People who discontinue using glucagon-like peptide-1 receptor agonist (GLP-1 RAs) medications often experience increased appetite and weight regain: challenges that can be helped with the addition of specific nutrients plus lifestyle improvements, according to a review published on July 3, 2026, in The Journal of Nutrition.¹

GLP-1Ras have revolutionized weight management. While GLP-1RA prescriptions have significantly increased, more than half of the people who have been prescribed these medications discontinue their use within the first year of treatment due to side effects and high cost. "Traditional dietary recommendations to maintain weight loss include eating breakfast, eating minimally processed foods, choosing foods higher in protein, fiber, and nutrients, and controlling portions and calorie intake," review author Brittany V. B. Johnson, PhD, RDN, wrote.  "A sole focus on only food intake misses opportunities to optimize long-term weight management."

She noted that green tea extract, green coffee bean extract and caffeine have been found to be generally safe and helpful for maintaining a healthy weight. Thermogenic ingredients, which may increase calorie expenditure, include capsaicinoids, the active components of chili peppers. Whey protein has been found to reduce hunger, weight and fat mass, in addition to helping support a higher protein need for weight maintenance. Fiber can reduce calorie intake during meals by improving satiety and reducing appetite.

A meta-analysis of 21 randomized, controlled trials found that alpha-lipoic acid was associated with a reduction in body mass index (BMI) and supported healthy weight. Alpha-lipoic acid, as well as mulberry leaf extract, cinnamon and vitamin D, are nutrients that improve glycemic control. Chromium picolinate helps stabilize blood glucose, aids in appetite control, and supports healthy body weight and BMI in overweight individuals.

"Lifestyle behaviors focused on healthy diets and exercise should lay the foundation for preventing weight gain," Dr Johnson recommended. She concluded that dietary additions "could potentially serve as an adjunct tool for patients transitioning off GLP-1RA treatments."