High Dose Folate May Protect Against Heart Attack

Life Extension Update Exclusive

March 28, 2008

High dose folate may protect against damage caused by heart attack

High dose folate may protect against damage caused by heart attack

An article published early online on March 24, 2008 in the journal Circulation reported the discovery by an international team of heart experts that giving a high dose of the B vitamin folic acid to rats provided a significant amount of protection against the damaging effects of myocardial infarction (heart attack).

Johns Hopkins University cardiology research fellow An Moens, MD and colleagues pretreated rats with 10 milligrams folic acid per day or a placebo for one week prior to inducing myocardial infarction by coronary artery occlusion. After 30 minutes of ischemia, blood flow was restored. Rats treated with folic acid were found to have less myocardial dysfunction during ischemia and lower levels of damaging superoxide than those that received the placebo. While the amount of blood pumped by the hearts of the rats that received the placebo, measured as ejection fraction, dropped to 27 percent during the simulated heart attacks, it remained close to normal for those that received folic acid, at an average 73 percent. The treated animals also had smaller areas of tissue death (infarcts), which averaged less than 10 percent of the size of those observed in the control group. In a separate experiment, intravenous injection of folic acid within the first ten minutes of induced heart attack was found to be nearly as effective as pretreatment with the vitamin.

Folate is involved in maintaining normal mitochondrial function, which is needed for healthy blood vessels. Dr Moens explained that the current study’s numerous findings suggest that folate acts as a cardiac energy reserve, “providing much needed energy for muscle contraction, in the form of ATP, at the same time the heart is being starved for oxygen-carrying blood by a blocked artery.”

“In future, we might just pop in an I.V., and give people high-dose folate while they are waiting for their catheterization or CT scans to search for blockages,” he said.

“We want to emphasize that it is premature for people to begin taking high doses of folic acid,” said senior study investigator David Kass, MD of Johns Hopkins. “But if human studies prove equally effective, then high-dose folate could be given to high-risk groups to guard against possible heart attack or to people while they are having one.”

“Folic acid is already well known to be safe to consume in high doses in the short term, and it is very inexpensive, costing pennies per milligram, so its prospects look promising,” he concluded.

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Health Concern

Coronary artery disease and atherosclerosis

Atherosclerosis is a far-reaching disease with devastating consequences. Life Extension’s program for reducing the risk associated with atherosclerosis is based on aggressive measures to promote a healthy endothelium and reduce risk factors associated with coronary artery disease. Because all adults are at risk of atherosclerosis, all adults should make the necessary lifestyle changes to protect their arteries. This means getting adequate exercise under the supervision of a physician and eating a diet rich in fruits and vegetables and low in saturated fat. Also, weight loss by obese and overweight adults is an important element in reducing risk of atherosclerosis.

    The following nutrients have been shown to improve endothelial function and reduce the damage caused by oxidized LDL, slowing the progression of atherosclerosis:
  • Folic acid—800 to 5000 micrograms (mcg) daily
  • Vitamin B12—300 to 2000 mcg daily
  • EPA and DHA—1400 milligrams (mg) EPA and 1000 mg DHA daily
  • PLC—1000 to 2000 mg daily
  • L-arginine——3000 to 12,000 mg daily (in 3 divided doses)
  • Lipoic acid—150 to 300 mg daily
  • Garlic—1200 mg daily (Kyolic aged garlic extract)
  • Ginkgo biloba— 120 mg daily
  • Green tea extract—725 mg daily (93 percent polyphenols)
  • Quercetin—500 to 1000 mg daily (water-soluble quercetin)
  • Vitamin C—1000 to 3000 mg daily
  • Vitamin E—400 international units (IU) daily (with 200 mg gamma tocopherol)
  • Vitamin K—10 mg daily
  • Vitamin B6—100 to 750 mg daily
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Dayna Dye
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