Magnesium supplements reduces glucose insulin triglycerides in prediabetic men and women

Magnesium supplementation reduces glucose, insulin resistance, triglycerides in prediabetic men and women

Life Extension Update

Tuesday, May 19, 2015. On April 27, 2015, the journal Diabetes & Metabolism reported the outcome of a trial of men and women with low magnesium levels and prediabetes which found an improvement in glycemic status among those who received magnesium.

The study included 116 participants between the ages of 30 to 65 years with newly diagnosed prediabetes and serum magnesium levels of 1.8 milligrams per deciliter (mg/dL) or less. Subjects were advised to follow dietary and physical activity guidelines over the course of the study and were randomized to groups that received a magnesium chloride solution providing 382 mg magnesium or a control solution daily for four months. Fasting and two-hour post-load plasma glucose, serum magnesium and other factors were assessed at the beginning and end of the treatment period.

At the study's conclusion, fasting and post-load glucose levels, insulin resistance and triglycerides had significantly decreased among those who received magnesium, and an increase was observed in magnesium levels and high density lipoprotein (HDL) cholesterol levels.

"The percentage of subjects who improved their prediabetic state was significantly larger among those taking magnesium chloride compared with those in the control group, whereas unfavorable changes in prediabetic state were significantly higher in the controls than in those taking magnesium," authors Martha Rodriguez-Morán and colleagues report. "Our results support the hypothesis that, as a complement to lifestyle interventional programs, people with prediabetes and hypomagnesemia also should take magnesium supplements to decrease plasma glucose levels and potentially reduce the transition rate from prediabetes to diabetes. In this regard, given that measurement of serum magnesium is easy and accessible, the potential benefits of magnesium supplementation could readily be achieved in clinical settings."


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Higher magnesium levels linked to lower risk of stroke
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August 20 2014. Findings derived from the Nurses' Health Study suggest a protective effect for magnesium against the risk of ischemic stroke in women.

The study, described online on August 12, 2014 in the American Heart Association journal Stroke, included 459 Nurses' Health Study participants who experienced an ischemic stroke prior to June 2006 and an equal number of control subjects matched for age, ethnicity and other factors. Blood samples collected between 1989 and 1990 were analyzed for plasma magnesium.

Subjects whose magnesium levels were among the lowest fifth of participants had a risk of stroke that was 34% higher than those whose levels were among the top fifth. Those whose levels were lower than 0.82 micromoles per liter had a 57% greater risk of total ischemic stroke, and a 66% higher risk of thrombotic stroke than women who had higher levels.

To authors Sally N. Akarolo-Anthony and her associates' knowledge, the association between magnesium levels and ischemic stroke risk has been evaluated in only one other prospective study. They remark that although only 1% of the body's magnesium exists in plasma, levels are strongly correlated with intracellular magnesium and could be a better indicator of the mineral's status than dietary intake. They note that risk factors for stroke, including diabetes and hypertension, have been associated with reduced magnesium levels, and that there is evidence that magnesium could help protect against blood clot formation.

"The results of this study suggest that low plasma magnesium may be associated with increased risk of ischemic stroke," the authors conclude. "If confirmed, our findings may have significant public health impact because magnesium deficiency is potentially modifiable."


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Health Concern


The most common clinical tests used to diagnose diabetes are measures of blood glucose. The fasting plasma glucose (FPG) test measures the amount of glucose in the blood after fasting. Prediabetes is diagnosed if the fasting blood glucose level is between 100 and 125 mg/dL. Diabetes is diagnosed if the fasting blood glucose level rises to 126 mg/dL or above.

The oral glucose tolerance test (OGTT) is used to measure insulin response to high glucose levels. During this test, patients are given glucose, and the rise in blood glucose levels is measured. Prediabetes is diagnosed if the glucose level rises to between 140 and 199 mg/dL. Diabetes is diagnosed if blood glucose levels rise to 200 mg/dL or higher.

The HbA1c test is also helpful in diagnosing less severe cases of diabetes. From this test, clinicians can estimate the average blood glucose level during the preceding two to four months. Normally 4 to 6 percent of hemoglobin is glycosylated, which corresponds to average blood glucose between 60 and 120 mg/dL. Mild hyperglycemia increases HbA1c to 8 to 10 percent (or 180 to 240 mg/dL), while severe hyperglycemia increases HbA1c values up to 20 percent. For diabetics, a healthy HbA1c level is less than 7 percent, which corresponds to an average blood glucose level of 150 mg/dL or less.

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