Life Extension Magazine®

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Green Coffee Supports Metabolic and Heart Health

Human data show that 400 mg of unroasted green coffee extract containing chlorogenic acid can improve metabolic health, helping to reduce numerous risk factors for heart disease.

Scientifically reviewed by: Dr. Gary Gonzalez, MD, in July 2023. Written by: Stan Lewis.

Every day, 62% of American adults consume coffee. On average they drink more than three cups a day.1

This simple drink contains nutrients that have the potential to improve metabolic health2 and reduce risk for cardiovascular disease.2,3

But there's a problem. Nearly all coffee beans are roasted, which breaks down many of the beneficial nutrients and reduces their content.4

The solution: Unroasted green coffee.

The nutrients in coffee that are most protective against metabolic and cardiovascular diseases are found in greater concentrations in green coffee.5

Human trials show that taking green coffee extract can support healthy metabolism. This has been shown to help restore insulin sensitivity,2,6-8 lower blood sugar, and reduce other risk factors for heart disease.2,12-14

Metabolic Problems and Cardiovascular Disease

Aging adversely affects metabolism15 and metabolic health issues are widespread. These may include elevated blood glucose, high blood pressure, and abnormal cholesterol and triglyceride levels.16

When three or more of these issues occur together, the condition is known as metabolic syndrome.17

A stunning one in three adults in the U.S. has metabolic syndrome.18 This condition greatly increases the risks of type II diabetes, cardiovascular disease, heart attack, and stroke.

Metabolic abnormalities also accelerate the aging process and increase risk for several other conditions,19 including cognitive decline and dementia, kidney disease, liver disease, and cancer.

Green Coffee Extract

Coffee beans contain a wide array of health- promoting compounds with potent antioxidant and anti-inflammatory activity, particularly a polyphenol called chlorogenic acid.5

Chlorogenic acid is most abundant in green coffee.5

Coffee beans are usually roasted before brewing, which breaks down chlorogenic acid. Green coffee beans have not been roasted, leaving them higher in chlorogenic acid and other bioactive components.

Population and prospective studies have found associations between higher chlorogenic acid intake and reduced risk for several chronic diseases, including metabolic syndrome,12 liver disease,8,20 and others.2,12

Chlorogenic acid displays anti-diabetic,11 and blood pressure-lowering effects that may improve health markers associated with metabolic syndrome.5,8

Green coffee extracts are often standardized to contain high levels of chlorogenic acid and other beneficial compounds.

Restoring Insulin Sensitivity

Insulin sensitivity refers to the ability of cells to respond appropriately to the hormone insulin, which helps the body use blood sugar for energy.

In metabolic disease, insulin sensitivity drops. Cells cannot take up and utilize blood glucose as efficiently. The result is high blood sugar levels and increased risk for type II diabetes.

High glucose levels are catastrophic to tissues over time, causing damage that culminates as disorders of the heart, blood vessels, kidneys, eyes, and peripheral nerves.21

Studies suggest that green coffee and chlorogenic acid can help support healthy insulin function and restore insulin sensitivity.

In rodent models of metabolic disease, green coffee extract improves cellular energy metabolism, which results in improved blood glucose control and improved sensitivity to insulin.22-24

In human studies, green coffee extract intake significantly improved insulin sensitivity and lowered fasting blood glucose levels.2,6-8,12-14

Studies that used at least 400 mg daily of green coffee extract more consistently demonstrated a benefit than studies with lower doses.7

What You Need to Know

Promote Metabolic Health with Green Coffee

  • Metabolic disease is common with aging and increases the risk of type II diabetes, cardiovascular disease, heart attacks, and strokes.
  • Markers of metabolic disease include high blood pressure, high blood sugar, and abnormal blood lipid levels.
  • Green coffee extract, a potent source of the nutrient chlorogenic acid, improves many aspects of metabolic health.
  • In animal studies and human trials, taking green coffee extract improved insulin sensitivity, blood glucose levels, lipid levels, and blood pressure.
  • These and other improvements help to reduce the risk for type II diabetes and cardiovascular disease.

Other Effects of Green Coffee Extract

In addition to improved insulin sensitivity and glucose control, taking green coffee extract leads to improvements in many other areas of metabolic health.

Animal studies show that green coffee augments cellular energy metabolism and reduces triglycerides and blood pressure.22-24

One mouse study found that green coffee bean extract reversed insulin resistance by reducing expression of genes involved in inflammation.24

Human studies have found that green coffee intake leads to beneficial changes in key markers of metabolism. Among other benefits, taking green coffee extract:

  • Reduced waist circumference,2,8,11,25
  • Lowered total cholesterol, LDL ("bad") cholesterol, and triglyceride levels, while boosting protective HDL cholesterol,2,6,11,12,14
  • Decreased blood pressure,2,9,10,13 and
  • Reduced markers of systemic inflammation.14,20,26

All of these effects improve metabolic health and reduce the risk for cardiovascular disease.


Metabolic disease significantly increases risk for type II diabetes, cardiovascular disease, heart attacks, and strokes.

Green coffee extracts containing chlorogenic acid have demonstrated the ability to improve markers of metabolic health in animal studies and human trials.

Oral intake of at least 400 mg of green coffee extract daily may help increase insulin sensitivity, reduce high blood sugar, lower elevated blood pressure and cholesterol, and improve overall metabolic health.

If you have any questions on the scientific content of this article, please call a Life Extension Wellness Specialist at 1-866-864-3027.


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