Robuvit® intake associated with improvements in work-related stress, oxidative stress

A group of nurses who received an extract of French oak wood known as Robuvit® had an improved response to stress, according to a recent pilot study.1  

The study included male and female nurses who were evaluated for signs of stress and fatigue as part of a cardiovascular screening program. All participants selected for the current study showed persistently higher levels of oxidative stress in screening measurements.

All participants received a self-care plan that recommended at least eight hours of sleep per night, going to bed no later than 10:30 pm, consuming a balanced diet with regular meals, reducing salt, sugar, and caffeine, limiting alcohol use, engaging in at least 20 minutes of exercise per day, limiting recreational screen time, and creating clear boundaries between time spent for work, and time spent for rest.

Half of the 40 participants received 300 milligrams per day of Robuvit® while the others did not.
After four weeks, compared to controls and the beginning of the study, the Robuvit® group had significant improvements in their average scores of overall physical and cognitive function in daily life, objective perception of fatigue, and all markers of professional attitude and stamina. The nurses taking Robuvit® also had reduced levels of oxidative stress compared to the control group.

“Professional stress leading to chronic, subclinical burnout may affect decisions, performance, essential management choices and eventually the quality of life for many dedicated individuals in high-intensity environments such as emergency care units,” authors Gianni Belcaro and associates observed. “The present study confirms previous investigations showing that Robuvit® provides the cells with the energy they need to cope with a stressful situation.”

“Robuvit® … appears to improve most symptoms related to work-induced fatigue, stress and cognitive function and supports stamina,” they concluded.

Robuvit® is a registered trademark of Horphag Research and the use of this product is under International patent applications.


Apply What You've Learned: Stress

  • Feelings of stress can be a normal reaction to a temporary situation; however, chronic stress has been associated with adverse physical symptoms and development of chronic disease.1 Lifestyle factors, including the intake of a nutritious diet, mild to moderate regular exercise, making time for relaxation, and obtaining adequate sleep are important for stress management.
  • Studies have provided evidence that certain herbs, including magnolia plus phellodendron, Holy basil, ashwagandha, Rhodiola rosea and more, may help support healthy stress management.2-6
  • Oxidative stress is another kind of stress. The term describes the condition in which oxidants and antioxidants are imbalanced within the cells, which can damage the body’s cells and tissues.7
  • Essential antioxidant nutrients such as beta-carotene, vitamins C and E, selenium and zinc help support a healthy balance between oxidants and antioxidants.8 Robuvit® also has been well studied and shown to decrease oxidative stress.9


  1. Agorastos A, Chrousos GP. Mol Psychiatry. 2021 Jul 21:1-2.
  2. Lee YJ et al. Pharmacol Ther. 2011 May;130(2):157-76.
  3. Talbott SM et al. J Int Soc Sports Nutr. 2013;10(1):37.
  4. Saxena RC et al. Evid Based Complement Alternat Med. 2012;2012:894509.
  5. Chandrasekhar K et al. Indian J Psychol Med. 2012 Jul;34(3):255-62.
  6. Kasper S et al. Neuropsychiatr Dis Treat. 2017 Mar 22;13:889-898.
  7. Pizzino G et al. Oxid Med Cell Longev.2017; 2017: 8416763.
  8. Shamseer L et al. Cochrane Database Syst Rev. 2010 Dec 8;(12):CD007020.
  9. Weichmann F et al. Journal of Medicinal Food. 2021 Jan 28.

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