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Resveratrol helps with anti-aging and is found in grapes

Maximize the Effects of Resveratrol

Researchers have discovered a method to improve delivery of resveratrol throughout the body.

Scientifically reviewed by: Gary Gonzalez, MD, in November 2023. Written by: John Johnson.

The potential of resveratrol to beneficially impact our health and longevity has been studied for many years.

Research in animals and cells have shown it can delay certain aging processes.1-5

Human studies of resveratrol over the past decade have shown beneficial effects.6,7

Resveratrol, however, has poor bioavailability.

Scientists developed a formula that allows 10 times as much resveratrol to make it to cells, where it can exert an array of benefits.8

With this innovation, it is thought that resveratrol can better combat the effects of aging.

Activating Anti-Aging Processes

Resveratrol is a polyphenol compound found in red grapes, some berries, and several other plants.

Preclinical studies have shown that resveratrol activates multiple anti-aging processes.1-3,5

Some of the protective mechanisms demonstrated by resveratrol include:

  • Anti-inflammatory support,
  • Increased activity of sirtuins, cellular protector proteins linked to longer life,
  • Improvements in insulin sensitivity and other areas of metabolic health,
  • Preventing harmful changes to DNA associated with cellular dysfunction,
  • Improved function of energy-generating mitochondria,
  • Activating autophagy, cellular "housekeeping," and
  • Promoting a healthy mix of microorganisms to improve gut health.

Resveratrol has demonstrated beneficial effects on all the above anti-aging factors.1-3,5

Extending Life

Resveratrol can exert body-wide protection to help protect the heart, muscles, bones, kidneys.

It has also been shown to prolong overall life. In numerous studies of organisms from yeast to mice, resveratrol extends lifespan.2,3,9

For example, giving resveratrol to short-lived flies resulted in mean lifespan extension of up to 29%.9,10 In honeybees, it increased the maximum lifespan by 38%.11

Because of the long lifespan of humans, it is difficult to evaluate a nutrient's ability to extend life in clinical trials. However, human studies do indicate that resveratrol can reduce major contributors to premature aging.

Fighting Metabolic Disease

Low insulin sensitivity and poor glucose control are major contributors to the aging process. They can lead to type II diabetes and increased risk for cardiovascular disease, cancer, and dementia.

Human trials show that resveratrol intake benefits metabolic health in adults with diabetes or other signs of metabolic disease. Doses from 150 to 1,500 mg daily led to improvements in markers of healthy aging, including: 12

  • Increased insulin sensitivity and improvements in a marker of insulin function,12-18
  • Better blood glucose control,19 including lower levels of fasting glucose, post-meal glucose,14,18,20 and glycated hemoglobin HbA1c (a marker of long-term blood sugar control),12,15-19,21
  • Reduction in markers of nonalcoholic fatty liver disease,17,20
  • Improved cholesterol levels,16,21
  • Reduction in signs of oxidative stress13,22 and markers of inflammation,17,23,24
  • Increased sirtuin and AMPK activity,12
  • Lower blood pressure,12,16,21 and
  • Reduction in body weight, waist circumference, and body mass index.15

Being overweight or obese is associated with metabolic disease and contributes to rapid aging and risk for disease.

In a clinical trial of diabetics (type II) participants on oral blood sugar medications were recruited. One group received 200 mg of resveratrol daily for 24 weeks and another received a placebo. At the end of the trial, the resveratrol recipients had reductions in glucose and insulin, as well as reduced insulin resistance, compared to the beginning, and to the placebo group.24

In a double blinded crossover trial of healthy obese men, with a four-week washout period, taking 150 mg of resveratrol daily for 30 days resulted in beneficial changes to fat tissue, including decreasing the size of fat cells.17,25

One human placebo-controlled study found that 1 gram of resveratrol per day for 45 days, compared to a placebo, provided antidiabetic effects in patients with type I diabetes, a lifelong condition with no cure.22

Not only did resveratrol improve metabolic health, but it also helped guard against complications of metabolic disease in a clinical trial of diabetics with foot ulcers.

For example, nonhealing foot ulcers are a frequent problem in those with type II diabetes. Resveratrol increased the healing rate and reduced ulcer size. In a clinical trial of diabetics with foot ulcers 50 mg of resveratrol two times per day for 60 days promoted reduction in foot ulcer size in the treatment group as compared to placebo.26

In another trial, diabetics suffering from chronic gum and tooth disease who took 480 mg resveratrol per day for four weeks had a significant improvement in periodontal status along with improved insulin sensitivity as compared to the placebo.27

What You Need to Know

Protect Against Accelerated Aging

  • Resveratrol is a polyphenol found in red grapes and other plants. It helps defend cells against accelerated aging and risk for disease.
  • In animal models and cell experiments, resveratrol was capable of significantly extending lifespan.
  • In human trials, resveratrol countered many factors associated with rapid aging, including reducing oxidative stress and chronic inflammation, improving insulin sensitivity and glucose control, and enhancing heart function.
  • Encasing resveratrol in a hydrogel of plant-derived fiber boosts its bioavailability by more than 10 times.

Cardiovascular Benefits

Preliminary studies have shown that resveratrol can support metabolic health associated with cardiovascular disease risk. And it may protect against the development of atherosclerosis (buildup of plaque in arteries) and other heart disease.7 Now, clinical studies are confirming these findings.

One clinical trial published in 2023 included 80 patients with high blood pressure who were randomized to receive either 400 mg resveratrol or placebo for six months. Results showed that resveratrol protected the heart against remodeling (harmful changes in size and shape that affect cardiac functioning), while also protecting against left ventricular function fibrosis (scarring).28

In a double-blind, placebo-controlled trial, 40 heart attack patients were randomized to receive a 10 mg resveratrol capsule daily for three months or a placebo. After three months the resveratrol group showed improved heart function, blood vessel function, and LDL cholesterol levels as compared to placebo.29 Platelet aggregation, which can lead to abnormal blood clotting, was also reduced.

Better Bioavailability

Many researchers have long believed that resveratrol's effectiveness is limited by its poor bioavailability. The body's metabolism of unformulated resveratrol causes it to be rapidly cleared from the bloodstream and eliminated.

Scientists have discovered that encasing resveratrol in a hydrogel made of indigestible plant-derived fiber called galactomannans shields it from this process and makes it more bioavailable.

In a human trial, this hydrogel boosted the bioavailability of resveratrol by more than 10 times compared to that of standard resveratrol.8 That means 10 times more resveratrol stayed in the bloodstream to get delivered to cells.

It also stayed in the bloodstream longer, with a four-fold greater half-life than standard resveratrol.

That may help resveratrol to fully achieve its many benefits throughout the body.


Resveratrol counters many of the factors that contribute to accelerated aging and risk for disease.

Animal models have shown that it extends life and reduces risk of disease.

Human trials have found that resveratrol improves insulin sensitivity, reduces chronic inflammation and helps protect the heart, and more.

Encasing resveratrol in a hydrogel of plant-derived fiber dramatically improves the bioavailability of this nutrient.

If you have any questions on the scientific content of this article, please call a Life Extension Health Advisor at 1-866-864-3027.


  1. Barber TM, Kabisch S, Randeva HS, et al. Implications of Resveratrol in Obesity and Insulin Resistance: A State-of-the-Art Review. Nutrients.2022Jul 13;14(14).
  2. Uddin MJ, Farjana M, Moni A, et al. Prospective Pharmacological Potential of Resveratrol in Delaying Kidney Aging. Int J Mol Sci.2021Jul 31;22(15).
  3. Zhou DD, Luo M, Huang SY, et al. Effects and Mechanisms of Resveratrol on Aging and Age-Related Diseases. Oxid Med Cell Longev. 2021;2021:9932218.
  4. Zhang LX, Li CX, Kakar MU, et al. Resveratrol (RV): A pharmacological review and call for further research. Biomed Pharmacother. 2021Nov;143:112164.
  5. Meng X, Zhou J, Zhao CN, et al. Health Benefits and Molecular Mechanisms of Resveratrol: A Narrative Review. Foods.2020Mar 14;9(3):340.
  6. Berman AY, Motechin RA, Wiesenfeld MY, et al. The therapeutic potential of resveratrol: a review of clinical trials. NPJ Precis Oncol. 2017;1.
  7. Bonnefont-Rousselot D. Resveratrol and Cardiovascular Diseases. Nutrients.2016May 2;8(5).
  8. Joseph A, Balakrishnan A, Shanmughan P, et al. Micelle/Hydrogel Composite as a "Natural Self-Emulsifying Reversible Hybrid Hydrogel (N'SERH)" Enhances the Oral Bioavailability of Free (Unconjugated) Resveratrol. ACS Omega.2022Apr 19;7(15):12835-45.
  9. Bhullar KS, Hubbard BP. Lifespan and healthspan extension by resveratrol. Biochim Biophys Acta.2015Jun;1852(6):1209-18.
  10. Khan M, Park S, Kim HJ, et al. The Resveratrol Rice DJ526 Callus Significantly Increases the Lifespan of Drosophila (Resveratrol Rice DJ526 Callus for Longevity). Nutrients.2019Apr 29;11(5).
  11. Rascon B, Hubbard BP, Sinclair DA, et al. The lifespan extension effects of resveratrol are conserved in the honey bee and may be driven by a mechanism related to caloric restriction. Aging (Albany NY).2012Jul;4(7):499-508.
  12. Hausenblas HA, Schoulda JA, Smoliga JM. Resveratrol treatment as an adjunct to pharmacological management in type 2 diabetes mellitus--systematic review and meta-analysis. Mol Nutr Food Res.2015Jan;59(1):147-59.
  13. Brasnyo P, Molnar GA, Mohas M, et al. Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients. Br J Nutr.2011Aug;106(3):383-9.
  14. Crandall JP, Oram V, Trandafirescu G, et al. Pilot study of resveratrol in older adults with impaired glucose tolerance. J Gerontol A Biol Sci Med Sci. 2012Dec;67(12):1307-12.
  15. Mendez-del Villar M, Gonzalez-Ortiz M, Martinez-Abundis E, et al. Effect of resveratrol administration on metabolic syndrome, insulin sensitivity, and insulin secretion. Metab Syndr Relat Disord.2014Dec;12(10):497-501.
  16. Movahed A, Nabipour I, Lieben Louis X, et al. Antihyperglycemic effects of short term resveratrol supplementation in type 2 diabetic patients. Evid Based Complement Alternat Med.2013;2013:851267.
  17. Timmers S, Konings E, Bilet L, et al. Calorie restriction-like effects of 30 days of resveratrol supplementation on energy metabolism and metabolic profile in obese humans. Cell Metab.2011Nov 2;14(5):612-22.
  18. Zhu X, Wu C, Qiu S, et al. Effects of resveratrol on glucose control and insulin sensitivity in subjects with type 2 diabetes: systematic review and meta-analysis. Nutr Metab (Lond).2017;14:60.
  19. Liu K, Zhou R, Wang B, et al. Effect of resveratrol on glucose control and insulin sensitivity: a meta-analysis of 11 randomized controlled trials. Am J Clin Nutr.2014Jun;99(6):1510-9.
  20. Chen S, Zhao X, Ran L, et al. Resveratrol improves insulin resistance, glucose and lipid metabolism in patients with non-alcoholic fatty liver disease: a randomized controlled trial. Dig Liver Dis.2015Mar;47(3):226-32.
  21. Bhatt JK, Thomas S, Nanjan MJ. Resveratrol supplementation improves glycemic control in type 2 diabetes mellitus. Nutr Res.2012Jul;32(7):537-41.
  22. Movahed A, Raj P, Nabipour I, et al. Efficacy and Safety of Resveratrol in Type 1 Diabetes Patients: A Two-Month Preliminary Exploratory Trial. Nutrients.2020Jan 6;12(1).
  23. Garcia-Martinez BI, Ruiz-Ramos M, Pedraza-Chaverri J, et al. Effect of Resveratrol on Markers of Oxidative Stress and Sirtuin 1 in Elderly Adults with Type 2 Diabetes. Int J Mol Sci.2023Apr 18;24(8).
  24. Mahjabeen W, Khan DA, Mirza SA. Role of resveratrol supplementation in regulation of glucose hemostasis, inflammation and oxidative stress in patients with diabetes mellitus type 2: A randomized, placebo-controlled trial. Complement Ther Med.2022Jun;66:102819.
  25. Konings E, Timmers S, Boekschoten MV, et al. The effects of 30 days resveratrol supplementation on adipose tissue morphology and gene expression patterns in obese men. Int J Obes (Lond).2014Mar;38(3):470-3.
  26. Bashmakov YK, Assaad-Khalil SH, Abou Seif M, et al. Resveratrol promotes foot ulcer size reduction in type 2 diabetes patients. ISRN Endocrinol. 2014;2014:816307.
  27. Zare Javid A, Hormoznejad R, Yousefimanesh HA, et al. The Impact of Resveratrol Supplementation on Blood Glucose, Insulin, Insulin Resistance, Triglyceride, and Periodontal Markers in Type 2 Diabetic Patients with Chronic Periodontitis. Phytother Res.2017Jan;31(1):108-14.
  28. Zheng X, Hai J, Yang Y, et al. Effects of resveratrol supplementation on cardiac remodeling in hypertensive patients: a randomized controlled clinical trial. Hypertens Res.2023Jun;46(6):1493-503.
  29. Magyar K, Halmosi R, Palfi A, et al. Cardioprotection by resveratrol: A human clinical trial in patients with stable coronary artery disease. Clin Hemorheol Microcirc.2012;50(3):179-87.