Reduced Zinc Levels Predict Death In Patients

Life Extension Update Exclusive

October 28, 2008

Reduced serum zinc levels predict death in patients at risk of cardiovascular events

Reduced serum zinc levels predict death in patients at risk of cardiovascular events

Research published online on October 24, 2008 in the British Journal of Nutrition revealed a correlation between insufficient zinc levels and a higher risk of death among patients referred for coronary angiography. To the authors’ knowledge, the study is the first to examine the relationship between zinc and mortality in men and women at an intermediate to high risk for future cardiovascular events.

Stefan Pilz, of the University of Heidelberg in Germany and the Medical University of Graz in Austria, and his associates evaluated data from 3316 participants in the Ludwigshafen Risk and Cardiovascular Health study of patients referred to coronary angiography in southwest Germany. Blood samples collected prior to angiography were analyzed for zinc, glucose and other factors.

The patients were followed for a median of 7.75 years, during which 484 participants died from cardiovascular disease and 261 died of noncardiovascular causes. For those whose zinc levels were among the lowest 25 percent of participants at less than 780 micrograms per liter there was a 44 percent greater adjusted risk of dying from all causes compared with those whose levels were among the top 25 percent, at greater than 960 mcg/L. Cardiovascular deaths were 24 percent greater among those whose zinc levels were lowest, and the risk of dying from noncardiovascular causes was more than double that of participants whose zinc levels were highest.

Oxidative stress, immune dysfunction and inflammatory processes are among the mechanisms proposed by the authors to explain the effects observed in the current study. While these mechanisms have been associated with zinc deficiency as well as age-related degenerative diseases such as infections and atherosclerosis, supplementation with zinc has been shown to reduce inflammatory cytokines and oxidative stress markers while lowering the incidence of infections. Zinc’s positive role in cardiovascular disease may be due to its antioxidant effects on endothelial cells which could help prevent early atherosclerotic lesion formation, although the mineral may be more important in early rather than late phases of the disease.

“The present results show that low serum zinc concentrations predict mortality in patients scheduled for coronary angiography and thus support considerations for supplementation of zinc plus other micronutrients in aging individuals with a deficiency for this essential trace element,” the authors conclude.

Printer Friendly Save as PDF Email this Page View Archive Subscribe Today
Health Concern Life Extension Highlight

Bacterial infections

Bacterial infections are occasionally life-threatening health concerns. Older and newly emerging antibiotic-resistant infections are an increasing danger for children, the elderly, and people who have chronic diseases. Bacterial infections can disrupt normal intestinal flora, reduce nutrient and mineral supplies, and compromise immune responses. A healthy immune system can prevent or neutralize bacterial infections.

When dealing with a possible bacterial infection, it is impossible to tell, short of laboratory tests, which pathogen is causing the problem. Therefore, it is important to visit a physician for proper testing and, if necessary, to obtain prescription antibiotics. In addition, many nutrients have been shown to help strengthen the immune system and inhibit bacterial infection. Nutrients that have been demonstrated to inhibit bacterial activity or enhance the immune system include:

  • Lactoferrin—300 milligrams (mg) daily
  • Oregano oil—400 to 1000 mg of essential oils daily
  • Garlic extract—600 to 1200 mg of Kyolic garlic daily
  • Norwegian shark liver oil—200 mg of active alkylglycerols
  • Bromelain—500 mg before each meal
  • L-arginine—900 mg daily
  • L-glutamine—1 to 2 grams (g) daily
  • Cranberry extract—500 mg daily
  • Probiotics—Follow directions on label.
  • Whey protein—1 to 2 scoops daily
  • Green tea extract—725 mg daily
  • Garlic bulb powder—1800 to 9000 mg of Pure Gar daily (if you already have an infection)

BHRT World Summit 2 - an internet video seminar
November 10-25, 2008


Bio-Identical Hormones, derived from vegetable sources, are the exact hormones that our bodies produce. When a person has the proper balance of natural hormones, they look great and feel wonderful. Low hormone levels are thought to be a root cause of some illnesses.

Ten top experts in the field of Bio-Identical Hormones, who usually present only to doctors, are being brought together to pass on to the public how they use Bio-Identical Hormones and natural treatments to make menopause a breeze, to improve and to even cure diabetes, to help men regain their muscle and sexual function and more. You'll learn the up to date natural treatments that work for osteoporosis, wound healing and energy medicine. Learn which hormones will get rid of brain fog and improve your memory. Digestive problems rob your hormones. You'll learn how to find out what the real cause of the digestive problem is and how to fix it. Did you know that there are more testosterone receptors in the heart then in any other organ and that using testosterone can help so many heart patients?

This is an excellent opportunity to learn from the experts. When you register for the BHRT World Summit 2, you will be watching the advancement of the forefront of medicine. This is medicine in its purest sense, based on medical research and years of clinical findings.

Click here to register:

Featured Products


add to cart

The typical American diet is loaded with foods that contain arachidonic acid (like egg yolk, red meat, poultry, and dairy products) or stimulate the production of excess arachidonic acid in the body (foods rich in high glycemic carbohydrates, saturated fats, and omega-6 fatty acids).

Scientific studies show that excess arachidonic acid increases levels of the 5-lipoxygenase (5-LOX) enzyme, which can induce undesirable effects in cells. This culminates in the excess accumulation of leukotriene B4, a proinflammatory compound that attacks the joints, the arterial wall, and other tissues.

In India, extracts from the Boswellia plant have been used for centuries as fluid balancing agents. Recent human studies have confirmed that a specific Boswellia extract known as AKBA (3-O-acetyl-11-keto-ß-boswellic acid) selectively inhibits 5-LOX. Unlike other boswellic acids that only partially inhibit 5-LOX, AKBA binds directly to 5-LOX, effectively suppressing its proinflammatory activity.

CarnoSoothe with PicroProtect™

add to cart

The gastrointestinal tract is a long muscular tube that functions as the food processor for the human body. The digestive system includes the following organs: the mouth and salivary glands, stomach, the small and large intestines, colon, liver, pancreas, and the gall bladder. The gastrointestinal tract is not a passive system; rather, it has the capability to sense and react to the materials that are passed through it. For a healthy digestive system, every person requires different food selections that matches the unique needs of their gastrointestinal tract.

An estimated 20 million Americans suffer stomach discomfort caused by erosion of the protective mucosal lining. A healthy mucosal lining is required to prevent acidic digestive juices from corroding the stomach wall.

Therefore, protecting against known factors that damage the gastric lining is essential to ensuring optimal stomach health. New and improved CarnoSoothe with PicroProtect™ combines four remarkable nutrient compounds that naturally protect the health of the gastric lining.

News Archive

Life Extension Update

What's Hot

Life Extension magazine

If you have questions or comments concerning this issue or past issues of Life Extension Update, send them to or call 1-800-678-8989.

For longer life,

Dayna Dye
Editor, Life Extension Update
954 766 8433 extension 7716