Newsletter

Newsletter

Pilot Trial Finds Boswellia Serrata Supplementation Associated with Reduced Arthritis Pain

September 10, 2019

Results of a double-blind, placebo-controlled trial reported in the May 2019 issue of Phytotherapy Research reveal a benefit for treatment with an extract of Boswellia serrata in men and women with osteoarthritis of the knee.

Gum resin derived from Boswellia serrata, commonly known as frankincense, has been used in Ayurvedic medicine for centuries and has more recently been the subject of scientific investigation that has added evidence to its anti-inflammatory and pain-relieving effects.

The trial included 42 participants between the ages of 35 and 75 years with newly diagnosed knee osteoarthritis. Subjects were given a placebo or tablets that contained Boswellia serrata extract to be consumed twice daily for 120 days.

Pain, stiffness and physical function were assessed at the beginning of the study and on days 30, 60, 90 and 120. Six-minute walking tests were conducted before the treatment period and at other visits. X-ray images obtained before and after the treatment period provided further information concerning treatment efficacy.

The safety of Boswellia serrata extract was evaluated using data collected during physical examinations conducted during each visit. Blood samples were analyzed for serum high-sensitivity C-reactive protein (hs-CRP), a marker of inflammation.

In comparison with the placebo, treatment with Boswellia serrata was associated with improvement in pain, stiffness and physical function by the end of the trial. Knee joint gap and bone spurs revealed by x-ray imaging also improved among those treated with Boswellia serrata. By the final visit, walking test scores had significantly improved in association with Boswellia serrata compared to the placebo.  

Boswellia serrata-treated individuals experienced a larger reduction in hs-CRP levels by the end of the study compared to the placebo group, indicating a greater decrease in inflammation. Treated patients also experienced more improvement in self-reported quality of life between the beginning and end of the trial. No serious adverse events occurred.

“This is the first study with Boswellia serrata extract conducted for a period of 120 days, longer than any other previous clinical trial on patients with osteoarthritis of the knee,” authors Muhammed Majeed and colleagues announce. They recommend further studies be conducted that include a larger number of subjects.

 

Latest Products

Optimized Broccoli and Cruciferous Blend
Promotes healthy cell division & hormone function
30 enteric coated tablets
Item #02368
Learn More $28.50
   
Bio-Quercetin
Highly absorbable quercetin for immune & cardiovascular support
30 vegetarian capsules
Item #02302
Learn More SALE: $6.00
   
 

Apply What You’ve Learned: Arthritis

 
  • The spaces between our bones are occupied by cartilage. Unlike many areas of the body, cartilage does not obtain its nourishment from a network of blood vessels, but from surrounding synovial fluid. Movement assists in the delivery of nutrients to cartilage cells. Therefore, exercise is one of the best ways to maintain the health of our joints. Exercise also improves joint support by enhancing muscle strength.
  • Glucosamine sulfate, chondroitin sulfate, curcumin, omega-3 fatty acids, vitamin D, S-adenosylmethionine and methylsulfonylmethane (MSM) are natural options that may help support joint health.1-7
  • Osteoarthritis is not an inevitable part of growing older. Avoidance of aggravating factors such as obesity, pro-inflammatory foods, high-impact sports and excessive oxidative stress caused by free radicals can help contribute to the maintenance of healthy joints.
  • For joint pain that does not go away, please consult your physician.

References

  1. Tsuji T et al Aging Clin Exp Res. 2016 Apr;28(2):197-205.
  2. Bishnoi M et al. Glycoconj J. 2016 Oct;33(5):693-705.
  3. Henrotin Y et al. Osteoarthritis Cartilage. 2010 Feb;18(2):141-9.
  4. Gruenwald J et al. Adv Ther. 2009 Sep;26(9):858-71.
  5. Zheng S et al. Am J Med. 2017 Oct;130(10):1211-1218.
  6. Hosea Blewett HJ et al. Crit Rev Food Sci Nutr. 2008 May;48(5):458-63.
  7. Butawan M et al. Nutrients. 2017 Mar 16;9(3).
 
 

September Lab Test Special


 

Energy Management Supplement Guide


So many supplements… it's easy to get confused. By answering a few simple questions, we will help you choose the energy supplements that are right for you.

Take the Quiz
 
 

What's Hot

Resveratrol boosts arthritis treatment
Read More

Health Concern

Osteoarthritis
Read More

 

Related Life Extension Magazine® Articles

 
 
 

Clinical Research Update

Clinical Research
 

Weight Management Program Study

Life Extension® is conducting a study to evaluate the effects of a Life Extension weight management program on body weight.

There is limited space so enroll today!

Easy to participate:

  • Overweight but generally healthy men and women, age 21 to 70
  • Able to read, speak and write English
  • Able to follow all study instructions and attend all scheduled visits
Easy to do:
  • This is a 60-day study requiring four visits to our Fort Lauderdale facility and two scheduled phone/email contacts.
  • You will take specified supplements and receive blood tests, blood pressure measurements, body composition analysis and more.
Limited spots available.

Enroll Now

Or call a study consultant for details:
1-866-517-4536
 
 
 

Find Out About Premier Premium Rewards

Premier is a subscription-based Life Extension rewards loyalty program. With Premier, you earn 4% LE Dollars back on eligible Life Extension purchases — twice as much as you would with Your Healthy Rewards, our free customer loyalty program. Premier participants also get unlimited free shipping on every order shipped to an address within the United States, including Alaska and Hawaii (U.S. territories excluded).

Premier gives you $50 LE Dollars instantly, which you can use now or save for later. This $50 instant credit offsets the cost of enrollment at sign-up and every time you renew.

Join or Learn More