Vinpocetine Shows Promise For Chronic Inflammation

Life Extension Featured Article

May 14, 2010

Vinpocetine shows promise for chronic inflammation

Vinpocetine shows promise for chronic inflammation

Findings reported in article published online on May 6, 2010 in the Proceedings of the National Academy of Sciences suggest that vinpocetine, a derivative of vincamine (from the periwinkle plant), could be useful for the treatment of chronic inflammatory diseases such as atherosclerosis, chronic obstructive pulmonary disease (COPD), arthritis, infectious diseases and cancer. Vinpocetine is a dietary supplement that has been used for many years to help prevent cerebrovascular disorders and memory loss, however, the compound's potential benefit in other disorders has not been explored.

Chen Yan, PhD of the University of Rochester Medical Center's Aab Cardiovascular Research Institute and colleagues report that vinpocetine acts as an anti-inflammatory agent in a mouse model of lung inflammation and in cell cultures. Vinpocetine was found to inhibit tumor necrosis factor-alpha induced nuclear factor-kappa-beta (NF-kB) activation and the subsequent induction of proinflammatory mediators in endothelial cells, epithelial cells, macrophages, and vascular smooth muscle cells. Vinpocetine works by inhibiting IKK, an enzyme that regulates inflammation by activating NF-kB.

The authors write that despite the well-known involvement of inflammation in disease, current therapies such as steroids and cyclooxygenase inhibitors can have significant long term side effects and new agents are urgently needed. "Inflammation is a hallmark of a wide range of human diseases, so there is great potential for vinpocetine to be used for several indications," noted coauthor and Rochester Medical Center CEO Bradford C. Berk, MD, PhD.

"What is extremely exciting and promising about these findings is vinpocetine's excellent safety profile," Dr Yan remarked. "Previously, most drugs tested in this area have failed, not because of a lack of efficacy, but because of safety issues. We're very encouraged by these results and believe vinpocetine has great potential for the treatment of COPD and other inflammatory diseases."

"In managing chronic conditions such as COPD, it is crucial to have a therapy that can be used safely over the long term," added coauthor Jian-Dong Li, MD, PhD, who is a professor at the University of Rochester's Department of Microbiology and Immunology "There is a great need for a drug like vinpocetine, because patients currently have no good options when it comes to long-term care."

Printer Friendly Save as PDF Email this Page View Archive Subscribe Today
Health Concern Life Extension Highlight

Chronic inflammation

The pathological consequences of inflammation are well-documented in the medical literature (Willard et al. 1999; Hogan et al. 2001). Regrettably, the dangers of systemic inflammation continue to be ignored, even though proven ways exist to reverse this process.

The following supplements are suggested:

  • The docosahexaenoic acid (DHA) fraction of fish oil may be the most effective nonprescription supplement to suppress pro-inflammatory cytokines. Gamma-linolenic acid (GLA) is a precursor of PGE1, a potent anti-inflammatory agent.
  • DHEA is a hormone that decreases with age. DHEA has been shown to suppress IL-6, an inflammatory cytokine that often increases as people age. Typical doses of DHEA are 25-50 mg daily, although some people take 100 mg daily. Refer to the DHEA Replacement protocol for suggested blood tests to safely and optimally use DHEA.
  • Nettle leaf has been shown to suppress the proinflammatory cytokine TNF-a. Take 1000 mg daily.
  • Vitamin E and N-acetyl-cysteine (NAC) are protective antioxidants with anti-inflammatory properties. Vitamin E that contains gamma-tocopherol and tocotrienols provides the most broad-spectrum protection. NAC is an amino acid with antiviral and liver protectant properties. One 600 mg capsule daily is recommended.
  • Vitamin K helps reduce levels of IL-6, a pro-inflammatory messenger. Vitamin K also helps in the treatment of osteoporosis by regulating calcium and promoting bone calcification.  If you are taking Coumadin or other anticoagulant medicine, consult your physician before taking vitamin K.
  • Consuming at least 1000 mg per day of carnosine and/or 300 mg of the European drug aminoguanidine can inhibit pathological glycation reactions in the body.

Life Extension Vacations

Life Extension Vacations

Nestled on a beautiful beach at the heart of the Riviera Maya, just ten minutes to Playa del Carmen, and 30 minutes from Cancun International Airport, The Royal Haciendas offers luxury and comfort in a splendid setting. It is an exceptional vacation hideaway, a home in paradise where you can enjoy the simpler things in life whether it is a walk along the beach at sunrise or stargazing on the terrace, and yet still be close to shopping, nightlife and all the area's natural and historical attractions.

Luxury suites start at $139.00 per night through July 2, 2010. Call 1 800 791 4403 8:00 am to 8:00 pm CT, or email

Subject to availability, rates for new reservations only and subject to change without prior notice.
Please note that Life Extension Vacations is not affiliated with or a part of the Life Extension Foundation®,
which supports anti-aging research, or the Life Extension Foundation Buyers Club.

Featured Products

Vitamin C with Dihydroquercetin

add to cart

Because humans do not manufacture vitamin C internally, it must be obtained through dietary sources or supplements. Few people realize, however, that vitamin C is a water-soluble nutrient that is quickly oxidized and excreted by the body, which limits its efficacy. Until now, those seeking to capture vitamin C’s optimal health benefits have had no choice but to consume it several times throughout the day.

Fortunately, a flavonoid antioxidant known as dihydroquercetin functions as a vitamin C “supercharger.” Studies demonstrate that dihydroquercetin acts to inhibit the oxidation of vitamin C, thereby helping maintain its concentration and recycle vitamin C throughout the body.


Se-Methyl L-Selenocysteine

add to cart

As an essential co-factor of glutathione peroxidase, selenium is an important antioxidant. Selenium is incorporated into proteins to make selenoproteins, which are important antioxidant enzymes. The antioxidant properties of selenoproteins help prevent cellular damage from free radicals.

Se-Methyl L-Selenocysteine (SeMC) is a naturally occurring seleno-amino acid that is synthesized by plants such as garlic and broccoli. SeMC is an organoselenium compound and also more bio-absorbable than other forms. Unlike selenomethionine, which is incorporated into proteins in place of methionine, SeMC is not incorporated into any proteins, thereby being fully available for the synthesis of selenium containing enzymes, such as glutathione peroxidase.

News Archive

Life Extension Update

What's Hot

Life Extension Magazine®

If you have questions or comments concerning this issue or past issues of Life Extension Update, send them to or call 1-800-678-8989.
Sign up for Life Extension Update

For copyright permission, please refer to Life Extension copyright policy.

For Customer Service inquiries, please email or call 1 800 678 8989.