• 1 mg, 60 capsules
  • Item # 27576


  • 1 mg, 60 capsules
  • Item # 27576

Folate helps maintain homocysteine levels within the normal range, which promotes cardiovascular health. And it also supports neurotransmitter synthesis — which in turn helps maintain cognitive abilities. However, not everyone has sufficient activity of the enzyme required to convert folate to its biologically active form, 5-methyltetrahydrofolate, or 5-MTHF.

Benefits at a Glance

  • Supports cardiovascular health
  • Supports neurotransmitter synthesis and critical enzyme reactions
  • Maintains healthy homocysteine levels

Supports Neurotransmitter Synthesis and Critical Enzyme Reactions

Folate is involved in neurotransmitter synthesis and critical enzymatic reactions throughout the body. By depleting excess homocysteine, folate benefits cardiovascular health and nervous system function.

Bioactive Form of Folate

Those who take ordinary folic acid supplements, however, may not be experiencing its full spectrum of effects. This is because once ingested, not everyone converts folate to its biologically active form 5-methyltetrahydrofolate (5-MTHF).

Research shows that in a large proportion of the population, genetic enzyme deficiencies prevent the conversion of folate to 5-MTHF, leaving many vulnerable to low blood folate levels (and higher-than-desired homocysteine). A more useful approach is to take the bioactive folate 5-MTHF directly. 5-MTHF has been shown to significantly raise red blood cell folate levels in comparison with folic acid supplementation.1

Bioactive folate is up to seven times more bioavailable than folic acid. This greater bioavailability is especially important in people who have a genetic enzyme deficiency since it requires no conversion to become metabolically active.2

Maintaining Healthy Homocysteine Levels

People with elevated homocysteine levels have a greater risk of cognitive decline.3 Unlike folic acid, 5-MTHF can cross the blood-brain barrier to enhance the synthesis of acetylcholine--the neurotransmitter associated with memory. Co-supplementing with methylcobalamin (the active form of vitamin B12), vitamin B6 and riboflavin will aid in the maintenance of healthy homocysteine levels.


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  1. Am J Clin Nutr. 2006 Jul;84(1):156-61.
  2. Br J Pharmacol. 2004 Mar;141(5):825-30.
  3. N Engl J Med. 2002 Feb 14;346(7):476-83.

Serving Size 1 capsules

Amount Per Serving

Folate (1 mg as L-5-Methyltetrahydrofolate†)

1.7 mg DFE

Other ingredients: Microcrystalline cellulose, hypromellose (derived from cellulose) capsule, leucine, silicon dioxide.

Gluten free

†This product uses Gnosis S.p.A.'s L-5-Methyltetrahydrofolate (Extrafolate-S®) Extrafolate-S is a registered trademark of Gnosis S.p.A.

Dosage and Use
  • Take one (1) capsule one to three times daily or as recommended by your healthcare practitioner.
Use only if bottle is sealed. Store in a cool, dry place. If pregnant, consult your healthcare practitioner before using this product.

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Life Extension. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer.

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