Omega 3 Fatty Acids Alpha Lipoic Acid Slow Decline In Alzheimers Disease Patients

Omega-3 fatty acids, alpha lipoic acid slow decline in Alzheimer's disease patients

Omega-3 fatty acids, alpha lipoic acid slow decline in Alzheimer's disease patients

Tuesday, December 3, 2013. The Journal of Alzheimer's Disease published the outcome of a recent trial conducted by researchers at Oregon Health & Science University in Portland which revealed that supplementation with omega-3 fatty acids and alpha lipoic acid slowed functional and cognitive decline in Alzheimer's disease patients.

Lynne Shinto and colleagues randomized thirty-nine men and women with Alzheimer's disease to receive a daily regimen consisting of three grams fish oil concentrate (providing 975 milligrams EPA and 675 milligrams DHA), fish oil plus 600 milligrams R-alpha lipoic acid, or a placebo for one year. Blood tests and evaluations of cognitive and functional performance were administered before and after the treatment period.

In comparison with the placebo group, participants who received omega-3 fatty acids plus alpha lipoic acid demonstrated a lesser decline in the Mini-Mental State Examination, which is an evaluation of global cognitive function, and in the Instrumental Activities of Daily Living (IADL) evaluation of functional ability. Those who received omega-3 fatty acids alone also showed less functional decline as indicated by IADL performance.

As possible mechanisms for omega-3 fatty acids and alpha lipoic acid, the authors remark that DHA has been shown in animal studies to help protect nerve cells, and that lipoic acid delayed cognitive decline in two studies involving Alzheimer's disease patients. The nutrients may also help reduce inflammation.

"Combining omega-3 with lipoic acid slowed both cognitive and functional decline in mild to moderately impaired Alzheimer's disease participants over 12 months, and the combination appears to be safe at the doses evaluated," the authors conclude. "A larger pilot trial is underway to further assess the benefit and potential mechanism of action of this novel combination for Alzheimer's disease."


What's Hot


Rosemary extract shows promise for memory enhancement

What's Hot

Neuroscience 2013, held November 9-13, 2013 in San Diego, was the site of a presentation by Susan Farr, PhD of Saint Louis University of a benefit for extracts of rosemary and spearmint in an animal model of memory loss. The extracts contain antioxidants which help reduce aging-associated oxidative stress, which is believed to contribute to cognitive impairment that occurs among the aged.

Using the SAMP8 mouse model of accelerated aging, Dr Farr's team tested the effect of three different doses of two rosemary extracts containing 60% or 10% carnosic acid. They additionally tested three doses of a spearmint extract that contained 5% rosmarinic acid. Another group of mice that received an inert substance served as controls.

After 90 days of treatment, administration of three behavioral tests revealed that animals that received the highest dose of the rosemary extract containing 60% carnosic acid had the strongest memory and learning enhancement effects. Benefits were also observed in association with the rosemary extract that contained 10% carnosic acid and with the spearmint extract. A marker of oxidative stress was reduced in the brains of all animals that received rosemary or spearmint in comparison with the control group.

"We found that these proprietary compounds reduce deficits caused by mild cognitive impairment, which can be a precursor to Alzheimer's disease," reported Dr Farr. "This probably means eating spearmint and rosemary is good for you. However, our experiments were in an animal model and I don't know how much--or if any amount--of these herbs people would have to consume for learning and memory to improve."

"Our research suggests these extracts made from herbs might have beneficial effects on altering the course of age-associated cognitive decline," she added. "It's worth additional study."

2013 Super Sale Issue of Life Extension Magazine® now Available in Electronic Format


2013 Super Sale Issue of Life Extension Magazine® now Available in Electronic Format


Broad-spectrum protection against brain aging, by Arlan Myerson

Balancing appetite hormones to reduce hunger and lose weight, by Michael Downey

Turn off your body's aging "switch," by Morris Eagleton

Surprising effects of probiotics outside the intestinal tract, by Michael Downey

Safely boost your energy reserves, by Margaret Powell

Block dangerous inflammatory signaling, by Julius Warshovski

Unprecedented liver protection, by Roger Morrison

Protect against destructive migraines, by Stephen Grant

If you have any questions about this e-issue please send us an e‑mail or call toll-free 1-866-638-8083 anytime.

Latest Products

Rich Rewards™ Dark Chocolate, 120 grams
Item #01809


The negative effects associated with eating chocolate don't come from its cocoa content, but from the sugar. Finally, there's a new chocolate that has all of the great taste without the harmful sugar content.

Rich Rewards™ Dark Chocolate is a unique 70% dark chocolate that is 100% sweetened with nature's own sweetener—xylitol. Xylitol is a natural sweetener derived from woody, fibrous plant material such as corn cobs or trees. It's present in small amounts of various fruits and vegetables—and your body even makes considerable amounts of xylitol on its own. Xylitol is classified as a low glycemic carbohydrate, but unlike many carbs, this natural sweetener does not cause rapid rises in blood glucose. The caloric impact of xylitol is typically about 40% lower than other carbohydrates. In addition, xylitol may reduce the risk of tooth decay, making it a healthy addition to any diet.

Rich Rewards™ Dark Chocolate is

  • 100% natural
  • Low glycemic
  • Vegan
  • Gluten free
  • Lactose free
  • Kosher
Kyolic® Garlic Formula 102

Advanced Bio-Curcumin® with Ginger & Turmerones, 30 softgels
Item #01808

add to cart

Curcumin is an active compound derived from the Indian spice turmeric. It has been widely acclaimed for its diverse health-promoting effects on nearly every organ system in the body, including its support for the body's natural inflammatory response system. But most curcumin is neither absorbed well nor retained well in the blood—posing a challenge to those who wish to maximize its benefits.

Life Extension® took the lead in resolving this issue several years ago by introducing Super Bio-Curcumin® containing BCM-95®, a patented, bioenhanced preparation of curcumin that has been shown to reach up to seven times higher concentration in the blood than standard curcumin.

In addition to BCM-95®, this new curcumin formula contains:

  • Turmerones: After curcumin is extracted from turmeric, what remains is turmeric oil rich in compounds called turmerones. Combining BCM-95® with a high content of turmerones provides health consumers with more beneficial turmeric compounds that further multiply absorption.
  • Ginger: Curcumin and ginger are close botanical relatives. Research demonstrates that they have overlapping and complementary health benefits, and scientists are focusing on the therapeutic effects of combining these two plants.
  • Phospholipids

Related Articles

Life Extension Update What's Hot
Omega-3 users are different Experiments show Alzheimer's plaques reduced by vitamin D and DHA
DHA supplementation improves memory in older individuals An ounce of prevention . . .
Omega-3 fatty acid supplements slow cognitive decline in early Alzheimer's disease Scientists discover how fish oil helps protect the brain from Alzheimer's disease
Life Extension Magazine® Health Topics
Nutritional strategies to combat Alzheimer's Alzheimer's disease
Fighting depression and improving cognition with omega-3 fatty acids Age related cognitive decline
Lipoic acid    

Bio-Curcumin® and BCM-95® are registered trademarks of Dolcas-Biotech, LLC. U.S. Patent Nos. 7,883,728, 7,736,679 and 7,879,373