Decreased Vitamin D Levels Associated With Greater Risk Of Infection In Surgery Patients

Decreased vitamin D levels associated with greater risk of infection in surgery patients

Decreased vitamin D levels associated with greater risk of infection in surgery patients

Friday, December 6, 2013. An article published online on November 27, 2013 in the American Medical Association journal JAMA Surgery reveals a greater risk of hospital-acquired infection among gastric bypass surgery patients with diminished levels of vitamin D.

Sadeq A. Quarishi, MD, MHA, of Massachusetts General Hospital and colleagues conducted a retrospective analysis of 770 obese adults who underwent Roux-en-Y gastric bypass surgery. Serum 25-hydroxyvitamin D [25(OH)D] levels were measured within 30 days prior to the procedure. Hospital-acquired infection, including surgical site infection, catheter-related urinary tract infection, pneumonia or bacteremia, occurred in 41 men and women between two and thirty days after admission.

Among subjects whose 25-hydroxyvitamin D levels were less than 30 nanograms per milliliter (ng/mL) the risk of acquiring an infection while hospitalized was three times as great as the risk experienced by those whose levels were higher. For surgical site infections, the risk among those with decreased vitamin D concentrations was four times as great in comparison with those who had higher levels. The authors observe that innate and adaptive immune system cells express the vitamin D receptor and respond to stimulation by 1,25-dihydroxyvitamin D, the active form of the vitamin. Vitamin D also upregulates the expression of antimicrobial peptides, one of which is active against a variety of infectious agents.

"Our results suggest that low preoperative 25(OH)D levels are associated with a higher risk for postoperative infections," the authors conclude. "We hypothesize that higher levels of vitamin D sufficiency are associated with optimal expression of endogenous antimicrobial peptides and that this may attenuate the effect of barrier site disruptions that are characteristic of postoperative hospital acquired infections. Prospective studies are needed to validate our findings, assess the potential benefit of optimizing preoperative vitamin D status, and identify the mechanism by which vitamin D sufficiency may confer protection against nosocomial infections."


What's Hot

Reduced vitamin D levels linked to pneumonia

What's Hot

A short report published online on April 17, 2013 in the Journal of Epidemiology and Community Health reveals a protective effect for higher vitamin D levels against the risk of developing pneumonia.

The current study included 723 men and 698 women between the ages of 53 and 73 enrolled in the Kuopio Ischemic Heart Disease Risk Factor Study. Subjects were free of pneumonia and other pulmonary diseases at the beginning of the current investigation. Blood samples obtained upon enrollment were analyzed for serum 25-hydroxyvitamin D3 levels, which averaged 43.5 nanomoles per liter (17.43 ng/mL). The participants were followed for an average of 9.8 years, during which 73 subjects were hospitalized at least once due to pneumonia.

A greater risk of pneumonia was observed in association with increasing age. Researchers Alex Aregbesola and his colleagues at the University of Eastern Finland Institute of Public Health and Clinical Nutrition found that men and women whose serum 25-hydroxyvitamin D3 levels were among the lowest one-third of participants had 2.6 times the risk of contracting pneumonia in comparison with those whose levels were highest. Men were likelier to develop pneumonia than women, and smokers more than nonsmokers. Adjustment of the data for several factors failed to modify the results.

The current study is the first to demonstrate an association between insufficient vitamin D levels and a greater risk of pneumonia among aging individuals in the general population. The findings corroborate those of previous research which indicated that reduced vitamin D levels are associated with an increased risk of infection. In northern countries such as Finland, sun exposure is insufficient during winter, necessitating vitamin D supplementation. The authors suggest that vitamin D deficiency is a public health issue, and recommend further research.

Latest Products

Pomi-T®, 60 vegetarian capsules
Item #01797

add to cart

A high percentage of men will endure some form of prostate-induced discomfort over the course of their lifetimes. A placebo-controlled, double-blind trial presented September 2013 found that a specific blend of pomegranate, green tea, turmeric, and broccoli—formulated together in a capsule called Pomi-T®—maintained healthy levels of prostate specific antigen (PSA).

Life Extension® now offers this same capsule for men who are serious about supporting and protecting their prostate as they age—by targeting PSA. The four foods in Pomi-T® have healthful benefits for your entire body. But their constituent molecules, naturally present in food, have now been shown to concentrate within prostate tissue and provide a rich array of complementary, prostate-supporting, PSA-modulating mechanisms.

Kyolic® Garlic Formula 102

New Zealand Whey Protein Concentrate, natural chocolate flavor, 660 grams
Item #01771

add to cart

As people age, they become more susceptible to muscle deterioration and a declining immune system. Fortunately, whey protein can have a positive impact on muscle construction and immunity due to its branched-chain amino acid profile (BCAAs) and naturally occurring lactoferrin and immunoglobins.

Unlike many commercial brands on the market, New Zealand Whey Protein Concentrate is uniquely derived from grass-fed, free range cows living healthy lives in New Zealand and not treated with growth hormone (rBST).

Life Extension's New Zealand Whey Protein Concentrate offers the following:

  • Non-GMO whey protein concentrate
  • Naturally high levels of essential branched-chain amino acids
  • High-quality muscle building protein
  • Easily mixes into water or milk
  • Great taste! Available in both natural chocolate and natural vanilla flavors.

Related Articles

Life Extension Update What's Hot
Reduced vitamin D levels associated with infection in ICU patients Higher vitamin D levels protect against hospital-acquired bloodstream infections
Correct vitamin D deficiency before surgery, orthopedist recommends Meta-analysis indicates preventive effect for vitamin D against risk of respiratory tract infection
Vitamin B3 offers superbug protection Immune function impairment correlated with reduced vitamin D levels
Life Extension Magazine® Health Topics
My recent life-altering event Bacterial infections
Unraveling a centuries-old mystery Surgical preparation
Death by medicine Trauma and wound healing