In human trials, magnesium improved sleep quantity and quality and increased daytime productivity.

A major 2025 study found that brain tissue from people with dementia was low in lithium. The same study showed that low-dose lithium nearly restored memory in aging mice.

Activated AMPK may delay certain aging processes. In separate clinical trials, two AMPK-activating plant extracts trimmed belly fat, lowered blood glucose, and improved blood vessel activity.

Millions of Americans take a multivitamin. Many commercial multivitamin formulas, however, contain low potencies and fail to utilize enzymatically active nutrients.

Creatine improved cognition in Alzheimer’s patients; melatonin improved multiple sclerosis symptoms; how statins help prevent cancer; curcumin improved GI symptoms in obese women.

Two large observational studies found an association between glucosamine, commonly used to support joint and cartilage health, with a 15-27% reduced risk of mortality from any cause.