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Health Protocols

Age Related Cognitive Decline

All aging humans will develop some degree of decline in cognitive capacity, usually including the following symptoms:

  • forgetfulness
  • decreased ability to maintain focus
  • decreased problem solving capacity

If left unchecked, symptoms oftentimes progress into more serious conditions, such as dementia and depression, or even Alzheimer’s disease.

Fortunately, proactive lifestyle changes, cognitive training, and nutritional interventions such as phosphatidylserine and glyceryl phosphoryl choline have been shown to decrease the rate of intellectual decay and potentially reverse age-related cognitive decline.

Causes of Age-Related Cognitive Decline

Many factors contribute to age-related cognitive decline:

  • Oxidative stress and free radical damage
  • Chronic low-level inflammation
  • Declining hormone levels like estrogen, testosterone, DHEA, pregnenolone
  • Inner arterial lining (endothelium) dysfunction
  • Insulin resistance
  • Excess body weight
  • Suboptimal nutrition
  • Loneliness, lack of social network, and high stress

Dietary and Lifestyle Changes

Several dietary and lifestyle changes can help reduce age-related cognitive decline:

  • Switch from a western diet high in simple sugars and saturated fats to a Mediterranean diet high in mono- and polyunsaturated omega-3 fats, fiber, and polyphenols
  • Caloric restriction may improve learning and memory
  • Cognitive stimulation and training, including playing chess and speaking more than one language, can enhance cognitive reserve and convey protection against loss of brain function
  • Exercise is known to increase levels of brain-derived neurotrophic factor, which can lead to enhanced cognitive function
  • Moderate alcohol consumption (up to 2 drinks/day) and caffeinated coffee consumption (~3 cups/day) may convey protection against cognitive decline

Integrative Interventions

  • Fish Oil: Daily omega-3 supplementation was independently associated with a dramatic reduction in cognitive decline over a 1.5-year period in an aging study population.
  • Phosphatidylserine: Human clinical trials have found that supplementing with phosphatidylserine improves cognitive function in aging subjects with cognitive impairment.
  • Glyceryl Phosphoryl Choline (GPC): Patients taking GPC showed neurological improvement and relief of clinical symptoms of chronic cerebral deterioration that was superior or equivalent to that obtained with prescription drugs.
  • Acetyl-L-carnitine: A meta-analysis of data from over 21 studies shows that supplementation with acetyl-L-carnitine improves cognitive deficits observed during aging and pathological brain deterioration.
  • Huperzine A: Patients with Alzheimer’s disease improved their scores on standard cognitive tests after supplementing with huperzine A.