui 2014).
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The protocols raise many issues that are subject to change as new data emerge. None of our suggested protocol regimens can guarantee health benefits. The publisher has not performed independent verification of the data contained herein, and expressly disclaim responsibility for any error in literature.