Vitamin K2 Supplements Reduce Bone Loss In Women

Vitamin K2 supplements reduce bone loss in women

Vitamin K2 supplements reduce bone loss in women

Friday, March 29, 2013. An article that appeared online on March 23, 2013 in the journal Osteoporosis International reports the outcome of a trial conducted by researchers in the Netherlands which found a benefit for supplementing with vitamin K2 in postmenopausal women—a group that has an increased risk of developing osteoporosis.

Two hundred forty-four women between the ages of 55 and 65 years were divided to receive 180 micrograms of menaquinone-7 (MK-7, a form of vitamin K2) or a placebo daily for three years. Lumbar spine, hip and femoral neck bone mineral density and bone mineral content, and vertebral fracture assessment were obtained by dual-energy X-ray absorptiometry (DXA) upon enrollment and yearly until the trial's conclusion. Femoral neck bone strength and vitamin K status as determined by the ratio of uncarboxylated to carboxylated osteocalcin were additionally assessed at these time points.

Women who received MK-7 had improved vitamin K status and a significant reduction in the decline of bone mineral content and bone mineral density of the femoral neck and lumbar spine in comparison with those who received a placebo. While women in the placebo group experienced the expected age-related decrease in bone mineral content and density in the lumbar spine, these values had decreased by less than 1 percent in those that received vitamin K in comparison with measurements obtained at the beginning of the study. Participants who received vitamin K also had better bone strength and a reduction in the loss of vertebral height in the middle site of the lower thoracic region after two and three years of supplementation.

"Long-term use of MK-7 supplements significantly decreased the age-related decline in bone mass and strength," authors M. H. J. Knapen and colleagues write. "We conclude therefore that postmenopausal women may benefit from taking MK-7 supplements to prevent the age-related bone loss."

What's Hot

Study defines osteocalcin's role in preventing fracture

What's Hot

Research described online on November 5, 2012 in the Proceedings of the National Academy of Sciences reveals a significant role for the protein osteocalcin in strengthening bone and reducing fracture risk.

By studying bone on a microscopic scale, Deepak Vashishth of Rensselaer Polytechnic Institute in Troy, New York and his associates found that fractures begin with the formation of dilatational bands measuring approximately 100 nanometers in size. The holes, which function as a defense mechanism by helping to prevent further damage to surrounding bone following an impact, can lead to fracture if the bone is deficient in osteocalcin and/or another bone protein known as osteopontin. "This study is important because it implicates, for the first time, the role of osteocalcin in giving bone the ability to resist fracture," stated Dr Vashishth, who is the head of Rensselaer's Department of Biomedical Engineering. "Since osteocalcin is always the point of fracture, we believe that strengthening it could lead to a strengthening of the overall bone."

For osteocalcin to be absorbed, it needs to be carboxylated by vitamin K. Increasing osteocalcin by boosting vitamin K intake could therefore be a useful strategy to help prevent osteoporosis. "Currently, all of the advice for treating osteoporosis is related to calcium," Dr Vashishth observed. "We believe there's more to the story than just calcium, and the results of this new study raise an important question about vitamin K. Leafy green vegetables are the best source of vitamin K—wouldn't it be great if eating spinach and broccoli was not only healthy, but also good for your bones? We plan to investigate this link in future."

Latest Supplements 

Policosanol 10 mg, 60 tablets
Item #00561

add to cart

Policosanol is a natural supplement derived from sugar cane. It is a mixture of eight higher primary aliphatic alcohols isolated and purified from sugar cane wax. If one expects to derive the benefits shown in the published studies, the other alcohols that make up policosanol product should be present.

Policosanol promotes healthy platelet function and helps to maintain cholesterol levels that are already within the normal range. Animal and human studies have also shown that policosanol is an antioxidant. When used in long-term clinical trials, policosanol was well tolerated and safe.

Memory Upgrade™, 600 grams powder
Item #01009

add to cart

Choline is a precursor for phosphatidylcholine biosynthesis. Phosphatidylcholine's role in the maintenance of cell membrane integrity is vital to information flow, intracellular communication, and bioenergetics. Choline is also a major part of another membrane phospholipid, sphingomyelin, also important for the maintenance of cell structure and function.

Memory Upgrade™ is a synergistic blend of choline and cofactors, designed by Durk Pearson & Sandy Shaw®. Memory Upgrade™ has been formulated with natural flavors and fructose that provides a great-tasting choline-containing drink when mixed with water or juice.



Life Extension Update What's Hot
Vitamin C supplementation shows potential for menopausal bone loss prevention Children with celiac disease need vitamins
Review recommends bone-building nutrients before drugs Supplementing with vitamin K2 improves bone strength
DHEA improves bone density in women Meta-analysis concludes vitamin K supplements reduce bone-loss
Life Extension Magazine® Health Topics
Protection against arterial calcification, bone loss, cancer, and aging! Osteoporosis
Vitamin K: the misunderstood vitamin Female hormone restoration
Weak bones cause heart attack and stroke