TMG Powder


  • 50 grams
  • Item # 00349

TMG Powder


  • 50 grams
  • Item # 00349

Promotes Healthy Homocysteine Levels

Our innovative formula helps support and maintain already-healthy homocysteine levels to support cardiovascular health.
Gluten free Non-GMO Vegetarian

Available versions:

liquid vegetarian capsules

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  • This Item: TMG Powder, 50 grams
  • Optimized Tryptophan Plus, 90 vegetarian capsules
TMG Powder. Trimethylglycine, 50 grams
Optimized Tryptophan Plus, 90 vegetarian capsules - Life Extension

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TMG Powder


50 grams


Trimethylglycine (TMG) has been linked to heart health by supporting already-healthy homocysteine levels to promote healthy cardiovascular function. By having a positive impact on your homocysteine levels, TMG helps you stay healthy by supporting multiple systems throughout your body.

TMG (also called glycine betaine) has been associated with beneficial effects on liver function and cardiovascular health.

TMG Powder Benefits

  • Promotes healthy homocysteine levels already within normal range
  • Helps inhibit inflammatory factors to encourage cardiovascular health
  • Supports already-healthy blood pressure levels
  • Encourages whole-body health
  • Helps maintain healthy mitochondrial function

Over 50 Years of Research

Trimethylglycine has been known as a heart-healthy amino acid compound since the 1950s. That’s more than 50 years of scientific research to rely upon.

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Trimethylglycine (TMG) is also called glycine betaine, but the name trimethylglycine signifies that it has three methyl groups attached to each molecule of glycine. Wheat bran is the main dietary source of TMG, with smaller amounts available in other cereal grains.1 TMG can also be made in the body from choline, an essential nutrient found in eggs, soybeans and many other foods.2,3

These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.
  1. Foods. 2018;7(4)
  2. ARYA Atheroscler. 2011;7(2):78-86.
  3. Am J Clin Nutr. 2008;88(6):1663-1669.
  4. Ann West Med Surg. 1951;5(10):825-829.
  5. Ann West Med Surg. 1951;5(10):830-855.
  6. Ann West Med Surg. 1951;5(10):863-875.
  7. J Inherit Metab Dis. 2011;34(1):3-15.
  8. Am J Clin Nutr. 2010;91(5):1303-10.
  9. Curr Opin Clin Nutr Metab Care. 2013;16(1):102-108.
  10. J Clin Hypertens (Greenwich). 2018;20(2):388-393.
  11. Biochem Biophys Res Commun. 2015;456(2):621-625.
  12. PLoS One. 2014;9(12):e114969.
  13. Vet Res Forum. 2018;9(2):129-135.
  14. Molecules. 2018;23(6)
  15. Eur Heart J. 2014;35(14):904-910.
  16. Microbiome. 2019;7(1):103.

Serving Size 1 rounded scoop (approx. 525 mg)

Servings Per Container about 97

Amount Per Serving

Trimethylglycine (TMG) (as betaine anhydrous)

500 mg

Other ingredients: none.


Dosage and Use
  • Take one (1) rounded scoop one to two times daily, or as recommended by a healthcare practitioner.
  • TMG should be taken with co-factors vitamins B6, B12, and folic acid.
If muscle tension or headaches occur, reduce dose or discontinue product, and inform your physician if they do not subside.
  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

Product reviews are provided for informational purposes only and reflect solely the views and opinions expressed by the contributors and not those of Life Extension. We do not verify or endorse any claims made in these reviews. Please read the full product reviews disclaimer.

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